Ruthenium polypyridine complexes combined with oligonucleotides for bioanalysis: A review

Molecules

Volumn 19, Issue 8, 2014, Pages 11933-11987

  Zhang, Shuyu ^a   Ding, Yubin ^a   Wei, Hui ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Aptamer; Bioanalysis; DNA detection; DNAzyme; Electrochemiluminescence; Electrochemistry; Functional nanomaterials; Ruthenium complexes

Indexed keywords

COORDINATION COMPOUND; DNA; LIGAND; OLIGONUCLEOTIDE; ORGANOMETALLIC COMPOUND; PYRIDINE; PYRIDINE DERIVATIVE; RUTHENIUM;

BIOASSAY; CATALYSIS; CHEMISTRY;

BIOLOGICAL ASSAY; CATALYSIS; COORDINATION COMPLEXES; DNA; LIGANDS; OLIGONUCLEOTIDES; ORGANOMETALLIC COMPOUNDS; PYRIDINES; RUTHENIUM;

EID: 84906662009     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules190811933     Document Type: Review

References (306)

1. Wenger, O.S. Vapochromism in organometallic and coordination complexes: Chemical sensors for volatile organic compounds. Chem. Rev. 2013, 113, 3686-3733.
2. Wei, H.; Chen, C.G.; Han, B.Y.; Wang, E.K. Enzyme colorimetric assay using unmodified silver nanoparticles. Anal. Chem. 2008, 80, 7051-7055.
3. MacKay, B.A.; Fryzuk, M.D. Dinitrogen coordination chemistry: On the biomimetic borderlands. Chem. Rev. 2004, 104, 385-401.
4. Becker, J.J.; Gagne, M.R. Exploiting the synergy between coordination chemistry and molecular imprinting in the quest for new catalysts. Acc. Chem. Res. 2004, 37, 798-804.
5. Ramaswamy, N.; Tylus, U.; Jia, Q.Y.; Mukerjee, S. Activity descriptor identification for oxygen reduction on nonprecious electrocatalysts: Linking surface science to coordination chemistry. J. Am. Chem. Soc. 2013, 135, 15443-15449.
6. Haas, K.L.; Franz, K.J. Application of metal coordination chemistry to explore and manipulate cell biology. Chem. Rev. 2009, 109, 4921-4960.
7. Wei, H.; Li, B.L.; Du, Y.; Dong, S.J.; Wang, E. Nucleobase-metal hybrid materials: Preparation of submicrometer-scale, spherical colloidal particles of adenine-gold(III) via a supramolecular hierarchical self-assembly approach. Chem. Mater. 2007, 19, 2987-2993.
8. Wei, H.; Wang, E.K. Submicrometre scale single-crystalline gold plates of nanometre thickness: Synthesis through a nucleobase process and growth mechanism. Nanotechnology 2007, 18, 295603.
9. Wei, H.; Li, J.; Wang, Y.L.; Wang, E.K. Silver nanoparticles coated with adenine: Preparation, self-assembly and application in surface-enhanced Raman scattering. Nanotechnology 2007, 18, 175610.
10. 2+ sensor. Analyst 2010, 135, 1406-1410.
11. Wei, H.; Wang, Z.D.; Zhang, J.; House, S.; Gao, Y.G.; Yang, L.M.; Robinson, H.; Tan, L.H.; Xing, H.; Hou, C.J.; et al. Time-dependent, protein-directed growth of gold nanoparticles within a single crystal of lysozyme. Nat. Nanotechnol. 2011, 6, 93-97.
12. Li, C.C.; Zeng, H.C. Coordination chemistry and antisolvent strategy to rare-earth solid solution colloidal spheres. J. Am. Chem. Soc. 2012, 134, 19084-19091.
13. Wei, H.; Lu, Y. Catalysis of gold nanoparticles within lysozyme single crystals. Chem. Asian J. 2012, 7, 680-683.
14. Wei, H.; Wang, E.K. Nanomaterials with enzyme-like characteristics (nanozymes): Next-generation artificial enzymes. Chem. Soc. Rev. 2013, 42, 6060-6093.
15. Wei, H.; House, S.; Wu, J.J.X.; Zhang, J.; Wang, Z.D.; He, Y.; Gao, E.J.; Gao, Y.G.; Robinson, H.; Li, W.; et al. Enhanced and tunable fluorescent quantum dots within a single crystal of protein. Nano. Res. 2013, 6, 627-634.
16. Guo, C.L.; Irudayaraj, J. Fluorescent Ag clusters via a protein-directed approach as a Hg(II) ion sensor. Anal. Chem. 2011, 83, 2883-2889.
17. Zhang, Y.; Xu, F.G.; Sun, Y.J.; Guo, C.L.; Cui, K.; Shi, Y.; Wen, Z.W.; Li, Z. Seed-mediated synthesis of Au nanocages and their electrocatalytic activity towards glucose oxidation. Chem. Eur. J. 2010, 16, 9248-9256.
18. Sun, L.L.; Song, Y.H.; Wang, L.; Sun, Y.J.; Guo, C.L.; Liu, Z.L.; Li, Z. DNA-templated gold nanoparticles formation. J. Nanosci. Nanotechnol. 2008, 8, 4415-4423.
19. Jurisson, S.; Berning, D.; Jia, W.; Ma, D.S. Coordination-compounds in nuclear-medicine. Chem. Rev. 1993, 93, 1137-1156.
20. Rey, A.M. Radiometal complexes in molecular imaging and therapy. Curr. Med. Chem. 2010, 17, 3673-3683.
21. Zhen, Z.P.; Tang, W.; Guo, C.L.; Chen, H.M.; Lin, X.; Liu, G.; Fei, B.W.; Chen, X.Y.; Xu, B.Q.; Xie, J. Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer. ACS Nano 2013, 7, 6988-6996.
22. Gianneschi, N.C.; Masar, M.S.; Mirkin, C.A. Development of a coordination chemistry-based approach for functional supramolecular structures. Acc. Chem. Res. 2005, 38, 825-837.
23. Wang, C.; Hao, X.Q.; Wang, M.; Guo, C.L.; Xu, B.Q.; Tan, E.N.; Zhang, Y.Y.; Yu, Y.H.; Li, Z.Y.; Yang, H.B.; et al. Self-assembly of giant supramolecular cubes with terpyridine ligands as vertices and metals on edges. Chem. Sci. 2014, 5, 1221-1226.
24. Song, Y.H.; Guo, C.L.; Sun, L.L.; Wei, G.; Peng, C.Y.; Wang, L.; Sun, Y.J.; Li, Z. Effects of bridge ions, DNA species, and developing temperature on flat-lying DNA monolayers. J. Phys. Chem. B 2007, 111, 461-468.
25. Song, Y.H.; Li, Z.; Liu, Z.G.; Wei, G.; Wang, L.; Sun, L.L.; Guo, C.L.; Sun, Y.J.; Yang, T. A novel strategy to construct a flat-lying DNA monolayer on a mica surface. J. Phys. Chem. B 2006, 110, 10792-10798.
26. Noffke, A.L.; Habtemariam, A.; Pizarro, A.M.; Sadler, P.J. Designing organometallic compounds for catalysis and therapy. Chem. Commun. 2012, 48, 5219-5246.
27. Nolan, S.P.; Clavier, H. Chemoselective olefin metathesis transformations mediated by ruthenium complexes. Chem. Soc. Rev. 2010, 39, 3305-3316.
28. Vos, J.G.; Kelly, J.M. Ruthenium polypyridyl chemistry; from basic research to applications and back again. Dalton Trans. 2006, 4869-4883.
29. Hu, L.Z.; Xu, G.B. Applications and trends in electrochemiluminescence. Chem. Soc. Rev. 2010, 39, 3275-3304.
30. Gill, M.R.; Thomas, J.A. Ruthenium(II) polypyridyl complexes and DNA-from structural probes to cellular imaging and therapeutics. Chem. Soc. Rev. 2012, 41, 3179-3192.
31. 2 semiconductor surfaces. Chem. Soc. Rev. 2009, 38, 115-164.
32. Zhu, Y.Y.; Gu, C.; Tang, S.; Fei, T.; Gu, X.; Wang, H.M.; Wang, Z.M.; Wang, F.F.; Lu, D.; Ma, Y.G. A new kind of peripheral carbazole substituted ruthenium(II) complexes for electrochemical deposition organic light-emitting diodes. J. Mater. Chem. 2009, 19, 3941-3949.
33. Troian-Gautier, L.; Moucheron, C. Ruthenium(II) complexes bearing fused polycyclic ligands: from fundamental aspects to potential applications. Molecules 2014, 19, 5028-5087.
