Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+ CD25+ T cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease

Journal of Experimental Medicine

Volumn 199, Issue 10, 2004, Pages 1367-1377

  Yamano, Yoshihisa ^a   Cohen, Cyril J ^b   Takenouchi, Norihiro ^a   Yao, Karen ^a   Tomaru, Utano ^a,c   Li, Hong Chuan ^d   Reiter, Yoram ^b   Jacobson, Steven ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

HAM TSP; IL 2R chain; Quantitative PCR; Regulatory T cell; Tetramer

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; HLA A ANTIGEN; HLA A201 ANTIGEN; INTERLEUKIN 2 RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX ANTIBODY; TAX 11-19 PEPTIDE; TAX PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIGEN DETECTION; ANTIGEN PRESENTING CELL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE ASSOCIATION; FLOW CYTOMETRY; HTLV 1 ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOPATHOLOGY; NEUROLOGIC DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVIRUS; SENSITIVITY AND SPECIFICITY; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; VIRUS LOAD;

ANTIGENS, CD; ANTIGENS, CD4; B-LYMPHOCYTES; CELL LINE; FLOW CYTOMETRY; GENE PRODUCTS, TAX; HLA-A ANTIGENS; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; NERVOUS SYSTEM DISEASES; PEPTIDE FRAGMENTS; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES;

EID: 2542432196     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032042     Document Type: Article

References (50)

