메뉴 건너뛰기




Volumn 3, Issue 2, 2014, Pages 46-62

Metastatic cancer stem cells: From the concept to therapeutics

Author keywords

Cancer stem cells; Invasion and metastasis; Therapeutics

Indexed keywords

ABC TRANSPORTER; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ARF PROTEIN; BIOLOGICAL MARKER; CD133 ANTIGEN; CD24 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; COLLAGENASE 3; DIPEPTIDYL PEPTIDASE IV; EPITHELIAL CELL ADHESION MOLECULE; GELATINASE A; GELATINASE B; HERMES ANTIGEN; NESTIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PRION PROTEIN; PROTEIN P53; STROMAL CELL DERIVED FACTOR 1; TELOMERASE; THROMBOPOIETIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN;

EID: 84906922339     PISSN: None     EISSN: 21604150     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (91)

References (170)
  • 1
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specific colonization
    • Nguyen DX, Bos PD and Massague J. Metasta-sis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009; 9: 274-284.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 2
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S and Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275-292.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 3
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AF and Groom AC. Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. Am J Patho 1998; 153: 865-873.
    • (1998) Am J Patho , vol.153 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 5
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • Li F, Tiede B, Massague J and Kang Y. Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 2007; 17: 3-14.
    • (2007) Cell Res , vol.17 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 6
    • 34748866686 scopus 로고    scopus 로고
    • Signaling pathways in cancer and embryonic stem cells
    • Dreesen O and Brivanlou AH. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 2007; 3: 7-17.
    • (2007) Stem Cell Rev , vol.3 , pp. 7-17
    • Dreesen, O.1    Brivanlou, A.H.2
  • 7
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • Baumann M, Krause M and Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 2008; 8: 545-554.
    • (2008) Nat Rev Cancer , vol.8 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 12
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O’Brien CA, Pollett A, Gallinger S and Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007; 445: 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • Ca, O.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 13
    • 33344476038 scopus 로고    scopus 로고
    • Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice
    • Huynh CK, Brodie AM and Njar VC. Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tu-mour xenografts in SCID mice. Br J Cancer 2006; 94: 513-523.
    • (2006) Br J Cancer , vol.94 , pp. 513-523
    • Huynh, C.K.1    Brodie, A.M.2    Njar, V.C.3
  • 14
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins AT, Berry PA, Hyde C, Stower MJ and Maitland NJ. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005; 65: 10946-10951.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3    Stower, M.J.4    Maitland, N.J.5
  • 16
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • Dalerba P, Cho RW and Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med 2007; 58: 267-284.
    • (2007) Annu Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 17
    • 84876489727 scopus 로고    scopus 로고
    • Cancer stem cells: The challenges ahead
    • Medema JP. Cancer stem cells: The challenges ahead. Nat Cell Biol 2013; 15: 338-344.
    • (2013) Nat Cell Biol , vol.15 , pp. 338-344
    • Medema, J.P.1
  • 18
    • 84863987696 scopus 로고    scopus 로고
    • Telomeres: Stem cells, cancer and telomerase linked by WNT
    • Stower H. Telomeres: stem cells, cancer and telomerase linked by WNT. Nat Rev Genet 2012; 13: 521.
    • (2012) Nat Rev Genet , vol.13 , pp. 521
    • Stower, H.1
  • 19
    • 73649139235 scopus 로고    scopus 로고
    • Side population and cancer stem cells: Therapeutic implications
    • Moserle L, Ghisi M, Amadori A and Indraccolo S. Side population and cancer stem cells: therapeutic implications. Cancer Lett 2010; 288: 1-9.
    • (2010) Cancer Lett , vol.288 , pp. 1-9
    • Moserle, L.1    Ghisi, M.2    Amadori, A.3    Indraccolo, S.4
  • 20
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli I and Trumpp A. The evolving concept of cancer and metastasis stem cells. J Cell Biol 2012; 198: 281-293.
    • (2012) J Cell Biol , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 21
    • 78650035864 scopus 로고    scopus 로고
    • Cancer stem cells: Problems for therapy?
    • Alison MR, Lim SM and Nicholson LJ. Cancer stem cells: problems for therapy? J Pathol 2011; 223: 147-161.
