CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells

Biochemical Pharmacology

Volumn 84, Issue 5, 2012, Pages 633-645

  Gireesh, K K ^a   Rashid, Aijaz ^b   Chakraborti, Soumyananda ^c   Panda, Dulal ^b   Manna, Tapas ^a  

^a INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^c BOSE INSTITUTE   (India)

Author keywords

CIL 102; Enthalpy; Entropy; p21; p53; Tubulin

Indexed keywords

1 [4 (FURO[2,3 B]QUINOLIN 4 YLAMINO)PHENYL]ETHANONE; ANTINEOPLASTIC AGENT; CIL 102; COLCHICINE; PROTEIN P21; PROTEIN P53; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL PROLIFERATION; CELL STRAIN MCF 7; CENTROMERE; COMPETITIVE INHIBITION; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DISSOCIATION CONSTANT; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; ENTHALPY; ENTROPY; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MONONUCLEAR CELL; MULTINUCLEAR CELL; PRIORITY JOURNAL;

APOPTOSIS; BINDING SITES; BREAST NEOPLASMS; CALORIMETRY; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; KINETICS; SPECTROMETRY, FLUORESCENCE; TETRAZOLIUM SALTS; THERMODYNAMICS; THIAZOLES; TUBULIN;

EID: 84864409103     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.008     Document Type: Article

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