Expression and function of growth hormone in the nervous system: A brief review

General and Comparative Endocrinology

Volumn 203, Issue , 2014, Pages 35-42

  Arámburo, Carlos ^a   Alba Betancourt, Clara ^a   Luna, Maricela ^a   Harvey, Steve ^b  

^a INSTITUTO DE NEUROBIOLOGÍA   (Mexico)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Apoptosis; Cerebellum; Growth hormone; Hippocampus; Neural GH; Neuroprotection

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; MESSENGER RNA; MICRORNA; MICRORNA 1; MICRORNA 132; MICRORNA 133; MICRORNA 134; MICRORNA 15A; MICRORNA 210; MICRORNA 29B; SOMATOMEDIN C; UNCLASSIFIED DRUG; UNTRANSLATED RNA; VASCULOTROPIN;

CELL PROLIFERATION; CELL SURVIVAL; CEREBELLUM; COGNITION; GENE EXPRESSION; GROWTH HORMONE SECRETING CELL; HIPPOCAMPUS; HORMONAL REGULATION; HORMONE ACTION; HUMAN; IMMUNOREACTIVITY; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; NERVOUS TISSUE; NEUROMODULATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; BRAIN; CELL DIFFERENTIATION; GENETICS; METABOLISM; PARACRINE SIGNALING; PHYSIOLOGY;

ANIMALS; BRAIN; CELL DIFFERENTIATION; GROWTH HORMONE; HUMANS; NEUROGENESIS; PARACRINE COMMUNICATION;

EID: 84906791006     PISSN: 00166480     EISSN: 10956840     Source Type: Journal    
DOI: 10.1016/j.ygcen.2014.04.035     Document Type: Review

References (107)

1. Aberg D. Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis. Endocr. Dev. 2010, 17:63-76.
2. Aberg N.D., Brywe K.G., Isgaard J. Aspects of growth hormone and insulin-like growth factor-1 related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci World J. 2006, 18:53-80.
3. Aberg N.D., Johansson I., Aberg M.A., Lind J., Johansson U.E., Cooper-Kuhn C.M., Kuhn H.G., Isgaard J. Peripheral administration of GH induces cell proliferation in the brain of adult hypophysectomized rats. J. Endocr. 2009, 201:141-150.
4. Aberg N.D., Lind J., Isgaard J., Kuhn H. Peripheral growth hormone induces cell proliferation in the intact adult rat brain. Growth Horm. IGF Res. 2010, 20:264-269.
5. Addison M.L., Rissman E.F. Sexual dimorphism of growth hormone in the hypothalamus: regulation by estradiol. Endocrinology 2012, 153:1898-1907.
6. Alba-Betancourt C., Arámburo C., Ávila-Mendoza J., Ahumada-Solórzano S.M., Carranza M., Rodríguez-Méndez A.J., Harvey S., Luna M. Expression, cellular distribution, and heterogeneity of growth hormone in the chicken cerebellum during development. Gen. Comp. Endocrinol. 2011, 170:528-540.
7. Alba-Betancourt C., Luna-Acosta J.L., Ramirez-Martinez C.E., Avila-Gonzalez D., Granados-Avalos E., Carranza M., Martinez-Coria H., Arámburo C., Luna M. Neuroprotective effects of growth hormone (GH) after hypoxia-ischemia injury in embryonic chicken cerebellum. Gen. Comp. Endocrinol. 2013, 183:17-31.
8. Almeida R.D., Manadas B.J., Melo C.V., Gomes J.R., Mendes C.S., Grãos M.M., Carvalho R.F., Carvalho A.P., Duarte C.B. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways. Cell Death Differ. 2005, 12:1329-1343.
9. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
10. Andres, A., 2013. Electrophysiological Actions of Growth Hormone in Retinal Ganglion Cells (MSc thesis). University of Alberta.
11. Arámburo C., Sánchez R., Fenton B., Perera C., Valverde-Rodríguez C. Desarrollo de un radioinmunoensayo homólogo y específico para la determinación de la hormona de crecimiento de pollo (cGH). Vet. Mex. 1989, 20:397-405.
