Altered microRNA expression profile in human pituitary GH adenomas: Down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 7, 2012, Pages

  D'Angelo, Daniela ^a   Palmieri, Dario ^a   Mussnich, Paula ^a   Roche, Magali ^b   Wierinckx, Anne ^b   Raverot, Gerald ^c,f   Fedele, Monica ^a   Croce, Carlo Maria ^d   Trouillas, Jacqueline ^c,f   Fusco, Alfredo ^a,e  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^c CNRS   (France)

^d OHIO STATE UNIVERSITY   (United States)

^e CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^f UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP A1 PROTEIN; HIGH MOBILITY GROUP A2 PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 326; MICRORNA 34B; MICRORNA 432; MICRORNA 548C 3P; MICRORNA 570; MICRORNA 603; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; E2F1 GENE; GENE; GENE ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE TARGETING; GROWTH HORMONE SECRETING ADENOMA; GROWTH REGULATION; HMGA1 GENE; HMGA2 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS; MICROARRAY ANALYSIS; PRIORITY JOURNAL; RNA ANALYSIS; TUMOR CELL;

ADENOMA; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH HORMONE-SECRETING PITUITARY ADENOMA; HEK293 CELLS; HMGA1A PROTEIN; HMGA2 PROTEIN; HUMANS; MICROARRAY ANALYSIS; MICRORNAS; PITUITARY NEOPLASMS; PROLACTINOMA;

EID: 84863583945     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3482     Document Type: Article

References (36)

