Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome

Journal of Autoimmunity

Volumn 38, Issue 1, 2012, Pages 49-58

  Barzaghi, F ^a,b   Passerini, L ^a   Gambineri, E ^c   Ciullini Mannurita, S ^c   Cornu, T ^d   Kang, E S ^e   Choe, Y H ^e   Cancrini, C ^f   Corrente, S ^f   Ciccocioppo, R ^g   Cecconi, M ^h   Zuin, G ⁱ   Discepolo, V ^j   Sartirana, C ^a   Schmidtko, J ^k   Ikinciogullari, A ^l   Ambrosi, A ^b   Roncarolo, M G ^a,b   Olek, S ^d   Bacchetta, R ^a  

^a SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d EPIONTIS GMBH   (Germany)

^e Sungkyunkwan University School of Medicine   (South Korea)

^f UNIVERSITY OF ROME TOR VERGATA   (Italy)

^g UNIVERSITY OF PAVIA   (Italy)

^h GALLIERA HOSPITAL   (Italy)

ⁱ V BUZZI CHILDREN S HOSPITAL   (Italy)

^j UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^k LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^l ANKARA UNIVERSITY   (Turkey)

more..

Author keywords

Autoimmune enteropathy; Forkhead box p3 (FOXP3); IPEX syndrome; IPEX like syndrome; Primary immunodeficiency (PID); Regulatory T (Treg) cells; Treg cell specific demethylated region (TSDR)

Indexed keywords

CD3 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; ARTICLE; CD25+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DEMETHYLATION; FEMALE; FLOW CYTOMETRY; HUMAN; INFANT; IPEX SYNDROME; MALE; NEWBORN; POINT MUTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; QUANTITATIVE TRAIT LOCUS; REGULATORY T LYMPHOCYTE; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTIGENS, CD3; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; GENETIC DISEASES, X-LINKED; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFANT; MALE; POLYENDOCRINOPATHIES, AUTOIMMUNE; SYNDROME; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

EID: 84856667596     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.12.009     Document Type: Article

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