메뉴 건너뛰기




Volumn 25, Issue 9, 2014, Pages 444-451

The multifaceted and controversial immunometabolic actions of adiponectin

Author keywords

Adiponectin; Glucose homeostasis; Immunometabolism; Insulin sensitivity

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CADHERIN; GLUCOSE; INSULIN; RECOMBINANT ADIPONECTIN; RECOMBINANT PROTEIN; STREPTOZOCIN; T CADHERIN; UNCLASSIFIED DRUG; ADIPOQ PROTEIN, HUMAN; IMMUNOLOGIC FACTOR;

EID: 84906794224     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2014.06.001     Document Type: Review
Times cited : (48)

References (71)
  • 1
    • 84883551010 scopus 로고    scopus 로고
    • Adiponectin in inflammatory and immune-mediated diseases
    • Fantuzzi G. Adiponectin in inflammatory and immune-mediated diseases. Cytokine 2013, 64:1-10.
    • (2013) Cytokine , vol.64 , pp. 1-10
    • Fantuzzi, G.1
  • 2
    • 80052409973 scopus 로고    scopus 로고
    • What's new in our understanding of the role of adipokines in rheumatic diseases?
    • Gomez R., et al. What's new in our understanding of the role of adipokines in rheumatic diseases?. Nat. Rev. Rheumatol. 2011, 7:528-536.
    • (2011) Nat. Rev. Rheumatol. , vol.7 , pp. 528-536
    • Gomez, R.1
  • 3
    • 84874262426 scopus 로고    scopus 로고
    • Adiponectin: a biomarker for rheumatoid arthritis?
    • Chen X., et al. Adiponectin: a biomarker for rheumatoid arthritis?. Cytokine Growth Factor Rev. 2013, 24:83-89.
    • (2013) Cytokine Growth Factor Rev. , vol.24 , pp. 83-89
    • Chen, X.1
  • 4
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer P.E., et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 1995, 270:26746-26749.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26746-26749
    • Scherer, P.E.1
  • 5
    • 17944362243 scopus 로고    scopus 로고
    • The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome
    • Comuzzie A.G., et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab. 2001, 86:4321-43215.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 4321-43215
    • Comuzzie, A.G.1
  • 6
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    • Tilg H., Moschen A.R. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 2006, 6:772-783.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 7
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E., et al. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 1996, 271:10697-10703.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10697-10703
    • Hu, E.1
  • 8
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 1999, 257:79-83.
    • (1999) Biochem. Biophys. Res. Commun. , vol.257 , pp. 79-83
    • Arita, Y.1
  • 9
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 2001, 7:941-946.
    • (2001) Nat. Med. , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 10
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu A., et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 2003, 112:91-100.
    • (2003) J. Clin. Invest. , vol.112 , pp. 91-100
    • Xu, A.1
  • 11
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T., et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Invest. 2006, 116:1784-1792.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1784-1792
    • Kadowaki, T.1
  • 12
    • 0037494960 scopus 로고    scopus 로고
    • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects
    • Yamauchi T., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-769.
    • (2003) Nature , vol.423 , pp. 762-769
    • Yamauchi, T.1
  • 13
    • 33847733103 scopus 로고    scopus 로고
    • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions
    • Yamauchi T., et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat. Med. 2007, 13:332-339.
    • (2007) Nat. Med. , vol.13 , pp. 332-339
    • Yamauchi, T.1
  • 14
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin
    • Hug C., et al. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:10308-10313.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10308-10313
    • Hug, C.1
  • 15
    • 33644820471 scopus 로고    scopus 로고
    • An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways
    • Adachi Y., et al. An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways. Virchows Arch. 2006, 448:311-318.
    • (2006) Virchows Arch. , vol.448 , pp. 311-318
    • Adachi, Y.1
  • 16
    • 79953765855 scopus 로고    scopus 로고
    • Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway
    • Awazawa M., et al. Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway. Cell Metab. 2011, 13:401-412.
    • (2011) Cell Metab. , vol.13 , pp. 401-412
    • Awazawa, M.1
  • 17
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg A.H., et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 2001, 7:947-953.
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1
  • 18
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
    • Combs T.P., et al. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J. Clin. Invest. 2001, 108:1875-1881.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1875-1881
    • Combs, T.P.1
  • 19
    • 33744972277 scopus 로고    scopus 로고
    • APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
    • Mao X., et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat. Cell Biol. 2006, 8:516-523.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 516-523
    • Mao, X.1
  • 20
    • 0033517348 scopus 로고    scopus 로고
    • Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
    • Mitsuuchi Y., et al. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 1999, 18:4891-4898.
    • (1999) Oncogene , vol.18 , pp. 4891-4898
    • Mitsuuchi, Y.1
  • 21
    • 79957902675 scopus 로고    scopus 로고
    • Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
    • Miller R.A., et al. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J. Clin. Invest. 2011, 121:2518-2528.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2518-2528
    • Miller, R.A.1
  • 22
    • 33646133412 scopus 로고    scopus 로고
    • PPAR-alpha and insulin sensitivity
    • Haluzik M.M., Haluzik M. PPAR-alpha and insulin sensitivity. Physiol. Res. 2006, 55:115-122.
    • (2006) Physiol. Res. , vol.55 , pp. 115-122
    • Haluzik, M.M.1    Haluzik, M.2
  • 23
    • 34547586298 scopus 로고    scopus 로고
    • Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice
    • Lin H.V., et al. Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice. Diabetes 2007, 56:1969-1976.
    • (2007) Diabetes , vol.56 , pp. 1969-1976
    • Lin, H.V.1
  • 24
    • 78651244727 scopus 로고    scopus 로고
    • Adiponectin sphings into action
    • Lancaster G.I., Febbraio M.A. Adiponectin sphings into action. Nat. Med. 2011, 17:37-38.
    • (2011) Nat. Med. , vol.17 , pp. 37-38
    • Lancaster, G.I.1    Febbraio, M.A.2
  • 25
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland W.L., et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat. Med. 2011, 17:55-63.
    • (2011) Nat. Med. , vol.17 , pp. 55-63
    • Holland, W.L.1
  • 26
    • 0037432152 scopus 로고    scopus 로고
    • Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue
    • Ouchi N., et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 2003, 107:671-674.
    • (2003) Circulation , vol.107 , pp. 671-674
    • Ouchi, N.1
  • 27
    • 0036063777 scopus 로고    scopus 로고
    • Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
    • Maeda N., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat. Med. 2002, 8:731-737.
    • (2002) Nat. Med. , vol.8 , pp. 731-737
    • Maeda, N.1
  • 28
    • 84903474732 scopus 로고    scopus 로고
    • Role of anti-inflammatory adipokines in obesity-related diseases
    • Ohashi K., et al. Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol. Metab. 2014, 10.1016/j.tem.2014.03.009.
    • (2014) Trends Endocrinol. Metab.
    • Ohashi, K.1
  • 29
    • 28844494503 scopus 로고    scopus 로고
    • Adiponectin inhibits Toll-like receptor family-induced signaling
    • Yamaguchi N., et al. Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Lett. 2005, 579:6821-6826.
    • (2005) FEBS Lett. , vol.579 , pp. 6821-6826
    • Yamaguchi, N.1
  • 30
    • 2442464884 scopus 로고    scopus 로고
    • Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages
    • Kumada M., et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 2004, 109:2046-2049.
    • (2004) Circulation , vol.109 , pp. 2046-2049
    • Kumada, M.1
  • 31
    • 77949881805 scopus 로고    scopus 로고
    • Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype
    • Ohashi K., et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J. Biol. Chem. 2010, 285:6153-6160.
    • (2010) J. Biol. Chem. , vol.285 , pp. 6153-6160
    • Ohashi, K.1
  • 32
    • 33846784058 scopus 로고    scopus 로고
    • Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies
    • Takemura Y., et al. Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. J. Clin. Invest. 2007, 117:375-386.
    • (2007) J. Clin. Invest. , vol.117 , pp. 375-386
    • Takemura, Y.1
  • 33
    • 35549006843 scopus 로고    scopus 로고
    • Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin
    • Haugen F., Drevon C.A. Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology 2007, 148:5478-5486.
    • (2007) Endocrinology , vol.148 , pp. 5478-5486
    • Haugen, F.1    Drevon, C.A.2
  • 34
    • 0037119375 scopus 로고    scopus 로고
    • Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30kDa (Acrp30)
    • Tsao T.S., et al. Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30kDa (Acrp30). J. Biol. Chem. 2002, 277:29359-29362.
    • (2002) J. Biol. Chem. , vol.277 , pp. 29359-29362
    • Tsao, T.S.1
  • 35
    • 84868219117 scopus 로고    scopus 로고
    • + T cells
    • + T cells. J. Biol. Chem. 2012, 287:36896-36904.
    • (2012) J. Biol. Chem. , vol.287 , pp. 36896-36904
    • Cheng, X.1
  • 36
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • Foster S.L., et al. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007, 447:972-978.
    • (2007) Nature , vol.447 , pp. 972-978
    • Foster, S.L.1
  • 37
    • 84880815366 scopus 로고    scopus 로고
    • Short-term memory of danger signals and environmental stimuli in immune cells
    • Monticelli S., Natoli G. Short-term memory of danger signals and environmental stimuli in immune cells. Nat. Immunol. 2013, 14:777-784.
