Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cells balance

Phytomedicine

Volumn 19, Issue 10, 2012, Pages 882-889

  Lu, Yue ^a   Xiao, Juan ^b   Wu, Zai Wang ^a   Wang, Zhe Ming ^a   Hu, Jia ^b   Fu, Hong Zheng ^b   Chen, Ying Yu ^b   Qian, Rui Qin ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Collagen induced arthritis; Herba Siegesbeckiae; Immunosuppression; Kirenol; Rheumatoid arthritis; T cell

Indexed keywords

ANTIRHEUMATIC AGENT; DITERPENOID; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; KIRENOL; MESSENGER RNA; PREDNISOLONE; SODIUM CHLORIDE; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ CD25+ FOXP3+ T REGULATORY CELL; CD4+ T LYMPHOCYTE; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG EFFECT; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNOMODULATION; IN VITRO STUDY; LYMPH NODE CELL; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SPLEEN CELL; T LYMPHOCYTE; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIRHEUMATIC AGENTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; ASTERACEAE; BONE AND BONES; CARTILAGE; CATTLE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COLLAGEN TYPE II; CYTOKINES; DITERPENES; DRUGS, CHINESE HERBAL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; JOINT DISEASES; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; PHYTOTHERAPY; PREDNISOLONE; RATS; RATS, WISTAR; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SPLEEN; SYNOVIAL FLUID; T-LYMPHOCYTES, REGULATORY;

BOVINAE; RATTUS; RATTUS NORVEGICUS;

EID: 84864409803     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.04.010     Document Type: Article

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