Development and validation of a chromatographic method for determining Clematichinenoside AR and related impurities

Chemistry Central Journal

Volumn 6, Issue 1, 2012, Pages

  Zhou, Yang ^a   Guan, Yue ^a   Shi, Ji ^a   Zhang, Xiaolin ^a   Yao, Lan ^a   Liu, Lifang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Clematichinenoside AR; Correction factors; HPLC UV; Related impurities

Indexed keywords

EID: 84870500759     PISSN: None     EISSN: 1752153X     Source Type: Journal    
DOI: 10.1186/1752-153X-6-150     Document Type: Article

References (19)

1. The State Pharmacopoeia Commission of The People's Republic of China Pharmacopoeia of the People's Republic of China. China Medical Science 2010, Volume 1:234. The State Pharmacopoeia Commission of The People's Republic of China.
2. Shi S, Jiang D, Zhao M, et al. Preparative isolation and purification of triterpene saponins from Clematis mandshurica by high-speed counter-current chromatography coupled with evaporative light scattering detection. J Chromatogr B 2007, 852:679-683.
3. Mimaki Y, Yokosuka A, Hamanaka M, et al. Triterpene saponins from the roots of Clematis chinensis. J Nat Prod 2004, 67:1511-1516. 10.1021/np040088k, 15387651.
4. Shi S, Jiang D, Dong C, et al. Triterpene saponins from Clematis mandshurica. J Nat Prod 2006, 69:1591-1595. 10.1021/np060287z, 17125227.
5. Liu L, Ma X, Wang YX, et al. Triterpenoid saponins from the roots of Clematis chinensis Osbeck. J Asian Nat Prod Res 2009, 11:389-396. 10.1080/10286020902867268, 19504380.
6. Wu W, Xu X, Dai Y, et al. Therapeutic effect of the saponin fraction from clematis chinensis osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage. Phytother Res 2010, 24:538-546.
7. Fu Q, Zan K, Zhao M, et al. Triterpene saponins from clematis chinensis and their potential anti-inflammatory activity. J Nat Prod 2010, 73:1234-1239. 10.1021/np100057y, 20540535.
8. Peng C, Perera PK, Li Y, et al. Anti-inflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-kB, TNF-a, and COX-2 in collagen-induced arthritis in rat. Rheumatol Int 2012, 32:3119-3125. 10.1007/s00296-011-2083-8, 21932136.
9. Lu X, Fang W, Li Y, et al. Analgesic and anti-inflammatory effect of clematichinenoside. Chinese Journal of New Drugs 2009, 18:1535-1539.
10. Sun S, Li Y, Fang W, et al. Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin Exp Med 2010, 10:113-121. 10.1007/s10238-009-0075-8, 19842015.
11. Dong C, Liu L, Li M, et al. The preparation and preliminary pharmacodynamics of clematichinenoside microemulsion. Chinese Traditional Patent Medicine 2011, 33(7):1159-1163.
12. Ma X, Xie L, Liu L, et al. Simultaneous quantification of seven main triterpenoid saponins in Radix et Rhizoma Clematidis by LC-ELSD. Chromatographia 2009, 69:437-443.
13. Wang D, Li F, Li P, et al. Validated LC-MS/MS assay for the quantitative determination of clematichinenoside AR in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr 2012, 26(10):1282-1285. 10.1002/bmc.2691, 22344977.
14. ICH Q3A Impurities in New Drug Substances. Proceedings of the international conference on harmonization 2006, 1-22. ICH.
15. Kizu H, Shimana H, Tommimori T. Studies on the constituents constituents of Clematis Species IV. The Constituents of Clematis stans Sieb. Et Zucc. Chem Pharm Bull 1995, 43(12):2187-2194. 10.1248/cpb.43.2187, 8582022.
16. Shao B, Qin G, Xu R, et al. Triterpenoid saponins fromClematis chinensis. Phytochemistry 1995, 38(6):1473-1479. 10.1016/0031-9422(94)00899-5, 7786477.
17. ICH Q1A Stability Testing of New Drug Substances and Products. In Proceedings of the international conference on harmonization 2003, 1-15. ICH.
18. Hou J, Wua W, Da J, et al. Ruggedness and robustness of conversion factors in method of simultaneous determination of multi-components with single reference standard. J Chromatogr A 2011, 1218:5618-5627. 10.1016/j.chroma.2011.06.058, 21741654.
19. ICH Q3B Impurities in New Drug Substances. In Proceedings of the international conference on harmonization 2006, 1-12. ICH.