In vivo anti-diabetic, antioxidant and molecular docking studies of 1, 2, 8-trihydroxy-6-methoxy xanthone and 1, 2-dihydroxy-6-methoxyxanthone-8-O-β- d-xylopyranosyl isolated from Swertia corymbosa

Phytomedicine

Volumn 21, Issue 11, 2014, Pages 1237-1248

  Mahendran, G ^a   Manoj, M ^a   Murugesh, E ^a   Kumar, R Sathish ^a   Shanmughavel, P ^a   Prasad, K J Rajendra ^a   Bai, V Narmatha ^a  

^a BHARATHIAR UNIVERSITY   (India)

Author keywords

2BEL; Antidiabetic activity; Antioxidant; SUR1; Swertia corymbosa; Xanthones

Indexed keywords

1,2 DIHYDROXY 6 METHOXYXANTHONE 8 O BETA DEXTRO XYLOPYRANOSYL; 1,2,8 TRIHYDROXY 6 METHOXY XANTHONE; 11BETA HYDROXYSTEROID DEHYDROGENASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CREATININE; FRUCTOSE BISPHOSPHATASE; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SULFONYLUREA RECEPTOR 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; 1,2,8-TRIHYDROXY-6-METHOXYXANTHONE; 1,2-DIHYDROXY-6-METHOXY-8-O-XYLOPYRANOSYLXANTHONE; ANTILIPEMIC AGENT; PLANT EXTRACT; XANTHONE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DRUG CONFORMATION; DRUG ISOLATION; DRUG POTENCY; DRUG PROTEIN BINDING; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IN VIVO STUDY; INDIA; INSULIN BLOOD LEVEL; KIDNEY INJURY; LIGAND BINDING; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; MALE; MEDICINAL PLANT; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL PROTECTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SWERTIA CORYMBOSA; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; ENZYMOLOGY; GLUCOSE TOLERANCE TEST; KIDNEY; LIVER; MOUSE; PATHOLOGY; PHYTOTHERAPY; PLANT; SWERTIA; TOXICITY TESTING; WISTAR RAT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; KIDNEY; LIVER; MALE; MICE; MOLECULAR DOCKING SIMULATION; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RATS, WISTAR; SWERTIA; TOXICITY TESTS, ACUTE; XANTHONES;

EID: 84906733304     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2014.06.011     Document Type: Article

References (78)

1. Z. Abraham Ethnobotany of the Todas, the Kotas, the Irulas of the Nilgiris S.K. Jain, Glimpses of Indian Ethnobotany 1981 Oxford & IBH New Delhi 26 30
2. A. Alfy, A. Ahmed, and A. Fatani Protective effect of red grape seed sproanthocyanidins against induction of diabetes by alloxan in rats Pharmacol. Res. 52 2005 264 270 (Pubitemid 40981928)
3. P. Anagnostis, V.G. Athyros, K. Tziomalos, A. Karagiannis, and D.P. Mikhailidis Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis J. Clin. Endocrinol. Metab. 94 8 2009 2692 2701
4. P. Basnet, S. Kadota, M. Shimizu, and T. Namba Bellidifolin: a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica Planta Med. 60 1994 507 511 (Pubitemid 24382557)
5. A. Bessadok, E. Garcia, H. Jacquet, S. Martin, A. Garrigues, N. Loiseau, F. Andre, S. Orlowski, and M. Vivaudou Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P glycoprotein (ABCB1): functional similarities based on common structural features between two multi specific ABC proteins J Biol Chem 286 5 2010 3552 3569
6. Bethesda US Renal Data System. Annual Data Report: Atlas of End Stage Renal Disease in the United States 2001 National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
7. G. Chandramohan, S. Ignacimuthu, and K.V. Pugalendi A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats Eur. J. Pharmacol. 590 2008 437 443
8. B. Chandrasekar, M.B. Bajpai, and S.K. Mukherjee Hypoglycemic activity of Swertia chirayita (Roxb ex Flem) Karst Indian J. Exp. Biol. 28 1990 616 618
9. R. Chen, M. Meseck, R.C. McEvoy, and S.L. Woo 7 Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells Gene Ther. 7 2000 1802 1809
10. B.L. Cussimanio, A.A. Booth, P. Todd, B.G. Hudson, and R.G. Khali-fah Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation Biophys. Chem. 105 2003 743 755 (Pubitemid 37123094)
11. M.D. Eldridge, C.W. Murray, T.R. Auton, G.V. Paolini, and R.P. Mee Empirical scoring functions: the development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes J. Comput. Aided Mol. Des. 11 1997 425 445 (Pubitemid 127505895)
12. J. Eliza, P. Daisy, S. Ignacimuthu, and V. Duraipandiyan Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ induced diabetic rats Chem. Biol. Interact. 182 2009 67 72
13. T. Ferre, E. Riu, F. Bosch, and A. Valera Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver FASEB J. 10 10 1996 1213 1218 (Pubitemid 26276964)
14. J. Grimsby, R. Sarabu, W.L. Corbett, N.E. Haynes, F.T. Bizzarro, J.W. Coffey, K.R. Guertin, D.W. Hilliard, R.F. Kester, P.E. Mahaney, L. Marcus, L. Qi, C.L. Spence, J. Tengi, M.A. Magnuson, C.A. Chu, M.T. Dvorozniak, F.M. Matschinsky, and J.F. Grippo Allosteric activators of glucokinase: potential role in diabetes therapy Science 301 2003 370 373 (Pubitemid 36877072)
15. S.W. Hahm, J. Park, and Y.S. Son Opuntia humifusa stems lower blood glucose and cholesterol levels in streptozotocin-induced diabetic rats Nutr. Res. 31 2011 479 487
16. P. Hebeisen, B. Kuhn, P. Kohler, M. Gubler, W. Huber, E. Kitas, B. Schott, J. Benz, C. Joseph, and A. Ruf Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites Bioorg. Med. Chem. Lett. 18 16 2008 4708 4712
17. H. Hikino, M. Kobayashi, Y. Suzuki, and C. Konno Mechanisms of hypoglycemic activity of aconitan A, a glycan from Aconitum carmichaeli roots J. Ethnopharmacol. 25 1989 295 304 (Pubitemid 19120367)
18. IDF Diabetes Atlas News, 5th Edition of the Diabetes Atlas Released on World Diabetes Day 2011 IDF
19. S.S. Irudayaraj, C. Sunil, V. Duraipandiyan, and S. Ignacimuthu Antidiabetic and antioxidant activities of Toddalia asiatica (L.) Lam. leaves in streptozotocin induced diabetic rats J. Ethnopharmacol. 143 2012 515 523
