Targets of glucocorticoid action on TNF-α release by macrophages

Inflammation Research

Volumn 50, Issue 7, 2001, Pages 337-340

  Joyce, D A ^a,b   Gimblett, G ^a   Steer, J H ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

Author keywords

Glucocorticoid; Macrophage; NF B; TNF ; Transcription

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C JUN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

BINDING SITE; CELL LINE; COMPLEX FORMATION; CYTOKINE RELEASE; DRUG TARGETING; HUMAN; IMMUNE RESPONSE; MACROPHAGE; NONHUMAN; REVIEW; TRANSCRIPTION REGULATION;

EID: 0034922882     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00012387     Document Type: Review

References (34)

1. Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates
2. Suppression on human monocyte tumour necrosis factor release by glucocorticoid therapy: Relationship to systemic monocytopaenia and cortisol suppression
3. Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intraarticular glucocorticoid treatment
4. Inhibition by glucocorticoids of the formation of interleukin-1 alpha, interleukin-1 beta, and interleukin-6: Mediation by decreased mRNA stability
5. Tumor necrosis factor-α and interleukin-1 α stimulate late shedding of p75 TNF receptors but not p55 TNF receptors from human monocytes
6. Molecular mechanisms involved in the regulation of prostaglandin biosynthesis by glucocorticoids
7. Role of tumor necrosis factor-α in disease states and inflammation
8. The essential role of UA-rich sequences in endotoxin-induced cacchectin/TNF synthesis
9. Glucocorticoids suppress tumor necrosis factor-alpha expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-κB and c-Jun-activating transcription factor-2 binding sites in the promoter
10. NF-kappa B: Ten years after
11. NF-kappaB and Rel proteins: Evolutionarily conserved mediators of immune responses
12. Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway
13. NF-κB and cell-cycle regulation: The cyclin connection
14. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
15. Rel/NF-kappaB/I kappaB family: Intimate tales of association and dissociation
16. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation
17. Inducible nuclear expression of newly synthesized I-kappaB alpha negatively regulates DNA-binding and transcriptional activities of NF-kappaB
18. Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-jun promoter
19. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: Glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK
20. Altering the specificity of signal transduction cascades: Positive regulation of c-Jun transcriptional activity by protein kinase A
21. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappaB and the glucocorticoid receptor
22. Dexamethasone attenuates NF-kappa B DNA binding activity without inducing I-kappaB levels in rat brain in vivo
23. Immunosupression by glucocorticoids: Inhibition of NF-kappaB activity through induction of I-kappaB synthesis
24. Role of transcriptional activation of I-kappaBα in mediation of immunosupression by glucocorticoids
25. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
26. Distinct functional properties of I-kappaB alpha and I-kappaB beta
27. Role of unphosphorylated, newly synthesized I-kappaB beta in persistent activation of NF-kappaB
28. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
29. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
30. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
31. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
32. Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein
33. Differential regulation of tumour necrosis factor-α mRNA degradation in macrophages by interleukin-4 and interferon-gamma
34. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions