메뉴 건너뛰기




Volumn 369, Issue 1652, 2014, Pages

Epigenetic setting and reprogramming for neural cell fate determination and differentiation

Author keywords

DNA methylation; Histone acetylation; Histone methylation; Non coding RNA; Polycomb repressive complex 2; REST

Indexed keywords

BRAIN; DNA FINGERPRINTING; GENE EXPRESSION; GENETIC DIFFERENTIATION; METHYLATION; RNA; TRANSPLANTATION;

EID: 84906089151     PISSN: 09628436     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rstb.2013.0511     Document Type: Review
Times cited : (30)

References (102)
  • 1
    • 0028011911 scopus 로고
    • Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways
    • (doi:10.1016/0925-4773(94)90030-2)
    • Yoshida K, Chambers I, Nichols J, Smith A, Saito M, Yasukawa K, Shoyab M, Taga T, Kishimoto T. 1994 Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Mech. Dev. 45, 163-171. (doi:10.1016/0925-4773(94)90030-2)
    • (1994) Mech. Dev. , vol.45 , pp. 163-171
    • Yoshida, K.1    Chambers, I.2    Nichols, J.3    Smith, A.4    Saito, M.5    Yasukawa, K.6    Shoyab, M.7    Taga, T.8    Kishimoto, T.9
  • 2
    • 84887403795 scopus 로고    scopus 로고
    • Mechanisms of astrocytogenesis in the mammalian brain
    • (doi:10.1016/j.conb. 2013.06.002)
    • Namihira M, Nakashima K. 2013 Mechanisms of astrocytogenesis in the mammalian brain. Curr. Opin. Neurobiol. 23, 921-927. (doi:10.1016/j.conb. 2013.06.002)
    • (2013) Curr. Opin. Neurobiol. , vol.23 , pp. 921-927
    • Namihira, M.1    Nakashima, K.2
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • (doi:10.1016/j.cell.2006.07.024)
    • Takahashi K, Yamanaka S. 2006 Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676. (doi:10.1016/j.cell.2006.07.024)
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 57149107578 scopus 로고    scopus 로고
    • Differentiating protein-coding and noncoding RNA: Challenges and ambiguities
    • (doi:10.1371/journal.pcbi.1000176)
    • Dinger ME, Pang KC, Mercer TR, Mattick JS. 2008 Differentiating protein-coding and noncoding RNA: challenges and ambiguities. PLoS Comput. Biol. 4, e1000176. (doi:10.1371/journal.pcbi.1000176)
    • (2008) PLoS Comput. Biol. , vol.4
    • Dinger, M.E.1    Pang, K.C.2    Mercer, T.R.3    Mattick, J.S.4
  • 5
    • 45449092537 scopus 로고    scopus 로고
    • Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation
    • (doi:10.1016/j.bbrc.2008.05.127)
    • Tochitani S, Hayashizaki Y. 2008 Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation. Biochem. Biophys. Res. Commun. 372, 691-696. (doi:10.1016/j.bbrc.2008.05.127)
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 691-696
    • Tochitani, S.1    Hayashizaki, Y.2
  • 7
    • 75149163987 scopus 로고    scopus 로고
    • Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells
    • (doi:10.1261/rna.1441510)
    • Sheik Mohamed J, Gaughwin PM, Lim B, Robson P, Lipovich L. 2010 Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA 16, 324-337. (doi:10.1261/rna.1441510)
    • (2010) RNA , vol.16 , pp. 324-337
    • Sheik Mohamed, J.1    Gaughwin, P.M.2    Lim, B.3    Robson, P.4    Lipovich, L.5
  • 8
    • 80052869283 scopus 로고    scopus 로고
    • LincRNAs act in the circuitry controlling pluripotency and differentiation
    • (doi:10.1038/nature10398)
    • Guttman M et al. 2011 lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477, 295-300. (doi:10.1038/nature10398)
    • (2011) Nature , vol.477 , pp. 295-300
    • Guttman, M.1
  • 9
    • 0033636521 scopus 로고    scopus 로고
    • Timing of CNS cell generation: A programmed sequence of neuron and glial cell production from isolated murine cortical stem cells
    • (doi:10.1016/S0896-6273(00) 00086-6)
    • Qian X, Shen Q, Goderie SK, He W, Capela A, Davis AA, Temple S. 2000 Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28, 69-80. (doi:10.1016/S0896-6273(00) 00086-6)
    • (2000) Neuron , vol.28 , pp. 69-80
    • Qian, X.1    Shen, Q.2    Goderie, S.K.3    He, W.4    Capela, A.5    Davis, A.A.6    Temple, S.7
  • 10
    • 77952678006 scopus 로고    scopus 로고
    • Epigenetic control of neural precursor cell fate during development
    • (doi:10.1038/nrn2810)
    • Hirabayashi Y, Gotoh Y. 2010 Epigenetic control of neural precursor cell fate during development. Nat. Rev. Neurosci. 11, 377-388. (doi:10.1038/nrn2810)
    • (2010) Nat. Rev. Neurosci. , vol.11 , pp. 377-388
    • Hirabayashi, Y.1    Gotoh, Y.2
  • 11
    • 2942709503 scopus 로고    scopus 로고
    • Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
    • (doi:10.1038/ ncb1138)
    • Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. 2004 Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat. Cell Biol. 6, 547-554. (doi:10.1038/ ncb1138)
    • (2004) Nat. Cell Biol. , vol.6 , pp. 547-554
    • Kamakura, S.1    Oishi, K.2    Yoshimatsu, T.3    Nakafuku, M.4    Masuyama, N.5    Gotoh, Y.6
  • 12
    • 0035656305 scopus 로고    scopus 로고
    • DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
    • (doi:10.1016/S1534-5807(01)00101-0)
    • Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T. 2001 DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev. Cell 1, 749-758. (doi:10.1016/S1534-5807(01)00101-0)
    • (2001) Dev. Cell , vol.1 , pp. 749-758
    • Takizawa, T.1    Nakashima, K.2    Namihira, M.3    Ochiai, W.4    Uemura, A.5    Yanagisawa, M.6    Fujita, N.7    Nakao, M.8    Taga, T.9
  • 13
    • 52649177210 scopus 로고    scopus 로고
    • Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation
    • (doi:10.1371/journal.pone.0003189)
    • Hatada I, Namihira M, Morita S, Kimura M, Horii T, Nakashima K. 2008 Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation. PLoS ONE 3, e3189. (doi:10.1371/journal.pone.0003189)
    • (2008) PLoS ONE , vol.3
    • Hatada, I.1    Namihira, M.2    Morita, S.3    Kimura, M.4    Horii, T.5    Nakashima, K.6
  • 14
    • 0028928684 scopus 로고
    • Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression
    • Timsit S, Martinez S, Allinquant B, Peyron F, Puelles L, Zalc B. 1995 Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J. Neurosci. 15, 1012-1024.