20. N. Kamalakkannan, and P. Prince Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic Wistar rats Basic Clin. Pharmacol. Toxicol. 98 2006 97 103
21. K. Kamata, M. Mitsuya, T. Nishimura, J. Eiki, and Y. Nagata Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase Structure 12 3 2004 429 438 (Pubitemid 38353064)
22. A. Kar, B.K. Choudhary, and N.G. Bandyopadhyay Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats J. Ethnopharmacol. 84 2003 105 108 (Pubitemid 36040359)
23. P.R.N. Kind, and E.J. King Estimation of plasma phosphatases by determination of hydrolyzed phenol with amino-antipyrine J. Clin. Pathol. 7 1954 322 330
24. R. Kurukulasuriya, J.T. Link, D.J. Madar, Z. Pei, J.J. Rohde, S.J. Richards, A.J. Souers, and B.G. Szczepankiewicz Prospects for pharmacologic inhibition of hepatic glucose production Curr. Med. Chem. 10 2 2003 99 121 (Pubitemid 36138690)
25. T. Kuzuya, S. Nakagawa, J. Satoh, Y. Kanazawa, Y. Iwamoto, M. Kobayashi, K. Nanjo, A. Sasaki, Y. Seino, C. Ito, K. Shima, K. Nonaka, and T. Kadowaki Report of the Committee on the classification and diagnostic criteria of diabetes mellitus Diabetes Res. Clin. Pract. 55 2002 65 85 (Pubitemid 34036538)
26. M. Latha, and L. Pari Preventive effects of Cassia auriculata L. flowers on brain lipid peroxidation in rats treated with streptozotocin Mol. Cell. Biochem. 243 2003 23 28 (Pubitemid 36240548)
27. R.C.R. Latha, and P. Daisy Insulin secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminalia bellerica Roxb. in streptozotocin induced diabetic rats Chem. Biol. Interact. 189 2011 112 118
28. Y.G. Li, D.F. Ji, S. Zhong, Z.Q. Lv, T.B. Lin, S. Chen, and G.Y. Hu Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice J. Ethnopharmacol. 134 2011 961 970
29. Y. Liu, J. Sun, S. Rao, Y. Su, and Y. Yang Antihyperglycemic, antihyperlipidemic and antioxidant activities of polysaccharides from Catathelasma ventricosum in streptozotocin-induced diabetic mice Food Chem. Toxicol. 57 2013 39 45
30. W.A. Loughlin Recent advances in the allosteric inhibition of glycogen phosphorylase Mini Rev. Med. Chem. 10 2010 1139 1155
31. M. Maghrani, A. Lemhadri, N. Zeggwagh, M. Amraoui, M. Haloui, H. Jouad, and M. Eddouks Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats J. Ethnopharmacol. 90 2004 331 337 (Pubitemid 38175422)
32. M. Mahboob, M.F. Rahman, and P. Grover Serum lipid peroxidation and antioxidant enzyme levels in male and female diabetic patients Singap. Med. J. 46 2005 322 324 (Pubitemid 40992146)
33. G. Mahendran, M. Manoj, K.J. Rajendra Prasad, and V. Narmatha Bai Evaluation of anti-inflammatory and anti-nociceptive activity of xanthones from Swertia corymbosa (Griseb.) Wight ex C.B. Clarke Int. J. Pharm. Pharm. Sci. 5 3 2013 459 463
34. G. Mahendran, and V. NarmathaBai Evaluation of analgesic, anti-inflammatory and antipyretic potential of methanol extract of aerial parts of Swertia corymbosa (Griseb.) wight ex C.B. Clarke Int. J. Pharm. Pharm. Sci. 5 2 2013 459 463
35. G. Mahendran, and V. NarmathaBai Antioxidant and anti-proliferative activity of Swertia corymbosa (Griseb.)Wight ex C.B. Clarke Int. J. Pharm. Pharm. Sci. 5 3 2013 551 558
36. G. Mahendran, G. Thamotharan, S. Sengottuvelu, and V. NarmathaBai Anti-diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats J. Ethnopharmacol. 151 2014 1175 1183
37. G. Mahendran, G. Thamotharan, S. Sengottuvelu, and V. NarmathaBai Evaluation of anticonvulsant, sedative, anxiolytic, and phytochemical profile of the methanol extract from the aerial Parts of Swertia corymbosa (Griseb.) Wight ex C. B. Clarke BioMed Res. Int. 2014 2014 10.1155/2014/542385 (Article ID 542385, 9 p.)
