Recombinant human growth hormone improves cognitive capacity in a pain patient exposed to chronic opioids

Acta Anaesthesiologica Scandinavica

Volumn 58, Issue 6, 2014, Pages 759-765

  Rhodin, A ^a   Von Ehren, M ^a   Skottheim, B ^a   Gronbladh A ^a   Ortiz Nieto, F ^a   Raininko, R ^a   Gordh, T ^a   Nyberg, F ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; METHADONE; N ACETYLASPARTIC ACID; ARGININE; ASPARTIC ACID; CREATINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; N-ACETYLASPARTATE; NARCOTIC AGENT;

ADULT; ARTICLE; CASE REPORT; COGNITION; COGNITIVE DEFECT; COMORBIDITY; FATIGUE; GROWTH HORMONE DEFICIENCY; HIPPOCAMPUS; HUMAN; KIDNEY SURGERY; LONG TERM CARE; LONG TERM EXPOSURE; MALE; METHADONE TREATMENT; MIDDLE AGED; NEURALGIA; NEUROPATHIC PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITY OF LIFE; SOMNOLENCE; SUBSTITUTION THERAPY; SWEATING; ANALOGS AND DERIVATIVES; APOPTOSIS; CHEMICALLY INDUCED; CHEMISTRY; COGNITION DISORDERS; DEFICIENCY; DRUG EFFECTS; HORMONE SUBSTITUTION; INTRAOPERATIVE COMPLICATIONS; KIDNEY; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY; PERIPHERAL NERVE INJURIES; SECRETION (PROCESS); SURGERY;

APOPTOSIS; ARGININE; ASPARTIC ACID; COGNITION DISORDERS; CREATINE; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HIPPOCAMPUS; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; INTRAOPERATIVE COMPLICATIONS; KIDNEY; MALE; METHADONE; MIDDLE AGED; NARCOTICS; NEURALGIA; NEUROGENESIS; PERIPHERAL NERVE INJURIES; PROTON MAGNETIC RESONANCE SPECTROSCOPY; QUALITY OF LIFE;

EID: 84903166593     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/aas.12309     Document Type: Article

References (29)

