MicroRNA function and neurotrophin BDNF

Neurochemistry International

Volumn 59, Issue 5, 2011, Pages 551-558

  Numakawa, Tadahiro ^a,b   Richards, Misty ^c   Adachi, Naoki ^a,b   Kishi, Soichiro ^a   Kunugi, Hiroshi ^a,b   Hashido, Kazuo ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c ALBANY MEDICAL COLLEGE   (United States)

Author keywords

BDNF; MicroRNA; Synaptic plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DICER; DOUBLE STRANDED DNA; EXPORTIN 5; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOD PROTEIN; MYOGENIN; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; RIBONUCLEASE III; RNA POLYMERASE II; STRESS ACTIVATED PROTEIN KINASE 1; UNTRANSLATED RNA; VOLTAGE GATED CALCIUM CHANNEL;

APOPTOSIS; CAENORHABDITIS ELEGANS; CALCIUM CELL LEVEL; CELL SURVIVAL; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HUMAN; MENTAL DISEASE; MUSCLE DEVELOPMENT; NERVE CELL; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RNA CLEAVAGE; RNA GENE; TRANSCRIPTION REGULATION;

EID: 80052957954     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.06.009     Document Type: Short Survey

References (113)

1. K. Abdelmohsen, E.R. Hutchison, E.K. Lee, Y. Kuwano, M.M. Kim, K. Masuda, S. Srikantan, S.S. Subaran, B.S. Marasa, M.P. Mattson, and M. Gorospe miR-375 inhibits differentiation of neurites by lowering HuD levels Mol. Cell Biol. 30 2010 4197 4210
2. J.E. Abrahante, A.L. Daul, M. Li, M.L. Volk, J.M. Tennessen, E.A. Miller, and A.E. Rougvie The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs Dev. Cell 4 2003 625 637 (Pubitemid 36564894)
3. C.A. Altar Neurotrophins and depression Trends Pharmacol. Sci. 20 1999 59 61 (Pubitemid 29323957)
4. V. Ambros A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans Cell 57 1989 49 57
5. R.E. Amir, I.B. Van den Veyver, M. Wan, C.Q. Tran, U. Francke, and H.Y. Zoghbi Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2 Nat. Genet. 23 1999 185 188 (Pubitemid 29455390)
6. J.R. Bamburg Proteins of the ADF/cofilin family: essential regulators of actin dynamics Annu. Rev. Cell Dev. Biol. 15 1999 185 230 (Pubitemid 32250375)
7. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
8. B. Bonev, A. Pisco, and N. Papalopulu MicroRNA-9 reveals regional diversity of neural progenitors along the anterior-posterior axis Dev. Cell 20 2011 19 32
9. J. Brennecke, D.R. Hipfner, A. Stark, R.B. Russell, and S.M. Cohen Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila Cell 113 2003 25 36 (Pubitemid 36411957)
10. M.J. Bueno, I. Pérez de Castro, M. Gómez de Cedrón, J. Santos, G.A. Calin, J.C. Cigudosa, C.M. Croce, J. Fernández-Piqueras, and M. Malumbres Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression Cancer Cell 13 2008 496 506 (Pubitemid 351763902)
11. X. Cai, C.H. Hagedorn, and B.R. Cullen Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs RNA 10 2004 1957 1966 (Pubitemid 39557833)
12. M.V. Caldeira, C.V. Melo, D.B. Pereira, R.F. Carvalho, A.L. Carvalho, and C.B. Duarte BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons Mol. Cell Neurosci. 35 2007 208 219 (Pubitemid 46843562)
13. M.V. Caldeira, C.V. Melo, D.B. Pereira, R. Carvalho, S.S. Correia, D.S. Backos, A.L. Carvalho, J.A. Esteban, and C.B. Duarte Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy- 5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons J. Biol. Chem. 282 2007 12619 12628 (Pubitemid 47100614)
14. M. Chalfie, H.R. Horvitz, and J.E. Sulston Mutations that lead to reiterations in the cell lineages of C. elegans Cell 24 1981 59 69 (Pubitemid 11157130)
15. E.J. Chapman, and J.C. Carrington Specialization and evolution of endogenous small RNA pathways Nat. Rev. Genet. 8 2007 884 896 (Pubitemid 47609087)