    • (1995) J. Neurosci. , vol.15 , pp. 1012-1024
    • Timsit, S.1    Martinez, S.2    Allinquant, B.3    Peyron, F.4    Puelles, L.5    Zalc, B.6
  • 15
    • 0033037861 scopus 로고    scopus 로고
    • Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors
    • Orentas DM, Hayes JE, Dyer KL, Miller RH. 1999 Sonic hedgehog signaling is required during the appearance of spinal cord oligodendrocyte precursors. Development 126, 2419-2429.
    • (1999) Development , vol.126 , pp. 2419-2429
    • Orentas, D.M.1    Hayes, J.E.2    Dyer, K.L.3    Miller, R.H.4
  • 16
    • 9344252804 scopus 로고    scopus 로고
    • Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells
    • (doi:10.1073/pnas.0407643101)
    • Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH. 2004 Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc. Natl Acad. Sci. USA 101, 16 659-16 664. (doi:10.1073/pnas.0407643101)
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 16659-16664
    • Hsieh, J.1    Nakashima, K.2    Kuwabara, T.3    Mejia, E.4    Gage, F.H.5
  • 17
    • 77950867183 scopus 로고    scopus 로고
    • Epigenetic regulation of oligodendrocyte identity
    • (doi:10.1016/j.tins.2010.01.007)
    • Liu J, Casaccia P. 2010 Epigenetic regulation of oligodendrocyte identity. Trends Neurosci. 33, 193-201. (doi:10.1016/j.tins.2010.01.007)
    • (2010) Trends Neurosci. , vol.33 , pp. 193-201
    • Liu, J.1    Casaccia, P.2
  • 18
    • 0036897351 scopus 로고    scopus 로고
    • Histone deacetylase activity is necessary for oligodendrocyte lineage progression
    • Marin-Husstege M, Muggironi M, Liu A, Casaccia-Bonnefil P. 2002 Histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci. 22, 10 333-10 345.
    • (2002) J. Neurosci. , vol.22 , pp. 10333-10345
    • Marin-Husstege, M.1    Muggironi, M.2    Liu, A.3    Casaccia-Bonnefil, P.4
  • 19
    • 67649797866 scopus 로고    scopus 로고
    • HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    • (doi:10.1038/nn.2333)
    • Ye F et al. 2009 HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12, 829-838. (doi:10.1038/nn.2333)
    • (2009) Nat. Neurosci. , vol.12 , pp. 829-838
    • Ye, F.1
  • 20
    • 55549108710 scopus 로고    scopus 로고
    • Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells
    • (doi:10.1074/jbc. M804899200)
    • Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. 2008 Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J. Biol. Chem. 283, 27 644-27 652. (doi:10.1074/jbc. M804899200)
    • (2008) J. Biol. Chem. , vol.283 , pp. 27644-27652
    • Li, X.1    Barkho, B.Z.2    Luo, Y.3    Smrt, R.D.4    Santistevan, N.J.5    Liu, C.6    Kuwabara, T.7    Gage, F.H.8    Zhao, X.9
  • 21
    • 77957680712 scopus 로고    scopus 로고
    • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
    • (doi:10.1073/pnas.1002530107)
    • Pereira JD, Sansom SN, Smith J, Dobenecker M-W, Tarakhovsky A, Livesey FJ. 2010 Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc. Natl Acad. Sci. USA 107, 15 957-15 962. (doi:10.1073/pnas.1002530107)
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15957-15962
    • Pereira, J.D.1    Sansom, S.N.2    Smith, J.3    Dobenecker, M.-W.4    Tarakhovsky, A.5    Livesey, F.J.6
  • 22
    • 79955557706 scopus 로고    scopus 로고
    • Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons
    • (doi:10. 1101/gr.112755.110)
    • Iwamoto K, Bundo M, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T. 2011 Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Res. 21, 688-696. (doi:10. 1101/gr.112755.110)
    • (2011) Genome Res. , vol.21 , pp. 688-696
    • Iwamoto, K.1    Bundo, M.2    Ueda, J.3    Oldham, M.C.4    Ukai, W.5    Hashimoto, E.6    Saito, T.7    Geschwind, D.H.8    Kato, T.9
  • 23
    • 84891766375 scopus 로고    scopus 로고
    • Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
    • (doi:10.1093/ nar/gkt838)
    • Kozlenkov A et al. 2013 Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites. Nucleic Acids Res. 42, 109-127. (doi:10.1093/ nar/gkt838)
    • (2013) Nucleic Acids Res. , vol.42 , pp. 109-127
    • Kozlenkov, A.1
  • 24
    • 24644519490 scopus 로고    scopus 로고
    • The transcriptional landscape of the mammalian genome
    • (doi:10.1126/science.1112014)
    • Carninci P et al. 2005 The transcriptional landscape of the mammalian genome. Science 309, 1559-1563. (doi:10.1126/science.1112014)
    • (2005) Science , vol.309 , pp. 1559-1563
    • Carninci, P.1
  • 25
    • 24644472515 scopus 로고    scopus 로고
    • Antisense transcription in the mammalian transcriptome
    • (doi:10.1126/science.1112009)
    • Katayama S et al. 2005 Antisense transcription in the mammalian transcriptome. Science 309, 1564-1566. (doi:10.1126/science.1112009)
    • (2005) Science , vol.309 , pp. 1564-1566
    • Katayama, S.1
  • 26
    • 0011823131 scopus 로고
    • A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs
    • (doi:10.1073/pnas.86.8.2647)
