Recombinant human growth hormone affects the density and functionality of GABAB receptors in the male rat brain

Neuroendocrinology

Volumn 97, Issue 3, 2013, Pages 203-211

  Grönbladh, Alfhild ^a   Johansson, Jenny ^a   Nyberg, Fred ^a   Hallberg, Mathias ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Autoradiography; Baclofen; GABAB receptors; Growth hormone

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; HUMAN GROWTH HORMONE; RECOMBINANT GROWTH HORMONE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE);

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; AUTORADIOGRAPHY; BRAIN REGION; CINGULATE GYRUS; COGNITION; CONTROLLED STUDY; DRUG EFFECT; GENICULATE NUCLEUS; MALE; NONHUMAN; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PUTAMEN; RAT; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SPRAGUE DAWLEY RAT; TREATMENT DURATION; BASOLATERAL AMYGDALA; BODY WEIGHT; BRAIN FUNCTION; CENTRAL NUCLEUS (AMYGDALA); CLAUSTRUM; COMPARATIVE STUDY; CORTICAL AMYGDALA; INTERPEDUNCULAR NUCLEUS; LOW DRUG DOSE; PARAVENTRICULAR THALAMIC NUCLEUS; PRELIMBIC CORTEX; SUBSTANTIA NIGRA; SUPERIOR COLLICULUS; THALAMUS NUCLEUS; UPREGULATION;

ANIMALS; BACLOFEN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMAN GROWTH HORMONE; MALE; RATS; RECEPTORS, GABA-B; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES;

EID: 84877925449     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000339821     Document Type: Article

References (61)

