Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant background

Experimental Neurology

Volumn 160, Issue 1, 1999, Pages 268-278

  Campbell, Daniel B ^a   North, Jesse B ^a   Hess, Ellen J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

c fos; Calcium channel; Cerebellum; DSP 4 (N (2 chloroethyl) N ethyl 2 bromobenzyl amine); Locus ceruleus; pcd; Purkinje cell degeneration; Tottering mice

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; CALCIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CEREBELLUM CORTEX; CONTROLLED STUDY; DENTATE GYRUS; DYSTONIA; GENE EXPRESSION; LOCUS CERULEUS; MOTOR DYSFUNCTION; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PURKINJE CELL; PUTAMEN;

EID: 0032710832     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7171     Document Type: Article

References (36)

1. Allen G., Buxton R. B., Wong E. C., Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science. 275:1997;1940-1943.
2. Bloom F. E., Battenberg E. L. F. A rapid, simple and sensitive method for the demonstration of central catecholamine-containing neurons and axons by glyoxylic acid-induced fluorescence. J. Histochem. Cytochem. 24:1976;561-571.
3. 2+ channel β subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse. Cell. 88:1997;385-392.
4. Burgess D. L., Kohrman D. C., Galt J., Plummer N. W., Jones J. M., Spear B., Meisler M. H. Mutation of a new sodium channel gene, Scn8a, in the mouse mutant "motor endplate disease." Nature Genet. 10:1995;461-465.
5. Campbell D. B., Hess E. J. Chromosomal localization of the neurological mouse mutants tottering (tg), Purkinje cell degeneration (pcd), and nervous (nr). Mol. Brain. Res. 37:1996;79-84.
6. Campbell D. B., Hess E. J. Rapid genotyping of mutant mice using dried blood spots for polymerase chain reaction (PCR) analysis. Brain. Res. Protein. 1:1997;117-123.
7. Campbell D. B., Hess E. J. Cerebellar circuitry is activated during convulsive episodes in the tottering (tg/tg) mutant mouse. Neuroscience. 85:1998;773-783.
8. Campbell D. B., Hess E. J. L-type calcium channels contribute to the tottering mouse dystonic episodes. Mol. Pharmacol. 55:1999;23-31.
9. Catterall W. A. Structure and function of voltage-gated ion channels. Annu. Rev. Biochem. 64:1995;493-531.
10. Chen L., Bao S., Lockard J. M., Kim J. J., Thompson R. F. Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. J. Neurosci. 16:1996;2829-2838.
11. Copeland N. G., Gilbert D. J., Jenkins N. A., Nadeau J. H., Eppig J. T., Maltais L. J., Miller J. C., Dietrich W. F., Steen R. G., Lincoln S. E., Weaver A., Joyce D. C., Merchant M., Wessel M., Katz H., Stein L. D., Reeve M. P., Daly M. J., Dredge R. D., Marquis A., Goodman N., Lander E. S. Genome maps IV 1993. Science. 262:1993;67-82.
12. Dietrich W. F., Miller J. C., Steen R. G., Merchant M., Damron D., Nahf R., Gross A., Joyce D. C., Wessel M., Dredge R. D., Marquis A., Stein L. D., Goodman N., Page D. C., Lander E. S. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet. 7:1994;220-245.
13. Fletcher C. F., Lutz C. M., O'Sullivan T. N., Shaughnessy J. D., Hawkes R., Frankel W. N., Copeland N. G., Jenkins N. A. Absence epilepsy in tottering mutant mice is associated with calcium channel defects. Cell. 87:1996;607-617.
14. Fritschy J. M., Grzanna R. Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals. Neuroscience. 30:1989;181-197.
15. Ghetti B., Alyea C. J., Muller J. Studies on the Purkinje cell degeneration (pcd) mutant: Primary pathology and transneuronal changes. J. Neuropathol. Exp. Neurol. 37:1978;617.
16. Ghetti B., Fuller R. W., Sawyer B. D., Hemrick-Leucke S. K., Schmidt M. J. Purkinje cell loss and the noradrenergic system in the cerebellum of pcd mutant mice. Brain Res. Bull. 7:1981;711-714.
17. Ghetti B., Perry K. W., Fuller R. W. Serotonin concentration and turnover in cerebellum and other brain regions of pcd mutant mice. Brain Res. 458:1988;367-371.
18. Green M. C., Sidman R. L. Tottering - A neuromuscular mutation in the mouse and its linkage with oligosyndactylysm. J. Hered. 53:1962;233-237.
19. Kaplan B. J., Seyfried T. N., Glaser G. H. Spontaneous polyspike discharges in an epileptic mutant mouse (tottering). Exp. Neurol. 66:1979;577-586.
20. Lalonde R., Manseau M., Botez M. I. Spontaneous alternation and habituation in Purkinje cell degeneration mutant mice. Brain Res. 411:1987;187-189.
21. Lavond D. G., Kim J. J., Thompson R. F. Mammalian brain substrates of aversive classical conditioning. Annu. Rev. Psych. 44:1993;317-342.
22. Ledoux M. S., Lorden J. F., Ervin J. M. Cerebellectomy eliminates the motor syndrome of the genetically dystonic rat. Exp. Neurol. 120:1993;302-310.
23. Ledoux M. S., Lorden J. F., Meinzen-Derr J. Selective elimination of cerebellar output in the genetically dystonic rat. Brain Res. 697:1995;91-103.
24. Levitt P., Noebels J. L. Mutant mouse tottering: selective increase of locus ceruleus axons in a defined single-locus mutation. Proc. Natl. Acad. Sci. USA. 78:1981;4630-4634.
25. Linden D. J. Long-term synaptic depression in the mammalian brain. Neuron. 12:1994;457-472.
26. McCormick D. A., Thompson R. F. Cerebellum: Essential involvement in the classically conditioned eyelid response. Science. 223:1984;296-299.
27. Mullen R. J., Eicher E. M., Sidman R. L. Purkinje cell degeneration, a new neurological mutation in the mouse. Proc. Natl. Acad. Sci. USA. 73:1976;208-212.
28. Mullen R. J. Site of pcd gene action and Purkinje cell mosaicism in cerebella of chimaeric mice. Nature. 270:1977;245-247.
29. Noebels J. L. A single gene error of noradrenergic axon growth synchronizes central neurones. Nature. 310:1984;409-411.
30. Patil N., Cox D. R., Bhat D., Faham M., Myers R. M. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat. Genet. 11:1995;126-129.
31. Racine R. J., Wilson D. A., Gingell R., Sunderland D. Long-term potentiation in the interpositus and vestibular nuclei of the rat. Exp. Brain Res. 63:1986;158-162.
32. Shojaeian H., Delhaye-Bouchard N., Mariani J. Stability of inferior olivary neurons in rodents. I. Moderate cell loss in adult Purkinje cell degeneration mutant mouse. Dev. Brain Res. 38:1988;211-218.
33. 1A calcium channel reflect similarities to neuronal Q- and P-type channels. Proc. Natl. Acad. Sci. USA. 91:1994;10576-10580.
34. 2+-channels: Four subtypes of α1- and β-subunits in developing and mature rat brain. Mol. Brain Res. 30:1995;1-16.
35. Triarhou L. C., Norton J., Ghetti B. Anterograde transsynaptic degeneration in the deep cerebellar nuclei of Purkinje cell degeneration (pcd) mutant mice. Exp. Brain Res. 66:1987;577-588.
36. Yang J., Ellinor P. T., Sather W. A., Zhang J.-F., Tsien R. W. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature. 356:1993;158-161.