16. L.Y. Chen, C.S. Rex, Y. Sanaiha, G. Lynch, and C.M. Gall Learning induces neurotrophin signaling at hippocampal synapses Proc. Natl. Acad. Sci. USA 107 2010 7030 7035
17. T.P. Chendrimada, R.I. Gregory, E. Kumaraswamy, J. Norman, N. Cooch, K. Nishikura, and R. Shiekhattar TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing Nature 436 2005 740 744 (Pubitemid 41117280)
18. L. Ding, A. Spencer, K. Morita, and M. Han The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans Mol. Cell 19 2005 437 447 (Pubitemid 41140002)
19. T. Du, and P.D. Zamore microPrimer: the biogenesis and function of microRNA Development 132 2005 4645 4652 (Pubitemid 41685275)
20. S.M. Eacker, T.M. Dawson, and V.L. Dawson Understanding microRNAs in neurodegeneration Nat. Rev. Neurosci. 10 2009 837 841
21. A. Eulalio, I. Behm-Ansmant, and E. Izaurralde P bodies: at the crossroads of post-transcriptional pathways Nat. Rev. Mol. Cell Biol. 8 2007 9 22 (Pubitemid 46012011)
22. A. Eulalio, F. Tritschler, and E. Izaurralde The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing RNA 15 2009 1433 1442
23. P. Fasanaro, S. Greco, M. Lorenzi, M. Pescatori, M. Brioschi, R. Kulshreshtha, C. Banfi, A. Stubbs, G.A. Calin, M. Ivan, M.C. Capogrossi, and F. Martelli An integrated approach for experimental target identification of hypoxia-induced miR-210 J. Biol. Chem. 284 2009 35134 35143
24. L.M. Friedman, A.A. Dror, E. Mor, T. Tenne, G. Toren, T. Satoh, D.J. Biesemeier, N. Shomron, D.M. Fekete, E. Hornstein, and K.B. Avraham MicroRNAs are essential for development and function of inner ear hair cells in vertebrates Proc. Natl. Acad. Sci. USA 106 2009 7915 7920
25. J. Gao, W.Y. Wang, Y.W. Mao, J. Gräff, J.S. Guan, L. Pan, G. Mak, D. Kim, S.C. Su, and L.H. Tsai A novel pathway regulates memory and plasticity via SIRT1 and miR-134 Nature 466 2010 1105 1109
26. N. Gervasoni, J.M. Aubry, G. Bondolfi, C. Osiek, M. Schwald, G. Bertschy, and F. Karege Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode Neuropsychobiology 51 2005 234 238 (Pubitemid 40976406)
27. K. Gottmann, T. Mittmann, and V. Lessmann BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses Exp. Brain Res. 199 2009 203 234
28. A.D. Haase, L. Jaskiewicz, H. Zhang, S. Lainé, R. Sack, A. Gatignol, and W. Filipowicz TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing EMBO Rep. 6 2005 961 967 (Pubitemid 41521952)
29. S. Hake MicroRNAs: a role in plant development Curr. Biol. 13 2003 R851 852
30. M. Hartmann, R. Heumann, and V. Lessmann Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses EMBO J. 20 2001 5887 5897 (Pubitemid 33049264)
31. T. Hashimoto, D. Arion, T. Unger, J.G. Maldonado-Avilés, H.M. Morris, D.W. Volk, K. Mirnics, and D.A. Lewis Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia Mol. Psychiatry 13 2008 147 161
32. S.S. Hébert, and B. De Strooper Alterations of the microRNA network cause neurodegenerative disease Trends Neurosci. 32 2009 199 206
33. S.S. Hébert, K. Horré, L. Nicolaï, A.S. Papadopoulou, W. Mandemakers, A.N. Silahtaroglu, S. Kauppinen, A. Delacourte, and B. De Strooper Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression Proc. Natl. Acad. Sci. USA 105 2008 6415 6420 (Pubitemid 351758360)
34. E.J. Huang, and L.F. Reichardt Trk receptors: roles in neuronal signal transduction Annu. Rev. Biochem. 72 2003 609 642 (Pubitemid 36930455)
35. G. Hutvágner, J. McLachlan, A.E. Pasquinelli, E. Bálint, T. Tuschl, and P.D. Zamore A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA Science 293 2001 834 838 (Pubitemid 32743968)