12. Arámburo C., Montiel J.L., Perera G., Navarrete S., Sánchez R. Molecular isoforms of chicken growth hormone (cGH): different bioactivities of cGH charge variants. Gen. Comp. Endocrinol. 1990, 80:59-67.
13. Arámburo C., Carranza M., Reyes M., Luna M., Martínez-Coria H., Berúmen L., Scanes C.G. Characterization of a bioactive 15kDa fragment produced by proteolytic cleavage of chicken. Endocrine 2001, 15:231-240.
14. Arce V.M., Devesa P., Devesa J. Role of growth hormone (GH) in the treatment on neural diseases: from neuroprotection to neural repair. Neurosci. Res. 2013, 76:179-186.
15. Azcoitia I., Perez-Martin M., Salazar V., Castillo C., Ariznavarreta C., Garcia-Segura L.M., Tresguerres J.A. Growth hormone prevents neuronal loss in the aged rat hippocampus. Neurobiol. Aging 2005, 26:697-703.
16. Baudet M.L., Sanders E.J., Harvey S. Retinal growth hormone in the chick embryo. Endocrinology 2003, 144:5459-5468.
17. Baudet M.L., Rattray D., Martin B.T., Harvey S. Growth hormone promotes axon growth in the developing nervous system. Endocrinology 2009, 150:2758-2766.
18. Blackmore D.G., Vukovic J., Waters M.J., Bartlett P.F. GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice. PLoS One 2012, 7:e49912.
19. Bohlooly Y.M., Olsson B., Bruder C.E., Linden D., Sjorgren K., Bjursell M., Egecioglu E., Svensson L., Brodin P., Waterton J.C., Isaksson O.G., Sundler F., Ahren B., Ohlsson C., Oscarsson J., Tornell J. Growth hormone expression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and hyslipidemia. Diabetes 2005, 54:51-62.
20. Cheung L., Gustavsson C., Norstedt G., Tollet-Egnell P. Sex-different and growth hormone-regulated expression of microRNA in rat liver. BMC Mol. Biol. 2009, 10:13-20.
21. Coculescu M. Blood-brain barrier for human growth hormone and insulin-like growth factor-I. J. Pediatr. Endocrinol. Metab. 1999, 12:113-124.
22. D'Angelo D., Pamieri D., Mussnich P., Roche M., Wierinckx A., Raverot G., Fedele M., Croce C.M., Trouillas J., Fusco A. Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1. J. Clin. Endocrinol. Metab. 2012, 97:E1128-E1138.
23. Deijen J.B., de Boer H., Blok G.J., van der Veen E.A. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996, 21:313-322.
24. Deijen J.B., de Boer H., van der Veen E.A. Cognitive changes during growth hormone replacement in adult men. Psychoneuroendocrinology 1998, 23:45-55.
25. Devesa P., Reimunde P., Gallego R., Devesa J., Arce V.M. Growth hormone (GH) treatment may cooperate with locally-produced GH in increasing the proliferative response of hippocampal progenitors to kainate-induced injury. Brain Inj. 2011, 25:503-513.
26. Devesa J., Reimunde P., Devesa P., Barbera M., Arce V. Growth hormone (GH) and brain trauma. Horm. Behav. 2013, 63:331-344.
27. Diniz B.S., Teixeira A.L. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromol. Med. 2011, 13:217-222.
28. Donahue A.N., Aschner M., Lash L.H., Syversen T., Sonntag W.E. Growth hormone administration to aged animals reduces disulfide glutathione levels in hippocampus. Mech. Ageing Dev. 2006, 127:57-63.
29. Donahue C.P., Kosik K.S., Shors T.J. Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc. Natl. Acad. Sci. USA 2006, 103:6031-6036.
30. Dong H., Zeng L., Duan D., Zhang H., Wang Y., Li W., Lin H. Growth hormone and two forms of insulin-like growth factors I in the giant grouper (Epinephelus lanceolatus): molecular cloning and characterization of tissue distribution. Fish Physiol. Biochem. 2010, 36:201-212.
31. Elia L., Contu R., Quintavalle M., Varrone F., Chimenti C., Russo M.A., Cimino V., De Marinis L., Frustaci A., Catalucci D., Condorelli G. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation 2009, 120:2377-2385.