1. Falleti MG, Maruff P, Burman P, Harris A: The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: a meta-analysis of the current literature. Psychoneuroendocrinol-ogy 2006; 31:681-691.
2. Laursen T, Jorgensen JO, Christiansen JS: The management of adult growth hormone deficiency syndrome. Expert Opin Pharma-cot her 2008; 9: 2435-2450.
3. van Nieuwpoort IC, Drent ML: Cognition in the adult with childhood-onset GH deficiency. Eur J Endocrinol 2008; 159(suppl 1):S53-S57.
4. Burman P, Deijen JB: Quality of life and cognitive function in patients with pituitary insufficiency. Psychother Psychosom 1998; 67: 154-167.
5. Nilsson AG, Svensson J, Johannsson G: Management of growth hormone deficiency in adults. Growth Horm IGF Res 2007; 17: 441-462.
6. Stabler B: Impact of growth hormone (GH) therapy on quality of life along the lifespan of GH-treated patients. Horm Res 2001; 56(suppl 1):55-58.
7. Webb SM, Badia X: Quality of life in growth hormone deficiency and acromegaly. Endo-crinol Metab Clin North Am 2007; 36:221-232.
8. Aberg ND, Brywe KG, Isgaard J: Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci World J 2006; 6: 53-80.
9. Svensson AL, Bucht N, Hallberg M, Nyberg F: Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuro-nal cell cultures. Proc Natl Acad Sci USA 2008; 105:7304-7308.
10. McLenachan S, Lum MG, Waters MJ, Turnley AM: Growth hormone promotes proliferation of adult neurosphere cultures. Growth Horm IGF Res 2009; 19: 212-218.
11. Nyberg F: Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21:330-348.
12. Andersson K, Fuxe K, Eneroth P, Isaksson O, Nyberg F, Roos P: Rat growth hormone and hypothalamic catecholamine nerve terminal systems. Evidence for rapid and discrete reductions in dopamine and noradrenaline levels and turnover in the median eminence of the hypophysectomized male rat. Eur J Pharmacol 1983; 95: 271-275.
13. B receptors: drugs meet clones. Curr Opin Neurobiol 1998; 8:345-350.
14. B receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. J Neurosci 2010; 30:749-759.
15. Dave KR, Lange-Asschenfeldt C, Raval AP, Prado R, Busto R, Saul I, Perez-Pinzon MA: Ischemic preconditioning ameliorates exci-totoxicity by shifting glutamate/gamma-aminobutyric acid release and biosynthesis. J Neurosci Res 2005; 82: 665-673.
16. Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E, Smart TG, Pangalos MN, Moss SJ: Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 2007; 53: 233-247.
17. Zhang F, Li C, Wang R, Han D, Zhang QG, Zhou C, Yu HM, Zhang GY: Activation of GABA receptors attenuates neuronal apop-tosis through inhibiting the tyrosine phos-phorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience 2007; 150: 938-949.
18. Bowery NG, Bettler B, Froestl W, Gallagher JP, Marshall F, Raiteri M, Bonner TI, Enna SJ: International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. Pharmacol Rev 2002; 54: 247-264.
19. Lasarge CL, Banuelos C, Mayse JD, Bizon JL: Blockade of GABA(B) receptors completely reverses age-related learning impairment. Neuroscience 2009; 164:941-947.
20. B re ceptor antagonist SGS742 i mproves spat ia l memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus. Neuropharmacology 2005; 48: 956-964.
21. Schuler V, Luscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, Kelly PH, Mosbacher J, Froestl W, Kaslin E, Korn R, Bischoff S, Kaupmann K, van der Putten H, Bettler B: Epilepsy, hyperalgesia, impaired memory, and loss of pre-and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron 2001; 31:47-58.
22. B(2)-de-ficient mice. J Neurosci 2004; 24: 6086-6097.
23. B receptor ligands. Adv Pharmacol 2010; 58: 19-62.
24. Froestl W, Gallagher M, Jenkins H, Madrid A, Melcher T, Teichman S, Mondadori CG, Pearlman R: SGS742:The first GABA(B) receptor antagonist in clinical trials. Biochem Pharmacol 2004; 68:1479-1487.
25. Nyberg F: The role of the somatotrophic axis in neuroprotection and neuroregeneration of the addictive brain. Int Rev Neurobiol 2009; 88: 399-427.
26. B agonist baclofen in major depressive disorder. Psychoneuroendocrinology 1997; 22:129-140.
27. B receptor 1, and the lissencephaly-1 protein (LIS-1) in adult hypophysectomized rats. Growth Horm IGF Res 2011; 21:16-24.
28. Le Greves M, Zhou Q, Berg M, Le Greves P, Fholenhag K, Meyerson B, Nyberg F: Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of nmda receptor sub-unit and PSD-95 gene transcript levels. Exp Brain Res 2006; 173: 267-273.
29. Cremer CM, Palomero-Gallagher N, Bid-mon HJ, Schleicher A, Speckmann EJ, Zilles K: Pentylenetetrazole-induced seizures affect binding site densities for GABA, gluta-mate and adenosine receptors in the rat brain. Neuroscience 2009; 163:490-499.
30. Sim LJ, Selley DE, Childers SR: In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35s]thio]-triphosphate binding. Proc Natl Acad Sci USA 1995; 92:7242-7246.
31. Sim LJ, Selley DE, Childers SR: Autoradiographic visualization in brain of receptor-G protein coupling using [35s]gtp gamma s binding. Methods Mol Biol 1997; 83:117-132.
