Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma

Carcinogenesis

Volumn 30, Issue 1, 2009, Pages 158-164

  Zhong, Yi ^a,b   Onuki, Janice ^b,c   Yamasaki, Toshinari ^b   Ogawa, Osamu ^b   Akatsuka, Shinya ^a,b   Toyokuni, Shinya ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c INSTITUTO BUTANTAN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACYLASE; NITRILOTRIACETATE IRON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHROMOSOME 8Q; CHROMOSOME LOSS; COLONY FORMING CELL; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE MAPPING; GENOME ANALYSIS; HETEROZYGOSITY; KIDNEY CARCINOMA; KIDNEY PROXIMAL TUBULE; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TUMOR SUPPRESSOR GENE; WISTAR RAT;

AMIDOHYDROLASES; ANIMALS; APOPTOSIS; BASE SEQUENCE; CARCINOMA, RENAL CELL; CELL PROLIFERATION; CHROMOSOME DELETION; DNA PRIMERS; GENES, TUMOR SUPPRESSOR; IRON; KIDNEY NEOPLASMS; LOSS OF HETEROZYGOSITY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58949085533     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn255     Document Type: Article

References (46)

1. Halliwell,B. et al. (2007) Free Radicals in Biology and Medicine, 4th edn. Oxford University Press, New York, NY.
2. Toyokuni,S. et al. (2007) Pathological investigation of oxidative stress in the postgenomic era. Pathol. Int., 57, 461-473.
3. Toyokuni,S. (1996) Iron-induced carcinogenesis: The role of redox regulation. Free Radic. Biol. Med., 20, 553-566.
4. Nishigori,C. et al. (2004) Role of reactive oxygen species in skin carcinogenesis. Antioxid. Redox Signal., 6, 561-570.
5. Valko,M. et al. (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact., 160, 1-40.
6. Toyokuni,S. (2008) Molecular mechanisms of oxidative stress-induced carcinogenesis: From epidemiology to oxygenomics. IUBMB Life, 60, 441-447.
7. Ebina,Y. et al. (1986) Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats. J. Natl Cancer Inst., 76, 107-113.
8. Li,J.L. et al. (1987) Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res., 47, 1867-1869.
9. Nishiyama,Y. et al. (1995) Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn. J. Cancer Res., 86, 1150-1158.
10. Toyokuni,S. et al. (1994) DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int. J. Cancer, 57, 123-128.
11. Toyokuni,S. et al. (1994) Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc. Natl Acad. Sci. USA, 91, 2616-2620.
12. 7-12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitrilotriacetate. Free Radic. Biol. Med., 22, 1019-1027.
13. Okada,K. et al. (1999) 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J. Biol. Chem., 274, 23787-23793.
14. Jiang,L. et al. (2006) Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment. Cancer Sci., 97, 1159-1167.
15. INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene, 18, 3793-3797.
16. INK4A tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis. Am. J. Pathol., 160, 419-424.
17. Liu,Y.-T. et al. (2007) Chronic oxidative stress causes amplification and overexpresson of ptprz1 protein tyrosine phosphatase to activate b-catenin pathway. Am. J. Pathol., 171, 1978-1988.
18. Tanaka,T. et al. (2004) Redox regulation of annexin 2 and its implications for oxidative stess-induced renal carcinogenesis and metastasis. Oncogene, 23, 3980-3989.
19. Dutta,K.K. et al. (2005) Two distinct mechanisms for loss of thioredox-inbiding protein-2 in oxidative stress-induced renal carcinogenesis. Lab. Invest., 85, 798-807.
20. Zacharski,L. et al. (2008) Decreased cancer risk after iron reduction in patients with peripheral arterial disease: Results from a randomized trial. J. Natl Cancer Inst., 100, 996-1002.