    • Wagner RW, Smith JE, Cooperman BS, Nishikura K. 1989 A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs. Proc. Natl Acad. Sci. USA 86, 2647-2651. (doi:10.1073/pnas.86.8.2647)
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2647-2651
    • Wagner, R.W.1    Smith, J.E.2    Cooperman, B.S.3    Nishikura, K.4
  • 27
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • (doi:10.1038/nature05874), ENCODE Project Consortium
    • ENCODE Project Consortium 2007 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816. (doi:10.1038/nature05874)
    • (2007) Nature , vol.447 , pp. 799-816
  • 28
    • 0034882101 scopus 로고    scopus 로고
    • The evolution of controlled multitasked gene networks: The role of introns and other noncoding RNAs in the development of complex organisms
    • (doi:10.1093/oxfordjournals. molbev.a003951)
    • Mattick JS, Gagen MJ. 2001 The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms. Mol. Biol. Evol. 18, 1611-1630. (doi:10.1093/oxfordjournals. molbev.a003951)
    • (2001) Mol. Biol. Evol. , vol.18 , pp. 1611-1630
    • Mattick, J.S.1    Gagen, M.J.2
  • 30
    • 0033214928 scopus 로고    scopus 로고
    • Targeted mutagenesis of Tsix leads to nonrandom X inactivation
    • (doi:10.1016/S0092-8674(00)80061-6)
    • Lee JT, Lu N. 1999 Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell 99, 47-57. (doi:10.1016/S0092-8674(00)80061-6)
    • (1999) Cell , vol.99 , pp. 47-57
    • Lee, J.T.1    Lu, N.2
  • 31
    • 0037075032 scopus 로고    scopus 로고
    • The noncoding Air RNA is required for silencing autosomal imprinted genes
    • (doi:10. 1038/415810a)
    • Sleutels F, Zwart R, Barlow DP. 2002 The noncoding Air RNA is required for silencing autosomal imprinted genes. Nature 415, 810-813. (doi:10. 1038/415810a)
    • (2002) Nature , vol.415 , pp. 810-813
    • Sleutels, F.1    Zwart, R.2    Barlow, D.P.3
  • 32
    • 23044507007 scopus 로고    scopus 로고
    • Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
    • (doi:10.1038/ng1611)
    • Ting AH, Schuebel KE, Herman JG, Baylin SB. 2005 Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat. Genet. 37, 906-910. (doi:10.1038/ng1611)
    • (2005) Nat. Genet. , vol.37 , pp. 906-910
    • Ting, A.H.1    Schuebel, K.E.2    Herman, J.G.3    Baylin, S.B.4
  • 34
    • 0037072661 scopus 로고    scopus 로고
    • Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi
    • (doi:10.1126/ science.1074973)
    • Volpe TA, Kidner C, Hall IM, Teng G, Grewal SIS, Martienssen RA. 2002 Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science 297, 1833-1837. (doi:10.1126/ science.1074973)
    • (2002) Science , vol.297 , pp. 1833-1837
    • Volpe, T.A.1    Kidner, C.2    Hall, I.M.3    Teng, G.4    Grewal, S.I.S.5    Martienssen, R.A.6
  • 35
    • 0036509836 scopus 로고    scopus 로고
    • Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component
    • (doi:10.1038/ng843)
    • Maison C, Bailly D, Peters AHFM, Quivy J-P, Roche D, Taddei A, Lachner M, Jenuwein T, Almouzni G. 2002 Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat. Genet. 30, 329-334. (doi:10.1038/ng843)
    • (2002) Nat. Genet. , vol.30 , pp. 329-334
    • Maison, C.1    Bailly, D.2    Peters, A.H.F.M.3    Quivy, J.-P.4    Roche, D.5    Taddei, A.6    Lachner, M.7    Jenuwein, T.8    Almouzni, G.9
  • 36
    • 67650921949 scopus 로고    scopus 로고
    • Many human large intergenic noncoding RNAs associate with chromatinmodifying complexes and affect gene expression
    • (doi:10.1073/pnas.0904715106)
    • Khalil AM et al. 2009 Many human large intergenic noncoding RNAs associate with chromatinmodifying complexes and affect gene expression. Proc. Natl Acad. Sci. USA 106, 11 667-11 672. (doi:10.1073/pnas.0904715106)
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 11667-11672
    • Khalil, A.M.1
  • 37
    • 62249133709 scopus 로고    scopus 로고
    • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    • (doi:10. 1038/nature07672)
    • Guttman M et al. 2009 Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458, 223-227. (doi:10. 1038/nature07672)
    • (2009) Nature , vol.458 , pp. 223-227
    • Guttman, M.1
  • 41
    • 84856492490 scopus 로고    scopus 로고
    • Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
    • (doi:10.1038/emboj. 2011.459)
    • Ng S-Y, Johnson R, Stanton LW. 2012 Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 31, 522-533. (doi:10.1038/emboj. 2011.459)
    • (2012) EMBO J. , vol.31 , pp. 522-533
    • Ng, S.-Y.1    Johnson, R.2    Stanton, L.W.3
  • 42
    • 1642603947 scopus 로고    scopus 로고
    • A small modulatory dsRNA specifies the fate of adult neural stem cells
    • (doi:10. 1016/S0092-8674(04)00248-X)
    • Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH. 2004 A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell 116, 779-793. (doi:10. 1016/S0092-8674(04)00248-X)
    • (2004) Cell , vol.116 , pp. 779-793
    • Kuwabara, T.1    Hsieh, J.2    Nakashima, K.3    Taira, K.4    Gage, F.H.5
