Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetly-L-tartaric anhydride

Clinical Chemistry

Volumn 50, Issue 8, 2004, Pages 1391-1395

  Struys, Eduard A ^a   Jansen, Erwin E W ^a   Verhoeven, Nanda M ^a   Jakobs, Cornelis ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACID ANHYDRIDE; BUTANOL; DEXTRO 2 HYDROXYGLUTARATE; GLUTARIC ACID DERIVATIVE; ISOTOPE; LEVO 2 HYDROXYGLUTARATE; METHANOL; NITROGEN; TARTARIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CHEMICAL REACTION; CHIRALITY; CONCENTRATION (PARAMETERS); DERIVATIZATION; DIASTEREOISOMER; ENANTIOMER; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIQUID CHROMATOGRAPHY; MEASUREMENT; TANDEM MASS SPECTROMETRY; TIME; URINALYSIS;

ANHYDRIDES; CHROMATOGRAPHY, LIQUID; GLUTARATES; HUMANS; INDICATOR DILUTION TECHNIQUES; INDICATORS AND REAGENTS; MASS SPECTROMETRY; STEREOISOMERISM; TARTRATES;

EID: 3242798206     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2004.033399     Document Type: Article

References (15)

1. Chalmers RA, Lawson AM, Watts RWE, Tavill AS, Kamerling JP, et al. D-2-Hydroxyglutaric aciduria: case report and biochemical studies. J Inherit Metab Dis 1980;3:11-5.
2. Duran M, Kamerling JP, Bakker HD, van Gennip AH, Wadman SK. L-2-Hydroxyglutaric aciduria: an inborn error of metabolism. J Inherit Metab Dis 1980;3:109-12.
3. Muntau AC, Röschinger W, Merkernschlager A, van der Knaap MS, Jakobs C, Duran M, et al. Combined D-2- and L-2-hydroxyglutaric aciduria with neonatal onset encephalopathy: a third biochemical variant of 2-hydroxyglutaric aciduria. Neuropediatrics 2000;31: 137-40.
4. Struys EA, Verhoeven NM, Brunegraber H, Jakobs C. Investigations by mass isotopomer analysis of the formation of D-2-hydroxyglutarate by cultured lymphoblasts from two patients with D-2-hydroxyglutaric aciduria. FEBS Lett 2004;557:115-20.
5. Gibson KM, ten Brink HJ, Schor DS, Kok RM, Bootsma AH, Hoffmann GF, et al. Stable-isotope dilution analysis of D- and L-2-hydroxyglutaric acid: application to the detection and prenatal diagnosis of D- and L-2-hydroxyglutaric acidemias. Pediatr Res 1993;34:277-80.
6. Kim KR, Lee J, Ha D, Jeon J, Park HG, Kim JH. Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2- butyl esters by achiral dual-capillary column gas chromatography. J Chromatogr A 2000;874:91-100.
7. Muth A, Mosandl A, Wanders RJ, Nowaczyk MJ, Baric I, Bohles H, et al. Stereoselective analysis of 2-hydroxysebacic acid in urine of patients with Zellweger syndrome and of premature infants fed with medium-chain triglycerides. J Inherit Metab Dis 2003;26: 583-92.
8. dasNeves HJC, Noronha JP, Rufino H. New method for the chiral HRGC assay of L-2-hydroxyglutaric aciduria in urine. J High Res Chromatogr 1996;19:161-4.
9. Kaunzinger A, Rechner A, Beck T, Mosandl A, Sewell AC, Bohles H. Chiral compounds as indicators of inherited metabolic disease. Simultaneous stereodifferentiation of lactic-, 2-hydroxyglutaric-and glyceric acid by enantioselective cGC. Enantiomer 1996;1: 177-82.
10. Rashed MS, AlAmoudi M, Aboul-Enein HY. Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of 2-hydroxyglutaric acid in urine. Biomed Chromatogr 2000;14:317-20.
11. Molven A, Matre GE, Duran M, Wanders RJ, Rishaug U, Njolstad PR, et al. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Diabetes 2004;53:221-7.
12. Brocks DR, Dennis MJ, Schaefer WH. A liquid chromatographic assay for the stereospecific quantitative analysis of halofantrine in human plasma. J Pharm Biomed Appl 1995;13:911-8.
13. Nicklassan M, Brjorkman S, Roth B, Jonsson M, Hoglund P. Stereoselective metabolism of pentoxifylline in vitro and vivo in humans. Chirality 2002;14:643-52.
14. Brocks DR, Pasutto FM, Jamali F. Analytical and semi-preparative high-performance liquid chromatographic separation and assay of hydroxychloroquine enantiomers. J Chromatogr B 1992;581:83-92.
15. Lindner W, Rath M, Stoschitzky K, Uray G. Enantioselective drug monitoring of (R)-propanolol and (S)-propanolol in human plasma via derivatization with optically-active (R,R)-O,Odiacetyltartaric acid anhydride. J Chromatogr B 1989;487:375-83.