32. Enhamre-Brolin E., Carlsson A., Hallberg M., Nyberg F. Growth hormone reverses streptozotocin-induced cognitive impairments in male mice. Behav. Brain Res. 2013, 238:273-278.
33. Garcia-Garcia F., De la Herran-Arita A.K., Juarez-Aguilar E., Regalado-Santiago C., Millan-Aldoco D., Blanco-Centurion C., Drucker-Colin R. Growth hormone improves hippocampal adult cell survival and counteracts the inhibitory effect of prolonged sleep deprivation on cell proliferation. Brain Res. Bull. 2011, 84:252-257.
34. Gronbladh A., Johansson J., Nostl A., Nyberg F., Hallberg M. GH improves spatial memory and reverses certain anabolic androgenic steroid-induced effects in intact rats. J. Endocrinol. 2013, 216:31-41.
35. Gronbladh A., Johansson J., Nyberg F., Hallberg H. Recombinant human growth hormone affects the density and functionality of GABAB receptors in the male rat brain. Neuroendocrinology 2013, 97:203-211.
36. Gustafson K., Hagberg H., Bengtsson B.A., Brantsing C., Isgaard J. Possible protective role of growth hormone in hypoxia-ischemia in neonatal rats. Pediatr. Res. 1999, 45:318-323.
37. Harvey S. Extrapituitary growth hormone. Endocrine 2010, 38:335-359.
38. Harvey S., Hull K. Neural growth hormone: an update. J. Mol. Neurosci. 2003, 20:1-13.
39. Harvey S., Johnson C.D., Sanders E.J. Growth hormone in neural tissues of the chick embryo. J. Endocrinol. 2001, 169:487-498.
40. Harvey S., Baudet M.L., Sanders E.J. Growth hormone-induced neuroprotection in the neural retina during chick embryogenesis. Ann. NY. Acad. Sci. 2009, 1163:414-416.
41. Harvey S., Baudet M.-L., Luna M., Arámburo C. Non-classical signaling of growth hormone in the chick neural retina?. Avian Biol. Res. 2014, 7:48-57.
42. Hébert S.S., De Strooper B. MiRNAs in neurodegeneration. Science 2007, 317:1179-1180.
43. Heredia M., Fuente A., Criado J., Yajeya J., Devesa J., Riolobos A.S. Early growth hormone (GH) treatment promotes relevant motor functional improvement after severe frontal cortex lesion in adult rats. Behav. Brain Res. 2013, 247:48-58.
44. Hollingshead P.G., Martin L., Pitts S.L., Stewart T.A. A dominant phenocopy of hypopituitarism in transgenic mice resulting from central nervous system synthesis of human growth hormone. Endocrinology 1989, 125:1556-1564.
45. Huang M.B., Xu H., Xie S.J., Zhoum H., Qu H. Insulin-like growth factor-1 receptor is regulated by microRNA-133 during skeletal myogenesis. PLoS One 2011, 6:e29173.
46. Hull K.L., Harvey S. Growth hormone therapy and quality of life: possibilities, pitfalls and mechanisms. J. Endocrinol. 2003, 179:311-333.
47. Isgaard J., Aberg D., Nilsson M. Protective and regenerative effects of the GH/IGF-1 axis of the brain. Minerva Endocrinol. 2007, 32:103-113.
48. Jaszberenyi M., Rick R.G., Szalontay L., Block N.L., Zarandi M., Cai R.-Z., Schally A.V. Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease. Aging 2012, 4:755-767.
49. Johansson V., Winberg S., Björnsson B.J. Growth hormone-induced stimulation of swimming and feeding behavior of rainbow trout is abolished by the D1 dopamine antagonist SCH23390. Gen. Comp. Endocrinol. 2005, 141:58-65.
50. Kato K., Suzuki M., Kanno H., Sekino S., Kusakabe K., Okada T., Mori T., Yoshida K., Hirabayashi Y. Distinct role of growth hormone on epilepsy progression in a model of temporal lobe epilepsy. J. Neurochem. 2009, 110:509-519.