21. Lee,W. et al. (2006) Alpha-tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage. Arch. Biochem. Biophys., 453, 168-178.
22. Toyokuni,S. et al. (2003) Intermittent microwave irradiation facilitates antigen-antibody reaction in western blot analysis. Pathol. Int., 53, 259-261.
23. Toyokuni,S. et al. (1997) Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest., 76, 365-374.
24. Zhong,Y. et al. (2007) Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice. Oncogene, 26 6937-6947.
25. Roomi,M. et al. (2006) Modulation of human renal cell carcinoma 786-0 MMP-2 and MMP-9 activity by inhibitors and inducers in vitro. Med. Oncol., 23, 245-250.
26. Munker,R. et al. (1986) Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells. J. Clin. Invest., 78, 424-430.
27. Reyal,F. et al. (2005) Visualizing chromosomes as transcriptome correlation maps: Evidence of chromosomal domains containing co-expressed genes-a study of 130 invasive ductal breast carcinomas. Cancer Res., 65, 1376-1383.
28. Maceyka,M. et al. (2004) Aminoacylase 1 is a sphingosine kinase 1- interacting protein. FEBS Lett., 568, 30-34.
29. Okada,S. et al. (1982) Induction of rat renal adenocarcinoma by Fenitrilotriacetate (Fe-NTA). Jpn. Arch. Intern. Med., 29, 485-491.
30. Miller,Y. et al. (1989) Lack of expression of aminoacylase-1 in small cell lung cancer. Evidence for inactivation of genes encoded by chromosome 3p. J. Clin. Invest., 83, 2120-2124.
31. Cook,R. et al. (1993) Human aminoacylase-1. Cloning, sequence, and expression analysis of a chromosome 3p21 gene inactivated in small cell lung cancer. J. Biol. Chem., 268, 17010-17017.
32. Kohno,T. et al. (1993) Chromosome 3p deletion in a renal cell carcinoma cell line established from a patient with von Hippel-Lindau disease. Jpn. J. Clin. Oncol., 23, 226-231.
33. Kohno,T. et al. (1993) Deletion mapping of chromosome 3p in human uterine cervical cancer. Oncogene, 8, 1825-1832.
34. Toyokuni,S. et al. (1995) Treatment of Wistar rats with a renal carcinogen, ferric nitrilotriacetate, causes DNA-protein cross-linking between thymine and tyrosine in their renal chromatin. Int. J. Cancer 62, 309-313.
35. Akatsuka,S. et al. (2006) Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Am. J. Pathol., 169, 1328-1342.
36. Cremer,T. et al. (2001) Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat. Rev. Genet. 2, 292-301.
37. Balabanov,S. et al. (2001) Tumour-related enzyme alterations in the clear cell type of human renal cell carcinoma identified by two-dimensional gel electrophoresis. Eur. J. Biochem., 268, 5977-5980.
38. Polevoda,B. et al. (2000) Nα-terminal acetylation of eukaryotic proteins. J. Biol. Chem., 275, 36479-36482.
39. Lindner,H. et al. (2003) Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family. J. Biol. Chem., 278, 44496-44504.
40. Perrier,J. et al. (2005) Catabolism of intracellular N-terminal acetylated proteins: Involvement of acylpeptide hydrolase and acylase. Biochimie, 87, 673-685.
41. Van Coster,R. et al. (2005) Aminoacylase I deficiency: A novel inborn error of metabolism. Biochem. Biophys. Res. Commun., 338 1322-1326.
42. Sass,J. et al. (2006) Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism. Am. J. Hum. Genet., 78, 401-409.
43. Lindner,H. et al. (2008) N-acetylamino acid utilization by kidney aminoacylase-1. Biochimie, 90, 773-780.
44. Hamazaki,S. et al. (1985) Acute renal failure and glucosuria induced by ferric nitrilotriacetate in rats. Toxicol. Appl. Pharmacol., 77, 267-274.
45. Hait,N. et al. (2006) Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta, 1758, 2016-2026.
46. Oskouian,B. et al. (2007) Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: Lipid signaling strikes again. Cell Cycle 6, 522-527.