Anti-arthritic effects of clematichinenoside (AR-6) on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis

Pharmaceutical Biology

Volumn 51, Issue 1, 2013, Pages 13-22

  Han, Wang ^a   Xiong, Ying ^a   Li, Yunman ^a   Fang, Weirong ^a   Ma, Yan ^a   Liu, Lifang ^a   Li, Fengwen ^a   Zhu, Xingxiang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Clematis chinensis Osbeck; Immunohistochemistry; Rheumatoid arthritis; RT PCR

Indexed keywords

ANTIRHEUMATIC AGENT; AR 6; CLEMATICHINENOSIDE; GLUCOSIDE; MESSENGER RNA; METHOTREXATE; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; GENE EXPRESSION; HERBAL MEDICINE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LOW DRUG DOSE; MALE; NONHUMAN; PAEONIA LACTIFLORA; PAW EDEMA; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS;

ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION; MALE; PHOSPHATIDYLINOSITOL 3-KINASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SAPONINS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

CLEMATIS CHINENSIS; RANUNCULACEAE; RATTUS;

EID: 84871382667     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.698287     Document Type: Article

References (29)

1. Arntz OJ, Geurts J, Veenbergen S, Bennink MB, van den Brand BT, Abdollahi-Roodsaz S, van den Berg WB, van de Loo FA. (2010). A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis. Arthritis Res Ther, 12, R61
2. Bingham CO 3rd. (2002). The pathogenesis of rheumatoid arthritis: Pivotal cytokines involved in bone degradation and inflammation. J Rheumatol Suppl, 65, 3-9 (Pubitemid 34988675)
3. Capria A, De Nardo D, Baffetti FR, Barbini U, Violo A, Tondo T, Fontana L. (2010). Long-term anti-TNF-α treatments reverse the endothelial dysfunction in rheumatoid arthritis: The biological coherence between synovial and endothelial inflammation. Int J Immunopathol Pharmacol, 23, 255-262
4. Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA. (2003). Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy. Leukemia, 17, 590-603 (Pubitemid 36395654)
5. Choy EH, Panayi GS. (2001). Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med, 344, 907-916 (Pubitemid 32224400)
6. Downward J. (2004). PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol, 15, 177-182 (Pubitemid 38251646)
7. Fingar DC, Blenis J. (2004). Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene, 23, 3151-3171 (Pubitemid 38638827)
8. Fishman P, Bar-Yehuda S, Madi L, Rath-Wolfson L, Ochaion A, Cohen S, Baharav E. (2006). The PI3K-NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis. Arthritis Res Ther, 8, R33
9. Fishman P, Madi L, Bar-Yehuda S, Barer F, Del Valle L, Khalili K. (2002). Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells. Oncogene, 21, 4060-4064 (Pubitemid 34679247)
10. Goldring SR. (2003). Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford), 42, 11-16
11. Gupta V, Wagner BJ. (2009). Search for a functional glucocorticoid receptor in the mammalian lens. Exp Eye Res, 88, 248-256
12. Hashiramoto A, Sakai C, Yoshida K, Tsumiyama K, Miura Y, Shiozawa K, Nose M, Komai K, Shiozawa S. (2007). Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt. Arthritis Rheum, 56, 2170-2179 (Pubitemid 47173564)
13. Herlaar E, Brown Z. (1999). p38 MAPK signalling cascades in inflammatory disease. Mol Med Today, 5, 439-447 (Pubitemid 29455026)
14. Kim JE, Son JE, Jung SK, Kang NJ, Lee CY, Lee KW, Lee HJ. (2010). Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells. Br J Nutr, 104, 957-964
15. Li T, Zuo X, Zhou Y, Wang Y, Zhuang H, Zhang L, Zhang H, Xiao X. (2010). The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis. J Clin Immunol, 30, 213-220
16. Ma X, Xie L, Liu L, Tang Q, Wan Z, Li Y. (2009). Simultaneous quantification of seven main triterpenoid saponins in Radix et Rhizoma Clematidis by LC-ELSD. Chromatographia, 69, 437-43
17. Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T, Yonezawa T, Saeki Y, Panayi GS, Pitzalis C, Kimura T. (2002). The role of TNF-α in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): A study using a human RA/SCID mouse chimera. Rheumatology (Oxford), 41, 329-337 (Pubitemid 34537871)
18. Miossec P. (2004). An update on the cytokine network in rheumatoid arthritis. Curr Opin Rheumatol, 16, 218-222 (Pubitemid 38530489)
19. Montalban AG, Boman E, Chang CD, Ceide SC, Dahl R, Dalesandro D, Delaet NG, Erb E, Ernst J, Gibbs A, Kahl J, Kessler L, Lundstrom J, Miller S, Nakanishi H, Roberts E, Saiah E, Sullivan R, Wang Z, Larson CJ. (2010). KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. Eur J Pharmacol, 632, 93-102
20. O'Dell Jr. (2004). Therapeutic strategies for rheumatoid arthritis. N Engl J Med, 350, 2591-2602
21. Ochaion A, Bar-Yehuda S, Cohen S, Amital H, Jacobson KA, Joshi BV, Gao ZG, Barer F, Patoka R, Del Valle L, Perez-Liz G, Fishman P. (2008). The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-κB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis rats. Biochem Pharmacol, 76, 482-494
22. Peng C, Perera PK, Li YM, Fang WR, Liu LF, Li FW. (2011). Antiinflammatory effects of Clematis chinensis Osbeck extract(AR-6) may be associated with NF-κB, TNF-α, and COX-2 in collageninduced arthritis in rat. Rheumatol Int. [Epub ahead of print].
23. Perera PK, Peng C, Xue L, Li Y, Han C. (2011). Ex vivo and in vivo effect of Chinese herbal pill Yi Shen Juan Bi (YJB) on experimental arthritis. J Ethnopharmacol, 134, 171-175
24. Setty AR, Sigal LH. (2005). Herbal medications commonly used in the practice of rheumatology: Mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum, 34, 773-784 (Pubitemid 40732452)
25. Sun SX, Li YM, Fang WR, Cheng P, Liu L, Li F. (2010). Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin Exp Med, 10, 113-121
26. Tong XM, Wang JC, Shen Y, Xie JJ, Zhang JY, Jin J. (2011). Inhibition of inflammatory mediators and related signaling pathways by macrophage-stimulating protein in rheumatoid arthritis synovial fibroblasts. Inflamm Res, 60, 823-829
27. Williams-Skipp C, Raman T, Valuck RJ, Watkins H, Palmer BE, Scheinman RI. (2009). Unmasking of a protective tumor necrosis factor receptor I-mediated signal in the collagen-induced arthritis model. Arthritis Rheum, 60, 408-418
28. Wu T, Mohan C. (2009). The AKT axis as a therapeutic target in autoimmune diseases. Endocr Metab Immune Disord Drug Targets, 9, 145-150
29. Zwerina J, Hayer S, Redlich K, Bobacz K, Kollias G, Smolen JS, Schett G. (2006). Activation of p38 MAPK is a key step in tumor necrosis factor-mediated inflammatory bone destruction. Arthritis Rheum, 54, 463-472 (Pubitemid 43228620)