메뉴 건너뛰기




Volumn 42, Issue 1, 2013, Pages 1-14

Brain Control of Insulin and Glucagon Secretion

Author keywords

Autonomic control of pancreas; Glucagon; Glucose sensing; Glucose stimulated insulin secretion; Hypoglycemia; Hypothalamus; Insulin; Islets of langerhans

Indexed keywords

ADENYLATE KINASE; GLUCAGON; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; MELANOCORTIN;

EID: 84873253557     PISSN: 08898529     EISSN: 15584410     Source Type: Journal    
DOI: 10.1016/j.ecl.2012.11.006     Document Type: Review
Times cited : (33)

References (85)
  • 1
    • 0014061137 scopus 로고
    • Effects of stimulation of the vagus nerve on insulin secretion
    • Kaneto A., Kosaka K., Nakao K. Effects of stimulation of the vagus nerve on insulin secretion. Endocrinology 1967, 80(3):530-536.
    • (1967) Endocrinology , vol.80 , Issue.3 , pp. 530-536
    • Kaneto, A.1    Kosaka, K.2    Nakao, K.3
  • 2
    • 0014104226 scopus 로고
    • Effect of vagotomy and vagal stimulation on insulin secretion
    • Frohman L.A., Ezdinli E.Z., Javid R. Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes 1967, 16(7):443-448.
    • (1967) Diabetes , vol.16 , Issue.7 , pp. 443-448
    • Frohman, L.A.1    Ezdinli, E.Z.2    Javid, R.3
  • 3
    • 0016732951 scopus 로고
    • Pancreatic endocrine responses to stimulation via the sympathetic innervation
    • Bloom S.R., Edwards A.V. Pancreatic endocrine responses to stimulation via the sympathetic innervation. J Physiol 1975, 245(2):120P-121P.
    • (1975) J Physiol , vol.245 , Issue.2
    • Bloom, S.R.1    Edwards, A.V.2
  • 4
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A., Lam T.K., Gutierrez-Juarez R., et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005, 434(7036):1026-1031.
    • (2005) Nature , vol.434 , Issue.7036 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3
  • 5
    • 0014776021 scopus 로고
    • Studies on pancreatic alpha cell function in normal and diabetic subjects
    • Unger R.H., Aquilar-Parado E., Muller W.A., et al. Studies on pancreatic alpha cell function in normal and diabetic subjects. J Clin Invest 1970, 49:837-848.
    • (1970) J Clin Invest , vol.49 , pp. 837-848
    • Unger, R.H.1    Aquilar-Parado, E.2    Muller, W.A.3
  • 6
    • 79551600048 scopus 로고    scopus 로고
    • Glucagon receptor knock-out prevents insulin-deficient type 1 diabetes in mice
    • Lee Y., Wang M.Y., Du X.Q., et al. Glucagon receptor knock-out prevents insulin-deficient type 1 diabetes in mice. Diabetes 2011, 60:391-397.
    • (2011) Diabetes , vol.60 , pp. 391-397
    • Lee, Y.1    Wang, M.Y.2    Du, X.Q.3
  • 7
    • 0014515508 scopus 로고
    • Increased insulin output following stimulation of the vagal supply to the perfused rabbit pancreas
    • Findlay J.A., Gill J.R., Lever J.D., et al. Increased insulin output following stimulation of the vagal supply to the perfused rabbit pancreas. J Anat 1969, 104(Pt 3):580.
    • (1969) J Anat , vol.104 , Issue.PART 3 , pp. 580
    • Findlay, J.A.1    Gill, J.R.2    Lever, J.D.3
  • 8
    • 0016708339 scopus 로고
    • The release of pancreatic glucagon and inhibition of insulin in response to stimulation of the sympathetic innervation
    • Bloom S.R., Edwards A.V. The release of pancreatic glucagon and inhibition of insulin in response to stimulation of the sympathetic innervation. J Physiol 1975, 253(1):157-173.
    • (1975) J Physiol , vol.253 , Issue.1 , pp. 157-173
    • Bloom, S.R.1    Edwards, A.V.2
  • 9
    • 0032426558 scopus 로고    scopus 로고
    • Autonomic brainstem projections to the pancreas: a retrograde transneuronal viral tracing study in the rat
    • Streefland C., Maes F.W., Bohus B. Autonomic brainstem projections to the pancreas: a retrograde transneuronal viral tracing study in the rat. J Auton Nerv Syst 1998, 74:71-81.