  • 43
    • 84881487023 scopus 로고    scopus 로고
    • The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis
    • (doi:10.1016/j.molcel.2013.07.017)
    • Ng S-Y, Bogu GK, Soh BS, Stanton LW. 2013 The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis. Mol. Cell 51, 349-359. (doi:10.1016/j.molcel.2013.07.017)
    • (2013) Mol. Cell , vol.51 , pp. 349-359
    • Ng, S.-Y.1    Bogu, G.K.2    Soh, B.S.3    Stanton, L.W.4
  • 44
    • 84867648038 scopus 로고    scopus 로고
    • A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development
    • (doi:10. 1073/pnas.1202956109)
    • Onoguchi M, Hirabayashi Y, Koseki H, Gotoh Y. 2012 A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development. Proc. Natl Acad. Sci. USA 109, 16 939-16 944. (doi:10. 1073/pnas.1202956109)
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 16939-16944
    • Onoguchi, M.1    Hirabayashi, Y.2    Koseki, H.3    Gotoh, Y.4
  • 45
    • 84863752340 scopus 로고    scopus 로고
    • Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes
    • (doi:10.1371/journal.pone.0040399)
    • Sher F, Boddeke E, Olah M, Copray S. 2012 Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes. PLoS ONE 7, e40399. (doi:10.1371/journal.pone.0040399)
    • (2012) PLoS ONE , vol.7
    • Sher, F.1    Boddeke, E.2    Olah, M.3    Copray, S.4
  • 46
    • 76649122999 scopus 로고    scopus 로고
    • Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation
    • (doi:10.1186/1471-2202-11-14)
    • Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF. 2010 Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci. 11, 14. (doi:10.1186/1471-2202-11-14)
    • (2010) BMC Neurosci. , vol.11 , pp. 14
    • Mercer, T.R.1    Qureshi, I.A.2    Gokhan, S.3    Dinger, M.E.4    Li, G.5    Mattick, J.S.6    Mehler, M.F.7
  • 47
    • 77956882723 scopus 로고    scopus 로고
    • A long nuclear-retained noncoding RNA regulates synaptogenesis by modulating gene expression
    • (doi:10.1038/emboj.2010.199)
    • Bernard D et al. 2010 A long nuclear-retained noncoding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29, 3082-3093. (doi:10.1038/emboj.2010.199)
    • (2010) EMBO J. , vol.29 , pp. 3082-3093
    • Bernard, D.1
  • 48
    • 84880510553 scopus 로고    scopus 로고
    • Promoter directionality is controlled by U1 snRNP and polyadenylation signals
    • (doi:10.1038/nature12349)
    • Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. 2013 Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature 499, 360-363. (doi:10.1038/nature12349)
    • (2013) Nature , vol.499 , pp. 360-363
    • Almada, A.E.1    Wu, X.2    Kriz, A.J.3    Burge, C.B.4    Sharp, P.A.5
  • 49
    • 80053428353 scopus 로고    scopus 로고
    • Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines
    • (doi:10. 1074/jbc.M111.275750)
    • Tomikawa J, Shimokawa H, Uesaka M, Yamamoto N, Mori Y, Tsukamura H, Maeda K-I, Imamura T. 2011 Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines. J. Biol. Chem. 286, 34 788-34 799. (doi:10. 1074/jbc.M111.275750)
    • (2011) J. Biol. Chem. , vol.286 , pp. 34788-34799
    • Tomikawa, J.1    Shimokawa, H.2    Uesaka, M.3    Yamamoto, N.4    Mori, Y.5    Tsukamura, H.6    Maeda, K.-I.7    Imamura, T.8
  • 50
    • 77952367798 scopus 로고    scopus 로고
    • Widespread transcription at neuronal activity-regulated enhancers
    • (doi:10.1038/nature09033)
    • Kim T-K et al. 2010 Widespread transcription at neuronal activity-regulated enhancers. Nature 465, 182-187. (doi:10.1038/nature09033)
    • (2010) Nature , vol.465 , pp. 182-187
    • Kim, T.-K.1
  • 51
    • 33744804277 scopus 로고    scopus 로고
    • The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator
    • (doi:10.1101/gad.1416106)
    • Feng J, Bi C, Clark BS, Mady R, Shah P, Kohtz JD. 2006 The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator. Genes Dev. 20, 1470-1484. (doi:10.1101/gad.1416106)
    • (2006) Genes Dev. , vol.20 , pp. 1470-1484
    • Feng, J.1    Bi, C.2    Clark, B.S.3    Mady, R.4    Shah, P.5    Kohtz, J.D.6
  • 52
    • 84859087611 scopus 로고    scopus 로고
    • R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters
    • (doi:10.1016/j.molcel.2012.01.017)
    • Ginno PA, Lott PL, Christensen HC, Korf I, Chédin F. 2012 R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters. Mol. Cell 45, 814-825. (doi:10.1016/j.molcel.2012.01.017)
    • (2012) Mol. Cell , vol.45 , pp. 814-825
    • Ginno, P.A.1    Lott, P.L.2    Christensen, H.C.3    Korf, I.4    Chédin, F.5
  • 53
    • 84877354511 scopus 로고    scopus 로고
    • R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus
    • (doi:10.1126/science. 1234848)
    • Sun Q, Csorba T, Skourti-Stathaki K, Proudfoot NJ, Dean C. 2013 R-loop stabilization represses antisense transcription at the Arabidopsis FLC locus. Science 340, 619-621. (doi:10.1126/science. 1234848)
    • (2013) Science , vol.340 , pp. 619-621
    • Sun, Q.1    Csorba, T.2    Skourti-Stathaki, K.3    Proudfoot, N.J.4    Dean, C.5