51. Kermani P., Hempstead B. Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends Cardiovasc. Med. 2007, 17:140-143.
52. Kozlowski Moreau O., Cortet-Rudelli C., Yollin E., Merlen E., Daveluy W., Rousseaux M. Growth hormone replacement therapy in patients with traumatic brain injury. J. Neurotrauma 2013, 30:998-1006.
53. Le Greves M., Steensland P., Le Greves P., Nyberg F. Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-d-aspartate receptor subunits genes transcripts in male rats. Proc. Natl. Acad. Sci. USA 2002, 99:7119-7123.
54. Le Greves M., Zhou Q., Berg M., Le Greves P., Fholenhag K., Meyerson B., Nyberg F. Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptors subunit and PSD-95 gene transcript levels. Exp. Brain Res. 2006, 173:267-273.
55. Li E., Kim D.H., Cai M., Lee S., Kim Y., Lim E., Hoon Ryu J., Unterman T.G., Park S. Hippocampus-dependent spatial learning and memory are impaired in growth hormone-deficient spontaneous dwarf rats. Endocr. J. 2011, 58:257-267.
56. Li R.C., Guo S.Z., Raccurt M., Moudilou E., Morel G., Brittian K.R., Gozal D. Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience 2011, 196:237-250.
57. Li H.M., Wang C.M., Li Q.Z., Gao X.J. MiR-15a decreases bovine mammary epithelial cell viability and lactation and regulates growth hormone receptor expression. Molecules 2012, 17:12037-12048.
58. Lin S., Li H., Mu H., Luo W., Li Y., Jia X., Wang S., Jia X., Nie Q., Li Y., Zhang X. Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens. BMC Genomics 2012, 13:306.
59. Lobie P.E., Zhu T., Graichen T., Goh E.L. Growth hormone, insulin-like growth factor I and the CNS: localization, function and mechanism of action. Growth Horm. IGF Res. 2000, 10(Suppl. B):S51-S56.
60. Mahmoud G.S., Grover L.M. Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus. J. Neurophysiol. 2006, 95:2962-2974.
61. Malek M., Zahedi Asl S., Sarkaki A., Farbood Y., Doulah A.H. The effect of intra-hippocampal injection of growth hormone on spatial learning and memory in animal model of Alzheimer'' disease. Pak. J. Biol. Sci. 2009, 12:1237-1245.
62. Martínez-Moreno C., Andres A., Giterman D., Karpinski E., Harvey S. Growth hormone and retinal ganglion cell function: QNR/D cells as an experimental model. Gen. Comp. Endocrinol. 2014, 195:183-189.
63. Modanlou H.D., Gharraee Z., Hasan J., Waltzman J., Nageotte S., Beharry K.D. Ontogeny of VEGF, IGF-I, and GH in neonatal rat serum, vitreous fluid, and retina from birth to weaning. Invest. Ophthalmol. Vis. Sci. 2006, 47:738-744.
64. Molina D.P., Ariwodola O.J., Linville C., Sonntag W.E., Weiner J.L., Brunso-Bechtold J.K., Adams M.M. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol. Aging 2012, 33:1938-1949.
65. Molina D.P., Ariwodola O.J., Weiner J.L., Brunso-Bechtold J.K., Adams M.M. Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age (Dordr) 2013, 35:1575-1587.
66. Muresanu D.F., Sharma A., Sharma H.S. Diabetes aggravates heat stress-induced blood-brain barrier breakdown, reduction in cerebral blood flow, edema formation, and brain pathology: possible neuroprotection with growth hormone. Ann. NY. Acad. Sci. 2010, 1199:15-26.
67. Nakazawa T., Tamai M., Mori N. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways. Invest. Ophthalmol. Vis. Sci. 2002, 3:3319-3326.
68. Nieves-Martinez E., Sonntag W.E., Wilson A., Donahue A., Molina D.P., Brunso-Bechtold J., Nicolle M.M. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J. Endocrinol. 2010, 204:31-36.
69. Numakawa T., Richards M., Adachi N., Kishi S., Kunugi H., Hashido K. MicroRNA function and neurotrophin BDNF. Neurochem. Int. 2011, 59:551-558.