    • (2011) J Pathol , vol.223 , pp. 147-161
    • Alison, M.R.1    Lim, S.M.2    Nicholson, L.J.3
  • 24
    • 65849401051 scopus 로고    scopus 로고
    • The tortoise and the hair: Slow-cycling cells in the stem cell race
    • Fuchs E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 2009; 137: 811-819.
    • (2009) Cell , vol.137 , pp. 811-819
    • Fuchs, E.1
  • 28
    • 84860332933 scopus 로고    scopus 로고
    • Cancer stem cells and tumor angiogenesis
    • Ribatti D. Cancer stem cells and tumor angiogenesis. Cancer Lett 2012; 321: 13-17.
    • (2012) Cancer Lett , vol.321 , pp. 13-17
    • Ribatti, D.1
  • 30
    • 77955060375 scopus 로고    scopus 로고
    • Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis
    • Ye XZ, Yu SC and Bian XW. Contribution of myeloid-derived suppressor cells to tumor-induced immune suppression, angiogenesis, invasion and metastasis. J Genet Genomics 2010; 37: 423-430.
    • (2010) J Genet Genomics , vol.37 , pp. 423-430
    • Ye, X.Z.1    Yu, S.C.2    Bian, X.W.3
  • 31
    • 80052666824 scopus 로고    scopus 로고
    • Contribution of cancer stem cells to tumor vasculogenic mimicry
    • Yao XH, Ping YF and Bian XW. Contribution of cancer stem cells to tumor vasculogenic mimicry. Protein Cell 2011; 2: 266-272.
    • (2011) Protein Cell , vol.2 , pp. 266-272
    • Yao, X.H.1    Ping, Y.F.2    Bian, X.W.3
  • 33
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D and Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 34
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • Wang Y, Yang J, Zheng H, Tomasek GJ, Zhang P, McKeever PE, Lee EY and Zhu Y. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. CanCer Cell 2009; 15: 514-526.
    • (2009) CanCer Cell , vol.15 , pp. 514-526
    • Wang, Y.1    Yang, J.2    Zheng, H.3    Tomasek, G.J.4    Zhang, P.5    McKeever, P.E.6    Lee, E.Y.7    Zhu, Y.8
  • 38
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 2006; 126: 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 39
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K and Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 41
    • 34249880066 scopus 로고    scopus 로고
    • Generation of germline-competent induced pluripotent stem cells
    • Okita K, Ichisaka T and Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007; 448: 313-317.
    • (2007) Nature , vol.448 , pp. 313-317
    • Okita, K.1    Ichisaka, T.2    Yamanaka, S.3
  • 47
    • 84857789336 scopus 로고    scopus 로고
    • Understanding cancer stem cell heterogeneity and plasticity
    • Tang DG. Understanding cancer stem cell heterogeneity and plasticity. Cell Res 2012; 22: 457-472.
    • (2012) Cell Res , vol.22 , pp. 457-472
    • Tang, D.G.1
  • 51
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
    • Hope KJ, Jin L and Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 2004; 5: 738-743.
    • (2004) Nat Immunol , vol.5 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 53
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • Park SY, Gonen M, Kim HJ, Michor F and Polyak K. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest 2010; 120: 636-644.
    • (2010) J Clin Invest , vol.120 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 55
    • 0345743651 scopus 로고    scopus 로고
    • Stem cell plasticity: The growing potential of cellular therapy
    • Horwitz EM. Stem cell plasticity: the growing potential of cellular therapy. Arch Med Res 2003; 34: 600-606.
    • (2003) Arch Med Res , vol.34 , pp. 600-606
    • Horwitz, E.M.1
  • 66
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S and Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275-292.
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 68
    • 0037708932 scopus 로고    scopus 로고
    • Metastatic potential: Generic predisposition of the primary tumor or rare, metastatic variants-or both?
    • Hynes RO. Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell 2003; 113: 821-823.
    • (2003) Cell , vol.113 , pp. 821-823
    • Hynes, R.O.1
  • 69
    • 0037158692 scopus 로고    scopus 로고
    • A progression puzzle
    • Bernards R and Weinberg RA. A progression puzzle. Nature 2002; 418: 823.
    • (2002) Nature , vol.418 , pp. 823
    • Bernards, R.1    Weinberg, R.A.2
  • 70
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY and Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 72
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repres-sors
    • Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M and Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transi-tions: a comparison with Snail and E47 repres-sors. J Cell Sci 2003; 116: 499-511.
