Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Abildgaard, Cecilie ^a   Dahl, Christina ^a   Basse, Astrid L ^b   Ma, Tao ^b   Guldberg, Per ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

ATP; Bioenergetics; BRAF; Dichloroacetate; Melanoma; Metabolism

Indexed keywords

ADENOSINE TRIPHOSPHATE; B RAF KINASE; DICHLOROACETIC ACID; VEMURAFENIB; BRAF PROTEIN, HUMAN; GLUTAMIC ACID; INDOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; SULFONAMIDE; VALINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOENERGY; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; DRUG INTERACTION; DRUG RESPONSE; DRUG SENSITIVITY; ENERGY YIELD; ENZYME INHIBITION; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MELANOMA; MELANOMA CELL; AMINO ACID SUBSTITUTION; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; ENERGY METABOLISM; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL CULTURE;

AMINO ACID SUBSTITUTION; CELL PROLIFERATION; DICHLOROACETIC ACID; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENERGY METABOLISM; GLUTAMIC ACID; HUMANS; INDOLES; MELANOMA; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; SULFONAMIDES; TUMOR CELLS, CULTURED; VALINE;

EID: 84906848648     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-014-0247-5     Document Type: Article

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