    • (2013) Nat. Immunol. , vol.14 , pp. 777-784
    • Monticelli, S.1    Natoli, G.2
  • 38
    • 34547556455 scopus 로고    scopus 로고
    • Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated interleukin-10 production
    • Park P.H., et al. Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated interleukin-10 production. J. Biol. Chem. 2007, 282:21695-21703.
    • (2007) J. Biol. Chem. , vol.282 , pp. 21695-21703
    • Park, P.H.1
  • 39
    • 84896742056 scopus 로고    scopus 로고
    • Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
    • Fairfax B.P., et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 2014, 10.1126/science.1246949.
    • (2014) Science
    • Fairfax, B.P.1
  • 40
    • 69949176863 scopus 로고    scopus 로고
    • Common regulatory variation impacts gene expression in a cell type-dependent manner
    • Dimas A.S., et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 2009, 325:1246-1250.
    • (2009) Science , vol.325 , pp. 1246-1250
    • Dimas, A.S.1
  • 41
    • 84860317030 scopus 로고    scopus 로고
    • Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
    • Fairfax B.P., et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nat. Genet. 2012, 44:502-510.
    • (2012) Nat. Genet. , vol.44 , pp. 502-510
    • Fairfax, B.P.1
  • 42
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 43
    • 84876771596 scopus 로고    scopus 로고
    • The immune system as a sensor of the metabolic state
    • Odegaard J.I., Chawla A. The immune system as a sensor of the metabolic state. Immunity 2013, 38:644-654.
    • (2013) Immunity , vol.38 , pp. 644-654
    • Odegaard, J.I.1    Chawla, A.2
  • 44
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce E.L., Pearce E.J. Metabolic pathways in immune cell activation and quiescence. Immunity 2013, 38:633-643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 45
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang C.H., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 2013, 153:1239-1251.
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1
  • 46
    • 84862016400 scopus 로고    scopus 로고
    • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
    • Haschemi A., et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 2012, 15:813-826.
    • (2012) Cell Metab. , vol.15 , pp. 813-826
    • Haschemi, A.1
  • 47
    • 84862000246 scopus 로고    scopus 로고
    • Polarizing macrophages through reprogramming of glucose metabolism
    • Blagih J., Jones R.G. Polarizing macrophages through reprogramming of glucose metabolism. Cell Metab. 2012, 15:793-795.
    • (2012) Cell Metab. , vol.15 , pp. 793-795
    • Blagih, J.1    Jones, R.G.2
  • 48
    • 79953863868 scopus 로고    scopus 로고
    • Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin
    • Mandal P., et al. Molecular mechanism for adiponectin-dependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J. Biol. Chem. 2011, 286:13460-13469.
    • (2011) J. Biol. Chem. , vol.286 , pp. 13460-13469
    • Mandal, P.1
  • 49
    • 84873804024 scopus 로고    scopus 로고
    • 07 Direct control of hepatic glucose production by interleukin-13 in mice
    • Stanya K.J., et al. 07 Direct control of hepatic glucose production by interleukin-13 in mice. J. Clin. Invest. 2013, 123:261-271.
    • (2013) J. Clin. Invest. , vol.123 , pp. 261-271
    • Stanya, K.J.1
  • 50
    • 44349161098 scopus 로고    scopus 로고
    • Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    • Odegaard J.I., et al. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008, 7:496-507.
    • (2008) Cell Metab. , vol.7 , pp. 496-507
    • Odegaard, J.I.1
  • 51
    • 84875611758 scopus 로고    scopus 로고
    • Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
    • Satoh T., et al. Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature 2013, 495:524-528.
    • (2013) Nature , vol.495 , pp. 524-528
    • Satoh, T.1
  • 52
    • 34848872799 scopus 로고    scopus 로고
    • Obesity-associated improvements in metabolic profile through expansion of adipose tissue
    • Kim J.Y., et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J. Clin. Invest. 2007, 117:2621-2637.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2621-2637
    • Kim, J.Y.1
  • 53
    • 84866002800 scopus 로고    scopus 로고
    • Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism
    • Liu Q., et al. Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:14568-14573.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 14568-14573
    • Liu, Q.1
  • 54
    • 84876804378 scopus 로고    scopus 로고
    • Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages
    • Luo N., et al. Enhanced adiponectin actions by overexpression of adiponectin receptor 1 in macrophages. Atherosclerosis 2013, 228:124-135.
    • (2013) Atherosclerosis , vol.228 , pp. 124-135
    • Luo, N.1
  • 55
    • 84896455567 scopus 로고    scopus 로고
    • Accumulation of adiponectin in inflamed adipose tissues of obese mice
    • Nakatsuji H., et al. Accumulation of adiponectin in inflamed adipose tissues of obese mice. Metabolism 2014, 63:542-553.