    • (1998) J Auton Nerv Syst , vol.74 , pp. 71-81
    • Streefland, C.1    Maes, F.W.2    Bohus, B.3
  • 10
    • 0022869282 scopus 로고
    • Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion
    • Ahrén B., Taborsky G.J., Porte D. Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion. Diabetologia 1986, 29(12):827-836.
    • (1986) Diabetologia , vol.29 , Issue.12 , pp. 827-836
    • Ahrén, B.1    Taborsky, G.J.2    Porte, D.3
  • 11
    • 0022552444 scopus 로고
    • Effect and mechanism of vagal nerve stimulation on somatostatin secretion in dogs
    • Ahren B., Paquette T.L., Taborsky G.J. Effect and mechanism of vagal nerve stimulation on somatostatin secretion in dogs. Am J Physiol 1986, 250:E212-E217.
    • (1986) Am J Physiol , vol.250
    • Ahren, B.1    Paquette, T.L.2    Taborsky, G.J.3
  • 12
    • 0018876506 scopus 로고
    • Cephalic insulin response as a test for completeness of vagotomy to the pancreas
    • Woods S.C., Bernstein I.L. Cephalic insulin response as a test for completeness of vagotomy to the pancreas. Physiol Behav 1980, 24:485-488.
    • (1980) Physiol Behav , vol.24 , pp. 485-488
    • Woods, S.C.1    Bernstein, I.L.2
  • 13
    • 0027141013 scopus 로고
    • Muscarinic receptor subtypes in carbachol-stimulated insulin and glucagon secretion in the mouse
    • Karlsson S., Ahren B. Muscarinic receptor subtypes in carbachol-stimulated insulin and glucagon secretion in the mouse. J Auton Pharmacol 1993, 13:439-446.
    • (1993) J Auton Pharmacol , vol.13 , pp. 439-446
    • Karlsson, S.1    Ahren, B.2
  • 14
    • 0030043558 scopus 로고    scopus 로고
    • Studies on the mechanisms by which gastrin releasing peptide stimulates insulin secretion from mouse islets
    • Gregersen S., Ahren B. Studies on the mechanisms by which gastrin releasing peptide stimulates insulin secretion from mouse islets. Pancreas 1996, 12:48-57.
    • (1996) Pancreas , vol.12 , pp. 48-57
    • Gregersen, S.1    Ahren, B.2
  • 15
    • 0030030660 scopus 로고    scopus 로고
    • A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide
    • Straub S.G., Sharp G.W. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide. J Biol Chem 1996, 271:1660-1668.
    • (1996) J Biol Chem , vol.271 , pp. 1660-1668
    • Straub, S.G.1    Sharp, G.W.2
  • 16
    • 0021287056 scopus 로고
    • Characteristics of the neuroendocrine responses to stimulation of the splanchnic nerves in bursts in the conscious calf
    • Bloom S.R., Edwards A.V. Characteristics of the neuroendocrine responses to stimulation of the splanchnic nerves in bursts in the conscious calf. J Physiol 1984, 346:533-545.
    • (1984) J Physiol , vol.346 , pp. 533-545
    • Bloom, S.R.1    Edwards, A.V.2
  • 18
    • 0019500867 scopus 로고
    • Effects of selective and nonselective beta-adrenergic agents on insulin secretion in vivo
    • Ahren B., Lundquist I. Effects of selective and nonselective beta-adrenergic agents on insulin secretion in vivo. Eur J Pharmacol 1981, 71:93-104.
    • (1981) Eur J Pharmacol , vol.71 , pp. 93-104
    • Ahren, B.1    Lundquist, I.2
  • 19
    • 0034001450 scopus 로고    scopus 로고
    • Autonomic regulation of islet hormone secretion. Implications for health and disease
    • Ahren B. Autonomic regulation of islet hormone secretion. Implications for health and disease. Diabetologia 2000, 43:393-410.
    • (2000) Diabetologia , vol.43 , pp. 393-410
    • Ahren, B.1
  • 20
    • 0030885584 scopus 로고    scopus 로고
    • CNS sites involved in sympathetic and parasympathetic control of the pancreas: a viral tracing study
    • Jansen A.S., Hoffman J.L., Loewy A.D. CNS sites involved in sympathetic and parasympathetic control of the pancreas: a viral tracing study. Brain Res 1997, 766:29-38.