36. H.I. Im, J.A. Hollander, P. Bali, and P.J. Kenny MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212 Nat. Neurosci. 13 2010 1120 1127
37. F. Karege, G. Vaudan, M. Schwald, N. Perroud, and R. La Harpe Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs Brain Res. Mol. Brain Res. 136 2005 29 37 (Pubitemid 40704606)
38. H. Kawashima, T. Numakawa, E. Kumamaru, N. Adachi, H. Mizuno, M. Ninomiya, H. Kunugi, and K. Hashido Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression Neuroscience 165 2010 1301 1311
39. J. Kim, K. Inoue, J. Ishii, W.B. Vanti, S.V. Voronov, E. Murchison, G. Hannon, and A. Abeliovich A MicroRNA feedback circuit in midbrain dopamine neurons Science 317 2007 1220 1224
40. D.D. Kline, M. Ogier, D.L. Kunze, and D.M. Katz Exogenous brain-derived neurotrophic factor rescues synaptic dysfunction in Mecp2-null mice J. Neurosci. 30 2010 5303 5310
41. M.B. Knable, B.M. Barci, M.J. Webster, J. Meador-Woodruff, E.F. Torrey Stanley Neuropathology Consortium Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium Mol. Psychiatry 9 2004 609 620 (Pubitemid 38850441)
42. W. Konopka, A. Kiryk, M. Novak, M. Herwerth, J.R. Parkitna, M. Wawrzyniak, A. Kowarsch, P. Michaluk, J. Dzwonek, T. Arnsperger, G. Wilczynski, M. Merkenschlager, F.J. Theis, G. Köhr, L. Kaczmarek, and G. Schütz MicroRNA loss enhances learning and memory in mice J. Neurosci. 30 2010 14835 14842
43. N. Kosaka, H. Iguchi, Y. Yoshioka, F. Takeshita, Y. Matsuki, and T. Ochiya Secretory mechanisms and intercellular transfer of microRNAs in living cells J. Biol. Chem. 285 2010 17442 17452
44. A. Kozomara, and S. Griffiths-Jones miRBase: integrating microRNA annotation and deep-sequencing data Nucleic Acids Res. 39 Database issue 2011 D152 157
45. N. Kuczewski, C. Porcher, V. Lessmann, I. Medina, and J.L. Gaiarsa Activity-dependent dendritic release of BDNF and biological consequences Mol. Neurobiol. 39 2009 37 49
46. E. Kumamaru, T. Numakawa, N. Adachi, Y. Yagasaki, A. Izumi, M. Niyaz, M. Kudo, and H. Kunugi Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase Mol. Endocrinol. 22 2008 546 558 (Pubitemid 351397784)
47. H. Kunugi, H. Hori, N. Adachi, and T. Numakawa Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression Psychiatry Clin. Neurosci. 64 2010 447 459
48. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl Identification of novel genes coding for small expressed RNAs Science 294 2001 853 858 (Pubitemid 33032103)
49. M. Lagos-Quintana, R. Rauhut, A. Yalcin, J. Meyer, W. Lendeckel, and T. Tuschl Identification of tissue-specific microRNAs from mouse Curr. Biol. 12 2002 735 739 (Pubitemid 34455427)
50. M. Lagos-Quintana, R. Rauhut, J. Meyer, A. Borkhardt, and T. Tuschl New microRNAs from mouse and human RNA 9 2003 175 179 (Pubitemid 36206285)
51. O.F. Laterza, L. Lim, P.W. Garrett-Engele, K. Vlasakova, N. Muniappa, W.K. Tanaka, J.M. Johnson, J.F. Sina, T.L. Fare, F.D. Sistare, and W.E. Glaab Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury Clin. Chem. 55 2009 1977 1983
52. N.C. Lau, L.P. Lim, E.G. Weinstein, and D.P. Bartel An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans Science 294 2001 858 862 (Pubitemid 33032104)
53. M.T. Le, H. Xie, B. Zhou, P.H. Chia, P. Rizk, M. Um, G. Udolph, H. Yang, B. Lim, and H.F. Lodish MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets Mol. Cell Biol. 29 2009 5290 5305
54. R.C. Lee, and V. Ambros An extensive class of small RNAs in Caenorhabditis elegans Science 294 2001 862 864 (Pubitemid 33032105)
55. R.C. Lee, R.L. Feinbaum, and V. Ambros The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 1993 843 854 (Pubitemid 24014542)
56. Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim, and V.N. Kim The nuclear RNase III Drosha initiates microRNA processing Nature 425 2003 415 419 (Pubitemid 37187272)
57. Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, S.H. Baek, and V.N. Kim MicroRNA genes are transcribed by RNA polymerase II EMBO J. 23 2004 4051 4060 (Pubitemid 39472426)
58. Y. Lee, I. Hur, S.Y. Park, Y.K. Kim, M.R. Suh, and V.N. Kim The role of PACT in the RNA silencing pathway EMBO J. 25 2006 522 532 (Pubitemid 43237659)
59. V. Lessmann, and T. Brigadski Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update Neurosci. Res. 65 2009 11 22
60. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798 (Pubitemid 38058492)
61. B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20 (Pubitemid 40094598)
62. D.A. Lewis, T. Hashimoto, and H.M. Morris Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia Neurotox. Res. 14 2008 237 248
63. L.P. Lim, M.E. Glasner, S. Yekta, C.B. Burge, and D.P. Bartel Vertebrate microRNA genes Science 299 2003 1540 (Pubitemid 36297696)
64. S.Y. Lin, S.M. Johnson, M. Abraham, M.C. Vella, A. Pasquinelli, C. Gamberi, E. Gottlieb, and F.J. Slack The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target Dev. Cell 4 2003 639 650 (Pubitemid 36564895)
65. C. Llave, K.D. Kasschau, M.A. Rector, and J.C. Carrington Endogenous and silencing-associated small RNAs in plants Plant Cell 14 2002 1605 1619 (Pubitemid 34817147)
66. E. Maniataki, and Z. Mourelatos A human, ATP-independent, RISC assembly machine fueled by pre-miRNA Genes Dev. 19 2005 2979 2990 (Pubitemid 41798114)
67. T. Matsumoto, T. Numakawa, D. Yokomaku, N. Adachi, S. Yamagishi, Y. Numakawa, H. Kunugi, and T. Taguchi Brain-derived neurotrophic factor-induced potentiation of glutamate and GABA release: different dependency on signaling pathways and neuronal activity Mol. Cell Neurosci. 31 2006 70 84 (Pubitemid 43049902)
68. B.S. McEwen Glucocorticoids, depression, and mood disorders: structural remodeling in the brain Metabolism 54 2005 20 23 (Pubitemid 40546018)
69. N. Mellios, H.S. Huang, A. Grigorenko, E. Rogaev, and S. Akbarian A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex Hum. Mol. Genet. 17 2008 3030 3042
70. N. Mellios, H.S. Huang, S.P. Baker, M. Galdzicka, E. Ginns, and S. Akbarian Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia Biol. Psychiatry 65 2009 1006 1014
71. Y. Meng, H. Takahashi, J. Meng, Y. Zhang, G. Lu, S. Asrar, T. Nakamura, and Z. Jia Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase Neuropharmacology 47 2004 746 754 (Pubitemid 39348956)
72. L. Minichiello TrkB signalling pathways in LTP and learning Nat. Rev. Neurosci. 10 2009 850 860
73. P.S. Mitchell, R.K. Parkin, E.M. Kroh, B.R. Fritz, S.K. Wyman, E.L. Pogosova-Agadjanyan, A. Peterson, J. Noteboom, K.C. O'Briant, A. Allen, D.W. Lin, N. Urban, C.W. Drescher, B.S. Knudsen, D.L. Stirewalt, R. Gentleman, R.L. Vessella, P.S. Nelson, D.B. Martin, and M. Tewari Circulating microRNAs as stable blood-based markers for cancer detection Proc. Natl. Acad. Sci. USA 105 2008 10513 10518
74. M. Muiños-Gimeno, Y. Espinosa-Parrilla, M. Guidi, B. Kagerbauer, T. Sipilä, E. Maron, K. Pettai, L. Kananen, R. Navinés, R. Martín-Santos, M. Gratacs, A. Metspalu, I. Hovatta, and X. Estivill Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways Biol. Psychiatry 69 2010 526 533
75. E.J. Nestler, M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold, and L.M. Monteggia Neurobiology of depression Neuron 34 2002 13 25 (Pubitemid 34270695)