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 74
    • 41649109459 scopus 로고    scopus 로고
    • Zeb1 links epithelial-mesenchymal transition and cellular senescence
    • Liu Y, El-Naggar S, Darling DS, Higashi Y and Dean DC. Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development 2008; 135: 579-588.
    • (2008) Development , vol.135 , pp. 579-588
    • Liu, Y.1    El-Naggar, S.2    Darling, D.S.3    Higashi, Y.4    Dean, D.C.5
  • 76
    • 65349132693 scopus 로고    scopus 로고
    • EMT, the cytoskeleton, and cancer cell invasion
    • Yilmaz M and Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28: 15-33.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 15-33
    • Yilmaz, M.1    Christofori, G.2
  • 78
    • 34548175512 scopus 로고    scopus 로고
    • Signaling net-works guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas A and Heldin CH. Signaling net-works guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 2007; 98: 1512-1520.
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 79
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K and Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9: 265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 80
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque H, Adams MS, Fishwick K, Bronner-Fraser M and Nieto MA. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J Clin Invest 2009; 119: 1438-1449.
    • (2009) J Clin Invest , vol.119 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 84
    • 79959863770 scopus 로고    scopus 로고
    • TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype
    • Asiedu MK, Ingle JN, Behrens MD, Radisky DC and Knutson KL. TGFbeta/TNF(alpha)-mediated epithelial-mesenchymal transition generates breast cancer stem cells with a claudin-low phenotype. Cancer Res 2011; 71: 4707-4719.
    • (2011) Cancer Res , vol.71 , pp. 4707-4719
    • Asiedu, M.K.1    Ingle, J.N.2    Behrens, M.D.3    Radisky, D.C.4    Knutson, K.L.5
  • 85
    • 79961126637 scopus 로고    scopus 로고
    • Gastric cancer stem-like cells possess higher capability of invasion and metastasis in association with a mesenchymal transition phenotype
    • Yang L, Ping YF, Yu X, Qian F, Guo ZJ, Qian C, Cui YH and Bian XW. Gastric cancer stem-like cells possess higher capability of invasion and metastasis in association with a mesenchymal transition phenotype. Cancer Lett 2011; 310: 46-52.
    • (2011) Cancer Lett , vol.310 , pp. 46-52
    • Yang, L.1    Ping, Y.F.2    Yu, X.3    Qian, F.4    Guo, Z.J.5    Qian, C.6    Cui, Y.H.7    Bian, X.W.8
  • 86
    • 79958003343 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget
    • Zlobec I and Lugli A. Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget. Oncotarget 2010; 1: 651-661.
    • (2010) Oncotarget , vol.1 , pp. 651-661
    • Zlobec, I.1    Lugli, A.2
  • 87
    • 80054728467 scopus 로고    scopus 로고
    • Prognostic significance of tumor budding in gastrointestinal tumors
    • Markl B and Arnholdt HM. Prognostic significance of tumor budding in gastrointestinal tumors. Expert Rev Anticancer Ther 2011; 11: 1521-1533.
    • (2011) Expert Rev Anticancer Ther , vol.11 , pp. 1521-1533
    • Markl, B.1    Arnholdt, H.M.2
  • 89
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S and Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22: 725-736.
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 94
    • 75849140296 scopus 로고    scopus 로고
    • Circulating tumor cells: A window into cancer biology and metastasis
    • Maheswaran S and Haber DA. Circulating tumor cells: a window into cancer biology and metastasis. Curr Opin Genet Dev 2010; 20: 96-99.
    • (2010) Curr Opin Genet Dev , vol.20 , pp. 96-99
    • Maheswaran, S.1    Haber, D.A.2
  • 95
    • 33750306612 scopus 로고    scopus 로고
    • Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype
    • Balic M, Lin H, Young L, Hawes D, Giuliano A, McNamara G, Datar RH and Cote RJ. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 2006; 12: 5615-5621.
    • (2006) Clin Cancer Res , vol.12 , pp. 5615-5621
    • Balic, M.1    Lin, H.2    Young, L.3    Hawes, D.4    Giuliano, A.5    McNamara, G.6    Datar, R.H.7    Cote, R.J.8
  • 97
    • 84876111096 scopus 로고    scopus 로고
    • Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection
    • Sun YF, Xu Y, Yang XR, Guo W, Zhang X, Qiu SJ, Shi RY, Hu B, Zhou J and Fan J. Circulating stem cell-like epithelial cell adhesion molecule-positive tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection. Hepatology 2013; 57: 1458-1468.