1. de The, G., and R. Bomford. 1993. An HTLV-I vaccine: why, how, for whom? AIDS Res. Hum. Retroviruses. 9:381-386.
2. Osame, M., K. Usuku, S. Izumo, N. Ijichi, H. Amitani, A. Igata, M. Matsumoto, and M. Tara. 1986. HTLV-I associated myelopathy, a new clinical entity. Lancet. 1:1031-1032.
3. Gessain, A., F. Barin, J.C. Vernant, O. Gout, L. Maurs, A. Calender, and G. de The. 1985. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet. 2:407-410.
4. Kaplan, J.E., M. Osame, H. Kubota, A. Igata, H. Nishitani, Y. Maeda, R.F. Khabbaz, and R.S. Janssen. 1990. The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J. Acquir. Immune Defic. Syndr. 3:1096-1101.
5. Trujillo, J.M., M. Concha, A. Munoz, G. Bergonzoli, C. Mora, I. Borrero, C.J. Gibbs, and C. Arango. 1992. Sero-prevalence and cofactors of HTLV-I infection in Tumaco, Colombia. AIDS Res. Hum. Retroviruses. 8:651-657.
6. Uchiyama, T. 1997. Human T cell leukemia virus type I (HTLV-I) and human diseases. Annu. Rev. Immunol. 15:15-37.
7. Jacobson, S., H. Shida, D.E. McFarlin, A.S. Fauci, and S. Koenig. 1990. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature. 348:245-248.
8. Elovaara, I., S. Koenig, A.Y. Brewah, R.M. Woods, T. Lehky, and S. Jacobson. 1993. High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I-associated neurological disease. J. Exp. Med. 177:1567-1573.
9. Kubota, R., T. Kawanishi, H. Matsubara, A. Manns, and S. Jacobson. 1998. Demonstration of human T lymphotropic virus type I (HTLV-I) tax-specific CD8+ lymphocytes directly in peripheral blood of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by intracellular cytokine detection. J. Immunol. 161:482-488.
10. Nagai, M., R. Kubota, T. Greten, J. Schneck, T. Leist, and S. Jacobson. 2000. Increased activated human T cell lymphotropic virus type I (HTLV-I) tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. J. Infect. Dis. 183:197-205.
11. Yamano, Y., M. Nagai, M. Brennan, C.A. Mora, S.S. Soldan, U. Tomaru, N. Takenouchi, S. Izumo, M. Osame, and S. Jacobson. 2002. Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP). Blood. 99:88-94.
12. Koenig, S., R.M. Woods, Y.A. Brewah, A.J. Newell, G.M. Jones, E. Boone, J.W. Adelsberger, M.W. Baseler, S.M. Robinson, and S. Jacobson. 1993. Characterization of MHC class I restricted cytotoxic T cell responses to tax in HTLV-1 infected patients with neurologic disease. J. Immunol. 151:3874-3883.
13. Parker, C.E., S. Nightingale, G.P. Taylor, J. Weber, and C.R. Bangham. 1994. Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J. Virol. 68:2860-2868.
14. Biddison, W.E., R. Kubota, T. Kawanishi, D.D. Taub, W.W. Cruikshank, D.M. Center, E.W. Connor, U. Utz, and S. Jacobson. 1997. Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase. J. Immunol. 159:2018-2025.
15. Greten, T.F., J.E. Slansky, R. Kubota, S.S. Soldan, E.M. Jaffee, T.P. Leist, D.M. Pardoll, S. Jacobson, and J.P. Schneck. 1998. Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19-specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/ TSP patients. Proc. Natl. Acad. Sci. USA. 95:7568-7573.
16. Nagai, M., Y. Yamano, M.B. Brennan, C.A. Mora, and S. Jacobson. 2001. Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP. Ann. Neurol. 50:807-812.
17. Umehara, F., S. Izumo, M. Nakagawa, A.T. Ronquillo, K. Takahashi, K. Matsumuro, E. Sato, and M. Osame. 1993. Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy. J. Neuropathol. Exp. Neurol. 52:424-430.
18. Umehara, F., A. Nakamura, S. Izumo, R. Kubota, S. Ijichi, N. Kashio, K. Hashimoto, K. Usuku, E. Sato, and M. Osame. 1994. Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system. J. Neuropathol. Exp. Neurol. 53:617-624.
19. Levin, M.C., T.J. Lehky, A.N. Flerlage, D. Katz, D.W. Kingma, E.S. Jaffe, J.D. Heiss, N. Patronas, H.F. McFarland, and S. Jacobson. 1997. Immunologic analysis of a spinal cord-biopsy specimen from a patient with human T-cell lymphotropic virus type I-associated neurologic disease. N. Engl. J. Med. 336:839-845.
20. Richardson, J.H., A.J. Edwards, J.K. Cruickshank, P. Rudge, and A.G. Dalgleish. 1990. In vivo cellular tropism of human T-cell leukemia virus type 1. J. Virol. 64:5682-5687.
21. Hanon, E., P. Goon, G.P. Taylor, H. Hasegawa, Y. Tanaka, J.N. Weber, and C.R. Bangham. 2001. High production of interferon-γ but not interleukin-2 by human T-lykphotropic virus type I-infected peripheral blood mononuclear cells. Blood. 98:721-726.
22. Nagai, M., M.B. Brennan, J.A. Sakai, C.A. Mora, and S. Jacobson. 2001. CD8(+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood. 98:1858-1861.
23. Hanon, E., J.C. Stinchcombe, M. Saito, B.E. Asquith, G.P. Taylor, Y. Tanaka, J.N. Weber, G.M. Griffiths, and C.R. Bangham. 2000. Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I. Immunity. 13:657-664.