1. Kovacs K, Horvath E 1986 Pathology of growth hormone-producing tumors of the human pituitary. Semin Diagn Pathol 3:18-33 (Pubitemid 16131708)
2. Monson JP 2000 The epidemiology of endocrine tumours. Endocr Relat Cancer 7:29-36 (Pubitemid 30305869)
3. Lopes MB 2010 Growth hormone-secreting adenomas: pathology and cell biology. Neurosurg Focus 29:E2
4. Johnson KR, Lehn DA, Reeves R 1989 Alternative processing of mRNA encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y. Mol Cell Biol 9:2114-2123 (Pubitemid 19117812)
5. Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA 1999 Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem 274: 22563-22568
6. Thanos D, Maniatis T 1992 The high mobility group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene. Cell 71:777-789
7. Thanos D, Du W, Maniatis T 1993 The high mobility group protein HMG I(Y) is an essential structural component of a virus-inducible enhancer complex. Cold Spring Harb Symp Quant Biol 58:73-81 (Pubitemid 24219466)
8. De Martino I, Visone R, Wierinckx A, Palmieri D, Ferraro A, Cappabianca P, Chiappetta G, Forzati F, Lombardi G, Colao A, Trouillas J, Fedele M, Fusco A 2009 HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res 69:1844-1850
9. Fusco A, Fedele M 2007 Roles of HMGA proteins in cancer. Nat Rev Cancer 7:899-910 (Pubitemid 350165857)
10. Fedele M, Battista S, Kenyon L, Baldassarre G, Fidanza V, Klein-Szanto AJ, Parlow AF, Visone R, Pierantoni GM, Outwater E, Santoro M, Croce CM, Fusco A 2002 Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas. Oncogene 21:3190-3198 (Pubitemid 34548089)
11. Fedele M, Pentimalli F, Baldassarre G, Battista S, Klein-Szanto AJ, Kenyon L, Visone R, De Martino I, Ciarmiello A, Arra C, Viglietto G, Croce CM, Fusco A 2005 Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Oncogene 24:3427-3435 (Pubitemid 40756244)
12. Finelli P, Pierantoni GM, Giardino D, Losa M, Rodeschini O, Fedele M, Valtorta E, Mortini P, Croce CM, Larizza L, Fusco A 2002 The high mobility group A2 gene is amplified and overexpressed in human prolactinomas. Cancer Res 62:2398-2405 (Pubitemid 34411724)
13. Fedele M, Visone R, De Martino I, Troncone G, Palmieri D, Battista S, Ciarmiello A, Pallante P, Arra C, Melillo RM, Helin K, Croce CM, Fusco A 2006 HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell 9:459-471 (Pubitemid 43832192)
14. Bartel DP 2004 MicroRNA: genomics, biogenesis, mechanism, and function. Cell 116:281-297
15. Miska EA 2005 How microRNA control cell division, differentiation and death. Curr Opin Genet Dev 15:563-568 (Pubitemid 41262414)
16. Zamore PD, Haley B 2005 Ribo-gnome: the big world of small RNA. Science 309:1519-1524 (Pubitemid 41266468)
17. Fabbri M, Croce CM, Calin GA 2008 MicroRNA. Cancer J 14:1-6
18. Bottoni A, Piccin D, Tagliati F, Luchin A, Zatelli MC, degli Uberti EC 2005 miR-15a and miR-16-1 down-regulation in pituitary adenomas. J Cell Physiol 204:280-285
19. Bottoni A, Zatelli MC, Ferracin M, Tagliati F, Piccin D, Vignali C, Calin GA, Negrini M, Croce CM, Degli Uberti EC 2007 Identification of differentially espressemicroRNAby microarray: a possible role for microRNA genes in pituitary adenomas. J Cell Physiol 210:370-377 (Pubitemid 44956882)
20. Amaral FC, Torres N, Saggioro F, Neder L, Machado HR, Silva Jr WA, Moreira AC, Castro M 2009 MicroRNA differentially expressed in ACTH-secreting pituitary tumors. J Clin Endocrinol Metab 94:320-323
21. Butz H, Likó I, Czirják S, Igaz P, Korbonits M, Rácz K, Patócs A MicroRNA profile indicates downregulation of the TGFßpathway in sporadic non-functioning pituitary adenomas. Pituitary 14:112-124
22. Mao ZG, He DS, Zhou J, Yao B, Xiao WW, Chen CH, Zhu YH, Wang HJ 2010 Differential expression of microRNA in GH-secreting pituitary adenomas. Diagn Pathol 5:79
23. Liu CG, Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Zupo S, Dono M, Alder H, Bullrich F, Negrini M, Croce CM 2004 An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA 101:9740-9744 (Pubitemid 38869306)
24. Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson Jr DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM 2010 Downregulation of p53-inducible microRNA 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 18:367-381
25. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 25:402-408 (Pubitemid 34164012)
26. Pierantoni GM, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G, Santoro M, Chiariotti L, Fusco A 2001 High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. Oncogene 20:6132-6141 (Pubitemid 32964425)
27. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D 1995 Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res 55:1613-1616
28. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T 1998 Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1+/- mice. Nat Genet 18:360-364 (Pubitemid 28158165)
29. Qian ZR, Asa SL, Siomi H, Siomi MC, Yoshimoto K, Yamada S, Wang EL, Rahman MM, Inoue H, Itakura M, Kudo E, SanoT2009 Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas. Mod Pathol 22:431-441
30. Pierantoni GM, Finelli P, Valtorta E, Giardino D, Rodeschini O, Esposito F, Losa M, Fusco A, Larizza L 2005 High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy. Endocr Relat Cancer 12:867-874 (Pubitemid 41815781)
31. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA 1992 Effects of an Rb mutation in the mouse. Nature 359:295-300
32. Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM 1996 A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 85:733-744
33. Franklin DS, Godfrey VL, Lee H, Kovalev GI, Schoonhoven R, Chen-Kiang S, Su L, Xiong Y 1998 CD Kinhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. Genes Dev 12:2899-2911 (Pubitemid 28440148)
34. Palmieri D, D'Angelo D, Valentino T, De Martino I, Ferraro A, Wierinckx A, Fedele M, Trouillas J, Fusco A 5 December 2011 Down regulation of HMGA-targeting microRNA has a critical role in human pituitary tumorigenesis. Oncogene 10.1038/onc.2011.557
35. Heaney AP, Horwitz GA, Wang Z, Singson R, Melmed S 1999 Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis. Nat Med 5:1317-1321 (Pubitemid 29535612)
36. Ishikawa H, Heaney AP, Yu R, Horwitz GA, Melmed S 2001 Human pituitary tumor-transforming gene induces angiogenesis. J Clin Endocrinol Metab 86:867-874 (Pubitemid 32207508)