  • 54
    • 84874779803 scopus 로고    scopus 로고
    • SOX2 cooccupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state
    • (doi:10.1371/journal.pgen. 1003288)
    • Lodato MA, Ng CW, Wamstad JA, Cheng AW, Thai KK, Fraenkel E, Jaenisch R, Boyer LA. 2013 SOX2 cooccupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state. PLoS Genet. 9, e1003288. (doi:10.1371/journal.pgen. 1003288)
    • (2013) PLoS Genet. , vol.9
    • Lodato, M.A.1    Ng, C.W.2    Wamstad, J.A.3    Cheng, A.W.4    Thai, K.K.5    Fraenkel, E.6    Jaenisch, R.7    Boyer, L.A.8
  • 55
    • 10344250458 scopus 로고    scopus 로고
    • Components of the DNA methylation system of chromatin control are RNAbinding proteins
    • (doi:10.1074/jbc.M409070200)
    • Jeffery L, Nakielny S. 2004 Components of the DNA methylation system of chromatin control are RNAbinding proteins. J. Biol. Chem. 279, 49 479-49 487. (doi:10.1074/jbc.M409070200)
    • (2004) J. Biol. Chem. , vol.279 , pp. 49479-49487
    • Jeffery, L.1    Nakielny, S.2
  • 56
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • (doi:10.1016/ S0092-8674(00)81656-6)
    • Okano M, Bell DW, Haber DA, Li E. 1999 DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257. (doi:10.1016/ S0092-8674(00)81656-6)
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 57
    • 84866889114 scopus 로고    scopus 로고
    • RNA modulation of the human DNA methyltransferase 3A
    • (doi:10.1093/ nar/gks537)
    • Holz-Schietinger C, Reich NO. 2012 RNA modulation of the human DNA methyltransferase 3A. Nucleic Acids Res. 40, 8550-8557. (doi:10.1093/ nar/gks537)
    • (2012) Nucleic Acids Res. , vol.40 , pp. 8550-8557
    • Holz-Schietinger, C.1    Reich, N.O.2
  • 58
    • 84888057006 scopus 로고    scopus 로고
    • DNMT1-interacting RNAs block gene-specific DNA methylation
    • (doi:10.1038/nature12598)
    • Di Ruscio A et al. 2013 DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503, 371-376. (doi:10.1038/nature12598)
    • (2013) Nature , vol.503 , pp. 371-376
    • Di Ruscio, A.1
  • 59
    • 40449123137 scopus 로고    scopus 로고
    • Cyclical DNA methylation of a transcriptionally active promoter
    • (doi:10.1038/nature06544)
    • Métivier R et al. 2008 Cyclical DNA methylation of a transcriptionally active promoter. Nature 452, 45-50. (doi:10.1038/nature06544)
    • (2008) Nature , vol.452 , pp. 45-50
    • Métivier, R.1
  • 60
    • 84878260646 scopus 로고    scopus 로고
    • TETonic shift: Biological roles of TET proteins in DNA demethylation and transcription
    • (doi:10.1038/nrm3589)
    • Pastor WA, Aravind L, Rao A. 2013 TETonic shift: biological roles of TET proteins in DNA demethylation and transcription. Nat. Rev. Mol. Cell Biol. 14, 341-356. (doi:10.1038/nrm3589)
    • (2013) Nat. Rev. Mol. Cell Biol. , vol.14 , pp. 341-356
    • Pastor, W.A.1    Aravind, L.2    Rao, A.3
  • 61
    • 84881178902 scopus 로고    scopus 로고
    • Tet1 regulates adult hippocampal neurogenesis and cognition
    • (doi:10.1016/j.stem.2013.05.006)
    • Zhang R-R et al. 2013 Tet1 regulates adult hippocampal neurogenesis and cognition. Cell Stem Cell 13, 237-245. (doi:10.1016/j.stem.2013.05.006)
    • (2013) Cell Stem Cell , vol.13 , pp. 237-245
    • Zhang, R.-R.1
  • 63
    • 59149096820 scopus 로고    scopus 로고
    • MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression
    • (doi:10.1074/jbc.M806514200)
    • Ding N, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Boyer TG. 2009 MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J. Biol. Chem. 284, 2648-2656. (doi:10.1074/jbc.M806514200)
    • (2009) J. Biol. Chem. , vol.284 , pp. 2648-2656
    • Ding, N.1    Tomomori-Sato, C.2    Sato, S.3    Conaway, R.C.4    Conaway, J.W.5    Boyer, T.G.6
  • 64
    • 0142059234 scopus 로고    scopus 로고
    • The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord
    • (doi:10.1016/j.bbrc. 2003.09.158)
    • Nishihara S, Tsuda L, Ogura T. 2003 The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem. Biophys. Res. Commun. 311, 55-63. (doi:10.1016/j.bbrc. 2003.09.158)
    • (2003) Biochem. Biophys. Res. Commun. , vol.311 , pp. 55-63
    • Nishihara, S.1    Tsuda, L.2    Ogura, T.3
  • 65
    • 33750432857 scopus 로고    scopus 로고
    • Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression
    • (doi:10.1186/gb-2006-7-9-r85)
    • Wu J, Xie X. 2006 Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol. 7, R85. (doi:10.1186/gb-2006-7-9-r85)
    • (2006) Genome Biol. , vol.7
    • Wu, J.1    Xie, X.2
  • 66
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • (doi:10.1038/ nature08975)
    • Gupta RA et al. 2010 Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464, 1071-1076. (doi:10.1038/ nature08975)
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 67
    • 84887419464 scopus 로고    scopus 로고
    • Promiscuous RNA binding by polycomb repressive complex 2
    • (doi:10.1038/nsmb.2679)