34. Drummond, T.G.; Hill, M.G.; Barton, J.K. Electrochemical DNA sensors. Nat. Biotechnol. 2003, 21, 1192-1199.
35. Sassolas, A.; Leca-Bouvier, B.D.; Blum, L.J. DNA biosensors and microarrays. Chem. Rev. 2008, 108, 109-139.
36. Kolpashchikov, D.M. Binary probes for nucleic acid analysis. Chem. Rev. 2010, 110, 4709-4723.
37. Gooding, J.J. Electrochemical DNA hyhridization biosensors. Electroanalysis 2002, 14, 1149-1156.
38. Mickelsen, S.R. Electrochemical biosensors for DNA sequence detection. Electroanalysis 1996, 8, 15-19.
39. Palecek, E.; Jelen, F. Electrochemistry of nucleic acids and development of DNA sensors. Crit. Rev. Anal. Chem. 2002, 32, 261-270.
40. Wang, J. Electrochemical nucleic acid biosensors. Anal. Chim. Acta 2002, 469, 63-71.
41. Palecek, E. Oscillographic polarography of highly polymerized deoxyribonucleic acid. Nature 1960, 188, 656-657.
42. Palecek, E.; Bartosik, M. Electrochemistry of nucleic acids. Chem. Rev. 2012, 112, 3427-3481.
43. Labuda, J.; Brett, A.M.O.; Evtugyn, G.; Fojta, M.; Mascini, M.; Ozsoz, M.; Palchetti, I.; Palecek, E.; Wang, J. Electrochemical nucleic acid-based biosensors: Concepts, terms, and methodology (IUPAC Technical Report). Pure Appl. Chem. 2010, 82, 1161-1187.
44. Johnston, D.H.; Glasgow, K.C.; Thorp, H.H. Electrochemical measurement of the solvent accessibility of nucleobases using electron-transfer between dna and metal-complexes. J. Am. Chem. Soc. 1995, 117, 8933-8938.
45. Napier, M.E.; Loomis, C.R.; Sistare, M.F.; Kim, J.; Eckhardt, A.E.; Thorp, H.H. Probing biomolecule recognition with electron transfer: Electrochemical sensors for DNA hybridization. Bioconjugate Chem. 1997, 8, 906-913.
46. Ontko, A.C.; Armistead, P.M.; Kircus, S.R.; Thorp, H.H. Electrochemical detection of single-stranded DNA using polymer-modified electrodes. Inorg. Chem. 1999, 38, 1842-1846.
47. Sistare, M.F.; Holmberg, R.C.; Thorp, H.H. Electrochemical studies of polynucleotide binding and oxidation by metal complexes: Effects of scan rate, concentration, and sequence. J. Phys. Chem. B 1999, 103, 10718-10728.
48. Szalai, V.A.; Thorp, H.H. Electrocatalysis of guanine electron transfer: New insights from submillimeter carbon electrodes. J. Phys. Chem. B 2000, 104, 6851-6859.
49. Yang, I.V.; Thorp, H.H. Modification of indium tin oxide electrodes with repeat polynucleotides: Electrochemical detection of trinucleotide repeat expansion. Anal. Chem. 2001, 73, 5316-5322.
50. Szalai, V.A.; Jayawickamarajah, J.; Thorp, H.H. Electrocatalysis of guanine oxidation in polyethylene glycol solutions: The interplay of adsorption and reaction rate. J. Phys. Chem. B 2002, 106, 709-716.
51. Yang, I.V.; Ropp, P.A.; Thorp, H.H. Toward electrochemical resolution of two genes on one electrode: Using 7-deaza analogues of guanine and adenine to prepare PCR products with differential redox activity. Anal. Chem. 2002, 74, 347-354.
52. Armistead, P.M.; Thorp, H.H. Electrochemical detection of gene expression in tumor samples: Overexpression of Rak nuclear tyrosine kinase. Bioconjugate Chem. 2002, 13, 172-176.
53. 2+. Anal. Chem. 2001, 73, 4780-4786.
54. Wasalathanthri, D.P.; Mani, V.; Tang, C.K.; Rusling, J.F. Microfluidic electrochemical array for detection of reactive metabolites formed by cytochrome p450 enzymes. Anal. Chem. 2011, 83, 9499-9506.
55. Mugweru, A.; Rusling, J.F. Catalytic square-wave voltammetric detection of DNA with reversible metallopolymer-coated electrodes. Electrochem. Commun. 2001, 3, 406-409.
56. Xie, H.; Tansil, N.C.; Gao, Z.Q. A redox active and electrochemiluminescent threading bis-intercalator and its applications in DNA assays. Front. Biosci. (Landmark Ed.) 2006, 11, 1147-1157.
57. García, T.; Revenga-Parra, M.; Abruña, H.D.; Pariente, F.; Lorenzo, E. Single-mismatch position-sensitive detection of dna based on a bifunctional ruthenium complex. Anal. Chem. 2007, 80, 77-84.
58. Weizman, H.; Tor, Y. Redox-active metal-containing nucleotides: Synthesis, tunability, and enzymatic incorporation into DNA. J. Am. Chem. Soc. 2002, 124, 1568-1569.
59. Hurley, D.J.; Tor, Y. Ru(II) and Os(II) nucleosides and oligonucleotides: Synthesis and properties. J. Am. Chem. Soc. 2002, 124, 3749-3762.
60. Vrabel, M.; Hocek, M.; Havran, L.; Fojta, M.; Votruba, I.; Klepetarova, B.; Pohl, R.; Rulisek, L.; Zendlova, L.; Hobza, P.; et al. Purines bearing phenanthroline or bipyridine ligands and their Ru-II complexes in position 8 as model compounds for electrochemical DNA labeling-synthesis, crystal structure, electrochemistry, quantum chemical calculations, cytostatic and antiviral activity. Eur. J. Inorg. Chem. 2007, 1752-1769.
61. Vrabel, M.; Pohl, R.; Votruba, I.; Sajadi, M.; Kovalenko, S.A.; Ernsting, N.P.; Hocek, M. Synthesis and photophysical properties of 7-deaza-2'- deoxyadenosines bearing bipyridine ligands and their Ru(II)-complexes in position 7. Org. Biochem. Chem. 2008, 6, 2852-2860.
62. Vrabel, M.; Pohl, R.; Klepetarova, B.; Votruba, I.; Hocek, M. Synthesis of 2'-deoxyadenosine nucleosides bearing bipyridine-type ligands and their Ru-complexes in position 8 through cross-coupling reactions. Org. Biochem. Chem. 2007, 5, 2849-2857.
63. 2+ complexes: Construction by polymerase incorporation of modified nucleoside triphosphates, electrochemical and luminescent properties, and applications. Chem. Eur. J. 2009, 15, 1144-1154.
64. Jager, S.; Rasched, G.; Kornreich-Leshem, H.; Engeser, M.; Thum, O.; Famulok, M. A versatile toolbox for variable DNA functionalization at high density. J. Am. Chem. Soc. 2005, 127, 15071-15082.
65. Leland, J.K.; Powell, M.J. Electrogenerated chemiluminescence-an oxidative-reduction type ecl reaction sequence using tripropyl amine. J. Electrochem. Soc. 1990, 137, 3127-3131.
66. Kenten, J.H.; Gudibande, S.; Link, J.; Willey, J.J.; Curfman, B.; Major, E.O.; Massey, R.J. Improved electrochemiluminescent label for dna probe assays-rapid quantitative assays of hiv-1 polymerase chain-reaction products. Clin. Chem. 1992, 38, 873-879.
67. Deaver, D.R. A new nonisotopic detection system for immunoassays. Nature 1995, 377, 758-760.
68. Miao, W.J.; Bard, A.J. Electrogenerated chemluminescence. 72. Determination of immobilized DNA and C-reactive protein on Au(111) electrodes using Tris(2,2'-bipyridyl)ruthenium(II) labels. Anal. Chem. 2003, 75, 5825-5834.
69. Du, Y.; Wei, H.; Kang, J.Z.; Yan, J.L.; Yin, X.B.; Yang, X.R.; Wang, E.K. Microchip capillary electrophoresis with solid-state electrochemiluminescence detector. Anal. Chem. 2005, 77, 7993-7997.
70. Xu, Y.H.; Gao, Y.; Wei, H.; Du, Y.; Wang, E.K. Field-amplified sample stacking capillary electrophoresis with electrochemiluminescence applied to the determination of illicit drugs on banknotes. J. Chromatogr. A 2006, 1115, 260-266.
71. 2+ electrochemiluminescence detection. Electrophoresis 2006, 27, 4047-4051.
72. 2+-doped silica nanoparticle DNA probe for the electrogenerated chemiluminescence detection of DNA hybridization. Electrochim. Acta 2006, 52, 575-580.
73. 2(dcbpy)NHS and carrier protein. Luminescence 2007, 22, 53-59.
74. 2+- encapsulated liposomes as labels. Anal. Chem. 2007, 79, 459-463.
75. Wei, H.; Du, Y.; Kang, J.Z.; Wang, E.K. Label free electrochemiluminescence protocol for sensitive DNA detection with a tris(2,2'-bipyridyl)ruthenium(II) modified electrode based on nucleic acid oxidation. Electrochem. Commun. 2007, 9, 1474-1479.