    • (2014) Metabolism , vol.63 , pp. 542-553
    • Nakatsuji, H.1
  • 56
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    • Xu X., et al. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab. 2013, 18:816-830.
    • (2013) Cell Metab. , vol.18 , pp. 816-830
    • Xu, X.1
  • 57
    • 77951872309 scopus 로고    scopus 로고
    • 2+ and AMPK/SIRT1
    • 2+ and AMPK/SIRT1. Nature 2010, 464:1313-1319.
    • (2010) Nature , vol.464 , pp. 1313-1319
    • Iwabu, M.1
  • 58
    • 84888639952 scopus 로고    scopus 로고
    • A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
    • Okada-Iwabu M., et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013, 503:493-499.
    • (2013) Nature , vol.503 , pp. 493-499
    • Okada-Iwabu, M.1
  • 59
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
    • Rhee J., et al. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4012-4017.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 4012-4017
    • Rhee, J.1
  • 60
    • 84903171544 scopus 로고    scopus 로고
    • Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis
    • Handa P., et al. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology 2014, 10.1002/hep.26946.
    • (2014) Hepatology
    • Handa, P.1
  • 61
    • 33745865153 scopus 로고    scopus 로고
    • Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    • Burgess S.C., et al. Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J. Biol. Chem. 2006, 281:19000-19008.
    • (2006) J. Biol. Chem. , vol.281 , pp. 19000-19008
    • Burgess, S.C.1
  • 62
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M., et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J. Clin. Invest. 2010, 120:2355-2369.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2355-2369
    • Foretz, M.1
  • 63
    • 38449089987 scopus 로고    scopus 로고
    • Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway
    • Tang C.H., et al. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J. Immunol. 2007, 179:5483-5492.
    • (2007) J. Immunol. , vol.179 , pp. 5483-5492
    • Tang, C.H.1
  • 64
    • 33645804223 scopus 로고    scopus 로고
    • Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding
    • Thakur V., et al. Adiponectin normalizes LPS-stimulated TNF-alpha production by rat Kupffer cells after chronic ethanol feeding. Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290:G998-G1007.
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290
    • Thakur, V.1
  • 65
    • 77950625277 scopus 로고    scopus 로고
    • The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells
    • Mandal P., et al. The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells. Hepatology 2010, 51:1420-1429.
    • (2010) Hepatology , vol.51 , pp. 1420-1429
    • Mandal, P.1
  • 66
    • 84875825142 scopus 로고    scopus 로고
    • Relation of serum adiponectin levels to number of traditional atherosclerotic risk factors and all-cause mortality and major adverse cardiovascular events (from the Copenhagen City Heart Study)
    • Lindberg S., et al. Relation of serum adiponectin levels to number of traditional atherosclerotic risk factors and all-cause mortality and major adverse cardiovascular events (from the Copenhagen City Heart Study). Am. J. Cardiol. 2013, 111:1139-1145.
    • (2013) Am. J. Cardiol. , vol.111 , pp. 1139-1145
    • Lindberg, S.1
  • 67
    • 84871337477 scopus 로고    scopus 로고
    • Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study
    • Kizer J.R., et al. Associations of total and high-molecular-weight adiponectin with all-cause and cardiovascular mortality in older persons: the Cardiovascular Health Study. Circulation 2012, 126:2951-2961.
    • (2012) Circulation , vol.126 , pp. 2951-2961
    • Kizer, J.R.1
  • 68
    • 67650066805 scopus 로고    scopus 로고
    • Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis
    • Rho Y.H., et al. Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis. Arthritis Rheum. 2009, 60:1906-1914.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1906-1914
    • Rho, Y.H.1
  • 69
    • 79952054126 scopus 로고    scopus 로고
    • Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia
    • Honsawek S., et al. Serum adiponectin and transient elastography as non-invasive markers for postoperative biliary atresia. BMC Gastroenterol. 2011, 11:16.
    • (2011) BMC Gastroenterol. , vol.11 , pp. 16
    • Honsawek, S.1
  • 70
    • 24144497040 scopus 로고    scopus 로고
    • Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis
    • Kaser S., et al. Circulating adiponectin reflects severity of liver disease but not insulin sensitivity in liver cirrhosis. J. Intern. Med. 2005, 258:274-280.
    • (2005) J. Intern. Med. , vol.258 , pp. 274-280
    • Kaser, S.1
  • 71
    • 77956594638 scopus 로고    scopus 로고
    • Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease
    • Chan K.H., et al. Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease. Int. J. Tuberc. Lung Dis. 2010, 14:1193-1200.
    • (2010) Int. J. Tuberc. Lung Dis. , vol.14 , pp. 1193-1200
    • Chan, K.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.