    • Davidovich C, Zheng L, Goodrich KJ, Cech TR. 2013 Promiscuous RNA binding by polycomb repressive complex 2. Nat. Struct. Mol. Biol. 20, 1250-1257. (doi:10.1038/nsmb.2679)
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 1250-1257
    • Davidovich, C.1    Zheng, L.2    Goodrich, K.J.3    Cech, T.R.4
  • 68
    • 78650253763 scopus 로고    scopus 로고
    • Genome-wide identification of polycomb-associated RNAs by RIP-seq
    • (doi:10.1016/j.molcel.2010.12.011)
    • Zhao J et al. 2010 Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol. Cell 40, 939-953. (doi:10.1016/j.molcel.2010.12.011)
    • (2010) Mol. Cell , vol.40 , pp. 939-953
    • Zhao, J.1
  • 69
    • 77953107585 scopus 로고    scopus 로고
    • Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2
    • (doi:10.1016/j.molcel.2010.03.019)
    • Kanhere A et al. 2010 Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol. Cell 38, 675-688. (doi:10.1016/j.molcel.2010.03.019)
    • (2010) Mol. Cell , vol.38 , pp. 675-688
    • Kanhere, A.1
  • 71
    • 84865681429 scopus 로고    scopus 로고
    • TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
    • (doi:10. 1016/j.cell.2012.06.046)
    • Petruk S et al. 2012 TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell 150, 922-933. (doi:10. 1016/j.cell.2012.06.046)
    • (2012) Cell , vol.150 , pp. 922-933
    • Petruk, S.1
  • 72
    • 84857430552 scopus 로고    scopus 로고
    • Chromatin replication and epigenome maintenance
    • (doi:10.1038/nrm3288)
    • Alabert C, Groth A. 2012 Chromatin replication and epigenome maintenance. Nat. Rev. Mol. Cell Biol. 13, 153-167. (doi:10.1038/nrm3288)
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 153-167
    • Alabert, C.1    Groth, A.2
  • 73
    • 78650752402 scopus 로고    scopus 로고
    • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    • (doi:10.1038/nbt.1667)
    • Polo JM et al. 2010 Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nat. Biotechnol. 28, 848-855. (doi:10.1038/nbt.1667)
    • (2010) Nat. Biotechnol. , vol.28 , pp. 848-855
    • Polo, J.M.1
  • 74
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • (doi:10.1038/nature09342)
    • Kim K et al. 2010 Epigenetic memory in induced pluripotent stem cells. Nature 467, 285-290. (doi:10.1038/nature09342)
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1
  • 75
    • 84884844190 scopus 로고    scopus 로고
    • The cell-cycle state of stem cells determines cell fate propensity
    • (doi:10.1016/j.cell.2013.08.031)
    • Pauklin S, Vallier L. 2013 The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135-147. (doi:10.1016/j.cell.2013.08.031)
    • (2013) Cell , vol.155 , pp. 135-147
    • Pauklin, S.1    Vallier, L.2
  • 76
    • 41449108880 scopus 로고    scopus 로고
    • Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development
    • (doi:10.1016/j.ccr.2008.02.010)
    • Wiedemeyer R et al. 2008 Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell 13, 355-364. (doi:10.1016/j.ccr.2008.02.010)
    • (2008) Cancer Cell , vol.13 , pp. 355-364
    • Wiedemeyer, R.1
  • 77
    • 54549095950 scopus 로고    scopus 로고
    • p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    • (doi:10.1038/nature07443)
    • Zheng H et al. 2008 p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455, 1129-1133. (doi:10.1038/nature07443)
    • (2008) Nature , vol.455 , pp. 1129-1133
    • Zheng, H.1
  • 78
    • 77950675541 scopus 로고    scopus 로고
    • Histone demethylase LSD1 regulates neural stem cell proliferation
    • (doi:10.1128/MCB.01116-09)
    • Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y. 2010 Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30, 1997-2005. (doi:10.1128/MCB.01116-09)
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 1997-2005
    • Sun, G.1    Alzayady, K.2    Stewart, R.3    Ye, P.4    Yang, S.5    Li, W.6    Shi, Y.7
  • 79
    • 84880918955 scopus 로고    scopus 로고
    • The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage
    • (doi:10.1038/onc.2012.426)
    • Nicol SM, Bray SE, Black HD, Lorimore SA, Wright EG, Lane DP, Meek DW, Coates PJ, Fuller-Pace FV. 2013 The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage. Oncogene 32, 3461-3469. (doi:10.1038/onc.2012.426)
    • (2013) Oncogene , vol.32 , pp. 3461-3469
    • Nicol, S.M.1    Bray, S.E.2    Black, H.D.3    Lorimore, S.A.4    Wright, E.G.5    Lane, D.P.6    Meek, D.W.7    Coates, P.J.8    Fuller-Pace, F.V.9
  • 80
    • 67349216689 scopus 로고    scopus 로고
    • The non-apoptotic role of p53 in neuronal biology: Enlightening the dark side of the moon
    • (doi:10.1038/embor.2009.89)
    • Tedeschi A, Di Giovanni S. 2009 The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon. EMBO Rep. 10, 576-583. (doi:10.1038/embor.2009.89)
    • (2009) EMBO Rep. , vol.10 , pp. 576-583
    • Tedeschi, A.1    Di Giovanni, S.2
  • 81
    • 52449132322 scopus 로고    scopus 로고
    • Is there a code embedded in proteins that is based on posttranslational modifications?