76. 2+-doped silica nanoparticles on indium tin oxide electrode. Chem. Lett. 2007, 36, 210-211.
77. Wei, H.; Du, Y.; Kang, J.Z.; Xu, G.B.; Wang, E.K. Tris(2,2'-bipyridyl) ruthenium(II) doped silica film modified indium tin oxide electrode and its electrochemiluminescent properties. Chin. J. Anal. Chem. 2007, 25, 159-163.
78. Li, J.; Huang, M.H.; Liu, X.Q.; Wei, H.; Xu, Y.H.; Xu, G.B.; Wang, E.K. Enhanced electrochemiluminescence sensor from tris(2,2'-bipyridyl) ruthenium(II) incorporated into MCM-41 and an ionic liquid-based carbon paste electrode. Analyst 2007, 132, 687-691.
79. Li, J.; Xu, Y.H.; Wei, H.; Huo, T.; Wang, E.K. Electrochemiluminescence sensor based on partial sulfonation of polystyrene with carbon nanotubes. Anal. Chem. 2007, 79, 5439-5443.
80. Wei, H.; Wang, E. Solid-state electrochemiluminescence of tris(2,2'-bipyridyl) ruthenium. TrAC Trend. Anal. Chem. 2008, 27, 447-459.
81. Fang, L.Y.; Lv, Z.Z.; Wei, H.; Wang, E. A electrochemiluminescence aptasensor for detection of thrombin incorporating the capture aptamer labeled with gold nanoparticles immobilized onto the thio-silanized ITO electrode. Anal. Chim. Acta 2008, 628, 80-86.
82. 2+-doped silica nanoparticles within layer-by-layer biomolecular coatings and their application as a biocompatible electrochemiluminescent tag material. Chem. Eur. J. 2008, 14, 3687-3693.
83. Wei, H.; Yin, J.Y.; Wang, E. Bis(2,2'-bipyridine)(5,6-epoxy-5,6-dihydro- [1,10] phenanthroline)ruthenium: Synthesis and electrochemical and electrochemiluminescence characterization. Anal. Chem. 2008, 80, 5635-5639.
84. 2(dcbpy)NHS] labeling/aptamer-based biosensor for the detection of lysozyme by increasing sensitivity with gold nanoparticle amplification. Chem. Asian J. 2008, 3, 1935-1941.
85. 2+-doped silica nanoparticles with covalently grafted biomacromolecules. J. Colloid Interf. Sci. 2008, 321, 310-314.
86. Fang, L.Y.; Lu, Z.Z.; Wei, H.; Wang, E.K. Quantitative electrochemiluminescence detection of proteins: Avidin-based sensor and tris(2,2'-bipyridine) ruthenium(II) label. Biosens. Bioelectron. 2008, 23, 1645-1651.
87. Yao, W.; Wang, L.; Wang, H.Y.; Zhang, X.L.; Li, L. An aptamer-based electrochemiluminescent biosensor for ATP detection. Biosens. Bioelectron. 2009, 24, 3269-3274.
88. 2+ electrochemiluminescence switch and its applications for DNA interaction study and label-free ATP aptasensor. Anal. Chem. 2009, 81, 9807-9811.
89. Bertoncello, P.; Forster, R.J. Nanostructured materials for electrochemiluminescence (ECL)-based detection methods: Recent advances and future perspectives. Biosens. Bioelectron. 2009, 24, 3191-3200.
90. Ding, C.F.; Ge, Y.; Zhang, S.S. Electrochemical and electrochemiluminescence determination of cancer cells based on aptamers and magnetic beads. Chem. Eur. J. 2010, 16, 10707-10714.
91. Zhu, D.B.; Liu, J.F.; Tang, Y.B.; Xing, D. A reusable DNA biosensor for the detection of genetically modified organism using magnetic bead-based electrochemiluminescence. Sens. Actuator B Chem. 2010, 149, 221-225.
92. 2+-coated magnetic submicrobeads wrapped with carbon nanotubes. Electrochem. Commun. 2011, 13, 1499-1501.
93. Li, Y.P. Electrogenerated chemiluminescence detection of Mercury(II) ions based on DNA probe labeled with ruthenium complex. Anal. Sci. 2011, 27, 193-196.
94. Wei, H.; Wang, E. Electrochemiluminescence of tris(2,2'-bipyridyl) ruthenium and its applications in bioanalysis: A review. Luminescence 2011, 26, 77-85.
95. Zhang, F.; Chen, H.; He, P.G.; Fang, Y.Z. Research on DNA electrochemiluminescence biosensing. Chin. J. Anal. Chem. 2012, 41, 1-9.
96. Kurita, R.; Arai, K.; Nakamoto, K.; Kato, D.; Niwa, O. Determination of DNA methylation using electrochemiluminescence with surface accumulable coreactant. Anal. Chem. 2012, 84, 1799-1803.
97. Li, J.; Wang, E.K. Applications of tris(2,2'-bipyridyl)ruthenium(II) in electrochemiluminescence. Chem. Rec. 2012, 12, 177-187.
98. Li, J.; Guo, S.J.; Wang, E.K. Recent advances in new luminescent nanomaterials for electrochemiluminescence sensors. RSC Adv. 2012, 2, 3579-3586.
99. Yang, H.Y.; Wang, Y.Q.; Qi, H.L.; Gao, Q.; Zhang, C.X. Electrogenerated chemiluminescence biosensor incorporating ruthenium complex-labelled concanavalin a as a probe for the detection of Escherichia coli. Biosens. Bioelectron. 2012, 35, 376-381.
100. 2+-doped silica nanoparticle labeling and proximity-dependent surface hybridization assay. J. Solid State Electrochem. 2012, 16, 247-252.
101. Xu, Y.H.; Liu, Y.Q.; Zhu, J.B.; Wang, E.K. Discovered triethylamine as impurity in synthetic DNAs for and by electrochemiluminescence techniques. Talanta 2013, 116, 308-314.
102. Xu, Y.H.; Lv, Z.Z.; Xia, Y.; Han, Y.C.; Lou, B.H.; Wang, E.K. Highly porous magnetite/graphene nanocomposites for a solid-state electrochemiluminescence sensor on paper-based chips. Anal. Bioanal. Chem. 2013, 405, 3549-3558.
103. Qi, H.L.; Qiu, X.Y.; Wang, C.; Gao, Q.; Zhang, C.X. Digital electrogenerated chemiluminescence biosensor for the determination of multiple proteins based on Boolean logic gate. Anal. Methods 2013, 5, 612-615.
104. Guo, Z.H.; Yang, F.; Zhang, L.H.; Zheng, X.W. Electrogenerated chemiluminescence energy transfer for the label-free detection of DNA. Sensor. Actuat. B Chem. 2013, 177, 316-321.
105. Zhang, X.W.; Chen, C.G.; Li, J.; Zhang, L.B.; Wang, E.K. New insight into a microfluidic-based bipolar system for an electrochemiluminescence sensing platform. Anal. Chem. 2013, 85, 5335-5339.
106. Zhou, X.M.; Zhu, D.B.; Liao, Y.H.; Liu, W.P.; Liu, H.X.; Ma, Z.K.; Xing, D. Synthesis, labeling and bioanalytical applications of a tris(2,2'-bipyridyl) ruthenium(II)-based electrochemiluminescence probe. Nat. Protoc. 2014, 9, 1146-1159.
107. Gu, W.L.; Xu, Y.H.; Lou, B.H.; Lyu, Z.Z.; Wang, E.K. One-step process for fabricating paper-based solid-state electrochemiluminescence sensor based on functionalized graphene. Electrochem. Commun. 2014, 38, 57-60.
108. Gao, Y.; Li, J.; Yang, X.D.; Xiang, Q.; Wang, K.Q. Electrochemiluminescence biosensor based on PEDOT-PSS-graphene functionalized ITO electrode. Electroanalysis 2014, 26, 382-388.
109. Yuan, Y.L.; Gan, X.X.; Chai, Y.Q.; Yuan, R. A novel electrochemiluminescence aptasensor based on in situ generated proline and matrix polyamidoamine dendrimers as coreactants for signal amplication. Biosens. Bioelectron. 2014, 55, 313-317.
110. 2+-hairpin DNA composite film electrode. Biosens. Bioelectron. 2013, 44, 177-182.
111. Li, Y.; Huang, C.C.; Zheng, J.B.; Qi, H.L. Ultrasensitive electrogenerated chemiluminescent DNA-based biosensing switch for the determination of bleomycin. Talanta 2013, 103, 8-13.
112. Zhang, X.W.; Li, J.; Jia, X.F.; Li, D.Y.; Wang, E.K. Full-featured electrochemiluminescence sensing platform based on the multichannel closed bipolar system. Anal. Chem. 2014, 86, 5595-5599.
