CDK4/6 inhibitors have potent activity in combination with pathway selective therapeutic agents in models of pancreatic cancer

Oncotarget

Volumn 5, Issue 15, 2014, Pages 6512-6525

  Franco, Jorge ^a   Witkiewicz, Agnieszka K ^a,b   Knudsen, Erik S ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

CDK4 6; E2f; Palbocicllb; Pancreatic cancer; RB

Indexed keywords

ANTINEOPLASTIC AGENT; APITOLISIB; AZD 0855; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; CYCLIN E1; DACTOLISIB; FLUOROURACIL; GEMCITABINE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; CDK4 PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; PALBOCICLIB; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER MODEL; CANCER RESISTANCE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS; PANCREAS ADENOCARCINOMA; UPREGULATION; ANTAGONISTS AND INHIBITORS; CARCINOMA, PANCREATIC DUCTAL; DEFICIENCY; ENZYMOLOGY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; PANCREATIC NEOPLASMS; PROCEDURES; PROGNOSIS; TUMOR CELL LINE;

CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; PANCREATIC NEOPLASMS; PIPERAZINES; PROGNOSIS; PROTEIN KINASE INHIBITORS; PYRIDINES; TRANSFECTION;

EID: 84906238717     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2270     Document Type: Article

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