Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs

Journal of Neuroimmune Pharmacology

Volumn 9, Issue 4, 2014, Pages 522-532

  Anderson, Monique R ^a,b,c   Enose Akahata, Yoshimi ^a   Massoud, Raya ^a   Ngouth, Nyater ^a   Tanaka, Yuetsu ^d   Oh, Unsong ^e   Jacobson, Steven ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d UNIVERSITY OF THE RYUKYUS   (Japan)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Demethylation; Epigenetic regulation; HTLV 1; Regulatory T cells; Suppressive capacity; Treg specific demethylation region (TSDR)

Indexed keywords

TAX PROTEIN; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; DEMETHYLATION; EPIGENETICS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOLOGICAL TOLERANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; TROPICAL SPASTIC PARAPARESIS; ADULT; AGED; BIOSYNTHESIS; CASE CONTROL STUDY; CELL CULTURE; DNA METHYLATION; FEMALE; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADULT; AGED; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE PRODUCTS, TAX; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PARAPARESIS, TROPICAL SPASTIC; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84906350622     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9547-z     Document Type: Article

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