70. Nyberg F. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front. Neuroendocrinol. 2000, 21:330-348.
71. Nyberg F. The role of the somatotrophic axis in neuroprotection and neuroregeneration of the addictive brain. Int. Rev. Neurobiol. 2009, 88:399-427.
72. Pan W., Yu Y., Cain C.M., Nyberg F., Couraud P.O., Kastin A.J. Permeation of growth hormone across the blood-brain barrier. Endocrinology 2005, 146:4898-4904.
73. Pencea V., Bingaman K.D., Wiegand S.J., Luskin M.B. Infusion of brain-derived eurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J. Neurosci. 2001, 21:6706-6717.
74. Perry J.K., Liu D.X., Wu Z.S., Zhu T., Lobie P.E. Growth hormone and cancer: an update on progress. Curr. Opin. Endocrinol. Diabetes Obes. 2013, 20:307-313.
75. Ramesh R., Kuenzel W.J., Buntin J.D., Proudman J.A. Identification of growth-hormone-and prolactin-containing neurons within the avian brain. Cell Tissue Res. 2000, 299:371-383.
76. Render C.L., Hull K.L., Harvey S. Neural expression of the pituitary GH gene. J. Endocrinol. 1995, 147:413-422.
77. Rhee J.S., Kim B.M., Seo J.S., Kim I.C., Lee Y.M., Lee J.S. Cloning of growth hormone, somatolactin, and their receptor mRNAs, their expression in organs, during development, and on salinity stress in the hermaphroditic fish, Kryptolebias marmoratus. Comp. Biochem. Physiol. A 2012, 161:436-442.
78. Rhodin A., Von Ehren M., Skottheim B., Grönbladh A., Ortiz-Nieto F., Raininko R., Gordh T., Nyberg F. Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids. Acta Anaesthesiol. Scand 2014, 10.1111/aas.12309.
79. Sanders E.J., Harvey S. Peptide hormones as developmental growth and differentiation factors. Dev. Dyn. 2008, 237:1537-1552.
80. Sanders E.J., Parker E., Arámburo C., Harvey S. Retinal growth hormone is an anti-apoptotic factor in embryonic retinal ganglion cell differentiation. Exp. Eye Res. 2005, 81:551-560.
81. Sanders E.J., Parker E., Harvey S. Growth hormone-mediated survival of embryonic retinal ganglion cells: signaling mechanisms. Gen. Comp. Endocrinol. 2008, 156:613-621.
82. Sanders E.J., Baudet M.L., Parker E., Harvey S. Signaling mechanisms mediating local GH action in the neural retina of the chick embryo. Gen. Comp. Endocrinol. 2009, 163:63-69.
83. Sanders E.J., Lin W.Y., Parker E., Harvey S. Growth hormone expression and neuroprotective activity in a quail neural retina cell line. Gen. Comp. Endocrinol. 2010, 165:111-119.
84. Sanders E.J., Lin W.Y., Parker E., Harvey S. Growth hormone promotes the survival of retinal cells in vivo. Gen. Comp. Endocrinol. 2011, 172:140-150.
85. Scheepens A., Williams C.E., Breier B.H., Guan J., Gluckman P.D. A role for the somatotropic axis in neural development, injury and disease. J. Pediatr. Endocrinol. Metab. 2000, 13:1483-1491.
86. Schneider H.J., Pagotto U., Stalla G.K. Central effects of the somatotropic system. Eur. J. Endocrinol. 2003, 149:377-392.
87. Schratt G.M., Tuebing F., Nigh E.A., Kane C.G., Sabatini M.E., Kiebler M., Greenberg M.E. A brain-specific microRNA regulates dendritic spine development. Nature 2006, 439:283-289.
88. Sivapragasam M., Rotondo F., Lloyd R.V., Scheithauer B.W., Cusimano M., Syro L.V., Kovacs K. MicroRNAs in the human pituitary. Endocr. Pathol. 2011, 22:134-143.
89. Soto I., Rosenthal J.J.C., Blagburn J.M., Blanco R.E. Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways. J. Neurochem. 2006, 96:82-96.
