Interferon-γ is crucial for surviving a Brucella abortus infection in both resistant C57BL/6 and susceptible BALB/c mice

Immunology

Volumn 103, Issue 4, 2001, Pages 511-518

  Murphy, Erin A ^a   Sathiyaseelan, Janaki ^a   Parent, Michelle A ^a   Zou, Baixiang ^a   Baldwin, Cynthia L ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; BACTERIUM COLONY; BRUCELLA ABORTUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; GENE DELETION; INFECTION CONTROL; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE;

ANIMALS; BRUCELLA ABORTUS; BRUCELLOSIS; DISEASE SUSCEPTIBILITY; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN;

EID: 0034886064     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01258.x     Document Type: Article

References (24)

1. Ultrastructural morphometric analysis of Brucella abortus-infected trophoblasts in experimental placentitis
2. Macrophage activation during experimental murine brucellosis: A basis for chronic infection
3. Brucella infections and immunity
4. Effects of γ-interferon and indomethacin in preventing Brucella abortus infections in mice
5. Endogenous gamma interferon mediates resistance to Brucella abortus infection
6. IL-10 downregulates protective immunity to Brucella abortus
7. Macrophage control of Brucella abortus: Role of reactive oxygen intermediates and nitric oxide
8. Iron augments macrophage-mediated killing of Brucella abortus alone and in conjunction with IFN-γ
9. lo T lymphocytes control intracellular Brucella abortus infection as demonstrated in major histocompatibility complex class I and class II deficient mice
10. In vivo and in vitro effects of monoclonal antibody to Ly antigens on immunity to infection
11. Temporal development of protective cell-mediated and humoral immunity in BALB/c mice infected with Brucella abortus
12. Lack of a role for natural killer cells in early control of Brucella abortus
13. An antimicrobial activity of cytolytic T cells mediated by granulysin
14. Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice
15. Persistence of Brucella abortus in the livers of T cell-deficient nude mice
16. Essential roles of core starvation-stress response loci in carbon-starvation-inducible cross-resistance and hydrogen peroxide-inducible adaptive resistance to oxidative challenge in Salmonella typhimurium
17. T cell subsets in granulomatous inflammation and immunity to L. monocytogenes and B. abortus
18. Ingestion and intracellular survival of Brucella abortus in human and bovine polymorphonuclear leukocytes
19. IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite stubstrains
20. Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308
21. IL-10 acts on the antigen presenting cell to inhibit cytokine production by Th1 cells
22. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
23. T cell genetic background determines maintenance of IL-12 signaling. Effects on BALB/c and B10.D2 T helper cell type 1 phenotype development
24. Control of IL-12 and IFN-γ production in response to live or dead bacteria by TNF and other factors