38. S. Marklund, and G. Marklund Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase Eur. J. Biochem. 47 1974 469 474
39. L.D. May, J.H. Lefkowitch, M.T. Kram, and D.E. Rubin Mixed hepatocellular cholestatic liver injury after pioglitazone therapy Ann. Intern. Med. 136 2002 449 452 (Pubitemid 34233175)
40. S.K. Mitra, S. Gopumadhavan, T.S. Muralidhar, S.D. Anturlikar, and M.B. Sujatha Effect of D-400, a herbomineral preparation on lipid profile, glycated hemoglobin and glucose tolerance in streptozotocin induced diabetes in rats Indian J. Exp. Biol. 33 1995 798 800
41. J. Mohammadi, and P.R. Naik Evaluation of hypoglycemic effect of Morus alba in animal model Indian J. Pharmacol. 40 1 2008 15 18 (Pubitemid 351600807)
42. M.S. Moron, J.W. Depierre, and B. Mannervik Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver Biochim. Biophys. Acta 528 1979 67 78 (Pubitemid 9065588)
43. R.K. Murray, D.K. Granner, P.A. Mayes, and V.W. Rodwell Harper' Biochemistry 25th ed. 2000 Appleton and Lange Stanford, CT
44. S. Muruganandan, K. Srinivasan, S. Gupta, P.K. Gupta, and J. Lal Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats J. Ethnopharmacol. 97 2005 497 501 (Pubitemid 40312325)
45. S.R. Naik, N.T. Nitures, A.A. Ansari, and P.D. Shah Anti-diabetic activity of embelin: involvement of cellular inflammatory mediators, oxidative stress and other biomarkers Phytomedicine 20 10 2013 797 804
46. W.G. Niehaus, and B. Samuelson Formation of malondialdehyde from phospholipids arachidonate during microsomal lipid peroxidation Eur. J. Biochem. 6 1968 126 130
47. OECD OECD Guideline for the Testing of Chemicals. Acute Oral Toxicity - Acute Toxic Class Method: Test no-423 2001 Organization for Economic Co-operation and Development
48. O.C. Ohaeri Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats Biosci. Rep. 21 2001 19 24 (Pubitemid 32703509)
49. N.G. Oikonomakos, and L. Somsák Advances in glycogen phosphorylase inhibitor design Curr. Opin. Investig. Drugs 9 4 2008 379 395 (Pubitemid 351507664)
50. P. Oudhia Indigenous Medicinal Rice P5-C120A (Allelopathically Enriched) Compatibility in Swertia corymbosa (Griseb.) Wight ex Clarke var. Corymbosa based Herbal Formulations. Pankaj Oudhia's Expert Comments on Medicinal Rice of Asia 2012 Audio Bank on Biodiversity and Traditional Healing http://www.pankajoudhia.com
51. G. Papaccio, F.A. Pisanthi, M.Y. Latronico, E. Ammendola, and M. Galdieri Multiple low-dose and single high dose treatments with streptozotocin do not generate nitric oxide J. Cell. Biochem. 77 2000 82 91 (Pubitemid 30126897)
52. B.A. Pederson, J.M. Schroeder, G.E. Parker, M.W. Smith, A.A. De Paoli-Roach, and P.J. Roach Glucose metabolism in mice lacking muscle glycogen synthase Diabetes 54 2005 3466 3473 (Pubitemid 43334337)
53. F. Pen, and C.S. Fang Effect of Swertia punicea Hemsl. on protection of experimental diabetic mice Chin. J. Tradit. Med. Sci. Technol. 10 2003 96 97
54. P.K. Prabhakar, R. Prasad, S. Ali, and M. Doble Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats Phytomedicine 20 2013 488 494
55. B. Ramesh, and K.V. Pugalendi Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats J. Med. Food 9 2006 562 566 (Pubitemid 46095367)
56. B.K. Ramesh, D.R. Maddirala, K.K. Vinay, S.F. Shaik, K.E.G. Tiruvenkata, S. Swapna, B. Ramesh, and C.A. Rao Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats Food Chem. Toxicol. 48 2010 1078 1084