    • (2013) Hepatology , vol.57 , pp. 1458-1468
    • Sun, Y.F.1    Xu, Y.2    Yang, X.R.3    Guo, W.4    Zhang, X.5    Qiu, S.J.6    Shi, R.Y.7    Hu, B.8    Zhou, J.9    Fan, J.10
  • 100
    • 84855987633 scopus 로고    scopus 로고
    • Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells
    • Kasimir-Bauer S, Hoffmann O, Wallwiener D, Kimmig R and Fehm T. Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells. Breast Cancer Res 2012; 14: R15.
    • (2012) Breast Cancer Res , vol.14 , pp. R15
    • Kasimir-Bauer, S.1    Hoffmann, O.2    Wallwiener, D.3    Kimmig, R.4    Fehm, T.5
  • 101
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R and Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast CanCer Res 2009; 11: R46.
    • (2009) Breast CanCer Res , vol.11 , pp. R46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 103
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 1989; 8: 98-101.
    • (1889) Cancer Metastasis Rev , vol.1989 , Issue.8 , pp. 98-101
    • Paget, S.1
  • 104
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The ‘seed and soil’ hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 2003; 3: 453-458.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 105
    • 33644826473 scopus 로고    scopus 로고
    • Roots and stems: Stem cells in cancer
    • Polyak K and Hahn WC. Roots and stems: stem cells in cancer. Nat Med 2006; 12: 296-300.
    • (2006) Nat Med , vol.12 , pp. 296-300
    • Polyak, K.1    Hahn, W.C.2
  • 106
    • 33750339604 scopus 로고    scopus 로고
    • Cancer stem cells and metastasis: Lethal seeds
    • Wicha MS. Cancer stem cells and metastasis: lethal seeds. Clin Cancer Res 2006; 12: 5606-5607.
    • (2006) Clin Cancer Res , vol.12 , pp. 5606-5607
    • Wicha, M.S.1
  • 110
    • 28544440733 scopus 로고    scopus 로고
    • Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells
    • Su L, Zhang J, Xu H, Wang Y, Chu Y, Liu R and Xiong S. Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells. Clin CanCer Res 2005; 11: 8273-8280.
    • (2005) Clin CanCer Res , vol.11 , pp. 8273-8280
    • Su, L.1    Zhang, J.2    Xu, H.3    Wang, Y.4    Chu, Y.5    Liu, R.6    Xiong, S.7
  • 111
    • 46849102804 scopus 로고    scopus 로고
    • New insights on the role of CXCR4 in cancer metastasis
    • Zlotnik A. New insights on the role of CXCR4 in cancer metastasis. J Pathol 2008; 215: 211-213.
    • (2008) J Pathol , vol.215 , pp. 211-213
    • Zlotnik, A.1
  • 115
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith B and Simon MC. Hypoxia-inducible factors, stem cells, and cancer. Cell 2007; 129: 465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 117
    • 70349747011 scopus 로고    scopus 로고
    • Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1
    • Folkins C, Shaked Y, Man S, Tang T, Lee CR, Zhu Z, Hoffman RM and Kerbel RS. Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res 2009; 69: 7243-7251.
    • (2009) Cancer Res , vol.69 , pp. 7243-7251
    • Folkins, C.1    Shaked, Y.2    Man, S.3    Tang, T.4    Lee, C.R.5    Zhu, Z.6    Hoffman, R.M.7    Kerbel, R.S.8
  • 118
    • 49449117422 scopus 로고    scopus 로고
    • Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR
    • Yao XH, Ping YF, Chen JH, Xu CP, Chen DL, Zhang R, Wang JM and Bian XW. Glioblastoma stem cells produce vascular endothelial growth factor by activation of a G-protein coupled formylpeptide receptor FPR. J Pathol 2008; 215: 369-376.