76. T. Numakawa, E. Kumamaru, N. Adachi, Y. Yagasaki, A. Izumi, and H. Kunugi Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter Proc. Natl. Acad. Sci. USA 106 2009 647 652
77. T. Numakawa, S. Suzuki, E. Kumamaru, N. Adachi, M. Richards, and H. Kunugi BDNF function and intracellular signaling in neurons Histol. Histopathol. 25 2010 237 258
78. T. Numakawa, D. Yokomaku, M. Richards, H. Hori, N. Adachi, and H. Kunugi Functional interactions between steroid hormones and neurotrophin BDNF World J. Biol. Chem. 1 2010 133 143
79. T. Numakawa, T. Matsumoto, Y. Numakawa, M. Richards, S. Yamawaki, and H. Kunugi Protective action of neurotrophic factors and estrogen against oxidative stress-mediated neurodegeneration J. Toxicol. 2011 2011 405194 10.1155/2011/405194
80. P.H. Olsen, and V. Ambros The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation Dev. Biol. 216 1999 671 680 (Pubitemid 30013313)
81. I. Papp, M.F. Mette, W. Aufsatz, L. Daxinger, S.E. Schauer, A. Ray, J. van der Winden, M. Matzke, and A.J. Matzke Evidence for nuclear processing of plant micro RNA and short interfering RNA precursors Plant Physiol. 132 2003 1382 1390 (Pubitemid 36872888)
82. E.A. Parizotto, P. Dunoyer, N. Rahm, C. Himber, and O. Voinnet In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA Genes Dev. 18 2004 2237 2242 (Pubitemid 39209571)
83. R. Parker, and U. Sheth P bodies and the control of mRNA translation and degradation Mol. Cell. 25 2007 635 646 (Pubitemid 46341926)
84. A.E. Pasquinelli, B.J. Reinhart, F. Slack, M.Q. Martindale, M.I. Kuroda, B. Maller, D.C. Hayward, E.E. Ball, B. Degnan, P. Müller, J. Spring, A. Srinivasan, M. Fishman, J. Finnerty, J. Corbo, M. Levine, P. Leahy, E. Davidson, and G. Ruvkun Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA Nature 408 2000 86 89
85. S. Pfeffer, M. Zavolan, F.A. Grässer, M. Chien, J.J. Russo, J. Ju, B. John, A.J. Enright, D. Marks, C. Sander, and T. Tuschl Identification of virus-encoded microRNAs Science 304 2004 734 736 (Pubitemid 38560879)
86. S. Pfeffer, A. Sewer, M. Lagos-Quintana, R. Sheridan, C. Sander, F.A. Grässer, L.F. van Dyk, C.K. Ho, S. Shuman, M. Chien, J.J. Russo, J. Ju, G. Randall, B.D. Lindenbach, C.M. Rice, V. Simon, D.D. Ho, M. Zavolan, and T. Tuschl Identification of microRNAs of the herpesvirus family Nat. Methods 2 2005 269 276 (Pubitemid 41131008)
87. R.S. Pillai, S.N. Bhattacharyya, C.G. Artus, T. Zoller, N. Cougot, E. Basyuk, E. Bertrand, and W. Filipowicz Inhibition of translational initiation by Let-7 MicroRNA in human cells Science 309 2005 1573 1576 (Pubitemid 41266485)
88. R.S. Pillai, S.N. Bhattacharyya, and W. Filipowicz Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol. 17 2007 118 126 (Pubitemid 46357525)
89. P.K. Rao, R.M. Kumar, M. Farkhondeh, S. Baskerville, and H.F. Lodish Myogenic factors that regulate expression of muscle-specific microRNAs Proc. Natl. Acad. Sci. USA 103 2006 8721 8726 (Pubitemid 43878086)
90. L.F. Reichardt Neurotrophin-regulated signalling pathways Philos. Trans. R. Soc. Lond. B Biol. Sci. 361 2006 1545 1564 (Pubitemid 44450210)
91. B.J. Reinhart, F.J. Slack, M. Basson, A.E. Pasquinelli, J.C. Bettinger, A.E. Rougvie, H.R. Horvitz, and G. Ruvkun The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 403 2000 901 906 (Pubitemid 30130993)
92. B.J. Reinhart, E.G. Weinstein, M.W. Rhoades, B. Bartel, and D.P. Bartel MicroRNAs in plants Genes Dev. 16 2002 1616 1626 (Pubitemid 34743323)
93. J. Remenyi, C.J. Hunter, C. Cole, H. Ando, S. Impey, C.E. Monk, K.J. Martin, G.J. Barton, G. Hutvagner, and J.S. Arthur Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins Biochem. J. 428 2010 281 291