113. Hao, N.; Xiong, M.; Zhang, J.D.; Xu, J.J.; Chen, H.Y. Portable thermo-powered high-throughput visual electrochemiluminescence sensor. Anal. Chem. 2013, 85, 11715-11719.
114. Zhuo, Y.; Liao, N.; Chai, Y.Q.; Gui, G.F.; Zhao, M.; Han, J.; Xiang, Y.; Yuan, R. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal. Chem. 2014, 86, 1053-1060.
115. 2+-doped silica nanoparticles and its application in "Turnon" detection of ozone. Anal. Chem. 2013, 85, 3207-3212.
116. 2S nanoparticles electrochemiluminescence resonance energy transfer system for sensitive DNA detection. Anal. Chem. 2014, 86, 4559-4565.
117. Qi, H.L.; Li, M.; Dong, M.M.; Ruan, S.P.; Gao, Q.; Zhang, C.X. Electrogenerated chemiluminescence peptide-based biosensor for the determination of prostate-specific antigen based on target-induced cleavage of peptide. Anal. Chem. 2014, 86, 1372-1379.
118. Liao, Y.H.; Huang, R.; Ma, Z.K.; Wu, Y.X.; Zhou, X.M.; Xing, D. Target-triggered enzyme-free amplification strategy for sensitive detection of microrna in tumor cells and tissues. Anal. Chem. 2014, 86, 4596-4604.
119. Qi, W.J.; Xu, M.; Pang, L.; Liu, Z.Y.; Zhang, W.; Majeed, S.; Xu, G.B. Electrochemiluminescence detection of TNT by resonance energy transfer through the formation of a TNT-amine complex. Chem. Eur. J. 2014, 20, 4829-4835.
120. 2+/+ in aqueous solutions on tricresyl phosphate-based carbon paste electrode with extremely high hydrogen evolution potential. Anal. Bioanal. Chem. 2013, 405, 3427-3430.
121. Shi, L.H.; Liu, X.Q.; Li, H.J.; Xu, G.B. Electrochemiluminescent detection based on solid-phase extraction at tris(2,2'-bipyridyl)ruthenium(II)- modified ceramic carbon electrode. Anal. Chem. 2006, 78, 7330-7334.
122. Xu, G.B.; Pang, H.L.; Xu, B.; Dong, S.J.; Wong, K.Y. Enhancing the electrochemiluminescence of tris(2,2'-bipyridyl) ruthenium(II) by ionic surfactants. Analyst 2005, 130, 541-544.
123. Wang, H.Y.; Xu, G.B.; Dong, S.J. Electrochemiluminescence sensor using tris(2,2'-bipyridyl)ruthenium(II) immobilized in Eastman-AQ55D-silica composite thin-films. Anal. Chim. Acta 2003, 480, 285-290.
124. Wang, H.Y.; Xu, G.B.; Dong, S.J. Electrochemiluminescence of tris(2,2'-bipyridyl)ruthenium (II) ion-exchanged in polyelectrolyte-silica composite thin-films. Electroanalysis 2002, 14, 853-857.
125. Wang, H.; Xu, G.; Dong, S. Electrochemiluminescence of dichlorotris (1,10-phenanthroline) ruthenium (II) with peroxydisulfate in purely aqueous solution at carbon paste electrode. Microchem. J. 2002, 72, 43-48.
126. Wang, H.Y.; Xu, G.B.; Dong, S.J. Electrochemiluminescence of tris(2,2'-bipyridine)ruthenium(II) immobilized in poly(p-styrenesulfonate)- silica-Triton X-100 composite thin-films. Analyst 2001, 126, 1095-1099.
127. Xu, G.B.; Dong, S.J. Electrochemiluminescent detection of chlorpromazine by selective preconcentration at a lauric acid-modified carbon paste electrode using tris(2,2'-bipyridine)ruthenium(II). Anal. Chem. 2000, 72, 5308-5312.
128. 2- system in purely aqueous solution at carbon paste electrode. Electroanalysis 2000, 12, 583-587.
129. 2+ electrochemiluminescence. Analyst 1999, 124, 1085-1087.
130. Liu, X.Q.; Shi, L.H.; Niu, W.X.; Li, H.J. Xu, G.B. Environmentally friendly and highly sensitive Ruthenium(II) tris(2,2'-bipyridyl) electrochemiluminescent system using 2-(dibutylamino) ethanol as co-reactant. Angew. Chem. Int. Ed. 2007, 46, 421-424.
131. Liu, X.Q.; Shi, L.H.; Li, H.J.; Niu, W.X.; Xu, G.B. Tris(2,2'-bipyridyl) ruthenium(II) electrochemiluminescent detection of coreactants containing aromatic diol group by the interaction between diol and borate anion. Electrochem. Commun. 2007, 9, 2666-2670.
132. Xu, G.B.; Cheng, L.; Dong, S.J. Effects of heteropoly acids and surfactant on electrochemiluminescence of tris(2,2'-bipyridine) ruthenium(II). Anal. Lett. 1999, 32, 2311-2326.
133. Li, H.J.; Chen, J.A.; Han, S.; Niu, W.X.; Liu, X.Q.; Xu, G.B. Electrochemiluminescence from tris(2,2'-bipyridyl)ruthenium(II)-graphene-Nafion modified electrode. Talanta 2009, 79, 165-170.
134. Li, H.J.; Shi, L.H.; Liu, X.Q.; Niu, W.X.; Xu, G.B. Determination of isocyanates by capillary electrophoresis with tris(2,2'-bipyridine) ruthenium(II) electrochemiluminescence. Electrophoresis 2009, 30, 3926-3931.
135. Han, S.; Niu, W.X.; Li, H.J.; Hu, L.Z.; Yuan, Y.L.; Xu, G.B. Effect of hydroxyl and amino groups on electrochemiluminescence activity of tertiary amines at low tris(2,2'-bipyridyl)ruthenium(II) concentrations. Talanta 2010, 81, 44-47.
136. Han, S.A.; Li, H.J.; Hu, L.Z.; Yuan, Y.L.; Xu, G.B. Electrochemiluminescence of tris(2,2'-bipyridyl)ruthenium(II)/pyruvate system in the absence of cerium(III). Anal. Methods 2010, 2, 479-483.
137. Yuan, Y.L.; Li, H.J.; Han, S.A.; Hu, L.Z.; Xu, G.B. Application of cement as new electrode material and solid-phase microextraction material demonstrated by electrochemiluminescent detection of perphenazine. Talanta 2011, 84, 49-52.
138. 2+ electrochemiluminescence in the presence of formaldehyde or formic acid. J. Electroanal. Chem. 2011, 656, 289-292.
139. Hu, L.Z.; Gao, J.; Wang, Y.; Xu, G.B. Electrochemiluminescence of tris(2,2'-bipyridyl)ruthenium(II) in the presence of hydrazine and its derivatives. Anal. Methods 2011, 3, 1786-1789.
140. Yuan, Y.L.; Li, H.J.; Han, S.; Hu, L.Z.; Parveen, S.; Xu, G.B. Vitamin C derivatives as new coreactants for tris(2,2'-bipyridine)ruthenium(II) electrochemiluminescence. Anal. Chim. Acta 2011, 701, 169-173.
141. Yuan, Y.L.; Li, H.J.; Han, S.; Hu, L.Z.; Parveen, S.; Cai, H.R.; Xu, G.B. Immobilization of tris(1,10-phenanthroline)ruthenium with graphene oxide for electrochemiluminescent analysis. Anal. Chim. Acta 2012, 720, 38-42.
142. 2+/2-(dibutylamino)ethanol system. J. Electroanal. Chem. 2013, 688, 45-48.
143. Qi, W.J.; Gabr, M.T.; Liu, Z.Y.; Hu, L.Z.; Han, M.Y.; Zhu, S.Y.; Xu, G.B. Tris(2,2'-bipyridyl) ruthenium(II) electrochemiluminescence of glyoxal, glyoxylic acid, methylglyoxal, and acetaldehyde. Electrochim. Acta 2013, 89, 139-143.
144. Wu, M.-S.; Yuan, D.-J.; Xu, J.-J.; Chen, H.-Y. Sensitive electrochemiluminescence biosensor based on Au-ITO hybrid bipolar electrode amplification system for cell surface protein detection. Anal. Chem. 2013, 85, 11960-11965.
145. Song, B.; Pan, S.; Tang, C.; Li, D.; Rusling, J.F. Voltammetric microwell array for oxidized guanosine in intact ds-DNA. Anal. Chem. 2013, 85, 11061-11067.
146. Sardesai, N.P.; Barron, J.C.; Rusling, J.F. Carbon nanotube microwell array for sensitive electrochemiluminescent detection of cancer biomarker proteins. Anal. Chem. 2011, 83, 6698-6703.
147. Wu, M.-S.; Shi, H.-W.; He, L.-J.; Xu, J.-J.; Chen, H.-Y. Microchip device with 64-Site Electrode array for multiplexed immunoassay of cell surface antigens based on electrochemiluminescence resonance energy transfer. Anal. Chem. 2012, 84, 4207-4213.