1. Nyberg F,. Growth hormone in the brain: characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21: 330-348.
2. Le Greves M, Steensland P, Le Greves P, Nyberg F,. Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-D-aspartate receptor subunits gene transcripts in male rats. Proc Natl Acad Sci U S A 2002; 99: 7119-7123. (Pubitemid 34526265)
3. van Dam PS, Aleman A,. Insulin-like growth factor-I, cognition and brain aging. Eur J Pharmacol 2004; 490: 87-95. (Pubitemid 38482163)
4. Deijen JB, de Boer H, Blok GJ, van der Veen EA,. Cognitive impairments and mood disturbances in growth hormone deficient men. Psychoneuroendocrinology 1996; 21: 313-322. (Pubitemid 26246858)
5. Nyberg F,. The role of the somatotrophic axis in neuroprotection and neuroregeneration of the addictive brain. Int Rev Neurobiol 2009; 88: 399-427.
6. Sjogren P, Christrup LL, Petersen MA, Hojsted J,. Neuropsychological assessment of chronic non-malignant pain patients treated in a multidisciplinary pain centre. Eur J Pain 2005; 9: 453-462. (Pubitemid 40836039)
7. Gaertner J, Radbruch L, Giesecke T, Gebershagen H, Petzke F, Ostgathe C, Elsner F, Sabatowski R,. Assessing cognition and psychomotor function under long-term treatment with controlled release oxycodone in non-cancer pain patients. Acta Anaesthesiol Scand 2006; 50: 664-672.
8. Eisch AJ, Barrot M, Schad CA, Self DW, Nestler EJ,. Opiates inhibit neurogenesis in the adult rat hippocampus. Proc Natl Acad Sci U S A 2000; 97: 7579-7584. (Pubitemid 30431506)
9. Hu S, Sheng WS, Lokensgard JR, Peterson PK,. Morphine induces apoptosis of human microglia and neurons. Neuropharmacology 2002; 42: 829-836. (Pubitemid 34520444)
10. Mao J, Sung B, Ji RR, Lim G,. Neuronal apoptosis associated with morphine tolerance: evidence for an opioid-induced neurotoxic mechanism. J Neurosci 2002; 22: 7650-7661. (Pubitemid 35386364)
11. Svensson AL, Bucht N, Hallberg M, Nyberg F,. Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures. Proc Natl Acad Sci U S A 2008; 105: 7304-7308. (Pubitemid 351754473)
12. Le Greves M, Zhou Q, Berg M, Les Greves P, Fholenhag K, Meyerson B, Nyberg F,. Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels. Exp Brain Res 2006; 173: 267-273. (Pubitemid 44264890)
13. Oertel H, Schneider HJ, Stalla GK, Holsboer F, Zihl J,. The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism. Psychoneuroendocrinology 2004; 29: 839-850. (Pubitemid 38716109)
14. Arwert LI, Deijen JB, Muller M, Drent ML,. Long-term growth hormone treatment preserves GH-induced memory and mood improvements: a 10-year follow-up study in GH-deficient adult men. Horm Behav 2005; 47: 343-349. (Pubitemid 40222742)
15. Bennett R,. Growth hormone in musculoskeletal pain states. Curr Rheumatol Rep 2004; 6: 266-273.
16. Ahmad AM, Hopkins MT, Thomas J, Ibrahim H, Fraser WD, Vora JP,. Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement. Clin Endocrinol (Oxf) 2001; 54: 709-717. (Pubitemid 34208881)
17. Hjermstad MJ, Fayers PM, Bjordal K, Kaasa S,. Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3). J Clin Oncol 1998; 16: 1188-1196. (Pubitemid 28108757)
18. Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G,. The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 2005; 153: 257-264. (Pubitemid 41174451)
19. Gleissner U, Helmstaedter C, Elger CE,. Right hippocampal contribution to visual memory: a presurgical and postsurgical study in patients with temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 1998; 65: 665-669. (Pubitemid 128701493)
20. Graybiel AM, Morris R,. Behavioural and cognitive neuroscience. Curr Opin Neurobiol 2011; 21: 365-367.
21. Moriarty O, McGuire BE, Finn DP,. The effect of pain on cognitive function: a review of clinical and preclinical research. Prog Neurobiol 2011; 93: 385-404.
22. Lutz J, Jager L, de Quervain D, Krauseneck T, Padberg F, Wichnalek M, Beyer A, Stahl R, Zirngibi B, Morhard D, Reiser M, Schelling G,. White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study. Arthritis Rheum 2008; 58: 3960-3969.
23. Mutso AA, Radzicki D, Baliki MN, Huang M, Banisadr G, Centeno MV, Radulovic J, Martina M, Miller RJ, Apkarian AV,. Abnormalities in hippocampal functioning with persistent pain. J Neurosci 2012; 32: 5747-5756.
24. Kerr B, Hill H, Coda B, Calogero M, Chapman CR, Hunt E, Buffington V, Mackie A,. Concentration-related effects of morphine on cognition and motor control in human subjects. Neuropsychopharmacology 1991; 5: 157-166.
25. Zacny JP, Gutierrez S,. Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology (Berl) 2003; 170: 242-254. (Pubitemid 37491603)
26. Rapeli P, Fabritius C, Alho H, Salaspuro M, Wahlbeck K, Kalska H,. Methadone vs buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. BMC Clin Pharmacol 2007; 7: 5.
27. Soyka M, Zingg C, Koller G, Hennig-Fast K,. Cognitive function in short- and long-term substitution treatment: are there differences? World J Biol Psychiatry 2010; 11: 400-408.
28. Tramullas M, Martinez-Cue C, Hurle MA,. Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain. Psychopharmacology (Berl) 2007; 193: 107-120. (Pubitemid 46906624)
29. Isgaard J, Aberg D, Nilsson M,. Protective and regenerative effects of the GH/IGF-I axis on the brain. Minerva Endocrinol 2007; 32: 103-113.