The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation

International Journal of Biochemistry and Cell Biology

Volumn 55, Issue , 2014, Pages 65-71

  Xiao, Zhicheng ^a   Zhang, Jing ^a   Peng, Xiaogang ^a   Dong, Yanjun ^a   Jia, Lixin ^a   Li, Huihua ^b   Du, Jie ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Epithelial to mesenchymal transition; Fibroblast; Kidney fibrosis; Notch; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA1; COLLAGEN TYPE 3; COLLAGEN TYPE 3ALPHA1; FIBRONECTIN; GAMMA SECRETASE INHIBITOR; MESSENGER RNA; NOTCH INTRACELLULAR DOMAIN; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; PROTEIN; PROTEIN HEYL; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; DIBENZAZEPINE; DIBENZAZEPINE DERIVATIVE; NOTCH RECEPTOR; SECRETASE; SMAD2 PROTEIN, MOUSE; COLLAGEN 1ALPHA1; COLLAGEN 3ALPHA1; GAMMA SECRETASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; FIBROBLAST; FIBROGENESIS; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; URETER OBSTRUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; COMPLICATION; DRUG EFFECTS; FIBROSIS; GENETICS; KIDNEY; KIDNEY DISEASES; METABOLISM; PATHOLOGY; RANDOMIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; DRUG MECHANISM; HISTOPATHOLOGY; KIDNEY CELL; PROTEIN EXPRESSION; TUBULAR EPITHELIAL CEL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DIBENZAZEPINES; FIBROSIS; GENE EXPRESSION; KIDNEY; KIDNEY DISEASES; MICE, INBRED C57BL; RANDOM ALLOCATION; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION;

EID: 84906883380     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.08.009     Document Type: Article

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