    • (1997) Brain Res , vol.766 , pp. 29-38
    • Jansen, A.S.1    Hoffman, J.L.2    Loewy, A.D.3
  • 21
    • 0028788998 scopus 로고
    • Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response
    • Jansen A.S., Nguyen X.V., Karpitskiy V., et al. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 1995, 270:644-646.
    • (1995) Science , vol.270 , pp. 644-646
    • Jansen, A.S.1    Nguyen, X.V.2    Karpitskiy, V.3
  • 22
    • 0024378013 scopus 로고
    • CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus
    • Strack A.M., Sawyer W.B., Platt K.B., et al. CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res 1989, 491:274-296.
    • (1989) Brain Res , vol.491 , pp. 274-296
    • Strack, A.M.1    Sawyer, W.B.2    Platt, K.B.3
  • 23
    • 0028814649 scopus 로고
    • The nucleus raphe obscurus controls pancreatic hormone secretion in the rat
    • Krowicki Z.K., Hornby P.J. The nucleus raphe obscurus controls pancreatic hormone secretion in the rat. Am J Physiol 1995, 268(6 Pt 1):E1128-E1134.
    • (1995) Am J Physiol , vol.268 , Issue.6 PART 1
    • Krowicki, Z.K.1    Hornby, P.J.2
  • 24
    • 0029565899 scopus 로고
    • Pancreatic polypeptide, microinjected into the dorsal vagal complex, potentiates glucose-stimulated insulin secretion in the rat
    • Krowicki Z.K., Hornby P.J. Pancreatic polypeptide, microinjected into the dorsal vagal complex, potentiates glucose-stimulated insulin secretion in the rat. Regul Pept 1995, 60(2-3):185-192.
    • (1995) Regul Pept , vol.60 , Issue.2-3 , pp. 185-192
    • Krowicki, Z.K.1    Hornby, P.J.2
  • 25
    • 2942553044 scopus 로고    scopus 로고
    • Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei: involvement of astrocytes in cerebral glucose-sensing in rats
    • Guillod-Maximin E., Lorsignol A., Alquier T., et al. Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei: involvement of astrocytes in cerebral glucose-sensing in rats. J Neuroendocrinol 2004, 16(5):464-471.
    • (2004) J Neuroendocrinol , vol.16 , Issue.5 , pp. 464-471
    • Guillod-Maximin, E.1    Lorsignol, A.2    Alquier, T.3
  • 26
    • 33747039288 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing
    • Leloup C., Magnan C., Benani A., et al. Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes 2006, 55(7):2084-2090.
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 2084-2090
    • Leloup, C.1    Magnan, C.2    Benani, A.3
  • 27
    • 0036452672 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats
    • Clément L., Cruciani-Guglielmacci C., Magnan C., et al. Intracerebroventricular infusion of a triglyceride emulsion leads to both altered insulin secretion and hepatic glucose production in rats. Pflugers Arch 2002, 445(3):375-380.
    • (2002) Pflugers Arch , vol.445 , Issue.3 , pp. 375-380
    • Clément, L.1    Cruciani-Guglielmacci, C.2    Magnan, C.3
  • 28
    • 12144268025 scopus 로고    scopus 로고
    • Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats
    • Cruciani-Guglielmacci C., Hervalet A., Douared L., et al. Beta oxidation in the brain is required for the effects of non-esterified fatty acids on glucose-induced insulin secretion in rats. Diabetologia 2004, 47(11):2032-2038.
    • (2004) Diabetologia , vol.47 , Issue.11 , pp. 2032-2038
    • Cruciani-Guglielmacci, C.1    Hervalet, A.2    Douared, L.3
  • 29
    • 84856536388 scopus 로고    scopus 로고
    • Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion
    • Osundiji M.A., Lam D.D., Shaw J., et al. Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion. Diabetes 2012, 61(2):321-328.
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 321-328
    • Osundiji, M.A.1    Lam, D.D.2    Shaw, J.3
  • 30
    • 0017664740 scopus 로고
    • Immediate effect of lesion of the ventromedial hypothalamic area upon glucose-induced insulin secretion in anaesthetized rats
    • Rohner F., Dufour A.C., Karakash C., et al. Immediate effect of lesion of the ventromedial hypothalamic area upon glucose-induced insulin secretion in anaesthetized rats. Diabetologia 1977, 13(3):239-242.