94. S.F. Roush, and F.J. Slack Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1 Dev. Biol. 334 2009 523 534
95. S.J. Russo, M.S. Mazei-Robison, J.L. Ables, and E.J. Nestler Neurotrophic factors and structural plasticity in addiction Neuropharmacology 56 Suppl. 1 2009 73 82
96. G.M. Schratt, F. Tuebing, E.A. Nigh, C.G. Kane, M.E. Sabatini, M. Kiebler, and M.E. Greenberg A brain-specific microRNA regulates dendritic spine development Nature 439 2006 283 439
97. D.S. Schwarz, G. Hutvágner, T. Du, Z. Xu, N. Aronin, and P.D. Zamore Asymmetry in the assembly of the RNAi enzyme complex Cell 115 2003 199 208 (Pubitemid 37329583)
98. F.J. Seil TrkB receptor signaling and activity-dependent inhibitory synaptogenesis Histol. Histopathol. 18 2003 635 646 (Pubitemid 36362080)
99. L.F. Sempere, S. Freemantle, I. Pitha-Rowe, E. Moss, E. Dmitrovsky, and V. Ambros Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation Genome Biol. 5 2004 R13
100. F.J. Slack, M. Basson, Z. Liu, V. Ambros, H.R. Horvitz, and G. Ruvkun The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor Mol. Cell 5 2000 659 669
101. K.E. Szulwach, X. Li, R.D. Smrt, Y. Li, Y. Luo, L. Lin, N.J. Santistevan, W. Li, X. Zhao, and P. Jin Cross talk between microRNA and epigenetic regulation in adult neurogenesis J. Cell Biol. 189 2010 127 141
102. T. Tuerxun, T. Numakawa, N. Adachi, E. Kumamaru, H. Kitazawa, M. Kudo, and H. Kunugi SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression Neurosci. Lett. 469 2010 303 308
103. M.C. Vella, E.Y. Choi, S.Y. Lin, K. Reinert, and F.J. Slack The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR Genes Dev. 18 2004 132 137 (Pubitemid 38141781)
104. N. Vo, M.E. Klein, O. Varlamova, D.M. Keller, T. Yamamoto, R.H. Goodman, and S. Impey A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis Proc. Natl. Acad. Sci. USA 102 2005 16426 16431 (Pubitemid 41688930)
105. E. Vreugdenhil, C.S. Verissimo, R. Mariman, J.T. Kamphorst, J.S. Barbosa, T. Zweers, D.L. Champagne, T. Schouten, O.C. Meijer, E.R. de Kloet, and C.P. Fitzsimons MicroRNA 18 and 124a down-regulate the glucocorticoid receptor: implications for glucocorticoid responsiveness in the brain Endocrinology 150 2009 2220 2228
106. T. Watanabe, A. Takeda, K. Mise, T. Okuno, T. Suzuki, N. Minami, and H. Imai Stage-specific expression of microRNAs during Xenopus development FEBS Lett. 579 2005 318 324 (Pubitemid 40092406)
107. B. Wightman, T.R. Bürglin, J. Gatto, P. Arasu, and G. Ruvkun Negative regulatory sequences in the lin-14 3′-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development Genes Dev. 5 1991 1813 1824 (Pubitemid 21905876)
108. H. Wu, J. Tao, P.J. Chen, A. Shahab, W. Ge, R.P. Hart, X. Ruan, Y. Ruan, and Y.E. Sun Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome Proc. Natl. Acad. Sci. USA 107 2010 18161 18166
109. Z. Xie, L.K. Johansen, A.M. Gustafson, K.D. Kasschau, A.D. Lellis, D. Zilberman, S.E. Jacobsen, and J.C. Carrington Genetic and functional diversification of small RNA pathways in plants PLoS Biol. 2 2004 E104
110. X. Xie, J. Lu, E.J. Kulbokas, T.R. Golub, V. Mootha, K. Lindblad-Toh, E.S. Lander, and M. Kellis Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals Nature 434 2005 338 345 (Pubitemid 40469170)
111. R. Yi, Y. Qin, I.G. Macara, and B.R. Cullen Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev. 17 2003 3011 3016 (Pubitemid 38040764)
112. A. Yoshii, and M. Constantine-Paton Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease Dev. Neurobiol. 70 2010 304 322
113. J.Y. Yu, K.H. Chung, M. Deo, R.C. Thompson, and D.L. Turner MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation Exp. Cell Res. 314 2008 2618 2633