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Volumn 146, Issue 1, 2014, Pages 245-256

DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer

Author keywords

Acetylated Tubulin; Kras; Notch; PanIN

Indexed keywords

COMPLEMENTARY DNA; DOUBLECORTIN AND CALCIUM CALMODULIN DEPENDENT KINASE LIKE 1; GAMMA SECRETASE; PHOSPHOTRANSFERASE; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

EID: 84890725866     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.09.050     Document Type: Article
Times cited : (258)

References (38)
  • 1
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • J. Chen, Y. Li, and T.S. Yu A restricted cell population propagates glioblastoma growth after chemotherapy Nature 488 2012 522 526
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3
  • 2
    • 84865222310 scopus 로고    scopus 로고
    • Defining the mode of tumour growth by clonal analysis
    • G. Driessens, B. Beck, and A. Caauwe Defining the mode of tumour growth by clonal analysis Nature 488 2012 527 530
    • (2012) Nature , vol.488 , pp. 527-530
    • Driessens, G.1    Beck, B.2    Caauwe, A.3
  • 3
    • 84864854371 scopus 로고    scopus 로고
    • Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
    • A.G. Schepers, H.J. Snippert, and D.E. Stange Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas Science 337 2012 730 735
    • (2012) Science , vol.337 , pp. 730-735
    • Schepers, A.G.1    Snippert, H.J.2    Stange, D.E.3
  • 4
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • C. Li, D.G. Heidt, and P. Dalerba Identification of pancreatic cancer stem cells Cancer Res 67 2007 1030 1037
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 5
    • 77749292153 scopus 로고    scopus 로고
    • Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma
    • Z.A. Rasheed, J. Yang, and Q. Wang Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma J Natl Cancer Inst 102 2010 340 351
    • (2010) J Natl Cancer Inst , vol.102 , pp. 340-351
    • Rasheed, Z.A.1    Yang, J.2    Wang, Q.3
  • 7
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • P.C. Hermann, S.L. Huber, and T. Herrler Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer Cell Stem Cell 1 2007 313 323
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 8
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • S.R. Hingorani, E.F. Petricoin, and A. Maitra Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse Cancer Cell 4 2003 437 450
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 9
    • 33645824724 scopus 로고    scopus 로고
    • Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
    • N. Bardeesy, A.J. Aguirre, and G.C. Chu Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse Proc Natl Acad Sci U S A 103 2006 5947 5952
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 5947-5952
    • Bardeesy, N.1    Aguirre, A.J.2    Chu, G.C.3
  • 10
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • N. Habbe, G. Shi, and R.A. Meguid Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice Proc Natl Acad Sci U S A 105 2008 18913 18918
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18913-18918
    • Habbe, N.1    Shi, G.2    Meguid, R.A.3
  • 11
    • 84864858368 scopus 로고    scopus 로고
    • Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development
    • E. Provost, K.A. Wehner, and X. Zhong Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development Development 139 2012 3232 3241
    • (2012) Development , vol.139 , pp. 3232-3241
    • Provost, E.1    Wehner, K.A.2    Zhong, X.3
  • 12
    • 84879586965 scopus 로고    scopus 로고
    • Sphere-forming assays for assessment of benign and malignant pancreatic stem cells
    • Y.J. Wang, J.M. Bailey, and M. Rovira Sphere-forming assays for assessment of benign and malignant pancreatic stem cells Methods Mol Biol 980 2013 281 290
    • (2013) Methods Mol Biol , vol.980 , pp. 281-290
    • Wang, Y.J.1    Bailey, J.M.2    Rovira, M.3
  • 13
    • 58349099851 scopus 로고    scopus 로고
    • Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia
    • E.S. Seeley, C. Carriere, and T. Goetze Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia Cancer Res 69 2009 422 430
    • (2009) Cancer Res , vol.69 , pp. 422-430
    • Seeley, E.S.1    Carriere, C.2    Goetze, T.3
  • 14
    • 80052516480 scopus 로고    scopus 로고
    • Gastric tuft cells express DCLK1 and are expanded in hyperplasia