32. B receptor site distribution in the rat central nervous system. Neuroscience 1987; 20:365-383.
33. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH: Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 1998; 396: 679-682.
34. Cryan JF, Kaupmann K: Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends Pharmacol Sci 2005; 26: 36-43.
35. Mustafa A, Nyberg F, Mustafa M, Bakhiet M, Mustafa E, Winblad B, Adem A: Growth hormone stimulates production of interfer-on-gamma by human peripheral mononuclear cells. Horm Res 1997; 48:11-15.
36. Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM: Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology 1994; 134: 2397-2403.
37. Fuh G, Cunningham BC, Fukunaga R, Na-gata S, Goeddel DV, Wells JA: Rational design of potent antagonists to the human growth hormone receptor. Science 1992; 256: 1677-1680.
38. Balon N, Kriem B, Weiss M, Rostain JC: GABA(A) receptors in the pars compacta and GABA(B) receptors in the pars reticu-lata of rat substantia nigra modulate the stri-atal dopamine release. Neurochem Res 2002; 27: 373-379.
39. Santiago M, Westerink BH: The role of GABA receptors in the control of nigrostria-tal dopaminergic neurons: dual-probe mi-crodialysis study in awake rats. Eur J Pharmacol 1992; 219:175-181.
40. Santiago M, Machado A, Cano J: In vivo release of dopamine from rat striatum, sub-stantia nigra and prefrontal cortex: differential modulation by baclofen. Br J Pharmacol 1993; 109:814-818.
41. Da Cunha C, Wietzikoski S, Wietzikoski EC, Miyoshi E, Ferro MM, Anselmo-Franci JA, Canteras NS: Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system. Neurobiol Learn Mem 2003; 79: 236-242.
42. B receptors and depression. Current status. Adv Pharmacol 2010; 58: 427-451.
43. B receptor antagonists, in rodents. Br J Pharmacol 2006; 149: 581-590.
44. Mombereau C, Kaupmann K, Froestl W, Sansig G, van der Putten H, Cryan JF: Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety-and antidepressant-like behavior. Neuropsychopharmacology 2004; 29:1050-1062.
45. B receptor antagonist-mediated antidepres-sant-like behavior is serotonin-dependent. J Pharmacol Exp Ther 2005; 312:290-296.
46. B receptor function in dorsal raphe neurons upon chronic fluox-etine treatment of socially stressed rats. J Neurophysiol 2007; 98: 196-204.
47. Deijen JB, de Boer H, Blok GJ, van der Veen EA: Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996; 21: 313-322.
48. Hull KL, Harvey S: Growth hormone therapy and quality of life: possibilities, pitfalls and mechanisms. J Endocrinol 2003; 179: 311-333.
49. Burton KA, Kabigting EB, Clifton DK, Stein-er RA: Growth hormone receptor messenger ribonucleic acid distribution in the adult male rat brain and its colocalization in hypo-thalamic somatostatin neurons. Endocrinology 1992; 131: 958-963.
50. Lobie PE, Garcia-Aragon J, Lincoln DT, Barnard R, Wilcox JN, Waters MJ: Localization and ontogeny of growth hormone receptor gene expression in the central nervous system. Brain Res Dev Brain Res 1993; 74:225-233.
51. Kastrup Y, Le Greves M, Nyberg F, Blomqvist A: Distribution of growth hormone receptor mRNA in the brain stem and spinal cord of the rat. Neuroscience 2005; 130: 419-425.
52. Zhai Q, Lai Z, Roos P, Nyberg F: Characterization of growth hormone binding sites in rat brain. Acta Paediatr Suppl 1994; 406:92-95.
53. Pan W, Yu Y, Cain CM, Nyberg F, Couraud PO, Kastin AJ: Permeation of growth hormone across the blood-brain barrier. Endocrinology 2005; 146: 4898-4904.
54. Nyberg F, Burman P: Growth hormone and its receptors in the central nervous system-location and functional significance. Horm Res 1996; 45:18-22.
55. Coculescu M: Blood-brain barrier for human growth hormone and insulin-like growth factor-I. J Pediatr Endocrinol Metab 1999; 12:113-124.
56. Ramsey MM, Weiner JL, Moore TP, Carter CS, Sonntag WE: Growth hormone treatment attenuates age-related changes in hip-pocampal short-term plasticity and spatial learning. Neuroscience 2004; 129:119-127.
57. Castro-Alamancos MA, Arevalo MA, Tor-res-Aleman I: Involvement of protein kinase C and nitric oxide in the modulation by insulin-like growth factor-I of glutamate-in-duced GABA release in the cerebellum. Neu-roscience 1996; 70: 843-847.
58. Castro-Alamancos MA, Torres-Aleman I: Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I. Proc Natl Acad Sci USA 1993; 90: 7386-7390.
59. Le Greves M, Steensland P, Le Greves P, Ny-berg F: Growth hormone induces age-dependent alteration in the expression of hippo-campal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats. Proc Natl Acad Sci USA 2002; 99: 7119-7123.
60. Le Greves M, Le Greves P, Nyberg F: Age-related effects of IGF-1 on the NMDA-, GH-and IGF-1-receptor mRNA transcripts in the rat hippocampus. Brain Res Bull 2005; 65: 369-374.
61. Davies CH, Starkey SJ, Pozza MF, Collin-gridge GL: GABA autoreceptors regulate the induction of LTP. Nature 1991; 349: 609-611.