148. Kurita, R.; Niwa, O. DNA methylation analysis triggered by bulge specific immuno-recognition. Anal. Chem. 2012, 84, 7533-7538.
149. 2+ based on π-π interaction between nucleotides and ferrocene-graphene nanosheets. J. Mater. Chem. B 2014, 2, 3263-3270.
150. Lin, X.; Zheng, L.; Gao, G.; Chi, Y.; Chen, G. Electrochemiluminescence imaging-based high-throughput screening platform for electrocatalysts used in fuel cells. Anal. Chem. 2012, 84, 7700-7707.
151. Han, F.; Jiang, H.; Fang, D.; Jiang, D. Potential-resolved electrochemiluminescence for determination of two antigens at the cell surface. Anal. Chem. 2014, 86, 6896-6902.
152. Chikkaveeraiah, B.V.; Bhirde, A.A.; Morgan, N.Y.; Eden, H.S.; Chen, X. Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers. ACS Nano 2012, 6, 6546-6561.
153. Shao, K.; Wang, J.; Jiang, X.; Shao, F.; Li, T.; Ye, S.; Chen, L.; Han, H. Stretch-stowage-growth strategy to fabricate tunable triply-amplified electrochemiluminescence immunosensor for ultrasensitive detection of pseudorabies virus antibody. Anal. Chem. 2014, 86, 5749-5757.
154. Gui, G.-F.; Zhuo, Y.; Chai, Y.-Q.; Xiang, Y.; Yuan, R. In situ generation of self-enhanced luminophore by β-lactamase catalysis for highly sensitive electrochemiluminescent aptasensor. Anal. Chem. 2014, 86, 5873-5880.
155. 2+/tripropylamine while preserving optical transparency of indium tin oxide for sensitive electrochemiluminescence-based analyses. Anal. Chem. 2014, 86, 1654-1660.
156. Blackburn, G.F.; Shah, H.P.; Kenten, J.H.; Leland, J.; Kamin, R.A.; Link, J.; Peterman, J.; Powell, M.J.; Shah, A.; Talley, D.B.; et al. Electrochemiluminescence detection for development of immunoassays and DNA probe assays for clinical diagnostics. Clin. Chem. 1991, 37, 1534-1539.
157. Richter, M.M. Electrochemiluminescence (ECL). Chem. Rev. 2004, 104, 3003-3036.
158. Miao, W.J. Electrogenerated chemiluminescence and its biorelated applications. Chem. Rev. 2008, 108, 2506-2553.
159. Knight, A.W.; Greenway, G.M. Occurrence, mechanisms and analytical applications of electrogenerated chemiluminescence-review. Analyst 1994, 119, 879-890.
160. Lee, W.Y. Tris (2,2'-bipyridyl)ruthenium(II) electrogenerated chemiluminescence in analytical science. Microchim. Acta 1997, 127, 19-39.
161. Gerardi, R.D.; Barnett, N.W.; Lewis, S.W. Analytical applications of tris(2,2'-bipyridyl)ruthenium(III) as a chemiluminescent reagent. Anal. Chim. Acta 1999, 378, 1-41.
162. Knight, A.W. A review of recent trends in analytical applications of electrogenerated chemiluminescence. TrAC Trend. Anal. Chem. 1999, 18, 47-62.
163. Kukoba, A.V.; Bykh, A.I.; Svir, I.B. Analytical applications of electrochemiluminescence: An overview. Fresenius J. Anal. Chem. 2000, 368, 439-442.
164. Fahnrich, K.A.; Pravda, M.; Guilbault, G.G. Recent applications of electrogenerated chemiluminescence in chemical analysis. Talanta 2001, 54, 531-559.
165. Yin, X.B.; Dong, S.J.; Wang, E. Analytical applications of the electrochemiluminescence of tris (2.2'-bipyridyl) ruthenium and its derivatives. TrAC Trend. Anal. Chem. 2004, 23, 432-441.
166. Yin, X.B.; Wang, E. Capillary electrophoresis coupling with electrochemilurninescence detection: A review. Anal. Chim. Acta 2005, 533, 113-120.
167. Gorman, B.A.; Francis, P.S.; Barnett, N.W. Tris(2,2'-bipyridyl) ruthenium(II) chemiluminescence. Analyst 2006, 131, 616-639.
168. Pyati, R.; Richter, M.M. ECL-Electrochemical luminescence. Annu. Rep. Prog. Chem. Sect. C Phys. Chem. 2007, 103, 12-78.
169. Du, Y.; Wang, E.K. Capillary electrophoresis and microchip capillary electrophoresis with electrochemical and electrochemiluminescence detection. J. Sep. Sci. 2007, 30, 875-890.
170. 2+ electrogenerated chemiluminescence. Chin. J. Anal. Chem. 2009, 37, 1557-1565.
171. Forster, R.J.; Bertoncello, P.; Keyes, T.E. Electrogenerated chemiluminescence. Annu. Rev. Anal. Chem. 2009, 2, 359-385.
172. Kenten, J.H.; Casadei, J.; Link, J.; Lupold, S.; Willey, J.; Powell, M.; Rees, A.; Massey, R. Rapid electrochemiluminescence assays of polymerase chain-reaction products. Clin. Chem. 1991, 37, 1626-1632.
173. Xu, X.H.; Yang, H.C.; Mallouk, T.E.; Bard, A.J. Immobilization of DNA on an Aluminum(III) alkanebisphosphonate thin-film with electrogenerated chemiluminescent detection. J. Am. Chem. Soc. 1994, 116, 8386-8387.
174. Xu, X.H.; Bard, A.J. Immobilization and hybridization of DNA on an Aluminum(III) alkanebisphosphonate thin-film with electrogenerated chemiluminescent detection. J. Am. Chem. Soc. 1995, 117, 2627-2631.
175. 2+-containing microspheres. Anal. Chem. 2004, 76, 5379-5386.
176. Li, Y.; Qi, H.L.; Fang, F.; Zhang, C.X. Ultrasensitive electrogenerated chemiluminescence detection of DNA hybridization using carbon-nanotubes loaded with tris(2,2'-bipyridyl) ruthenium derivative tags. Talanta 2007, 72, 1704-1709.
177. Zhang, J.; Qi, H.L.; Li, Y.; Yang, J.; Gao, Q.; Zhang, C.X. Electrogenerated chemiluminescence DNA biosensor based on hairpin DNA probe labeled with ruthenium complex. Anal. Chem. 2008, 80, 2888-2894.
178. Li, Y.; Qi, H.L.; Yang, J.; Zhang, C.X. Detection of DNA immobilized on bare gold electrodes and gold nanoparticle-modified electrodes via electrogenerated chemiluminescence using a ruthenium complex as a tag. Microchim. Acta 2009, 164, 69-76.
179. Huang, R.F.; Wang, L.R.; Guo, L.H. Highly sensitive electrochemiluminescence displacement method for the study of DNA/small molecule binding interactions. Anal. Chim. Acta 2010, 676, 41-45.
180. 2+ for determination of trace DNA and its application in measurement of gene expression level. Talanta 2012, 89, 427-432.
181. 2+-doped silica nanoparticles. Analyst 2010, 135, 603-607.
182. Yao, W.; Wang, L.; Wang, H.Y.; Zhang, X.L.; Li, L. Electrochemiluminescent sensor for the detection of DNA hybridization using stem-loop structure DNA as capture probes. Microchim. Acta 2009, 165, 407-413.
183. Wang, X.; He, P.; Fang, Y. A solid-state electrochemiluminescence biosensing switch for detection of DNA hybridization based on ferrocene-labeled molecular beacon. J. Lumin. 2010, 130, 1481-1484.
184. Yao, W.; Wang, L.; Wang, H.Y.; Zhang, X.L.; Li, L.; Zhang, N.; Pan, L.; Xing, N.N. An electrochemiluminescent DNA sensor based on nano-gold enhancement and ferrocene quenching. Biosens. Bioelectron. 2013, 40, 356-361.
185. Li, F.; Yu, Y.Q.; Li, Q.; Zhou, M.; Cui, H. A homogeneous signal-on strategy for the detection of rpob genes of mycobacterium tuberculosis based on electrochemiluminescent graphene oxide and ferrocene quenching. Anal. Chem. 2014, 86, 1608-1613.
186. Tang, X.F.; Zhao, D.; He, J.C.; Li, F.W.; Peng, J.X.; Zhang, M.N. Quenching of the electrochemiluminescence of Tris(2,2'-bipyridine)ruthenium(II)/ Tri-n-propylamine by pristine carbon nanotube and its application to quantitative detection of DNA. Anal. Chem. 2013, 85, 1711-1718.
187. Chen, Y.; Xu, J.; Su, J.; Xiang, Y.; Yuan, R.; Chai, Y. In situ hybridization chain reaction amplification for universal and highly sensitive electrochemiluminescent detection of DNA. Anal. Chem. 2012, 84, 7750-7755.
