Study on intestinal absorption of clematichinenoside AR in rats by in-situ single-pass perfusion model

Chinese Journal of New Drugs

Volumn 21, Issue 7, 2012, Pages 800-803

  Wang, Da Wei ^a,b   Zhang, Ji ^a   Li, Pei ^a   Li, Feng ^a   Liu, Xiao Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Provincial Academy of Traditional Chinese Medicine   (China)

Author keywords

Absorption; Clematichinenoside AR; In situ single pass intestine perfusion model; Pharmacokinetics; Rat

Indexed keywords

CHINESE DRUG; CLEMATICHINENOSIDE AR; CYCLOSPORIN A; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; DUODENUM; ILEUM; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; JEJUNUM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; RAT;

EID: 84861785986     PISSN: 10033734     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. AMIDON G L, LENNERNAS H, SHAH V P, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability[J]. Pharm Res, 1995, 12 (3): 413-420.
2. FAGERHOLM U, JOHANSSON M, LENNERNAS H. Comparison between permeability coefficients in rat and human jejunum[J]. Pharm Res, 1996, 13 (9): 1336-1342.
3. 2008, 31 (3): 465-470.
4. MA X, XIE L, LIU L, et al. Simultaneous quantification of seven main triterpenoid saponins in Radix et Rhizoma clematidis by LC-ELSD[J]. Chromatographia, 2009, 69(5-6): 437-443.
5. LIU LF, MA X L, WANG Y X, et al. Triterpenoid saponins from the roots of Clematis chinensis Osbeck[J]. J Asian Nat Prod Res, 2009, 11 (5): 389-396.
6. 2009, 18 (16): 1535-1539.
7. BERGGREN S, HOOGSTRAATE J, FAGERHOLM U, et al. Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models[J]. Eur J Pharm Sci, 2004, 21 (4): 553-560.
8. 2009, 44 (8): 922-926.
9. 2008, 29 (8): 994-996.
10. 2008, 24 (5): 443-446.