Dose-response for glucagonostatic effect of amylin in rats

Metabolism: Clinical and Experimental

Volumn 46, Issue 1, 1997, Pages 67-70

  Gedulin, Bronislava R ^a   Rink, Timothy J ^a   Young, Andrew A ^a  

^a AMYLIN PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; GLUCAGON; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HORMONE INHIBITION; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0031037318     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90170-0     Document Type: Article

References (21)

1. Ashcroft FM, Ashcroft SJH: Mechanism of insulin secretion, in Ashcroft FM, Ashcroft SJH (eds): Insulin: Molecular Biology to Pathology. New York, NY, Oxford University Press, 1992, pp 97-150
2. Argoud GM, Schade DS, Eaton RP: Insulin suppresses its own secretion in vivo. Diabetes 36:959-962, 1987
3. Dégano P, Silvestre RA, Salas M, et al: Amylin inhibits glucose-induced insulin secretion in a dose-dependent manner - Study in the perfused rat pancreas. Regul Pept 43:91-96, 1993
4. Raskin P, Fujita Y, Unger RH: Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics. J Clin Invest 56:1132-1138, 1975
5. Unger RH, Foster DW: Diabetes mellitus, in Wilson JD, Foster DW (eds): Williams Textbook of Endocrinology (ed 8). Philadelphia, PA, Saunders, 1992, pp 1273-1275
6. Samols E, Bonner-Weir S, Weir GC: Intra-islet insulin-glucagonsomatostatin relationships. Clin Endocrinol Metab 15:33-58, 1986
7. Ritzel R, Orskov C, Holst JJ, et al: Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response relationships. Diabetologia 38:720-725, 1995
8. Inoue K, Hiramatsu S, Hisatomi A, et al: Effects of amylin on the release of insulin and glucagon from the perfused rat pancreas. Horm Metab Res 25:135-137, 1993
9. Silvestre RA, Peiro E, Degano P, et al: Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas. Regul Pep 31:23-31, 1990
10. Young AA, Jodka CM, Green DE, et al: Inhibition of arginineinduced glucagon secretion by amylin in rats. Diabetes 44:238A, 1995 (abstr)
11. Lindsey CA, Faloona GR, Unger RH: Plasma glucagon levels during rapid exsanguination with and without adrenergic blockade. Diabetes 24:313-316, 1975
12. Young AA, Vine W, Gedulin BR, et al: Preclinical pharmacology of pramlintide in the rat: Comparisons with human and rat amylin. Drug Dev Res 37:231-248, 1996
13. Young AA, Wang MW, Cooper GJS: Amylin injection causes elevated plasma lactate and glucose in the rat. FEBS Lett 291:101-104, 1991
14. Vine W, Smith P, Lachappell R, et al: Lactate production from the rat hindlimb is increased after glucose administration and is suppressed by a selective amylin antagonist: Evidence for action of endogenous amylin in skeletal muscle. Biochem Biophys Res Commun 216:554-559, 1995
15. Pittner R, Beaumont K, Young A, et al: Dose-dependent elevation of cyclic AMP, activation of glycogen phosphorylase, and release of lactate by amylin in rat skeletal muscle. BBA-Mol Cell Res 1267:75-82, 1995
16. Pieber TR, Roitelman J, Lee Y, et al: Direct plasma radioimmunoassay for rat amylin-(1-37): Concentrations with acquired and genetic obesity. Am J Physiol 267:E156-E164, 1994
17. Young AA: Amylin regulation of fuel metabolism. J Cell Biochem 55:12-18, 1994
18. Young AA, Rink TJ, Wang MW: Dose response characteristics for the hyperglycemic, hyperlactemic, hypotensive and hypocalcemic actions of amylin and calcitonin gene-related peptide-I (CGRP-alpha) in the fasted, anaesthetized rat. Life Sci 52:1717-1726, 1993
19. Lickley HLA, Kemmer FW, Wasserman DH, et al: Glucagon and its relationship to other glucoregulatory hormones in exercise and stress in normal and diabetic subjects, in Lefèbvre PJ (ed): Glucagon, vol 2. Berlin, Germany, Springer-Verlag, 1983, pp 297-350
20. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
21. Bonner-Weir S, Orci L: New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes 31:883-889, 1982