    • (1977) Diabetologia , vol.13 , Issue.3 , pp. 239-242
    • Rohner, F.1    Dufour, A.C.2    Karakash, C.3
  • 31
    • 80055011903 scopus 로고    scopus 로고
    • Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain
    • Paranjape S.A., Chan O., Zhu W., et al. Chronic reduction of insulin receptors in the ventromedial hypothalamus produces glucose intolerance and islet dysfunction in the absence of weight gain. Am J Physiol Endocrinol Metab 2011, 301(5):E978-E983.
    • (2011) Am J Physiol Endocrinol Metab , vol.301 , Issue.5
    • Paranjape, S.A.1    Chan, O.2    Zhu, W.3
  • 32
    • 31044456099 scopus 로고    scopus 로고
    • Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
    • Knauf C., Cani P.D., Perrin C., et al. Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest 2005, 115(12):3554-3563.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3554-3563
    • Knauf, C.1    Cani, P.D.2    Perrin, C.3
  • 33
    • 79953889813 scopus 로고    scopus 로고
    • Inflammation of the hypothalamus leads to defective pancreatic islet function
    • Calegari V.C., Torsoni A.S., Vanzela E.C., et al. Inflammation of the hypothalamus leads to defective pancreatic islet function. J Biol Chem 2011, 286(15):12870-12880.
    • (2011) J Biol Chem , vol.286 , Issue.15 , pp. 12870-12880
    • Calegari, V.C.1    Torsoni, A.S.2    Vanzela, E.C.3
  • 34
    • 0034456475 scopus 로고    scopus 로고
    • The central melanocortin system can directly regulate serum insulin levels
    • Fan W., Dinulescu D.M., Butler A.A., et al. The central melanocortin system can directly regulate serum insulin levels. Endocrinology 2000, 141:3072-3079.
    • (2000) Endocrinology , vol.141 , pp. 3072-3079
    • Fan, W.1    Dinulescu, D.M.2    Butler, A.A.3
  • 35
    • 0038042206 scopus 로고    scopus 로고
    • Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms
    • Muzumdar R., Ma X., Yang X., et al. Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms. FASEB J 2003, 17(9):1130-1132.
    • (2003) FASEB J , vol.17 , Issue.9 , pp. 1130-1132
    • Muzumdar, R.1    Ma, X.2    Yang, X.3
  • 36
    • 78650912045 scopus 로고    scopus 로고
    • Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion
    • Martinelli C.E., Keogh J.M., Greenfield J.R., et al. Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. J Clin Endocrinol Metab 2011, 96(1):E181-E188.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.1
    • Martinelli, C.E.1    Keogh, J.M.2    Greenfield, J.R.3
  • 37
    • 79551555006 scopus 로고    scopus 로고
    • Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis
    • Rossi J., Balthasar N., Olson D., et al. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab 2011, 13:195-204.
    • (2011) Cell Metab , vol.13 , pp. 195-204
    • Rossi, J.1    Balthasar, N.2    Olson, D.3
  • 38
    • 0014709362 scopus 로고
    • Plasma insulin levels during imaginary food ingestion under hypnosis
    • Goldfine I.D., Abraira C., Gruenwald D., et al. Plasma insulin levels during imaginary food ingestion under hypnosis. Proc Soc Exp Biol Med 1970, 133:274-286.
    • (1970) Proc Soc Exp Biol Med , vol.133 , pp. 274-286
    • Goldfine, I.D.1    Abraira, C.2    Gruenwald, D.3
  • 40
    • 10444260480 scopus 로고    scopus 로고
    • The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904
    • Wood J. The first Nobel prize for integrated systems physiology: Ivan Petrovich Pavlov, 1904. Physiology (Bethesda) 2004, 19(6):326-330.
    • (2004) Physiology (Bethesda) , vol.19 , Issue.6 , pp. 326-330
    • Wood, J.1
  • 41
    • 0019997835 scopus 로고
    • Pancreatic secretory response to sham feeding in humans
    • Defilippi C.C., Solomon T.E., Valenzuela J.E. Pancreatic secretory response to sham feeding in humans. Digestion 1982, 23(4):217-223.
