-
1
-
-
79959795786
-
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, et al. (2011) Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation. New England Journal of Medicine 364: 2507-2516.
-
(2011)
New England Journal of Medicine
, vol.364
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
-
2
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, et al. (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363: 711-723.
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
-
3
-
-
54749094792
-
Expression and function of bcl-2 proteins in melanoma
-
Eberle J, Hossini AM, (2008) Expression and function of bcl-2 proteins in melanoma. Curr Genomics 9: 409-419.
-
(2008)
Curr Genomics
, vol.9
, pp. 409-419
-
-
Eberle, J.1
Hossini, A.M.2
-
4
-
-
65549096830
-
Mcl-1 is required for melanoma cell resistance to anoikis
-
Boisvert-Adamo K, Longmate W, Abel EV, Aplin AE, (2009) Mcl-1 is required for melanoma cell resistance to anoikis. Mol Cancer Res 7: 549-556.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 549-556
-
-
Boisvert-Adamo, K.1
Longmate, W.2
Abel, E.V.3
Aplin, A.E.4
-
5
-
-
73949089935
-
Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
-
Zhuang L, Scolyer RA, Murali R, McCarthy SW, Zhang XD, et al. (2010) Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins. Mod Pathol 23: 45-53.
-
(2010)
Mod Pathol
, vol.23
, pp. 45-53
-
-
Zhuang, L.1
Scolyer, R.A.2
Murali, R.3
McCarthy, S.W.4
Zhang, X.D.5
-
8
-
-
84865068502
-
Metabolic symbiosis in cancer: Refocusing the Warburg lens
-
Jan 6 [Epub ahead of print]
-
Nakajima EC, Van Houten B (2012) Metabolic symbiosis in cancer: Refocusing the Warburg lens. Mol Carcinog Jan 6 [Epub ahead of print].
-
(2012)
Mol Carcinog
-
-
Nakajima, E.C.1
van Houten, B.2
-
9
-
-
53349153454
-
Elesclomol induces cancer cell apoptosis through oxidative stress
-
Kirshner JR, He S, Balasubramanyam V, Kepros J, Yang CY, et al. (2008) Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther 7: 2319-2327.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2319-2327
-
-
Kirshner, J.R.1
He, S.2
Balasubramanyam, V.3
Kepros, J.4
Yang, C.Y.5
-
10
-
-
84876446576
-
The oxidative stress inducer STA-4783 enhances the in vivo efficacy of multiple anti-cancer therapies in mouse tumor models (abstr A290)
-
Foley KP, Bertin J, Chan K, Inoue T, Kirshner JR, et al. (2007) The oxidative stress inducer STA-4783 enhances the in vivo efficacy of multiple anti-cancer therapies in mouse tumor models (abstr A290). AACR-NCI-EORTC Symposium on Molecular Targets and Cancer Therapeutics San Francisco, CA.
-
(2007)
AACR-NCI-EORTC Symposium on Molecular Targets and Cancer Therapeutics San Francisco, CA
-
-
Foley, K.P.1
Bertin, J.2
Chan, K.3
Inoue, T.4
Kirshner, J.R.5
-
11
-
-
73949153317
-
Phase II, randomized, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma
-
O'Day S, Gonzalez R, Lawson D, Weber R, Hutchins L, et al. (2009) Phase II, randomized, controlled, double-blinded trial of weekly elesclomol plus paclitaxel versus paclitaxel alone for stage IV metastatic melanoma. J Clin Oncol 27: 5452-5458.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5452-5458
-
-
O'Day, S.1
Gonzalez, R.2
Lawson, D.3
Weber, R.4
Hutchins, L.5
-
12
-
-
84865081609
-
Phase III, randomized, double-blind study of elesclomol and paclitaxel versus paclitaxel alone in stage IV metastatic melanoma (LBA9012)
-
Hauschild A, Eggermont AM, Jacobson E, O'Day SJ. (2009) Phase III, randomized, double-blind study of elesclomol and paclitaxel versus paclitaxel alone in stage IV metastatic melanoma (LBA9012). ASCO Annual Meeting Orlando, Fl.
-
(2009)
ASCO Annual Meeting Orlando, Fl
-
-
Hauschild, A.1
Eggermont, A.M.2
Jacobson, E.3
O'Day, S.J.4
-
13
-
-
0034669656
-
Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials
-
Manola J, Atkins M, Ibrahim J, Kirkwood J, (2000) Prognostic factors in metastatic melanoma: a pooled analysis of Eastern Cooperative Oncology Group trials. J Clin Oncol 18: 3782-3793.
