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Volumn 39, Issue 12, 2011, Pages 1152-1160

Isolation strategies of regulatory T cells for clinical trials: Phenotype, function, stability, and expansion capacity

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 81155151462     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.08.010     Document Type: Article
Times cited : (47)

References (32)
  • 1
    • 78751696183 scopus 로고    scopus 로고
    • Infusion of ex vivo expanded t regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    • Brunstein C.G., Miller J.S., Cao Q., et al. Infusion of ex vivo expanded t regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117:1061-1070.
    • (2011) Blood , vol.117 , pp. 1061-1070
    • Brunstein, C.G.1    Miller, J.S.2    Cao, Q.3
  • 2
    • 79953809817 scopus 로고    scopus 로고
    • Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation
    • di Ianni M., Falzetti F., Carotti A., et al. Tregs prevent GvHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011, 117:3921-3928.
    • (2011) Blood , vol.117 , pp. 3921-3928
    • di Ianni, M.1    Falzetti, F.2    Carotti, A.3
  • 3
    • 0035413350 scopus 로고    scopus 로고
    • CD4+CD25 (High) regulatory cells in human peripheral blood
    • Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25 (High) regulatory cells in human peripheral blood. J Immunol 2001, 167:1245-1253.
    • (2001) J Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 4
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25(+) CD4(+) regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25(+) CD4(+) regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005, 6:345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 5
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4(+)CD25(+) regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 6
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor
    • Miyara M., Yoshioka Y., Kitoh A., et al. Functional delineation and differentiation dynamics of human CD4(+) T cells expressing the FoxP3 transcription factor. Immunity 2009, 30:899-911.
    • (2009) Immunity , vol.30 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 7
    • 44649189089 scopus 로고    scopus 로고
    • Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery
    • Ito T., Hanabuchi S., Wang Y.H., et al. Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity 2008, 28:870-880.
    • (2008) Immunity , vol.28 , pp. 870-880
    • Ito, T.1    Hanabuchi, S.2    Wang, Y.H.3
  • 8
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells
    • Liu W.H., Putnam A.L., Xu-Yu Z., et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells. J Exp Med 2006, 203:1701-1711.
    • (2006) J Exp Med , vol.203 , pp. 1701-1711
    • Liu, W.H.1    Putnam, A.L.2    Xu-Yu, Z.3
  • 9
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N., Santner-Nanan B., Martinson J., et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006, 203:1693-1700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 10
    • 33645510596 scopus 로고    scopus 로고
    • Persistence of naive CD45RA(+) regulatory T cells in adult life
    • Seddiki N., Santner-Nanan B., Tangye S.G., et al. Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood 2006, 107:2830-2838.
    • (2006) Blood , vol.107 , pp. 2830-2838
    • Seddiki, N.1    Santner-Nanan, B.2    Tangye, S.G.3
  • 11
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA(+) subpopulation of CD4(+)CD25(High) T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann P., Eder R., Boeld T.J., et al. Only the CD45RA(+) subpopulation of CD4(+)CD25(High) T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 2006, 108:4260-4267.
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 12
    • 59649091305 scopus 로고    scopus 로고
    • CD49d provides access to "untouched" human Foxp3(+) Treg free of contaminating effector cells
    • Kleinewietfeld M., Starke M., Di Mitri D., et al. CD49d provides access to "untouched" human Foxp3(+) Treg free of contaminating effector cells. Blood 2009, 113:827-836.
    • (2009) Blood , vol.113 , pp. 827-836
    • Kleinewietfeld, M.1    Starke, M.2    Di Mitri, D.3
  • 13
    • 58349116249 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue
    • Wieczorek G., Asemissen A., Model F., et al. Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res 2009, 69:599-608.
    • (2009) Cancer Res , vol.69 , pp. 599-608
    • Wieczorek, G.1    Asemissen, A.2    Model, F.3
  • 14
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the Foxp3 locus in regulatory T cells
    • Floess S., Freyer J., Siewert C., et al. Epigenetic control of the Foxp3 locus in regulatory T cells. PLoS Biol 2007, 5:169-178.
    • (2007) PLoS Biol , vol.5 , pp. 169-178
    • Floess, S.1    Freyer, J.2    Siewert, C.3
  • 15
    • 49649107703 scopus 로고    scopus 로고
    • DNA methylation controls Foxp3 gene expression
    • Polansky J.K., Kretschmer K., Freyer J., et al. DNA methylation controls Foxp3 gene expression. Eur J Immunol 2008, 38:1654-1663.
    • (2008) Eur J Immunol , vol.38 , pp. 1654-1663
    • Polansky, J.K.1    Kretschmer, K.2    Freyer, J.3
  • 16
    • 34548755672 scopus 로고    scopus 로고
    • DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    • Baron U., Floess S., Wieczorek G., et al. DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol 2007, 37:2378-2389.
    • (2007) Eur J Immunol , vol.37 , pp. 2378-2389
    • Baron, U.1    Floess, S.2    Wieczorek, G.3
  • 17
    • 64649098714 scopus 로고    scopus 로고
    • Immunomagnetic isolation of CD4(+)CD25(+)FoxP3(+) natural T regulatory lymphocytes for clinical applications