    • (1982) Digestion , vol.23 , Issue.4 , pp. 217-223
    • Defilippi, C.C.1    Solomon, T.E.2    Valenzuela, J.E.3
  • 42
    • 0014271360 scopus 로고
    • Cephalic phase of pancreatic secretion in man
    • Sarles H., Dani R., Prezelin G., et al. Cephalic phase of pancreatic secretion in man. Gut 1968, 9(2):214-221.
    • (1968) Gut , vol.9 , Issue.2 , pp. 214-221
    • Sarles, H.1    Dani, R.2    Prezelin, G.3
  • 43
    • 0027143882 scopus 로고
    • Cephalic-phase insulin in obese and normal-weight men: relation to postprandial insulin
    • Teff K.L., Mattes R.D., Engelman J., et al. Cephalic-phase insulin in obese and normal-weight men: relation to postprandial insulin. Metabolism 1993, 42:1600-1608.
    • (1993) Metabolism , vol.42 , pp. 1600-1608
    • Teff, K.L.1    Mattes, R.D.2    Engelman, J.3
  • 44
    • 0019459685 scopus 로고
    • Cephalic phase, reflex insulin secretion. Neuroanatomical and physiological characterization
    • Berthoud H.R., Bereiter D.A., Trimble E.R., et al. Cephalic phase, reflex insulin secretion. Neuroanatomical and physiological characterization. Diabetologia 1981, 20:393-401.
    • (1981) Diabetologia , vol.20 , pp. 393-401
    • Berthoud, H.R.1    Bereiter, D.A.2    Trimble, E.R.3
  • 45
    • 0026722978 scopus 로고
    • Parasympathetic involvement in rapid meal-associated conditioned insulin secretion in the rat
    • Strubbe J.H. Parasympathetic involvement in rapid meal-associated conditioned insulin secretion in the rat. Am J Physiol 1992, 263:R615-R618.
    • (1992) Am J Physiol , vol.263
    • Strubbe, J.H.1
  • 46
    • 0023274222 scopus 로고
    • Cephalic phase metabolic response in normal weight adults
    • Bruce D.G., Storlien L.H., Furler S.M., et al. Cephalic phase metabolic response in normal weight adults. Metabolism 1987, 36:721-725.
    • (1987) Metabolism , vol.36 , pp. 721-725
    • Bruce, D.G.1    Storlien, L.H.2    Furler, S.M.3
  • 47
    • 0019003702 scopus 로고
    • Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats
    • Berthoud H.R., Trimble E.R., Siegel E.G., et al. Cephalic-phase insulin secretion in normal and pancreatic islet-transplanted rats. Am J Physiol 1980, 238:E336-E340.
    • (1980) Am J Physiol , vol.238
    • Berthoud, H.R.1    Trimble, E.R.2    Siegel, E.G.3
  • 48
    • 0029554948 scopus 로고
    • Cephalic-phase insulin and glucagon release in normal subjects and in patients receiving pancreas transplantation
    • Secchi A., Caldara R., Caumo A., et al. Cephalic-phase insulin and glucagon release in normal subjects and in patients receiving pancreas transplantation. Metabolism 1995, 44:1153-1158.
    • (1995) Metabolism , vol.44 , pp. 1153-1158
    • Secchi, A.1    Caldara, R.2    Caumo, A.3
  • 49
    • 0021277392 scopus 로고
    • Oral glucose is the prime elicitor of preabsorptive insulin secretion
    • Grill H.J., Berridge K.C., Ganster D.J. Oral glucose is the prime elicitor of preabsorptive insulin secretion. Am J Physiol 1984, 246:R88-R95.
    • (1984) Am J Physiol , vol.246
    • Grill, H.J.1    Berridge, K.C.2    Ganster, D.J.3
  • 50
    • 0022457316 scopus 로고
    • Pre- and postabsorptive insulin secretion in chronic decerebrate rats
    • Flynn F.W., Berridge K.C., Grill H.J. Pre- and postabsorptive insulin secretion in chronic decerebrate rats. Am J Physiol 1986, 250:R539-R548.
    • (1986) Am J Physiol , vol.250
    • Flynn, F.W.1    Berridge, K.C.2    Grill, H.J.3
  • 51
    • 0025278729 scopus 로고
    • Identification of vagal preganglionics that mediate cephalic phase insulin response
    • Berthoud H.R., Powley T.L. Identification of vagal preganglionics that mediate cephalic phase insulin response. Am J Physiol 1990, 258(2 Pt 2):R523-R530.