-
(2000)
J Clin Oncol
, vol.18
, pp. 3782-3793
-
-
Manola, J.1
Atkins, M.2
Ibrahim, J.3
Kirkwood, J.4
-
14
-
-
0037902555
-
Melanin as a target for melanoma chemotherapy: pro-oxidant effect of oxygen and metals on melanoma viability
-
Farmer PJ, Gidanian S, Shahandeh B, Di Bilio AJ, Tohidian N, et al. (2003) Melanin as a target for melanoma chemotherapy: pro-oxidant effect of oxygen and metals on melanoma viability. Pigment Cell Res 16: 273-279.
-
(2003)
Pigment Cell Res
, vol.16
, pp. 273-279
-
-
Farmer, P.J.1
Gidanian, S.2
Shahandeh, B.3
Di Bilio, A.J.4
Tohidian, N.5
-
15
-
-
37849009181
-
Emerging applications of network and pathway analysis in drug discovery and development
-
Ganter B, Giroux CN, (2008) Emerging applications of network and pathway analysis in drug discovery and development. Curr Opin Drug Discov Devel 11: 86-94.
-
(2008)
Curr Opin Drug Discov Devel
, vol.11
, pp. 86-94
-
-
Ganter, B.1
Giroux, C.N.2
-
16
-
-
77952541558
-
The sites and topology of mitochondrial superoxide production
-
Brand MD, (2010) The sites and topology of mitochondrial superoxide production. Exp Gerontol 45: 466-472.
-
(2010)
Exp Gerontol
, vol.45
, pp. 466-472
-
-
Brand, M.D.1
-
17
-
-
4544359229
-
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals
-
Jonas EA, Hickman JA, Chachar M, Polster BM, Brandt TA, et al. (2004) Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals. Proc Natl Acad Sci U S A 101: 13590-13595.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 13590-13595
-
-
Jonas, E.A.1
Hickman, J.A.2
Chachar, M.3
Polster, B.M.4
Brandt, T.A.5
-
18
-
-
0026913511
-
The cytosensor microphysiometer: biological applications of silicon technology
-
McConnell HM, Owicki JC, Parce JW, Miller DL, Baxter GT, et al. (1992) The cytosensor microphysiometer: biological applications of silicon technology. Science 257: 1906-1912.
-
(1992)
Science
, vol.257
, pp. 1906-1912
-
-
McConnell, H.M.1
Owicki, J.C.2
Parce, J.W.3
Miller, D.L.4
Baxter, G.T.5
-
19
-
-
0024347177
-
Detection of cell-affecting agents with a silicon biosensor
-
Parce JW, Owicki JC, Kercso KM, Sigal GB, Wada HG, et al. (1989) Detection of cell-affecting agents with a silicon biosensor. Science 246: 243-247.
-
(1989)
Science
, vol.246
, pp. 243-247
-
-
Parce, J.W.1
Owicki, J.C.2
Kercso, K.M.3
Sigal, G.B.4
Wada, H.G.5
-
20
-
-
80053166769
-
Metabolic state of glioma stem cells and nontumorigenic cells
-
Vlashi E, Lagadec C, Vergnes L, Matsutani T, Masui K, et al. (2011) Metabolic state of glioma stem cells and nontumorigenic cells. Proc Natl Acad Sci U S A 108: 16062-16067.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 16062-16067
-
-
Vlashi, E.1
Lagadec, C.2
Vergnes, L.3
Matsutani, T.4
Masui, K.5
-
21
-
-
70350694223
-
Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal
-
Hill BG, Dranka BP, Zou L, Chatham JC, Darley-Usmar VM, (2009) Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J 424: 99-107.
-
(2009)
Biochem J
, vol.424
, pp. 99-107
-
-
Hill, B.G.1
Dranka, B.P.2
Zou, L.3
Chatham, J.C.4
Darley-Usmar, V.M.5
-
22
-
-
57049167019
-
Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease
-
Huttemann M, Lee I, Pecinova A, Pecina P, Przyklenk K, et al. (2008) Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease. J Bioenerg Biomembr 40: 445-456.