    • (2008) J Pathol , vol.215 , pp. 369-376
    • Yao, X.H.1    Ping, Y.F.2    Chen, J.H.3    Xu, C.P.4    Chen, D.L.5    Zhang, R.6    Wang, J.M.7    Bian, X.W.8
  • 120
    • 84890314061 scopus 로고    scopus 로고
    • The pre-metastatic niche: Finding common ground
    • Sceneay J, Smyth MJ and Moller A. The pre-metastatic niche: finding common ground. Cancer Metastasis Rev 2013; 32: 449-464.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 449-464
    • Sceneay, J.1    Smyth, M.J.2    Moller, A.3
  • 121
    • 33846044750 scopus 로고    scopus 로고
    • Bone marrow cells in the ‘pre-metastatic niche’: Within bone and beyond
    • Kaplan RN, Psaila B and Lyden D. Bone marrow cells in the ‘pre-metastatic niche’: within bone and beyond. Cancer Metastasis Rev 2006; 25: 521-529.
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 521-529
    • Kaplan, R.N.1    Psaila, B.2    Lyden, D.3
  • 122
    • 63049121364 scopus 로고    scopus 로고
    • The metastatic niche: Adapting the foreign soil
    • Psaila B and Lyden D. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 2009; 9: 285-293.
    • (2009) Nat Rev Cancer , vol.9 , pp. 285-293
    • Psaila, B.1    Lyden, D.2
  • 123
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche
    • Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT and Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche. Cancer Cell 2009; 15: 35-44.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6    Le, Q.T.7    Giaccia, A.J.8
  • 124
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33: 207-214.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 126
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
    • Lu X and Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010; 16: 5928-5935.
    • (2010) Clin Cancer Res , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 127
    • 79953870540 scopus 로고    scopus 로고
    • Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies
    • Wang Y, Liu Y, Malek SN, Zheng P and Liu Y. Targeting HIF1alpha eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 2011; 8: 399-411.
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4    Liu, Y.5
  • 129
    • 84881481392 scopus 로고    scopus 로고
    • Crosstalk between breast cancer stem cells and metastatic niche: Emerging molecular metastasis pathway?
    • Fazilaty H, Gardaneh M, Bahrami T, Salmaninejad A and Behnam B. Crosstalk between breast cancer stem cells and metastatic niche: emerging molecular metastasis pathway? Tumour Biol 2013; 34: 2019-2030.
    • (2013) Tumour Biol , vol.34 , pp. 2019-2030
    • Fazilaty, H.1    Gardaneh, M.2    Bahrami, T.3    Salmaninejad, A.4    Behnam, B.5
  • 130
    • 84866742560 scopus 로고    scopus 로고
    • TGFbeta signalling in context
    • Massague J. TGFbeta signalling in context. Nat Rev Mol Cell Biol 2012; 13: 616-630.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 131
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F and Kirchner T. Opinion: migrating cancer stem cells an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5: 744-749.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 134
    • 79960470354 scopus 로고    scopus 로고
    • Metastatic breast cancer cells in the bone marrow microenvironment: Novel insights into oncoprotection
    • Patel SA, Dave MA, Murthy RG, Helmy KY and Rameshwar P. Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection. Oncol Rev 2011; 5: 93-102.
    • (2011) Oncol Rev , vol.5 , pp. 93-102
    • Patel, S.A.1    Dave, M.A.2    Murthy, R.G.3    Helmy, K.Y.4    Rameshwar, P.5
  • 135
    • 77953288958 scopus 로고    scopus 로고
    • ALDH high adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating me-tastasis
    • Sun S and Wang Z. ALDH high adenoid cystic carcinoma cells display cancer stem cell properties and are responsible for mediating metastasis. Biochem Biophys Res Commun 2010; 396: 843-848.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 843-848
    • Sun, S.1    Wang, Z.2
  • 137
    • 77954921889 scopus 로고    scopus 로고
    • Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells
    • Moriyama T, Ohuchida K, Mizumoto K, Cui L, Ikenaga N, Sato N and Tanaka M. Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells. Cancer 2010; 116: 3357-3368.
    • (2010) Cancer , vol.116 , pp. 3357-3368
    • Moriyama, T.1    Ohuchida, K.2    Mizumoto, K.3    Cui, L.4    Ikenaga, N.5    Sato, N.6    Tanaka, M.7
  • 140
    • 84883178190 scopus 로고    scopus 로고
    • Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential
    • Gao W, Chen L, Ma Z, Du Z, Zhao Z, Hu Z and Li Q. Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology 2013; 145: 636-646, e635.