    • (1990) Am J Physiol , vol.258 , Issue.2 PART 2
    • Berthoud, H.R.1    Powley, T.L.2
  • 52
    • 0019570590 scopus 로고
    • Prior vagotomy blocks VMH obesity in pair fed rats
    • Cox J.E., Powley T. Prior vagotomy blocks VMH obesity in pair fed rats. Am J Physiol 1981, 240:E573-E583.
    • (1981) Am J Physiol , vol.240
    • Cox, J.E.1    Powley, T.2
  • 53
    • 17444435435 scopus 로고
    • Sham feeding-induced cephalic phase insulin release in the rat
    • Berthoud H.R., Jeanrenaud B. Sham feeding-induced cephalic phase insulin release in the rat. Am J Physiol 1982, 242:E280-E285.
    • (1982) Am J Physiol , vol.242
    • Berthoud, H.R.1    Jeanrenaud, B.2
  • 54
    • 0035029806 scopus 로고    scopus 로고
    • The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia
    • Ahren B., Holst J. The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 2001, 50:1030-1038.
    • (2001) Diabetes , vol.50 , pp. 1030-1038
    • Ahren, B.1    Holst, J.2
  • 55
    • 0026602267 scopus 로고
    • Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
    • Mitrakou A., Kelley D., Mokam M., et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 1992, 326:22-29.
    • (1992) N Engl J Med , vol.326 , pp. 22-29
    • Mitrakou, A.1    Kelley, D.2    Mokam, M.3
  • 56
    • 0032941723 scopus 로고    scopus 로고
    • Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients
    • Bruttomesso D., Pianta A., Mari A., et al. Restoration of early rise in plasma insulin levels improves the glucose tolerance of type 2 diabetic patients. Diabetes 1999, 48:99-105.
    • (1999) Diabetes , vol.48 , pp. 99-105
    • Bruttomesso, D.1    Pianta, A.2    Mari, A.3
  • 57
    • 0029801084 scopus 로고    scopus 로고
    • Oral sensory stimulation improves glucose tolerance in humans: effects on insulin, C-peptide, and glucagon
    • Teff K.L., Engelman K. Oral sensory stimulation improves glucose tolerance in humans: effects on insulin, C-peptide, and glucagon. Am J Physiol 1996, 270:R1371-R1379.
    • (1996) Am J Physiol , vol.270
    • Teff, K.L.1    Engelman, K.2
  • 58
    • 0023273475 scopus 로고
    • Effect of sham-feeding on glucose tolerance and insulin secretion
    • Lorentzen M., Madsbad S., Kehlet H., et al. Effect of sham-feeding on glucose tolerance and insulin secretion. Acta Endocrinol (Copenh) 1987, 115:84-86.
    • (1987) Acta Endocrinol (Copenh) , vol.115 , pp. 84-86
    • Lorentzen, M.1    Madsbad, S.2    Kehlet, H.3
  • 59
    • 0023264686 scopus 로고
    • Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose
    • Calles-Escandon J., Robbins D.C. Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes 1987, 36:1167-1172.
    • (1987) Diabetes , vol.36 , pp. 1167-1172
    • Calles-Escandon, J.1    Robbins, D.C.2
  • 60
    • 84857408980 scopus 로고    scopus 로고
    • Minireview: glucagon in energy and stress homoeostasis
    • Jones B.J., Tan T., Bloom S.R. Minireview: glucagon in energy and stress homoeostasis. Endocrinology 2012, 153(3):1049-1054.
    • (2012) Endocrinology , vol.153 , Issue.3 , pp. 1049-1054
    • Jones, B.J.1    Tan, T.2    Bloom, S.R.3
  • 61
    • 2642593026 scopus 로고    scopus 로고
    • Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired beta-cell responses in type 1 diabetes
    • Taborsky G.J., Ahrén B., Havel P.J. Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired beta-cell responses in type 1 diabetes. Diabetes 1998, 47:995-1005.
    • (1998) Diabetes , vol.47 , pp. 995-1005
    • Taborsky, G.J.1    Ahrén, B.2    Havel, P.J.3
  • 62
    • 0024520153 scopus 로고
    • Role of brain in counterregulation of insulin-induced hypoglycemia in dogs
    • Biggers D.W., Myers S.R., Neal D., et al. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 1989, 38(1):7-16.