-
(2008)
J Bioenerg Biomembr
, vol.40
, pp. 445-456
-
-
Huttemann, M.1
Lee, I.2
Pecinova, A.3
Pecina, P.4
Przyklenk, K.5
-
23
-
-
79551521189
-
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells
-
Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, et al. (2011) A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci 124: 348-358.
-
(2011)
J Cell Sci
, vol.124
, pp. 348-358
-
-
Birket, M.J.1
Orr, A.L.2
Gerencser, A.A.3
Madden, D.T.4
Vitelli, C.5
-
24
-
-
33846317064
-
Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
-
Wu M, Neilson A, Swift AL, Moran R, Tamagnine J, et al. (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol 292: C125-136.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
-
-
Wu, M.1
Neilson, A.2
Swift, A.L.3
Moran, R.4
Tamagnine, J.5
-
25
-
-
77955266829
-
Alterations in bioenergetics due to changes in mitochondrial DNA copy number
-
Qian W, Van Houten B, (2010) Alterations in bioenergetics due to changes in mitochondrial DNA copy number. Methods 51: 452-457.
-
(2010)
Methods
, vol.51
, pp. 452-457
-
-
Qian, W.1
van Houten, B.2
-
26
-
-
70350743120
-
Metabolic approaches to treatment of melanoma
-
Hersey P, Watts RN, Zhang XD, Hackett J, (2009) Metabolic approaches to treatment of melanoma. Clin Cancer Res 15: 6490-6494.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6490-6494
-
-
Hersey, P.1
Watts, R.N.2
Zhang, X.D.3
Hackett, J.4
-
27
-
-
80052242132
-
Targeting cancer metabolism: a therapeutic window opens
-
Vander Heiden MG, (2011) Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov 10: 671-684.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 671-684
-
-
van der Heiden, M.G.1
-
28
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA, (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
29
-
-
84855702746
-
Mitochondrial electron transport is the cellular target of the oncology drug elesclomol
-
Blackman RK, Cheung-Ong K, Gebbia M, Proia DA, He S, et al. (2012) Mitochondrial electron transport is the cellular target of the oncology drug elesclomol. PLoS One 7: e29798.
-
(2012)
PLoS One
, vol.7
-
-
Blackman, R.K.1
Cheung-Ong, K.2
Gebbia, M.3
Proia, D.A.4
He, S.5
-
30
-
-
0032052209
-
Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase
-
Gnaiger E, Lassnig B, Kuznetsov A, Rieger G, Margreiter R, (1998) Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase. J Exp Biol 201: 1129-1139.
-
(1998)
J Exp Biol
, vol.201
, pp. 1129-1139
-
-
Gnaiger, E.1
Lassnig, B.2
Kuznetsov, A.3
Rieger, G.4
Margreiter, R.5
-
31
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, et al. (2012) Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481: 380-384.
-
(2012)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
-
32
-
-
84865313576
-
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
-
Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW, (2012) Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res 25: 375-383.
-
(2012)
Pigment Cell Melanoma Res
, vol.25
, pp. 375-383
-
-
Filipp, F.V.1
Scott, D.A.2
Ronai, Z.A.3
Osterman, A.L.4
Smith, J.W.5
-
33
-
-
0032483497
-
Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells
-
Buchet K, Godinot C, (1998) Functional F1-ATPase essential in maintaining growth and membrane potential of human mitochondrial DNA-depleted rho degrees cells. J Biol Chem 273: 22983-22989.
-
(1998)
J Biol Chem
, vol.273
, pp. 22983-22989
-
-
Buchet, K.1
Godinot, C.2
-
34
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O, (1956) On the origin of cancer cells. Science 123: 309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
35
-
-
0024311944
-
Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts
-
Kallinowski F, Schlenger KH, Runkel S, Kloes M, Stohrer M, et al. (1989) Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res 49: 3759-3764.
-
(1989)
Cancer Res
, vol.49
, pp. 3759-3764
-
-
Kallinowski, F.1
Schlenger, K.H.2
Runkel, S.3
Kloes, M.4
Stohrer, M.5
-
36
-
-
77952402960
-
Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect
-
Berridge MV, Tan AS, (2010) Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect. Rejuvenation Res 13: 139-141.
-
(2010)
Rejuvenation Res
, vol.13
, pp. 139-141
-
-
Berridge, M.V.1
Tan, A.S.2
-
37
-
-
82755183511
-
Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect
-
Scott DA, Richardson AD, Filipp FV, Knutzen CA, Chiang GG, et al. (2011) Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem 286: 42626-42634.
