Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1

Journal of Thoracic and Cardiovascular Surgery

Volumn 146, Issue 3, 2013, Pages 702-709

  Singh, Krishna K ^a   Shukla, Praphulla C ^a   Yanagawa, Bobby ^a   Quan, Adrian ^a   Lovren, Fina ^a   Pan, Yi ^a   Wagg, Cory S ^b   Teoh, Hwee ^a   Lopaschuk, Gary D ^b   Verma, Subodh ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

5 adenosine monophosphate activated protein kinase; ACC; acetyl coenzyme A carboxylase; adenosine triphosphate; AMPK; ATP; BRCA1; breast cancer 1 early onset; carnitine palmitoyltransferase 1; CoA; coenzyme A; CPT1; glucose transporter; GLUT; malonyl CoA decarboxylase; MCD; peroxisome proliferator activated receptor coactivator 1 ; peroxisome proliferator activated receptors; PGC1 ; PPARs

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 2; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BRCA1 PROTEIN; CARNITINE PALMITOYLTRANSFERASE I; FATTY ACID TRANSPORTER; MALONYL COENZYME A DECARBOXYLASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; BIOENERGY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENERGY METABOLISM; ENZYME ACTIVATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FEMALE; GENE TARGETING; GLUCOSE METABOLISM; HEART MUSCLE METABOLISM; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

29; 31.2; 5′-ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE; ACC; ACETYL-COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; AMPK; ATP; BRCA1; BREAST CANCER 1, EARLY ONSET; CARNITINE PALMITOYLTRANSFERASE 1; COA; COENZYME A; CPT1; GLUCOSE TRANSPORTER; GLUT; MALONYL-COA DECARBOXYLASE; MCD; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-Γ COACTIVATOR 1Α; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PGC1Α; PPARS;

ACETYL-COA CARBOXYLASE; ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BRCA1 PROTEIN; CARBOXY-LYASES; DNA DAMAGE; DNA REPAIR; ENERGY METABOLISM; FATTY ACIDS; GENE EXPRESSION REGULATION; GLUCOSE; HETEROZYGOTE; HOMOZYGOTE; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTO-ONCOGENE PROTEINS C-AKT; TRANSCRIPTION FACTORS;

EID: 84881609139     PISSN: 00225223     EISSN: 1097685X     Source Type: Journal    
DOI: 10.1016/j.jtcvs.2012.12.046     Document Type: Article

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