188. Dennany, L.; Forster, R.J.; Rusling, J.F. Simultaneous direct electrochemiluminescence and catalytic voltammetry detection of DNA in ultrathin films. J. Am. Chem. Soc. 2003, 125, 5213-5218.
189. Zhu, D.B.; Ma, W.G.; Xing, X.B. Application of electrochemiluminescence assay in nucleic acid detection. Prog. Chem. 2012, 24, 2367-2373.
190. Rampazzo, E.; Bonacchi, S.; Genovese, D.; Juris, R.; Marcaccio, M.; Montalti, M.; Paolucci, F.; Sgarzi, M.; Valenti, G.; Zaccheroni, N.; et al. Nanoparticles in metal complexes-based electrogenerated chemiluminescence for highly sensitive applications. Coord. Chem. Rev. 2012, 256, 1664-1681.
191. Cao, W.D.; Ferrance, J.P.; Demas, J.; Landers, J.P. Quenching of the electrochemiluminescence of tris(2,2'-bipyridine) ruthenium(II) by ferrocene and its potential application to quantitative DNA detection. J. Am. Chem. Soc. 2006, 128, 7572-7578.
192. 2+ electrochemiluminescence film based on conformation change of ferrocene-labeled DNA molecular beacon. Langmuir 2008, 24, 2200-2205.
193. Carter, M.T.; Bard, A.J. Electrochemical investigations of the interaction of metal chelates with DNA. 3. Electrogenerated chemiluminescent investigation of the interaction of tris (1,10-phenanthroline) ruthenium (II) with DNA. Bioconjugate Chem. 1990, 1, 257-263.
194. Tombelli, S.; Minunni, A.; Mascini, A. Analytical applications of aptamers. Biosens. Bioelectron. 2005, 20, 2424-2434.
195. Liu, J.W.; Cao, Z.H.; Lu, Y. Functional nucleic acid sensors. Chem. Rev. 2009, 109, 1948-1998.
196. Wang, Y.; Wei, H.; Li, B.; Ren, W.; Guo, S.; Dong, S.; Wang, E. SERS opens a new way in aptasensor for protein recognition with high sensitivity and selectivity. Chem. Commun. 2007, 5220-5222.
197. Li, B.L.; Wang, Y.L.; Wei, H.; Dong, S.J. Amplified electrochemical aptasensor taking AuNPs based sandwich sensing platform as a model. Biosens. Bioelectron. 2008, 23, 965-970.
198. Li, B.L.; Du, Y.; Wei, H.; Dong, S.J. Reusable, label-free electrochemical aptasensor for sensitive detection of small molecules. Chem. Commun. 2007, 3780-3782.
199. Du, Y.; Li, B.L.; Wei, H.; Wang, Y.L.; Wang, E.K. Multifunctional label-free electrochemical biosensor based on an integrated aptamer. Anal. Chem. 2008, 80, 5110-5117.
200. Wang, B.; Guo, C.L.; Zhang, M.M.; Park, B.; Xu, B.Q. High-resolution single-molecule recognition imaging of the molecular details of ricin-aptamer interaction. J. Phys. Chem. B 2012, 116, 5316-5322.
201. Wang, B.; Guo, C.L.; Chen, G.J.; Park, B.; Xu, B.Q. Following aptamer-ricin specific binding by single molecule recognition and force spectroscopy measurements. Chem. Commun. 2012, 48, 1644-1646.
202. Wei, H.; Li, B.L.; Li, J.; Wang, E.K.; Dong, S.J. Simple and sensitive aptamer-based colorimetric sensing of protein using unmodified gold nanoparticle probes. Chem. Commun. 2007, 3735-3737.
203. Li, B.L.; Wei, H.; Dong, S.J. Sensitive detection of protein by an aptamer-based label-free fluorescing molecular switch. Chem. Commun. 2007, 73-75.
204. 2+) using unmodified gold nanoparticle probes. Nanotechnology 2008, 19, 095501.
205. Zhang, L.B.; Wei, H.; Li, J.; Li, T.; Li, D.; Li, Y.H.; Wang, E.K. A carbon nanotubes based ATP apta-sensing platform and its application in cellular assay. Biosens. Bioelectron. 2010, 25, 1897-1901.
206. Lv, Z.Z.; Wei, H.; Li, B.L.; Wang, E.K. Colorimetric recognition of the coralyne-poly(dA) interaction using unmodified gold nanoparticle probes, and further detection of coralyne based upon this recognition system. Analyst 2009, 134, 1647-1651.
207. Zhu, X.; Lin, Z.Y.; Chen, L.F.; Qiu, B.; Chen, G.A. A sensitive and specific electrochemiluminescent sensor for lead based on DNAzyme. Chem. Commun. 2009, 6050-6052.
208. Ma, F.; Sun, B.; Qi, H.L.; Zhang, H.G.; Gao, Q.A.; Zhang, C.X. A signal-on electrogenerated chemiluminescent biosensor for lead ion based on DNAzyme. Anal. Chim. Acta 2011, 683, 234-241.
209. Sun, B.; Qi, H.L.; Ma, F.; Gao, Q.A.; Zhang, C.X.; Miao, W.J. Double covalent coupling method for the fabrication of highly sensitive and reusable electrogenerated chemiluminescence sensors. Anal. Chem. 2010, 82, 5046-5052.
210. Li, Y.; Qi, H.L.; Gao, Q.A.; Yang, J.; Zhang, C.X. Nanomaterial-amplified "signal off/on" electrogenerated chemiluminescence aptasensors for the detection of thrombin. Biosens. Bioelectron. 2010, 26, 754-759.
211. Yu, F.L.; Li, G.; Mao, C.M. An electrochemiluminescence aptasensor for tumor cells assay based on signal amplification of Ru(II) covalently doped silica nanoparticles. Electrochem. Commun. 2011, 13, 1244-1247.
212. Li, Y.; Qi, H.L.; Peng, Y.; Gao, Q.; Zhang, C.X. Electrogenerated chemiluminescence aptamer-based method for the determination of thrombin incorporating quenching of tris(2,2'-bipyridine)ruthenium by ferrocene. Electrochem. Commun. 2008, 10, 1322-1325.
213. 2+ based on DNA hybridization optimization with gold nanoparticles array patterned self-assembly platform. Biosens. Bioelectron. 2013, 49, 139-145.
214. Wang, X.Y.; Dong, P.; Yun, W.; Xu, Y.; He, P.G.; Fang, Y.Z. A solid-state electrochemiluminescence biosensing switch for detection of thrombin based on ferrocene-labeled molecular beacon aptamer. Biosens. Bioelectron. 2009, 24, 3288-3292.
215. Wang, X.Y.; Dong, P.; He, P.G.; Fang, Y.Z. A solid-state electrochemiluminescence sensing platform for detection of adenosine based on ferrocene-labeled structure-switching signaling aptamer. Anal. Chim. Acta 2010, 658, 128-132.
216. Ye, S.J.; Li, H.X.; Cao, W. Electrogenerated chemiluminescence detection of adenosine based on triplex DNA biosensor. Biosens. Bioelectron. 2011, 26, 2215-2220.
217. Liao, Y.H.; Yuan, R.; Chai, Y.Q.; Mao, L.; Zhuo, Y.; Yuan, Y.L.; Bai, L.J.; Yuan, S.R. Electrochemiluminescence quenching via capture of ferrocene-labeled ligand-bound aptamer molecular beacon for ultrasensitive detection of thrombin. Sens. Actuator B Chem. 2011, 158, 393-399.
218. Li, Z.J.; Qi, H.L.; Yang, H.Y.; Gao, Q.; Zhang, C.X. Simple and highly sensitive electrogenerated chemiluminescence adenosine aptasensor formed by adsorbing a ruthenium complex-tagged aptamer on single-walled carbon nanotubes. Anal. Methods 2014, 6, 1317-1323.
219. 2+-Double-Strand DNA Composite Film Electrode. Anal. Chem. 2009, 81, 9299-9305.
220. 2+ into ds-DNA. Chem. Commun. 2010, 46, 9022-9024.
221. Zhao, Y.; He, X.W.; Yin, X.B. Analyte-induced formation of partial duplexes for the preparation of a label-free electrochemiluminescent aptasensor. Chem. Commun. 2011, 47, 6419-6421.
222. Liu, D.Y.; Xin, Y.Y.; He, X.W.; Yin, X.B. A sensitive, non-damaging electrochemiluminescent aptasensor via a low potential approach at DNA-modified gold electrodes. Analyst 2011, 136, 479-485.
223. Li, Y.; Qi, H.L.; Gao, Q.A.; Zhang, C.X. Label-free and sensitive electrogenerated chemiluminescence aptasensor for the determination of lysozyme. Biosens. Bioelectron. 2011, 26, 2733-2736.