    • di Ianni M., Del Papa B., Cecchini D., et al. Immunomagnetic isolation of CD4(+)CD25(+)FoxP3(+) natural T regulatory lymphocytes for clinical applications. Clin Exp Immunol 2009, 156:246-253.
    • (2009) Clin Exp Immunol , vol.156 , pp. 246-253
    • di Ianni, M.1    Del Papa, B.2    Cecchini, D.3
  • 18
    • 52049118092 scopus 로고    scopus 로고
    • Clinical grade Treg: GMP isolation, improvement of purity by CD127 depletion, Treg expansion, and Treg cryopreservation
    • Peters J.H., Preijers F.W., Woestenenk R., et al. Clinical grade Treg: GMP isolation, improvement of purity by CD127 depletion, Treg expansion, and Treg cryopreservation. PLoS ONE 2008, 3:e3161.
    • (2008) PLoS ONE , vol.3
    • Peters, J.H.1    Preijers, F.W.2    Woestenenk, R.3
  • 19
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4(+)CD25(high) regulatory T cells
    • Hoffmann P., Eder R., Kunz-Schughart L.A., Andreesen R., Edinger M. Large-scale in vitro expansion of polyclonal human CD4(+)CD25(high) regulatory T cells. Blood 2004, 104:895-903.
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3    Andreesen, R.4    Edinger, M.5
  • 20
    • 0035806323 scopus 로고    scopus 로고
    • Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings M.K., Sangregorio R., Roncarolo M.G. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001, 193:1295-1301.
    • (2001) J Exp Med , vol.193 , pp. 1295-1301
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 21
    • 33751189601 scopus 로고    scopus 로고
    • CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation
    • Carrasco J., Godelaine D., Van Pel A., Boon T., van der Bruggen P. CD45RA on human CD8 T cells is sensitive to the time elapsed since the last antigenic stimulation. Blood 2006, 108:2897-2905.
    • (2006) Blood , vol.108 , pp. 2897-2905
    • Carrasco, J.1    Godelaine, D.2    Van Pel, A.3    Boon, T.4    van der Bruggen, P.5
  • 22
    • 77955266744 scopus 로고    scopus 로고
    • Decrease of CD4(+)CD25(+) regulatory T cells and TGF-beta at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation
    • Li Q., Zhai Z., Xu X., et al. Decrease of CD4(+)CD25(+) regulatory T cells and TGF-beta at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation. Leuk Res 2010, 34:1158-1168.
    • (2010) Leuk Res , vol.34 , pp. 1158-1168
    • Li, Q.1    Zhai, Z.2    Xu, X.3
  • 23
    • 65449141433 scopus 로고    scopus 로고
    • Loss of FOXP3 expression in natural human CD4(+)CD25(+) regulatory T cells upon repetitive in vitro stimulation
    • Hoffmann P., Boeld T.J., Eder R. Loss of FOXP3 expression in natural human CD4(+)CD25(+) regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 2009, 39:1088-1097.
    • (2009) Eur J Immunol , vol.39 , pp. 1088-1097
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3
  • 24
    • 79952470341 scopus 로고    scopus 로고
    • Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation
    • Schmitt A., Tonn T., Busch D.H., et al. Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation. Transfusion 2011, 51:591-599.
    • (2011) Transfusion , vol.51 , pp. 591-599
    • Schmitt, A.1    Tonn, T.2    Busch, D.H.3
  • 25
    • 34548848237 scopus 로고    scopus 로고
    • Deficient CD4(+) CD25(+) FOXP3(+) T regulatory cells in acquired aplastic anemia
    • Solomou E.E., Rezvani K., Mielke S., et al. Deficient CD4(+) CD25(+) FOXP3(+) T regulatory cells in acquired aplastic anemia. Blood 2007, 110:1603-1606.
    • (2007) Blood , vol.110 , pp. 1603-1606
    • Solomou, E.E.1    Rezvani, K.2    Mielke, S.3
  • 26
    • 51649127854 scopus 로고    scopus 로고
    • Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura
    • Yu J., Heck S., Patel V., et al. Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood 2008, 112:1325-1328.
    • (2008) Blood , vol.112 , pp. 1325-1328
    • Yu, J.1    Heck, S.2    Patel, V.3
  • 28
    • 80755139679 scopus 로고    scopus 로고
    • Pathogenic and regulatory T cells in type 1 diabetes: losing self-control, restoring it, and how to take the temperature
    • [Epub ahead of print]
    • Culina S., Mallone R. Pathogenic and regulatory T cells in type 1 diabetes: losing self-control, restoring it, and how to take the temperature. Curr Diab Rep 2011, [Epub ahead of print].
    • (2011) Curr Diab Rep
    • Culina, S.1    Mallone, R.2
  • 29
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont S.A., Putnam A.L., Lee M.R., et al. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol 2011, 186:3918-3926.
    • (2011) J Immunol , vol.186 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3
  • 30
    • 78649526238 scopus 로고    scopus 로고
    • Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases
    • Buckner J.H. Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nature Rev Immunol 2010, 10:849-859.
    • (2010) Nature Rev Immunol , vol.10 , pp. 849-859
    • Buckner, J.H.1
  • 31
    • 79957602397 scopus 로고    scopus 로고
    • Regulatory T cells get their chance to shine
    • Leslie M. Regulatory T cells get their chance to shine. Science 2011, 332:1020-1021.
    • (2011) Science , vol.332 , pp. 1020-1021
    • Leslie, M.1
  • 32
    • 79959852905 scopus 로고    scopus 로고
    • Do CD4(+)Foxp3(+) Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation
    • Shan J., Guo Y., Luo L., et al. Do CD4(+)Foxp3(+) Treg cells correlate with transplant outcomes: a systematic review on recipients of solid organ transplantation. Cell Immunol 2011, 270:5-12.
    • (2011) Cell Immunol , vol.270 , pp. 5-12
    • Shan, J.1    Guo, Y.2    Luo, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.