Purkinje cell-specific ablation of CaV2.1 Channels is sufficient to cause cerebellar ataxia in mice

Cerebellum

Volumn 11, Issue 1, 2012, Pages 246-258

  Todorov, Boyan ^a   Kros, Lieke ^b   Shyti, Reinald ^a   Plak, Petra ^b   Haasdijk, Elize D ^b   Raike, Robert S ^c   Frants, Rune R ^a   Hess, Ellen J ^c   Hoebeek, Freek E ^b   De Zeeuw, Chris I ^b,d   Van Den Maagdenberg, Arn M J M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Ataxia; Cacna1a; Cell specific knockout; Conditional; P Q type Ca2+ channels

Indexed keywords

CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LOSS; CELL TYPE; CEREBELLAR ATAXIA; CEREBELLUM; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CONTROLLED STUDY; DYSTONIA; GENE EXPRESSION; GOLGI COMPLEX; IMMUNOHISTOCHEMISTRY; LETHALITY; LOCOMOTION; MOUSE; NEUROTRANSMISSION; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PURKINJE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; CALCIUM CHANNELS, N-TYPE; CEREBELLAR ATAXIA; CEREBELLAR CORTEX; DISEASE MODELS, ANIMAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PURKINJE CELLS;

EID: 84858998444     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1007/s12311-011-0302-1     Document Type: Article

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