    • (1989) Diabetes , vol.38 , Issue.1 , pp. 7-16
    • Biggers, D.W.1    Myers, S.R.2    Neal, D.3
  • 63
    • 0027327113 scopus 로고
    • Counterregulation during hypoglycemia is directed by widespread brain regions
    • Frizzell R.T., Jones E.M., Davis S.N., et al. Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes 1993, 42(9):1253-1261.
    • (1993) Diabetes , vol.42 , Issue.9 , pp. 1253-1261
    • Frizzell, R.T.1    Jones, E.M.2    Davis, S.N.3
  • 64
    • 34248226806 scopus 로고    scopus 로고
    • Localized glucoprivation of hindbrain sites elicits corticosterone and glucagon secretion
    • Andrew S.F., Dinh T.T., Ritter S. Localized glucoprivation of hindbrain sites elicits corticosterone and glucagon secretion. Am J Physiol Regul Integr Comp Physiol 2007, 292(5):R1792-R1849.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292 , Issue.5
    • Andrew, S.F.1    Dinh, T.T.2    Ritter, S.3
  • 65
    • 48449097409 scopus 로고    scopus 로고
    • Describe GS and GI. The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing
    • Saberi M., Bohland M., Donovan C.M. Describe GS and GI. The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing. Diabetes 2008, 57(5):1380-1386.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1380-1386
    • Saberi, M.1    Bohland, M.2    Donovan, C.M.3
  • 66
    • 77957608055 scopus 로고    scopus 로고
    • The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia
    • Zhou L., Podolsky N., Sang Z., et al. The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia. Diabetes 2010, 59(10):2646-2652.
    • (2010) Diabetes , vol.59 , Issue.10 , pp. 2646-2652
    • Zhou, L.1    Podolsky, N.2    Sang, Z.3
  • 67
    • 84859402380 scopus 로고    scopus 로고
    • Recurrent hypoglycemia is associated with loss of activation in rat brain cingulate cortex
    • Hurst P., Garfield A.S., Marrow C., et al. Recurrent hypoglycemia is associated with loss of activation in rat brain cingulate cortex. Endocrinology 2012, 153(4):1908-1914.
    • (2012) Endocrinology , vol.153 , Issue.4 , pp. 1908-1914
    • Hurst, P.1    Garfield, A.S.2    Marrow, C.3
  • 68
    • 0028296222 scopus 로고
    • Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia
    • Borg W.P., During M.J., Sherwin R.S., et al. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 1994, 93(4):1677-1682.
    • (1994) J Clin Invest , vol.93 , Issue.4 , pp. 1677-1682
    • Borg, W.P.1    During, M.J.2    Sherwin, R.S.3
  • 69
    • 0028931891 scopus 로고
    • Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release
    • Borg W.P., Sherwin R.S., During M.J., et al. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 1995, 44(2):180-184.
    • (1995) Diabetes , vol.44 , Issue.2 , pp. 180-184
    • Borg, W.P.1    Sherwin, R.S.2    During, M.J.3
  • 70
    • 0031038124 scopus 로고    scopus 로고
    • Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
    • Borg M.A., Sherwin R.S., Borg W.P., et al. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 1997, 99(2):361-365.
    • (1997) J Clin Invest , vol.99 , Issue.2 , pp. 361-365
    • Borg, M.A.1    Sherwin, R.S.2    Borg, W.P.3
  • 71
    • 34247616021 scopus 로고    scopus 로고
    • Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    • Tong Q., Ye C., McCrimmon R.J., et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 2007, 5(5):383-393.
    • (2007) Cell Metab , vol.5 , Issue.5 , pp. 383-393
    • Tong, Q.1    Ye, C.2    McCrimmon, R.J.3
  • 72
    • 4644298411 scopus 로고    scopus 로고
    • + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
    • + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 2004, 53(10):2542-2551.
    • (2004) Diabetes , vol.53 , Issue.10 , pp. 2542-2551
    • Evans, M.L.1    McCrimmon, R.J.2    Flanagan, D.E.3
  • 73
    • 33644696261 scopus 로고    scopus 로고
    • + channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    • + channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes 2005, 54(11):3169-3174.
