TLR2 and TLR4 signaling pathways are required for recombinant Brucella abortus BCSP31-induced cytokine production, functional upregulation of mouse macrophages, and the Th1 immune response in vivo and in vitro

Cellular and Molecular Immunology

Volumn 11, Issue 5, 2014, Pages 477-494

  Li, Jia Yun ^a   Liu, Yuan ^a   Gao, Xiao Xue ^a   Gao, Xiang ^b   Cai, Hong ^a  

^a PEKING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

BCSP31; Brucella abortus; cytokine; macrophage; Th1 immune response; TLR

Indexed keywords

31-KDA CELL SURFACE PROTEIN, BRUCELLA ABORTUS; AUTACOID; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT PROTEIN; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL; ANTIGEN PRESENTATION; BRUCELLA ABORTUS; BRUCELLOSIS; C57BL MOUSE; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; MACROPHAGE; METABOLISM; MICROBIOLOGY; MOUSE; SIGNAL TRANSDUCTION; TH1 CELL;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BRUCELLA ABORTUS; BRUCELLOSIS; CYTOKINES; HEK293 CELLS; HUMANS; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; RECOMBINANT PROTEINS; TH1 CELLS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84906858463     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2014.28     Document Type: Article

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