Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence

Journal of Medicinal Chemistry

Volumn 57, Issue 15, 2014, Pages 6364-6382

  Zhu, Cuige ^a   Zuo, Yinglin ^a   Wang, Ruimin ^a   Liang, Baoxia ^a   Yue, Xin ^a   Wen, Gesi ^a   Shang, Nana ^a   Huang, Lei ^a   Chen, Yu ^a   Du, Jun ^a   Bu, Xianzhang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(5 (3 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 OXOPROP 1 EN 1 YL) 2 METHOXYPHENYL)BORONIC ACID; 1 (2 BROMOPHENYL) 3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2 BROMOPHENYL) 3 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (2 BROMOPHENYL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3',4' DIMETHOXY [1,1' BIPHENYL] 2 YL) 3 (2,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3',4' DIMETHOXY [1,1' BIPHENYL] 2 YL) 3 (4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 (3',4' DIMETHOXY [1,1' BIPHENYL] 2 YL) 3 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 1 (3',4' DIMETHOXY [1,1' BIPHENYL] 2 YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 (4 HYDROXY 3 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 (5 METHYLFURAN 2 YL)PROP 2 EN 1 ONE; 1 (4' FLUORO [1,1' BIPHENYL] 2 YL) 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 (3 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 (4 HYDROXY 3 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 (4' FLUORO [1,1' BIPHENYL] 2 YL)PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 (4' FLUORO [1,1' BIPHENYL] 2 YL)PROP 2 EN 1 ONE; 3 (3,4 DIMETHOXYPHENYL) 1 (4' FLUORO [1,1' BIPHENYL] 2 YL)PROP 2 EN 1 ONE; 3 (4 (DIMETHYLAMINO)PHENYL) 1 (4' FLUORO [1,1' BIPHENYL] 2 YL)PROP 2 EN 1 ONE; 3 (4 BROMOPHENYL) 1 (3',4' DIMETHOXY [1,1' BIPHENYL] 2 YL))PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; COLCHICINE; DOXORUBICIN; PACLITAXEL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; TUBULIN; TUBULIN MODULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST CARCINOMA; CANCER CELL LINE; CANCER INHIBITION; CANCER RESISTANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG PROTEIN BINDING; FLUORESCENCE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MICROTUBULE ASSEMBLY; MITOSIS; MOUSE; NONHUMAN; OVARY CARCINOMA; PROTEIN TARGETING; TUMOR XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; FEMALE; METABOLISM; MICROTUBULE; NUDE MOUSE; POLYMERIZATION; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ULTRASTRUCTURE; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CHALCONES; COLCHICINE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLUORESCENCE; G2 PHASE CELL CYCLE CHECKPOINTS; HETEROGRAFTS; HUMANS; MICE, NUDE; MICROTUBULES; MITOSIS; NEOPLASM TRANSPLANTATION; POLYMERIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84906094004     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500024v     Document Type: Article

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