    • (2013) Gastroenterology , vol.145 , pp. 636-646
    • Gao, W.1    Chen, L.2    Ma, Z.3    Du, Z.4    Zhao, Z.5    Hu, Z.6    Li, Q.7
  • 144
    • 84884769367 scopus 로고    scopus 로고
    • ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer
    • Chen D, Bhat-Nakshatri P, Goswami C, Badve S and Nakshatri H. ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer. Cancer Res 2013; 73: 5821-5833.
    • (2013) Cancer Res , vol.73 , pp. 5821-5833
    • Chen, D.1    Bhat-Nakshatri, P.2    Goswami, C.3    Badve, S.4    Nakshatri, H.5
  • 145
    • 84877638037 scopus 로고    scopus 로고
    • Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node me-tastasis
    • Wei W, Hu H, Tan H, Chow LW, Yip AY and Loo WT. Relationship of CD44+CD24-/low breast cancer stem cells and axillary lymph node metastasis. J Transl Med 2012; 10 Suppl 1: 6.
    • (2012) J Transl Med , vol.10 , pp. 6
    • Wei, W.1    Hu, H.2    Tan, H.3    Chow, L.W.4    Yip, A.Y.5    Loo, W.T.6
  • 146
    • 67349111975 scopus 로고    scopus 로고
    • CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro
    • Krohn A, Song YH, Muehlberg F, Droll L, Beckmann C and Alt E. CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro. Cancer Lett 2009; 280: 65-71.
    • (2009) Cancer Lett , vol.280 , pp. 65-71
    • Krohn, A.1    Song, Y.H.2    Muehlberg, F.3    Droll, L.4    Beckmann, C.5    Alt, E.6
  • 147
    • 84856680480 scopus 로고    scopus 로고
    • Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis
    • Pilati P, Mocellin S, Bertazza L, Galdi F, Briarava M, Mammano E, Tessari E, Zavagno G and Nitti D. Prognostic value of putative circulating cancer stem cells in patients undergoing hepatic resection for colorectal liver metastasis. Ann Surg Oncol 2012; 19: 402-408.
    • (2012) Ann Surg Oncol , vol.19 , pp. 402-408
    • Pilati, P.1    Mocellin, S.2    Bertazza, L.3    Galdi, F.4    Briarava, M.5    Mammano, E.6    Tessari, E.7    Zavagno, G.8    Nitti, D.9
  • 149
    • 80052971224 scopus 로고    scopus 로고
    • Head neck squamous cell carcinoma c-Met(+) cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis
    • Sun S and Wang Z. Head neck squamous cell carcinoma c-Met(+) cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis. Int J Cancer 2011; 129: 2337-2348.
    • (2011) Int J Cancer , vol.129 , pp. 2337-2348
    • Sun, S.1    Wang, Z.2
  • 150
    • 77953170540 scopus 로고    scopus 로고
    • CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance
    • Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR and Iwakuma T. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 2010; 70: 4602-4612.
    • (2010) Cancer Res , vol.70 , pp. 4602-4612
    • Adhikari, A.S.1    Agarwal, N.2    Wood, B.M.3    Porretta, C.4    Ruiz, B.5    Pochampally, R.R.6    Iwakuma, T.7
  • 152
    • 80051545801 scopus 로고    scopus 로고
    • CXCR4 positive cells from Lewis lung carcinoma cell line have cancer metastatic stem cell characteristics
    • Nian WQ, Chen FL, Ao XJ and Chen ZT. CXCR4 positive cells from Lewis lung carcinoma cell line have cancer metastatic stem cell characteristics. Mol Cell Biochem 2011; 355: 241-248.
    • (2011) Mol Cell Biochem , vol.355 , pp. 241-248
    • Nian, W.Q.1    Chen, F.L.2    Ao, X.J.3    Chen, Z.T.4
  • 153
    • 42649100970 scopus 로고    scopus 로고
    • Detection, clinical relevance and specific biological properties of disseminating tumour cells
    • Pantel K, Brakenhoff RH and Brandt B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat Rev Cancer 2008; 8: 329-340.