224. Tang, X.F.; Zhao, D.; Zhang, M.N. Sensitive and reusable electrochemiluminescent aptasensor achieved with diblock oligonucleotides immobilized solely through preferential adenine-Au interaction. Analyst 2013, 138, 5706-5712.
225. 2+ functionalized hollow gold nanoparticles as signal-amplifying tags. Biosens. Bioelectron. 2013, 47, 524-529.
226. 2+. J. Am. Chem. Soc. 1990, 112, 4960-4962.
227. Chen, Y.-M.; Liu, Y.-J.; Li, Q.; Wang, K.-Z. pH- and DNA-induced dual molecular light switches based on a novel ruthenium(II) complex. J. Inorg. Biochem. 2009, 103, 1395-1404.
228. Moucheron, C.; Kirsch-De Mesmaeker, A. New DNA-binding ruthenium(II) complexes as photo-reagents for mononucleotides and DNA. J. Phys. Org. Chem. 1998, 11, 577-583.
229. II(dppz)/DNA light-switch complex. Angew. Chem. Int. Ed. 2012, 51, 12107-12110.
230. O'Connor, N.A.; Stevens, N.; Samaroo, D.; Solomon, M.R.; Marti, A.A.; Dyer, J.; Vishwasrao, H.; Akins, D.L.; Kandel, E.R.; Turro, N.J. A covalently linked phenanthridine-ruthenium(II) complex as a RNA probe. Chem. Commun. 2009, 2640-2642.
231. 2+. Dalton Trans. 2010, 39, 2490-2493.
232. Xu, L.; Zhang, D.; Huang, J.; Deng, M.G.; Zhang, M.; Zhou, X. High fluorescence selectivity and visual detection of G-quadruplex structures by a novel dinuclear ruthenium complex. Chem. Commun. 2010, 46, 743-745.
233. 2+ with human telomeric DNA: Preferential binding to G-quadruplexes over i-motif. Biochimie 2010, 92, 370-377.
234. Liao, G.L.; Chen, X.; Ji, L.N.; Chao, H. Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex. Chem. Commun. 2012, 48, 10781-10783.
235. Shi, S.; Zhao, J.; Gao, X.; Lv, C.; Yang, L.; Hao, J.; Huang, H.; Yao, J.; Sun, W.; Yao, T.; et al. Molecular "light switch" for G-quadruplex DNA: Cycling the switch on and off. Dalton Trans. 2012, 41, 5789-5793.
236. 2+: A colorimetric molecular "light switch" and powerful stabilizer for G-quadruplex DNA. Dalton Trans. 2013, 42, 5661-5672.
237. Rajput, C.; Rutkaite, R.; Swanson, L.; Haq, I.; Thomas, J.A. Dinuclear monointercalating Ru-II complexes that display high affinity binding to duplex and quadruplex DNA. Chem. Eur. J. 2006, 12, 4611-4619.
238. Liu, F.; Wang, K.; Bai, G.; Zhang, Y.; Gao, L. The pH-induced emission switching and interesting DNA-binding properties of a novel dinuclear Ruthenium(II) complex. Inorg. Chem. 2004, 43, 1799-1806.
239. Zhang, A.-G.; Zhang, Y.-Z.; Duan, Z.-M.; Wang, K.-Z.; Wei, H.-B.; Bian, Z.-Q.; Huang, C.-H. Dual molecular light switches for pH and DNA BASED on a novel Ru(II) complex. A non-intercalating Ru(II) complex for DNA molecular light switch. Inorg. Chem. 2011, 50, 6425-6436.
240. Yao, J.-L.; Gao, X.; Sun, W.; Fan, X.-Z.; Shi, S.; Yao, T.-M. A naked-eye on-off-on molecular "light switch" based on a reversible "conformational switch" of G-quadruplex DNA. Inorg. Chem. 2012, 51, 12591-12593.
241. 2+. Inorg. Chem. 1998, 37, 139-141.
242. 2+ and transition metal ions. Inorg. Chem. 1999, 38, 5196-5197.
243. Liu, Y.; Chouai, A.; Degtyareva, N.N.; Lutterman, D.A.; Dunbar, K.R.; Turro, C. Chemical control of the DNA light switch: Cycling the switch on and off. J. Am. Chem. Soc. 2005, 127, 10796-10797.
244. Lutterman, D.A.; Chouai, A.; Liu, Y.; Sun, Y.; Stewart, C.D.; Dunbar, K.R.; Turro, C. Intercalation is not required for DNA light-switch behavior. J. Am. Chem. Soc. 2008, 130, 1163-1170.
245. 2+ with single-stranded DNA-What degree of protection is required for operation of the "light-switch effect"? J. Phys. Chem. B 2001, 105, 730-735.
246. Andersson, J.; Lincoln, P. Stereoselectivity for DNA threading intercalation of short binuclear ruthenium complexes. J. Phys. Chem. B 2011, 115, 14768-14775.
247. Choi, M.S.; Yoon, M.; Baeg, J.O.; Kim, J. Label-free dual assay of DNA sequences and potassium ions using an aptamer probe and a molecular light switch complex. Chem. Commun. 2009, 7419-7421.
248. 2+ using mismatched DNA and a molecular light switch complex in aqueous solution. Biosens. Bioelectron. 2010, 25, 1338-1343.
249. Oh, B.N.; Park, S.; Ren, J.; Jang, Y.J.; Kim, S.K.; Kim, J. Label-free emission assay of mercuric ions using DNA duplexes of poly(dT). Dalton Trans. 2011, 40, 6494-6499.
250. Chan, H.-L.; Liu, H.-Q.; Tzeng, B.-C.; You, Y.-S.; Peng, S.-M.; Yang, M.; Che, C.-M. Syntheses of Ruthenium(II) quinonediimine complexes of cyclam and characterization of their dna-binding activities and cytotoxicity. Inorg. Chem. 2002, 41, 3161-3171.
251. Andersson, J.; Fornander, L.H.; Abrahamsson, M.; Tuite, E.; Nordell, P.; Lincoln, P. Lifetime heterogeneity of dna-bound dppz complexes originates from distinct intercalation geometries determined by complex-complex interactions. Inorg. Chem. 2012, 52, 1151-1159.
252. Rebarz, M.; Marcelis, L.; Menand, M.; Cornut, D.; Moucheron, C.; Jabin, I.; Kirsch-De Mesmaeker, A. Revisited photophysics and photochemistry of a Ru-TAP complex using chloride ions and a calix 6 crypturea. Inorg. Chem. 2014, 53, 2635-2644.
253. Xiao, Q.; Huang, S.; Ge, Y.S.; He, Z.K.; Liu, Y.; Liang, J.G. A novel fluorescent silver ion biosensor based on nucleic acid molecular "light switch". J. Fluoresc. 2010, 20, 541-549.
254. Pierroz, V.; Joshi, T.; Leonidova, A.; Mari, C.; Schur, J.; Ott, I.; Spiccia, L.; Ferrari, S.; Gasser, G. Molecular and cellular characterization of the biological effects of Ruthenium(II) complexes incorporating 2-pyridyl-2-pyrimidine-4-carboxylic acid. J. Am. Chem. Soc. 2012, 134, 20376-20387.
255. Stephenson, M.; Reichardt, C.; Pinto, M.; Wächtler, M.; Sainuddin, T.; Shi, G.; Yin, H.; Monro, S.; Sampson, E.; Dietzek, B.; et al. Ru(II) Dyads derived from 2-(1-Pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: Versatile photosensitizers for photodynamic applications. J. Phys. Chem. A 2014, doi:10.1021/jp504330s. [Epub ahead of print].
256. Ma, Y.-Z.; Yin, H.-J.; Wang, K.-Z. A β-d-allopyranoside-grafted Ru(II) complex: Synthesis and acid-base and DNA-binding properties. J. Phys. Chem. B 2009, 113, 11039-11047.
257. Sun, W.; Shi, S.; Yao, T. Graphene oxide-Ru complex for label-free assay of DNA sequence and potassium ions via fluorescence resonance energy transfer. Anal. Methods 2011, 3, 2472-2474.
258. Sun, W.L.; Yao, T.M.; Shi, S. A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin. Analyst 2012, 137, 1550-1552.
259. Sun, W.L.; Yao, J.L.; Yao, T.M.; Shi, S. Label-free fluorescent DNA sensor for the detection of silver ions based on molecular light switch Ru complex and unmodified quantum dots. Analyst 2013, 138, 421-424.
260. Wang, L.; Yao, T.; Shi, S.; Cao, Y.; Sun, W. A label-free fluorescent probe for Hg(2+) and biothiols based on graphene oxide and Ru-complex. Sci. Rep. 2014, 4, 5320-5320.
261. Shi, S.; Wang, X.; Sun, W.L.; Wang, X.Y.; Yao, T.M.; Ji, L.N. Label-free fluorescent DNA biosensors based on metallointercalators and nanomaterials. Methods 2013, 64, 305-314.