90. Sun L.Y., Evans M.S., Hsieh J., Panici J., Bartke A. Increased neurogenesis in dentate gyrus of long-lived dwarf mice. Endocrinology 2005, 146:1138-1144.
91. Svensson A.L., Bucht N., Hallberg M., Nyberg F. Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine fetus primary hippocampal neuronal cell cultures. Proc. Natl. Acad. Sci. USA 2008, 105:7304-7308.
92. Tang H., Zhang Y., Yu X., Song J., Xu C., Wan Y. Changes in growth hormone (GH), GH receptor, and GH signal transduction in hippocampus of congenital hypothyroid rats. J. Neurosci. Res. 2011, 89:248-255.
93. Turnley A.M., Faux C.H., Rietz R.L., Coonan J.R., Bartlett P.F. Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Nat. Neurosci. 2002, 5:1155-1162.
94. Van Dam P.S., Aleman A., de Vries W.R., Deijen J.B., van der Veen E.A., de Haan E.H.F., Koppeschaar H.P.F. Growth hormone, insulin-like growth factor-I and cognitive function in adults. Growth Horm. IGF-I Res. 2000, 10(Suppl. B):S69-S73.
95. Vo N., Klein M.E., Varlamova O., Keller D.M., Yamamoto T., Goodman R.H., Impey S. A cAMP response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 2005, 102:16426-16431.
96. Walser M., Hansen A., Svensson P.A., Jenas M., Oscarsson J., Aberg N.D. Peripheral administration of bovine GH regulates the expression of cerebrocortical beta-globin, GABAB receptor 1, and the Lissncephaly-1 protein (LIS-1) in adult hypophysectomized rats. Growth Horm. IGF Res. 2011, 21:16-24.
97. Walser M., Sama M.T., Wickelgren R., Aberg M., Bohlooly-Y M., Olsson B., Tornell J., Isgaard J., Aberg N.D. Local overexpression of GH and GH/IGF-1 effects in the adult mouse hippocampus. J. Endocrinol. 2012, 215:257-268.
98. Waters M.J., Blackmore D.G. Growth hormone (GH), brain development and neural stem cells. Pediatr. Endocrinol. Rev. 2011, 9:549-553.
99. Wells T., Flavell D.M., Wells S.E., Carmignac D.F., Robinson I.C.A.P. Effects of growth hormone secretagogues in the transgenic growth-retarded (Tgr) rat. Endocrinology 1997, 138:580-587.
100. Wells S.E., Flavell D.M., Bisset G.W., Houston P.A., Christian H., Fairhall K.M., Robinson I.C.A.F. Transgenesis and neuroendocrine physiology: a transgenic rat model expression growth hormone in vasopressin neurons. J. Physiol. 2003, 55:323-336.
101. Wilkinson-Berka J.L., Wraight C., Werther G. The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy. Curr. Med. Chem. 2006, 13:3307-3317.
102. Wilkinson-Berka J.L., Lofthouse S., Jaworski K., Ninkovic S., Tachas G., Wraight C.J. An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy. Mol. Vis. 2007, 13:1529-1538.
103. Yang B.Y., Green M., Chen T.T. Early embryonic expression of the growth hormone family protein genes in the developing rainbow trout, Oncorhynchus mykiss. Mol. Reprod. Dev. 1999, 53:127-134.
104. Yoshizato H., Fujikawa T., Soya H., Tanaka M., Nakashima K. The growth hormone (GH) gene is expressed in the lateral hypothalamus: enhancement by GH-releasing hormone and repression by restraint stress. Endocrinology 1998, 139:2545-2551.
105. Yoshizato H., Fujikawa T., Shibata M., Tanaka M., Nakashima K. Stimulation of growth hormone gene expression in the pituitary and brain by Panax ginseng C.A. MEYER. Endocr. J. 1999, 46(Suppl.):S85-S88.
106. Zearfoss N.R., Alarcon J.M., Trifilieff P., Kandel E., Richter J.D. A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus. J. Neurosci. 2008, 28:8502-8509.
107. Zeng L., He X., Wang Y., Tang Y., Zheng C., Cai H., Liu J., Wang Y., Fu Y., Yang G.Y. MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain. Gene Ther. 2014, 21:37-43.