The first knockin mouse model of episodic ataxia type 2

Experimental Neurology

Volumn 261, Issue , 2014, Pages 553-562

  Rose, Samuel J ^a   Kriener, Lisa H ^a   Heinzer, Ann K ^b   Fan, Xueliang ^a   Raike, Robert S ^a   van den Maagdenberg, Arn M J M ^c   Hess, Ellen J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Ataxia; CACNA1A; Cerebellar granule cell; Channelopathy; Cre; EA2; Episodic ataxia type 2; Knockin; Purkinje cell; Voltage gated calcium channel

Indexed keywords

MESSENGER RNA; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL CAV2.1; UNCLASSIFIED DRUG; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; SH3GL1 PROTEIN, HUMAN; SIGNAL PEPTIDE; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; VOLTAGE-DEPENDENT CALCIUM CHANNEL (P-Q TYPE);

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CACNA1A GENE; CONTROLLED STUDY; EPISODIC ATAXIA TYPE 2; FEMALE; GENE TARGETING; GENETIC MODEL; GRANULE CELL; HEMIZYGOTE; HOMOZYGOTE; KNOCKOUT MOUSE; MALE; MISSENSE MUTATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE MODEL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PURKINJE CELL; ROTAROD TEST; DISEASE MODEL; GENE; GENETIC ENGINEERING; HEMIZYGOSITY; HOMOZYGOSITY; IN VIVO STUDY; MOUSE; ANIMAL; C57BL MOUSE; CEREBELLUM; DRUG EFFECTS; GENETICS; HUMAN; MEMBRANE POTENTIAL; MOTOR ACTIVITY; NERVE CELL; NYSTAGMUS; PATCH CLAMP TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REACTION TIME; TRANSGENIC MOUSE;

ANIMALS; ATAXIA; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, N-TYPE; CEREBELLUM; DISEASE MODELS, ANIMAL; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION, MISSENSE; NEURONS; NYSTAGMUS, PATHOLOGIC; PATCH-CLAMP TECHNIQUES; REACTION TIME; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 84906659269     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.08.001     Document Type: Article

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