Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Zheng, Yue Hong ^a   Li, Fang Da ^a   Tian, Cui ^b,c   Ren, Hua Liang ^a   Du, Jie ^b,c   Li, Hui Hua ^b,c  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c BEIJING INSTITUTE OF HEART   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; DIBENZAZEPINE DERIVATIVE; GELATINASE A; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 4; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 1;

ABDOMINAL AORTA ANEURYSM; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE SEVERITY; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VIVO STUDY; INCIDENCE; KNOCKOUT MOUSE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH2 CELL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANGIOTENSIN II; ANIMALS; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; DIBENZAZEPINES; DISEASE MODELS, ANIMAL; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 84892778890     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083310     Document Type: Article

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