262. Ling, L.S.; He, Z.K.; Wu, F.W.; Luo, Q.Y.; Zeng, Y.E. Progress of the nucleic acid molecular "Light Switch". Chem. J. Chin. Univ. Chin. 2000, 21, 527-531.
263. Shi, S.; Yao, T.; Ji, L. DNA molecular light switch and biosensors based on ruthenium(II) polypyridyl complexes. Sci. Sin. Chim. 2014, 44, 460-470.
264. Ma, D.L.; Ma, V.P.Y.; Chan, D.S.H.; Leung, K.H.; He, H.Z.; Leung, C.H. Recent advances in luminescent heavy metal complexes for sensing. Coord. Chem. Rev. 2012, 256, 3087-3113.
265. Hartshorn, R.M.; Barton, J.K. Novel dipyridophenazine complexes of Ruthenium(II)-exploring luminescent reporters of DNA. J. Am. Chem. Soc. 1992, 114, 5919-5925.
266. Jenkins, Y.; Friedman, A.E.; Turro, N.J.; Barton, J.K. Characterization of dipyridophenazine complexes of Ruthenium(ii)-the light switch effect as a function of nucleic-acid sequence and conformation. Biochemistry 1992, 31, 10809-10816.
267. 2+ light-switch on and off with temperature. J. Am. Chem. Soc. 2002, 124, 15094-15098.
268. 2+. J. Am. Chem. Soc. 1997, 119, 11458-11467.
269. Liu, Y.; Hammitt, R.; Lutterman, D.A.; Thummel, R.P.; Turro, C. Marked differences in light-switch behavior of Ru(II) complexes possessing a tridentate DNA intercalating ligand. Inorg. Chem. 2007, 46, 6011-6021.
270. Sun, Y.; Lutterman, D.A.; Turro, C. Role of electronic structure on DNA light-switch behavior of Ru(II) intercalators. Inorg. Chem. 2008, 47, 6427-6434.
271. 2+ light switch emission to ionic strength, temperature, and DNA sequence and conformation. Dalton Trans. 2013, 42, 4081-4090.
272. Baggaley, E.; Weinstein, J.A.; Williams, J.A.G. Lighting the way to see inside the live cell with luminescent transition metal complexes. Coord. Chem. Rev. 2012, 256, 1762-1785.
273. Coogan, M.P.; Fernandez-Moreira, V. Progress with, and prospects for, metal complexes in cell imaging. Chem. Commun. 2014, 50, 384-399.
274. Baggaley, E.; Gill, M.R.; Green, N.H.; Turton, D.; Sazanovich, I.V.; Botchway, S.W.; Smythe, C.; Haycock, J.W.; Weinstein, J.A.; Thomas, J.A. Dinuclear Ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA. Angew. Chem. Int. Ed. Engl. 2014, 53, 3367-3371.
275. 2+ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes. Nat. Chem. 2012, 4, 621-628.
276. 2+ bound to mismatched DNA reveals side-by-side metalloinsertion and intercalation. Nat. Chem. 2012, 4, 615-620.
277. Ma, D.L.; He, H.Z.; Leung, K.H.; Chan, D.S.H.; Leung, C.H. Bioactive luminescent transition-metal complexes for biomedical applications. Angew. Chem. Int. Ed. Engl. 2013, 52, 7666-7682.
278. Li, F.F.; Harry, E.J.; Bottomley, A.L.; Edstein, M.D.; Birrell, G.W.; Woodward, C.E.; Keene, F.R.; Collins, J.G. Dinuclear ruthenium(II) antimicrobial agents that selectively target polysomes in vivo. Chem. Sci. 2014, 5, 685-693.
279. 2+ light-switch mechanism in protic solvents as studied through temperature-dependent lifetime measurements. J. Phys. Chem. A 2004, 108, 9938-9944.
280. 2+. J. Am. Chem. Soc. 1993, 115, 3448-3454.
281. 2: Luminescent metal complexes that bind DNA base mismatches. Inorg. Chem. 2004, 43, 4570-4578.
282. Barton, J.K.; Danishefsky, A.T.; Goldberg, J.M. Tris(phenanthroline) ruthenium(II): Stereoselectivity in binding to DNA. J. Am. Chem. Soc. 1984, 106, 2172-2176.
283. 2 Shows Enantiomer Orientations and Water Ordering. J. Am. Chem. Soc. 2013, 135, 12652-12659.
284. 2+ enantiomers. Chem. Eur. J. 2012, 18, 15142-15150.
285. Foxon, S.P.; Metcalfe, C.; Adams, H.; Webb, M.; Thomas, J.A. Electrochemical and photophysical properties of DNA metallo-intercalators containing the ruthenium(II) tris(1-pyrazolyl)methane unit. Inorg. Chem. 2007, 46, 409-416.
286. Foxon, S.P.; Phillips, T.; Gill, M.R.; Towrie, M.; Parker, A.W.; Webb, M.; Thomas, J.A. A multifunctional light switch: DNA binding and cleavage properties of a heterobimetallic ruthenium-rhenium dipyridophenazine complex. Angew. Chem. Int. Ed. Engl. 2007, 46, 3686-3688.
287. Metcalfe, C.; Adams, H.; Haq, I.; Thomas, J.A. A ruthenium dipyridophenazine complex that binds preferentially to GC sequences. Chem. Commun. 2003, 1152-1153.
288. 2+: A novel "Light Switch" for DNA and photo-oxidant for mononucleotides. Inorg. Chem. 1997, 36, 584-592.
289. Nordell, P.; Westerlund, F.; Reymer, A.; El-Sagheer, A.H.; Brown, T.; Norden, B.; Lincoln, P. DNA Polymorphism as an origin of adenine-thymine tract length-dependent threading intercalation rate. J. Am. Chem. Soc. 2008, 130, 14651-14658.
290. Wilhelmsson, L.M.; Westerlund, F.; Lincoln, P.; Norden, B. DNA-binding of semirigid binuclear ruthenium complex Delta,Delta-mu-(11,11'-bidppz)(phen)(4) Ru-2 (4+): Extremely slow intercalation kinetics. J. Am. Chem. Soc. 2002, 124, 12092-12093.
291. 2+: Distinct excited-state species with two, one, or no hydrogen bonds from solvent. J. Phys. Chem. A 2004, 108, 4391-4398.
292. 2+ (n=0-2). Inorg. Chem. 2010, 49, 5025-5032.
293. 2+ luminescence: Dependence on DNA sequences and groove-binding agents. Inorg. Chem. 1998, 37, 29-34.
294. 2+ luminescence to DNA defects. Inorg. Chem. 2009, 48, 5392-5397.
295. McConnell, A.J.; Lim, M.H.; Olmon, E.D.; Song, H.; Dervan, E.E.; Barton, J.K. Luminescent properties of Ruthenium(II) complexes with sterically expansive ligands bound to DNA defects. Inorg. Chem. 2012, 51, 12511-12520.
296. 2+ with poly(dTdA-dT) triplex. Ligand size effect on third-strand stabilization. Biochemistry 1997, 36, 214-223.
297. Smith, F.W.; Feigon, J. Quadruplex structure of oxytricha telomeric DNA oligonucleotides. Nature 1992, 356, 164-168.
298. Rankin, S.; Reszka, A.P.; Huppert, J.; Zloh, M.; Parkinson, G.N.; Todd, A.K.; Ladame, S.; Balasubramanian, S.; Neidle, S. Putative DNA quadruplex formation within the human c-kit oncogene. J. Am. Chem. Soc. 2005, 127, 10584-10589.
299. Sun, D.Y.; Guo, K.X.; Rusche, J.J.; Hurley, L.H. Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res. 2005, 33, 6070-6080.
300. Dexheimer, T.S.; Sun, D.; Hurley, L.H. Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J. Am. Chem. Soc. 2006, 128, 5404-5415.
301. Petraccone, L.; Trent, J.O.; Chaires, J.B. The tail of the telomere. J. Am. Chem. Soc. 2008, 130, 16530-16532.
302. Chang, C.C.; Kuo, I.C.; Ling, I.F.; Chen, C.T.; Chen, H.C.; Lou, P.J.; Lin, J.J.; Chang, T.C. Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal. Chem. 2004, 76, 4490-4494.
303. Paeschke, K.; Simonsson, T.; Postberg, J.; Rhodes, D.; Lipps, H.J. Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat. Struct. Mol. Biol. 2005, 12, 847-854.
304. Paeschke, K.; Juranek, S.; Simonsson, T.; Hempel, A.; Rhodes, D.; Lipps, H.J. Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates. Nat. Struct. Biol. 2008, 15, 598-604.
305. Lipps, H.J.; Rhodes, D. G-quadruplex structures: in vivo evidence and function. Trends Cell Biol. 2009, 19, 414-422.
306. Smolensky, E.D.; Peterson, K.L.; Weitz, E.A.; Lewandowski, C.; Pierre, V.C. Magnetoluminescent light switches-dual modality in DNA detection. J. Am. Chem. Soc. 2013, 135, 8966-8972.