    • M. Saqui-Salces, T.M. Keeley, and A.S. Grosse Gastric tuft cells express DCLK1 and are expanded in hyperplasia Histochem Cell Biol 136 2011 191 204
    • (2011) Histochem Cell Biol , vol.136 , pp. 191-204
    • Saqui-Salces, M.1    Keeley, T.M.2    Grosse, A.S.3
  • 15
    • 84861620580 scopus 로고    scopus 로고
    • Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature
    • K.T. Nam, R. O'Neal, and Y.S. Lee Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature Lab Invest 92 2012 883 895
    • (2012) Lab Invest , vol.92 , pp. 883-895
    • Nam, K.T.1    O'Neal, R.2    Lee, Y.S.3
  • 16
    • 43049128928 scopus 로고    scopus 로고
    • Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    • R. May, T.E. Riehl, and C. Hunt Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice Stem Cells 26 2008 630 637
    • (2008) Stem Cells , vol.26 , pp. 630-637
    • May, R.1    Riehl, T.E.2    Hunt, C.3
  • 17
    • 0029988978 scopus 로고    scopus 로고
    • Cytoskeletal markers allowing discrimination between brush cells and other epithelial cells of the gut including enteroendocrine cells
    • D. Hofer, and D. Drenckhahn Cytoskeletal markers allowing discrimination between brush cells and other epithelial cells of the gut including enteroendocrine cells Histochem Cell Biol 105 1996 405 412
    • (1996) Histochem Cell Biol , vol.105 , pp. 405-412
    • Hofer, D.1    Drenckhahn, D.2
  • 18
    • 79952748822 scopus 로고    scopus 로고
    • DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
    • S.M. Sureban, R. May, and S.A. Lightfoot DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism Cancer Res 71 2011 2328 2338
    • (2011) Cancer Res , vol.71 , pp. 2328-2338
    • Sureban, S.M.1    May, R.2    Lightfoot, S.A.3
  • 19
    • 84865016748 scopus 로고    scopus 로고
    • The intestinal epithelium tuft cells: Specification and function
    • F. Gerbe, C. Legraverend, and P. Jay The intestinal epithelium tuft cells: specification and function Cell Mol Life Sci 69 2012 2907 2917
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2907-2917
    • Gerbe, F.1    Legraverend, C.2    Jay, P.3
  • 20
    • 77955599004 scopus 로고    scopus 로고
    • Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas
    • R. May, S.M. Sureban, and S.A. Lightfoot Identification of a novel putative pancreatic stem/progenitor cell marker DCAMKL-1 in normal mouse pancreas Am J Physiol Gastrointest Liver Physiol 299 2010 G303 G310
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299
    • May, R.1    Sureban, S.M.2    Lightfoot, S.A.3
  • 21
    • 85027944761 scopus 로고    scopus 로고
    • Dclk1 distinguishes between tumor and normal stem cells in the intestine
    • Y. Nakanishi, H. Seno, and A. Fukuoka Dclk1 distinguishes between tumor and normal stem cells in the intestine Nat Genet 45 2012 98 103
    • (2012) Nat Genet , vol.45 , pp. 98-103
    • Nakanishi, Y.1    Seno, H.2    Fukuoka, A.3
  • 22
    • 78650731392 scopus 로고    scopus 로고
    • The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation
    • T. Shida, J.G. Cueva, and Z. Xu The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation Proc Natl Acad Sci U S A 107 2010 21517 21522
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 21517-21522
    • Shida, T.1    Cueva, J.G.2    Xu, Z.3
  • 23
    • 0034671293 scopus 로고    scopus 로고
    • DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization
    • P.T. Lin, J.G. Gleeson, and J.C. Corbo DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization J Neurosci 20 2000 9152 9161
    • (2000) J Neurosci , vol.20 , pp. 9152-9161
    • Lin, P.T.1    Gleeson, J.G.2    Corbo, J.C.3
  • 24
    • 84867398827 scopus 로고    scopus 로고
    • ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion
    • A. Castro-Castro, C. Janke, and G. Montagnac ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion Eur J Cell Biol 91 2012 950 960
    • (2012) Eur J Cell Biol , vol.91 , pp. 950-960
    • Castro-Castro, A.1    Janke, C.2    Montagnac, G.3
  • 25
    • 79958064073 scopus 로고    scopus 로고
    • Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease
    • A. Bobrowska, P. Paganetti, and P. Matthias Hdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's disease PLoS One 6 2011 e20696
    • (2011) PLoS One , vol.6 , pp. 20696
    • Bobrowska, A.1    Paganetti, P.2    Matthias, P.3
  • 26
    • 79953311481 scopus 로고    scopus 로고
    • HDAC6 alpha-tubulin deacetylase: A potential therapeutic target in neurodegenerative diseases
