Establishment of a high content assay for the identification and characterisation of bioactivities in crude bacterial extracts that interfere with the eukaryotic cell cycle

Journal of Biotechnology

Volumn 140, Issue 1-2, 2009, Pages 124-134

  Jensen, Nickels A ^a   Gerth, Klaus ^b   Grotjohann, Tim ^a   Kapp, Dieter ^a   Keck, Matthias ^a   Niehaus, Karsten ^a  

^a BIELEFELD UNIVERSITY   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Drug discovery; High content screening microscopy; Myxobacteria; ScanR; Sf9 cells

Indexed keywords

DRUG DISCOVERY; HIGH CONTENT SCREENING MICROSCOPY; MYXOBACTERIA; SCANR; SF9 CELLS;

BACTERIOLOGY; BIOACTIVITY; CELL PROLIFERATION; POPULATION STATISTICS;

CELL CULTURE;

BISBENZIMIDE; BLASTICIDIN S; CALCEIN; COLCHICINE; CYTOCHALASIN D; HOE 33342; PACLITAXEL; PROPIDIUM IODIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASSAY; BACTERIUM; BACTERIUM MUTANT; CELL COUNT; CELL CYCLE; CELL POPULATION; CELL VIABILITY; COMPUTER PROGRAM; CONTROLLED STUDY; CYTOSTASIS; CYTOTOXICITY; DIPLOIDY; DRUG ACTIVITY; EUKARYOTE; HIGH CONTENT ASSAY; IMAGING; INSECT CELL; MICROSCOPY; MYXOCOCCALES; NONHUMAN; PLOIDY; POLYPLOIDY; PRIORITY JOURNAL; SCREENING; TETRAPLOIDY;

ANIMALS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; COLCHICINE; COLORING AGENTS; COMPLEX MIXTURES; CYTOCHALASIN D; CYTOSTATIC AGENTS; DRUG DISCOVERY; FLUORESCENT DYES; IMAGE PROCESSING, COMPUTER-ASSISTED; MACROLIDES; MICROSCOPY; MYXOCOCCALES; PACLITAXEL; PLOIDIES; PYRROLIDINONES;

BACTERIA (MICROORGANISMS); EUKARYOTA; HEXAPODA; MYXOCOCCALES; POLYANGIUM CELLULOSUM;

EID: 61649096564     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2008.12.002     Document Type: Article

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