24. Okayama, A., N. Tachibana, S. Ishihara, Y. Nagatomo, K. Murai, M. Okamoto, T. Shima, K. Sagawa, H. Tsubouchi, S. Stuver, et al. 1997. Increased expression of interleukin-2 receptor alpha on peripheral blood mononuclear cells in HTLV-I tax/rex mRNA-positive asymptomatic carriers. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 15:70-75.
25. Satoh, M., H. Toma, K. Sugahara, K. Etoh, Y. Shiroma, S. Kiyuna, M. Takara, M. Matsuoka, K. Yamaguchi, K. Nakada, et al. 2002. Involvement of IL-2/IL-2R system activation by parasite antigen in polyclonal expansion of CD4(+)25(+) HTLV-1-infected T-cells in human carriers of both HTLV-1 and S. stercoralis. Oncogene. 21:2466-2475.
26. Janeway, C.A., P. Travers, M. Walport, and M.J. Shlomchik. 2001. Immuno Biology. Fifth edition. Garland Publishing, New York. 105 pp.
27. Kubota, R., T. Kawanishi, H. Matsubara, A. Manns, and S. Jacobson. 2000. HTLV-I specific IFN-gamma+ CD8+ lymphocytes correlate with the proviral load in peripheral blood of infected individuals. J. Neuroimmunol. 102:208-215.
28. Denkberg, G., C.J. Cohen, A. Lev, P. Chames, H.R. Hoogenboom, and Y. Reiter. 2002. Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC-restricted T cell receptor-like specificity. Proc. Natl. Acad. Sci. USA. 99:9421-9426.
29. Cohen, C.J., O. Sarig, Y. Yamano, U. Tomaru, S. Jacobson, and Y. Reiter. 2003. Direct phenotypic analysis of human MHC class I antigen presentation: visualization, quantitation, and in situ detection of human viral epitopes using peptidespecific, MHC-restricted human recombinant antibodies. J. Immunol. 170:4349-4361.
30. Winter, C.C., B.M. Carreno, R.V. Turner, S. Koenig, and W.E. Biddison. 1991. The 45 pocket of HLA-A2.1 plays a role in presentation of influenza virus matrix peptide and alloantigens. J. Immunol. 146:3508-3512.
31. Parham, P., and F.M. Brodsky. 1981. Partial purification and some properties of BB7.2. A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Hum. Immunol. 3:277-299.
32. Hanon, E., S. Hall, G.P. Taylor, M. Saito, R. Davis, Y. Tanaka, K. Usuku, M. Osame, J.N. Weber, and C.R. Bangham. 2000. Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood. 95:1386-1392.
33. Inoue, J., M. Seiki, T. Taniguchi, S. Tsuru, and M. Yoshida. 1986. Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type 1. EMBO J. 5:2883-2888.
34. Altman, J.D., P.A. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science. 274:94-96.
35. Howard, M.C., E.G. Spack, K. Choudhury, T.F. Greten, and J.P. Schneck. 1999. MHC-based diagnostics and therapeutics-clinical applications for disease-linked genes. Immunol. Today. 20:161-165.
36. Poiesz, B.J., F.W. Ruscetti, A.F. Gazdar, P.A. Bunn, J.D. Minna, and R.C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA. 77:7415-7419.
37. Gallo, R.C., S.Z. Salahuddin, M. Popovic, G.M. Shearer, M. Kaplan, B.F. Haynes, T.J. Palker, R. Redfield, J. Oleske, B. Safai, et al. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 224:500-503.
38. Popovic, M., G. Lange-Wantzin, P.S. Sarin, D. Mann, and R.C. Gallo. 1983. Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc. Natl. Acad. Sci. USA. 80:5402-5406.
39. Popovic, M., E. Read-Connole, and R.C. Gallo. 1984. T4 positive human neoplastic cell lines susceptible to and permissive for HTLV-III. Lancet. 2:1472-1473.
40. Dalgleish, A.G., P.C. Beverley, P.R. Clapham, D.H. Crawford, M.F. Greaves, and R.A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature. 312:763-767.
41. Klatzmann, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J.C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature. 312:767-768.
42. Trejo, S.R., and L. Ratner. 2000. The HTLV receptor is a widely expressed protein. Virology. 268:41-48.
43. Manel, N., S. Kinet, J.L. Battini, F.J. Kim, N. Taylor, and M. Sitbon. 2003. The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis. Blood. 101:1913-1918.
44. Wucherpfennig, K.W., P. Hollsberg, J.H. Richardson, D. Benjamin, and D.A. Hafler. 1992. T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc. Natl. Acad. Sci. USA. 89:2110-2114.
45. Scholz, C., G.J. Freeman, E.A. Greenfield, D.A. Hafler, and P. Hollsberg. 1996. Activation of human T cell lymphotropic virus type I-infected T cells is independent of B7 costimulation. J. Immunol. 157:2932-2938.
46. Scholz, C., D.A. Hafler, and P. Hollsberg. 1996. Downregulation of IL-10 secretion and enhanced antigen-presenting abilities following HTLV-I infection of T cells. J. Neurosci. Res. 45:786-794.
47. Bangham, C.R. 2000. The immune response to HTLV-I. Curr. Opin. Immunol. 12:397-402.
48. Tomaru, U., Y. Yamano, M. Nagai, D. Maric, P.T.P. Kaumaya, W. Biddison, and S. Jacobson. 2003. Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections. Nat. Med. 9:469-475.
49. Sakaguchi, S., N. Sakaguchi, J. Shimizu, S. Yamazaki, T. Sakihama, M. Itoh, Y. Kuniyasu, T. Nomura, M. Toda, and T. Takahashi. 2001. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
50. Shevach, E.M. 2002. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.