DNA-binding of semirigid binuclear ruthenium complex Δ,Δ-[μ-(11,11′-bidppz)(phen)4 Ru2]4+: Extremely slow intercalation kinetics

Journal of the American Chemical Society

Volumn 124, Issue 41, 2002, Pages 12092-12093

  Wilhelmsson, L Marcus ^a   Westerlund, Fredrik ^a   Lincoln, Per ^a   Nordén, Bengt ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; DIPYRIDO[3,2 A:2',3' C]PHENAZINE; DNA; PHENAZINE DERIVATIVE; RUTHENIUM COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CHEMICAL ANALYSIS; COMPLEX FORMATION; DNA BINDING; INTERCALATION COMPLEX;

EID: 0037120894     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027252f     Document Type: Article

References (25)

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17. +) of 10 μM 1 and 160 μM ([bases]) CT DNA was used in the experiments performed on a Jasco J-700 spectrodichrometer at room temperature.
18. The P/Ru value is a DNA to ligand ratio, where P is the concentration of phosphates (DNA-bases), and Ru is the concentration of ruthenium-centra.
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20. +, pH 7) was added to a preequilibrated (24 h at 50 °C) solution of ct-DNA and 1 to an SDS concentration of 0.6%.
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24. +). To reach the final binding mode, all solutions were preequilibrated at 50 °C overnight.
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