    • (2008) Nat Rev Cancer , vol.8 , pp. 329-340
    • Pantel, K.1    Brakenhoff, R.H.2    Brandt, B.3
  • 154
    • 33846698253 scopus 로고    scopus 로고
    • The clinical significance of circulating tumor cells
    • Pantel K and Alix-Panabieres C. The clinical significance of circulating tumor cells. Nat Clin Pract Oncol 2007; 4: 62-63.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 62-63
    • Pantel, K.1    Alix-Panabieres, C.2
  • 155
    • 70349100257 scopus 로고    scopus 로고
    • CD133 as a marker for Cancer stem cells: Progresses and concerns
    • Wu Y and Wu PY. CD133 as a marker for CanCer stem cells: progresses and concerns. Stem Cells Dev 2009; 18: 1127-1134.
    • (2009) Stem Cells Dev , vol.18 , pp. 1127-1134
    • Wu, Y.1    Wu, P.Y.2
  • 157
    • 40749150740 scopus 로고    scopus 로고
    • CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma S, Lee TK, Zheng BJ, Chan KW and Guan XY. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008; 27: 1749-1758.
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 159
    • 58049201990 scopus 로고    scopus 로고
    • The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
    • Rappa G, Fodstad O and Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells 2008; 26: 3008-3017.
    • (2008) Stem Cells , vol.26 , pp. 3008-3017
    • Rappa, G.1    Fodstad, O.2    Lorico, A.3
  • 160
    • 4143149778 scopus 로고    scopus 로고
    • CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells
    • Draffin JE, McFarlane S, Hill A, Johnston PG and Waugh DJ. CD44 potentiates the adherence of metastatic prostate and breast cancer cells to bone marrow endothelial cells. Cancer Res 2004; 64: 5702-5711.
    • (2004) Cancer Res , vol.64 , pp. 5702-5711
    • Draffin, J.E.1    McFarlane, S.2    Hill, A.3    Johnston, P.G.4    Waugh, D.J.5
  • 161
    • 50049134725 scopus 로고    scopus 로고
    • Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • Riechelmann H, Sauter A, Golze W, Hanft G, Schroen C, Hoermann K, Erhardt T and Gronau S. Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncol 2008; 44: 823-829.
    • (2008) Oral Oncol , vol.44 , pp. 823-829
    • Riechelmann, H.1    Sauter, A.2    Golze, W.3    Hanft, G.4    Schroen, C.5    Hoermann, K.6    Erhardt, T.7    Gronau, S.8
  • 162
    • 81055127027 scopus 로고    scopus 로고
    • A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells
    • Piotrowicz RS, Damaj BB, Hachicha M, Incardona F, Howell SB and Finlayson M. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther 2011; 10: 2072-2082.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2072-2082
    • Piotrowicz, R.S.1    Damaj, B.B.2    Hachicha, M.3    Incardona, F.4    Howell, S.B.5    Finlayson, M.6
  • 163
    • 84882822844 scopus 로고    scopus 로고
    • Liver tumorinitiating cells as a therapeutic target for hepatocellular carcinoma
    • Lee TK, Cheung VC and Ng IO. Liver tumorinitiating cells as a therapeutic target for hepatocellular carcinoma. Cancer Lett 2013; 338: 101-109.
    • (2013) Cancer Lett , vol.338 , pp. 101-109
    • Lee, T.K.1    Cheung, V.C.2    Ng, I.O.3
  • 164
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe N, Harris PJ, Warren RQ and Ivy SP. Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 2011; 8: 97-106.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 167
    • 84902968221 scopus 로고    scopus 로고
    • The cancer stem cell niche: Cross talk between cancer stem cells and their microenvironment
    • Ye J, Wu D, Wu P, Chen Z and Huang J. The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment. Tumour Biol 2014; 35: 3945-3951.
    • (2014) Tumour Biol , vol.35 , pp. 3945-3951
    • Ye, J.1    Wu, D.2    Wu, P.3    Chen, Z.4    Huang, J.5
  • 168
    • 84874000632 scopus 로고    scopus 로고
    • Cancer stem cells niche: A target for novel cancer therapeutics
    • Yi SY, Hao YB, Nan KJ and Fan TL. Cancer stem cells niche: A target for novel cancer therapeutics. Cancer Treat Rev 2013; 39: 290-296.
    • (2013) Cancer Treat Rev , vol.39 , pp. 290-296
    • Yi, S.Y.1    Hao, Y.B.2    Nan, K.J.3    Fan, T.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.