-
(2011)
J Biol Chem
, vol.286
, pp. 42626-42634
-
-
Scott, D.A.1
Richardson, A.D.2
Filipp, F.V.3
Knutzen, C.A.4
Chiang, G.G.5
-
39
-
-
77949486311
-
Constitutive HIF-1 activity in malignant melanoma
-
Kuphal S, Winklmeier A, Warnecke C, Bosserhoff AK, (2010) Constitutive HIF-1 activity in malignant melanoma. Eur J Cancer 46: 1159-1169.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1159-1169
-
-
Kuphal, S.1
Winklmeier, A.2
Warnecke, C.3
Bosserhoff, A.K.4
-
40
-
-
76049100577
-
HIF-1: upstream and downstream of cancer metabolism
-
Semenza GL, (2010) HIF-1: upstream and downstream of cancer metabolism. Curr Opin Genet Dev 20: 51-56.
-
(2010)
Curr Opin Genet Dev
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
41
-
-
84255192093
-
Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4
-
Wang X, Katayama A, Wang Y, Yu L, Favoino E, et al. (2011) Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4. Cancer Res 71: 7410-7422.
-
(2011)
Cancer Res
, vol.71
, pp. 7410-7422
-
-
Wang, X.1
Katayama, A.2
Wang, Y.3
Yu, L.4
Favoino, E.5
-
42
-
-
77950954465
-
Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032
-
Sondergaard JN, Nazarian R, Wang Q, Guo D, Hsueh T, et al. (2010) Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. J Transl Med 8: 39.
-
(2010)
J Transl Med
, vol.8
, pp. 39
-
-
Sondergaard, J.N.1
Nazarian, R.2
Wang, Q.3
Guo, D.4
Hsueh, T.5
-
43
-
-
84863116743
-
Antitumor activity of vemurafenib in previously treated patients with BRAFV600 mutated metastatic melanoma (BRIM2)
-
Sosman J, Kim K, Schuchter L, Gonzalez R, Pavlick A, et al. (2012) Antitumor activity of vemurafenib in previously treated patients with BRAFV600 mutated metastatic melanoma (BRIM2). N Engl J Med 366: 707-714.
-
(2012)
N Engl J Med
, vol.366
, pp. 707-714
-
-
Sosman, J.1
Kim, K.2
Schuchter, L.3
Gonzalez, R.4
Pavlick, A.5
-
44
-
-
75749094458
-
Glyceraldehyde-3-phosphate dehydrogenase expression is altered by hypoxia in melanoma cells and primary human melanocytes
-
Silverthorn CF, Alani RM, (2010) Glyceraldehyde-3-phosphate dehydrogenase expression is altered by hypoxia in melanoma cells and primary human melanocytes. Melanoma Res 20: 61-63.
-
(2010)
Melanoma Res
, vol.20
, pp. 61-63
-
-
Silverthorn, C.F.1
Alani, R.M.2
-
45
-
-
70349838735
-
Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway
-
Flint MS, Kim G, Hood BL, Bateman NW, Stewart NA, et al. (2009) Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway. Psychoneuroendocrinology 34: 1533-1541.
-
(2009)
Psychoneuroendocrinology
, vol.34
, pp. 1533-1541
-
-
Flint, M.S.1
Kim, G.2
Hood, B.L.3
Bateman, N.W.4
Stewart, N.A.5
-
46
-
-
73549118073
-
Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation
-
Moschos SJ, Dodd NR, Jukic DM, Fayewicz SL, Wang X, et al. (2009) Suppressing the high-level expression and function of ATM in advanced-stage melanomas does not sensitize the cells to ionizing radiation. Cancer Biol Ther 8: 1815-1825.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1815-1825
-
-
Moschos, S.J.1
Dodd, N.R.2
Jukic, D.M.3
Fayewicz, S.L.4
Wang, X.5
-
47
-
-
77951749645
-
Yip1A structures the mammalian endoplasmic reticulum
-
Dykstra KM, Pokusa JE, Suhan J, Lee TH, (2010) Yip1A structures the mammalian endoplasmic reticulum. Mol Biol Cell 21: 1556-1568.
-
(2010)
Mol Biol Cell
, vol.21
, pp. 1556-1568
-
-
Dykstra, K.M.1
Pokusa, J.E.2
Suhan, J.3
Lee, T.H.4
|