    • G. Li, H. Jiang, and M. Chang HDAC6 alpha-tubulin deacetylase: a potential therapeutic target in neurodegenerative diseases J Neurol Sci 304 2011 1 8
    • (2011) J Neurol Sci , vol.304 , pp. 1-8
    • Li, G.1    Jiang, H.2    Chang, M.3
  • 27
    • 10744223624 scopus 로고    scopus 로고
    • Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    • Y. Miyamoto, A. Maitra, and B. Ghosh Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis Cancer Cell 3 2003 565 576
    • (2003) Cancer Cell , vol.3 , pp. 565-576
    • Miyamoto, Y.1    Maitra, A.2    Ghosh, B.3
  • 28
    • 38149142478 scopus 로고    scopus 로고
    • Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt
    • H. Doucas, C.D. Mann, and C.D. Sutton Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt J Surg Oncol 97 2008 63 68
    • (2008) J Surg Oncol , vol.97 , pp. 63-68
    • Doucas, H.1    Mann, C.D.2    Sutton, C.D.3
  • 29
    • 65249125270 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma
    • e6
    • R. Plentz, J.S. Park, and A.D. Rhim Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma Gastroenterology 136 2009 1741 1749 e6
    • (2009) Gastroenterology , vol.136 , pp. 1741-1749
    • Plentz, R.1    Park, J.S.2    Rhim, A.D.3
  • 30
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • A.D. Rhim, E.T. Mirek, and N.M. Aiello EMT and dissemination precede pancreatic tumor formation Cell 148 2012 349 361
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1    Mirek, E.T.2    Aiello, N.M.3
  • 31
    • 84858832154 scopus 로고    scopus 로고
    • Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma
    • K.J. Vega, R. May, and S.M. Sureban Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma J Gastroenterol Hepatol 27 2012 773 780
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 773-780
    • Vega, K.J.1    May, R.2    Sureban, S.M.3
  • 32
    • 67650991981 scopus 로고    scopus 로고
    • Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism
    • 659 e1-2
    • S.M. Sureban, R. May, and S. Ramalingam Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism Gastroenterology 137 2009 649 659 659 e1-2
    • (2009) Gastroenterology , vol.137 , pp. 649-659
    • Sureban, S.M.1    May, R.2    Ramalingam, S.3
  • 33
    • 57749116315 scopus 로고    scopus 로고
    • Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
    • O.J. De La, L.L. Emerson, and J.L. Goodman Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia Proc Natl Acad Sci U S A 105 2008 18907 18912
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 18907-18912
    • De La, O.J.1    Emerson, L.L.2    Goodman, J.L.3
  • 34
    • 77955827414 scopus 로고    scopus 로고
    • Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
    • P.K. Mazur, H. Einwachter, and M. Lee Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma Proc Natl Acad Sci U S A 107 2010 13438 13443
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13438-13443
    • Mazur, P.K.1    Einwachter, H.2    Lee, M.3
  • 35
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • B. Bao, Z. Wang, and S. Ali Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells Cancer Lett 307 2011 26 36
    • (2011) Cancer Lett , vol.307 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3
  • 36
    • 35348840335 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of imatinib mesylate (Gleevec) and gemcitabine in patients with refractory solid tumors
    • Y. Ali, Y. Lin, and M.M. Gharibo Phase I and pharmacokinetic study of imatinib mesylate (Gleevec) and gemcitabine in patients with refractory solid tumors Clin Cancer Res 13 2007 5876 5882
    • (2007) Clin Cancer Res , vol.13 , pp. 5876-5882
    • Ali, Y.1    Lin, Y.2    Gharibo, M.M.3
  • 37
    • 79958106621 scopus 로고    scopus 로고
    • Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer
    • S. Rieder, C.W. Michalski, and H. Friess Insulin-like growth factor signaling as a therapeutic target in pancreatic cancer Anticancer Agents Med Chem 11 2011 427 433
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 427-433
    • Rieder, S.1    Michalski, C.W.2    Friess, H.3
  • 38
    • 67650444760 scopus 로고    scopus 로고
    • ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
    • Y Hu, and GK Smyth ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays J Immunological Methods 347 2009 70 78
    • (2009) J Immunological Methods , vol.347 , pp. 70-78
    • Hu, Y.1    Smyth, G.K.2


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