57. K. Ravi, B. Ramachandran, and S. Subramanian Effect of Eugenia jambolana seed kernel on antioxidant defense system in streptozotocin-induced diabetes in rats Life Sci. 75 2004 2717 2731 (Pubitemid 39215063)
58. S. Reitman, and S. Frankel For the determination of SGPT (ALAT) activity in serum Am. J. Clin. Pathol. 28 1957 53 56
59. A. Renu, K. Sunil, K. Dinesh, M. Ajay, and K. Tarun Antidiabetic activity of ethanolic extract of Swertia chirayita Buch-Ham Int. Res. J. Pharm. 2 2011 230 232
60. J.T. Rotruck, A.L. Pope, H.E. Ganther, and A.B. Swason Selenium: biochemical role as a component of glutathione peroxidase Science 179 1973 588 590
61. A.M. Saxena, M.B. Bajpai, P.S. Murthy, and S.K. Mukherjee Mechanism of blood sugar lowering by a Swerchirin-containing hexane fraction (SWI) of Swertia chirayita Indian J. Exp. Biol. 31 1993 178 181 (Pubitemid 23044044)
62. A.M. Saxena, S. Johri, P. Sharma, and R. Gupta Blood sugar lowering activity of Swertia chirayita (Roxb. ex Flem.) Karst. in different experimental rat models Flora Fauna 13 2007 415 418
63. J.R. Seckl, and B.R. Walker Mini review: 11beta-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action Endocrinology 142 4 2001 1371 1376 (Pubitemid 32299662)
64. P. Selvameena, T. Baluprakash, K. Arumugasamy, K. Kokilavani, U. Danya, and M.R. Udyashankar Studies on the hypoglycemic and hypolipidemic effect of Swertia minor (Griseb.) Knobl. (Gentianaceae) - an endemic and endangered medicinal plant from The Nigiris South Asian J. Biol. Sci. 1 2011 21 29
65. G.P. Senthilkumar, P. Arulselvan, D. Sathishkumar, and S.P. Subramanian Antidiabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats J. Health Sci. 52 2006 283 291 (Pubitemid 43824821)
66. C.G. Sheela, and K.T. Augusti Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Indian J. Exp. Biol. 30 1992 523 526
67. T. Shimazu Neuronal regulation of hepatic glucose metabolism in mammals Diabetes Metab. Rev. 3 1987 185 206 (Pubitemid 17002813)
68. K.A. Sinha Colorimetric assay of catalase Anal. Biochem. 47 1972 389 394
69. J.E. Sun, Z.H. Ao, Z.M. Lu, H.Y. Xu, X.M. Zhang, W.F. Dou, and Z.H. Xu Antihyperglycemic and antilipid peroxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice J. Ethnopharmacol. 118 2008 7 13
70. R. Sundaram, R. Naresh, P. Shanthi, and P. Sachdanandam Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats Phytomedicine 20 2013 577 584
71. T. Szkudelski The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas Physiol. Res. 50 2001 536 546
72. L.Y. Tian, X. Bai, X.H. Chen, J.B. Fang, S.H. Liu, and J.C. Chen Anti-diabetic effect of methylswertianin and bellidifolin from Swertia punicea Hemsl. and its potential mechanism Phytomedicine 17 2010 533 539
73. L. Wan, C. Chen, Z. Xiao, Y. Wang, Q. Min, Y. Yue, and J. Chen In vitro and in vivo anti-diabetic activity of Swertia kouitchensis extract J. Ethnopharmacol. 147 2013 622 630
74. Y.L. Wang, Z.Q. Xiao, S. Liu, L.S. Wan, Y.D. Yue, Y.T. Zhang, Z.X. Liu, and J.C. Chen Antidiabetic effects of Swertia macrosperma extracts in diabetic rats J. Ethnopharmacol. 150 2013 536 544
75. N.F. Wiernsperger, and C.J. Bailey The antihyperglycaemic effect of metformin: therapeutic and cellular mechanisms Drugs 58 1999 75 82
76. P. Wilson High density lipoprotein, low density lipoprotein and coronary heart disease Am. J. Cardiol. 66 1990 7 10
77. C. Wu, D.A. Okar, J. Kang, and A.J. Lange Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes Curr. Drug Targets Immune Endocr. Metab. Disord. 5 1 2005 51 59 (Pubitemid 40394303)
78. L. Zhang, X. Chen, J. Liu, Q. Zhu, Y. Leng, X. Luo, H. Jiang, and H. Liu Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase Eur. J. Med. Chem. 58 2012 624 639