Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 1920-1925

  Bennani, Youssef L ^a   Gu, Wenxin ^a   Canales, Angeles ^b   Díaz, Fernando J ^c   Eustace, Brenda K ^a   Hoover, Russell R ^a   Jiménez Barbero, Jesus ^c   Nezami, Azin ^a   Wang, Tiansheng ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE; DIMETHYL SULFOXIDE; DOCETAXEL; EPOTHILONE DERIVATIVE; NOCODAZOLE; NOSCAPINE; TUBULIN; VINCRISTINE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; DRUG PROTEIN BINDING; LIVER CELL CARCINOMA; NUCLEAR MAGNETIC RESONANCE; PROTEIN BLOOD LEVEL; PROTEIN CONFORMATION;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; NOSCAPINE; PROTEIN BINDING; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84863266654     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200848t     Document Type: Article

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