New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 3995-4003

  Kawaratani, Yasuyuki ^a   Harada, Tomohiko ^a   Hirata, Yoshiyuki ^a   Nagaoka, Yasuo ^a   Tanimura, Susumu ^b   Shibano, Makio ^c   Taniguchi, Masahiko ^c   Yasuda, Masahide ^c   Baba, Kimiye ^c   Uesato, Shinichi ^a  

^a KANSAI UNIVERSITY   (Japan)

^b NAGASAKI UNIVERSITY   (Japan)

^c OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

HCT116 xenograft; M phase regulator; Nitrooxymethylphenyl group; Phospho histone H3; Tubulin polymerization inhibitor

Indexed keywords

2 [3 (CHLOROMETHYL)BENZAMIDO]PHENYL 3 (CHLOROMETHYL)BENZOATE; 2 [3 (NITROOXYMETHYL)BENZAMIDO]PHENYL 3 (NITROOXYMETHYL)BENZOATE; 2 [4 (CHLOROMETHYL)BENZAMIDO]PHENYL 4 (CHLOROMETHYL)BENZOATE; 2 [4 (NITROXYMETHYL)BENZAMIDO]PHENYL 4 (NITROOXYMETHYL)BENZOATE; 3 (CHLOROMETHYL) N PHENYLBENZAMIDE; 3 (PHENYLCARBAMOYL)BENZYL NITRATE; 3 [4 (CHLOROMETHYL)BENZAMIDO]PHENYL 4 (CHLOROMETHYL)BENZOATE; 3 [4 (NITROOXYMETHYL)BENZAMIDO]PHENYL 4 (NITROOXYMETHYL)BENZOATE; 4 (CHLOROMETHYL) N PHENYLBENZAMIDE; 4 (HYDROXYMETHYL) N PHENYLBENZAMIDE; 4 (PHENYLCARBAMOYL)BENZYL NITRATE; 4 ETHYL N PHENYLBENZAMIDE; 4,4' [1,2 PHENYLENEBIS(AZANEDIYL)]BIS(OXOMETHYLENE)BIS(4,1 PHENYLENE)BIS(METHYLENE)DINITRATE; ANTINEOPLASTIC AGENT; BENZANILIDE; MICROTUBULE POLYMERIZATION INHIBITOR; N,N' (1,2 PHENYLENE)BIS 4 (CHLOROMETHYL)BENZAMIDE; NCX 4040; NCX 530; NITRIC OXIDE ACETYLSALICYLIC ACID; NITRIC OXIDE INDOMETACIN; PACLITAXEL; PHENYL 4 (CHLOROMETHYL)BENZOATE; PHENYL 4 (NITROOXYMETHYL)BENZOATE; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL CYCLE M PHASE; CELL STRAIN HCT116; COLON CARCINOMA; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; FIBROSARCOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; NUDE MOUSE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ACETATES; ANIMALS; ASPIRIN; BENZOATES; CARBAMATES; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; G2 PHASE; HUMANS; INDOLES; MICE; MICE, NUDE; NITRATES; NITRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUBULIN; TUBULIN MODULATORS; VINCRISTINE;

MUS MUSCULUS;

EID: 79959522374     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.031     Document Type: Article

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