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3169-3174
    • McCrimmon, R.J.1    Evans, M.L.2    Fan, X.3
  • 74
    • 0035042796 scopus 로고    scopus 로고
    • + channels in the hypothalamus are essential for the maintenance of glucose homeostasis
    • + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 2001, 4(5):507-512.
    • (2001) Nat Neurosci , vol.4 , Issue.5 , pp. 507-512
    • Miki, T.1    Liss, B.2    Minami, K.3
  • 75
    • 34047114378 scopus 로고    scopus 로고
    • ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia
    • Chan O., Lawson M., Zhu W., et al. ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes 2007, 56:1120-1126.
    • (2007) Diabetes , vol.56 , pp. 1120-1126
    • Chan, O.1    Lawson, M.2    Zhu, W.3
  • 76
    • 33745327159 scopus 로고    scopus 로고
    • Sherwin RS blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia
    • Chan O., Zhu W., Ding Y., et al. Sherwin RS blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 2006, 55(4):1080-1087.
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1080-1087
    • Chan, O.1    Zhu, W.2    Ding, Y.3
  • 77
    • 77950805120 scopus 로고    scopus 로고
    • Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia
    • Zhu W., Czyzyk D., Paranjape S.A., et al. Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. Am J Physiol Endocrinol Metab 2010, 298(5):E971-E977.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.5
    • Zhu, W.1    Czyzyk, D.2    Paranjape, S.A.3
  • 78
    • 48449103821 scopus 로고    scopus 로고
    • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia
    • Levin B.E., Becker T.C., Eiki J.-I., et al. Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Diabetes 2008, 57(5):1371-1379.
    • (2008) Diabetes , vol.57 , Issue.5 , pp. 1371-1379
    • Levin, B.E.1    Becker, T.C.2    Eiki, J.-I.3
  • 79
    • 84873255936 scopus 로고    scopus 로고
    • Increased counter-regulatory responses to hypoglycaemia in mice with mutant glucokinase
    • A84
    • Hurst P.H., Marsh W., Riches C.R., et al. Increased counter-regulatory responses to hypoglycaemia in mice with mutant glucokinase. Diabet Med 2011, 28(Suppl 1):30-31. A84.
    • (2011) Diabet Med , vol.28 , Issue.SUPPL 1 , pp. 30-31
    • Hurst, P.H.1    Marsh, W.2    Riches, C.R.3
  • 80
    • 82655180434 scopus 로고    scopus 로고
    • BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding
    • Osundiji M.A., Godes M.L., Evans M.L., et al. BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding. PLoS One 2011, 6(12):e28016.
    • (2011) PLoS One , vol.6 , Issue.12
    • Osundiji, M.A.1    Godes, M.L.2    Evans, M.L.3
  • 81
    • 0034604731 scopus 로고    scopus 로고
    • Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
    • Thorens B., Guillam M.T., Beermann F., et al. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 2000, 275(31):23751-23758.
    • (2000) J Biol Chem , vol.275 , Issue.31 , pp. 23751-23758
    • Thorens, B.1    Guillam, M.T.2    Beermann, F.3
  • 82
    • 31044444108 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors
    • Marty N., Dallaporta M., Foretz M., et al. Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest 2005, 115(12):3545-3553.
    • (2005) J Clin Invest , vol.115 , Issue.12 , pp. 3545-3553
    • Marty, N.1    Dallaporta, M.2    Foretz, M.3
  • 83
    • 84866113299 scopus 로고    scopus 로고
    • Ashford ML mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
    • Beall C., Hamilton D.L., Gallagher J., et al. Ashford ML mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia 2012, 55(9):2432-2444.
    • (2012) Diabetologia , vol.55 , Issue.9 , pp. 2432-2444
    • Beall, C.1    Hamilton, D.L.2    Gallagher, J.3
  • 84
    • 40749132626 scopus 로고    scopus 로고
    • Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    • McCrimmon R.J., Shaw M., Fan X., et al. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes 2008, 57(2):444-450.
    • (2008) Diabetes , vol.57 , Issue.2 , pp. 444-450
    • McCrimmon, R.J.1    Shaw, M.2    Fan, X.3
  • 85
    • 33748296106 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    • McCrimmon R.J., Fan X., Cheng H., et al. Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes 2006, 55(6):1755-1760.
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1755-1760
    • McCrimmon, R.J.1    Fan, X.2    Cheng, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.