    • (doi:10.1038/nrm2502)
    • Sims RJ, Reinberg D. 2008 Is there a code embedded in proteins that is based on posttranslational modifications? Nat. Rev. Mol. Cell Biol. 9, 815-820. (doi:10.1038/nrm2502)
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 815-820
    • Sims, R.J.1    Reinberg, D.2
  • 83
    • 0034529241 scopus 로고    scopus 로고
    • Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation
    • (doi:10.1074/jbc.M003146200)
    • Hughes AL, Gollapudi L, Sladek TL, Neet KE. 2000 Mediation of nerve growth factor-driven cell cycle arrest in PC12 cells by p53. Simultaneous differentiation and proliferation subsequent to p53 functional inactivation. J. Biol. Chem. 275, 37 829-37 837. (doi:10.1074/jbc.M003146200)
    • (2000) J. Biol. Chem. , vol.275 , pp. 37829-37837
    • Hughes, A.L.1    Gollapudi, L.2    Sladek, T.L.3    Neet, K.E.4
  • 84
    • 0035906958 scopus 로고    scopus 로고
    • Analysis of trk A and p53 association
    • (doi:10.1016/S0014-5793(01)02429-2)
    • Browes C, Rowe J, Brown A, Montano X. 2001 Analysis of trk A and p53 association. FEBS Lett. 497, 20-25. (doi:10.1016/S0014-5793(01)02429-2)
    • (2001) FEBS Lett. , vol.497 , pp. 20-25
    • Browes, C.1    Rowe, J.2    Brown, A.3    Montano, X.4
  • 85
    • 19944429405 scopus 로고    scopus 로고
    • Nerve growth factor receptor signaling induces histone acetyltransferase domaindependent nuclear translocation of p300/CREBbinding protein-associated factor and hGCN5 acetyltransferases
    • (doi:10.1074/jbc.M408174200)
    • Wong K et al. 2004 Nerve growth factor receptor signaling induces histone acetyltransferase domaindependent nuclear translocation of p300/CREBbinding protein-associated factor and hGCN5 acetyltransferases. J. Biol. Chem. 279, 55 667-55 674. (doi:10.1074/jbc.M408174200)
    • (2004) J. Biol. Chem. , vol.279 , pp. 55667-55674
    • Wong, K.1
  • 86
    • 34347209447 scopus 로고    scopus 로고
    • NGFmediated transcriptional targets of p53 in PC12 neuronal differentiation
    • (doi:10.1186/1471-2164-8-139)
    • Brynczka C, Labhart P, Merrick BA. 2007 NGFmediated transcriptional targets of p53 in PC12 neuronal differentiation. BMC Genomics 8, 139. (doi:10.1186/1471-2164-8-139)
    • (2007) BMC Genomics , vol.8 , pp. 139
    • Brynczka, C.1    Labhart, P.2    Merrick, B.A.3
  • 87
    • 10644277060 scopus 로고    scopus 로고
    • Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis
    • (doi:10.1002/jnr.20299)
    • Hudson CD, Podesta J, Henderson D, Latchman DS, Budhram-Mahadeo V. 2004 Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis. J. Neurosci. Res. 78, 803-814. (doi:10.1002/jnr.20299)
    • (2004) J. Neurosci. Res. , vol.78 , pp. 803-814
    • Hudson, C.D.1    Podesta, J.2    Henderson, D.3    Latchman, D.S.4    Budhram-Mahadeo, V.5
  • 88
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • (doi:10.1038/nature06468)
    • Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H. 2008 Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451, 202-206. (doi:10.1038/nature06468)
    • (2008) Nature , vol.451 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3    Muldoon-Jacobs, K.4    Karp, J.5    Feinberg, A.P.6    Cui, H.7
  • 89
    • 57149110631 scopus 로고    scopus 로고
    • Bidirectional transcription directs both transcriptional gene activation and suppression in human cells
    • (doi:10. 1371/journal.pgen.1000258)
    • Morris KV, Santoso S, Turner A-M, Pastori C, Hawkins PG. 2008 Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. PLoS Genet. 4, e1000258. (doi:10. 1371/journal.pgen.1000258)
    • (2008) PLoS Genet. , vol.4
    • Morris, K.V.1    Santoso, S.2    Turner, A.-M.3    Pastori, C.4    Hawkins, P.G.5
  • 90
    • 0036205049 scopus 로고    scopus 로고
    • Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    • (doi:10.1101/gad.975202)
    • Hitoshi S et al. 2002 Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 16, 846-858. (doi:10.1101/gad.975202)
    • (2002) Genes Dev. , vol.16 , pp. 846-858
    • Hitoshi, S.1
  • 91
    • 79957613988 scopus 로고    scopus 로고
    • Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors
    • (doi:10. 1002/stem.641)
    • Kim J et al. 2011 Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors. Stem Cells 29, 992-1000. (doi:10. 1002/stem.641)
    • (2011) Stem Cells , vol.29 , pp. 992-1000
    • Kim, J.1
  • 92
    • 78650084131 scopus 로고    scopus 로고
    • High-efficient generation of induced pluripotent stem cells from human astrocytes
    • (doi:10. 1371/journal.pone.0015526)
    • Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage FH, Izpisua Belmonte JC. 2010 High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS ONE 5, e15526. (doi:10. 1371/journal.pone.0015526)
    • (2010) PLoS ONE , vol.5
    • Ruiz, S.1    Brennand, K.2    Panopoulos, A.D.3    Herrerías, A.4    Gage, F.H.5    Izpisua Belmonte, J.C.6
  • 93
    • 59349108302 scopus 로고    scopus 로고
    • Oct4-induced pluripotency in adult neural stem cells
    • (doi:10. 1016/j.cell.2009.01.023)
    • Kim JB et al. 2009 Oct4-induced pluripotency in adult neural stem cells. Cell 136, 411-419. (doi:10. 1016/j.cell.2009.01.023)
    • (2009) Cell , vol.136 , pp. 411-419
    • Kim, J.B.1
  • 94
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • (doi:10.1038/ nature08797)
    • Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. 2010 Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041. (doi:10.1038/ nature08797)
    • (2010) Nature , vol.463 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3    Kokubu, Y.4    Südhof, T.C.5    Wernig, M.6
  • 95
    • 84893761684 scopus 로고    scopus 로고
    • In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
    • (doi:10.1016/j.stem.2013.12.001)
    • Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G. 2013 In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model. Cell Stem Cell 14, 188-202. (doi:10.1016/j.stem.2013.12.001)
    • (2013) Cell Stem Cell , vol.14 , pp. 188-202
    • Guo, Z.1    Zhang, L.2    Wu, Z.3    Chen, Y.4    Wang, F.5    Chen, G.6
  • 96
    • 84885174320 scopus 로고    scopus 로고
    • In vivo reprogramming of astrocytes to neuroblasts in the adult brain
    • (doi:10.1038/ncb2843)
    • Niu W, Zang T, Zou Y, Fang S, Smith DK, Bachoo R, Zhang C-L. 2013 In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat. Cell Biol. 15, 1164-1175. (doi:10.1038/ncb2843)
    • (2013) Nat. Cell Biol. , vol.15 , pp. 1164-1175
    • Niu, W.1    Zang, T.2    Zou, Y.3    Fang, S.4    Smith, D.K.5    Bachoo, R.6    Zhang, C.-L.7
  • 98
    • 77950583698 scopus 로고    scopus 로고
    • BMPinduced REST regulates the establishment and maintenance of astrocytic identity
    • (doi:10.1083/jcb.200908048)
    • Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K. 2010 BMPinduced REST regulates the establishment and maintenance of astrocytic identity. J. Cell Biol. 189, 159-170. (doi:10.1083/jcb.200908048)
    • (2010) J. Cell Biol. , vol.189 , pp. 159-170
    • Kohyama, J.1    Sanosaka, T.2    Tokunaga, A.3    Takatsuka, E.4    Tsujimura, K.5    Okano, H.6    Nakashima, K.7
  • 99
    • 84867353088 scopus 로고    scopus 로고
    • Reprogramming of pericytederived cells of the adult human brain into induced neuronal cells
    • (doi:10. 1016/j.stem.2012.07.007)
    • Karow M et al. 2012 Reprogramming of pericytederived cells of the adult human brain into induced neuronal cells. Cell Stem Cell 11, 471-476. (doi:10. 1016/j.stem.2012.07.007)
    • (2012) Cell Stem Cell , vol.11 , pp. 471-476
    • Karow, M.1
  • 100
    • 84862123720 scopus 로고    scopus 로고
    • Programming and reprogramming neuronal subtypes in the central nervous system
    • (doi:10.1002/dneu.22018)
    • Rouaux C, Bhai S, Arlotta P. 2012 Programming and reprogramming neuronal subtypes in the central nervous system. Dev. Neurobiol. 72, 1085-1098. (doi:10.1002/dneu.22018)
    • (2012) Dev. Neurobiol. , vol.72 , pp. 1085-1098
    • Rouaux, C.1    Bhai, S.2    Arlotta, P.3
  • 101
    • 84873410997 scopus 로고    scopus 로고
    • Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo
    • (doi:10.1038/ncb2660)
    • Rouaux C, Arlotta P. 2013 Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo. Nat. Cell Biol. 15, 214-221. (doi:10.1038/ncb2660)
    • (2013) Nat. Cell Biol. , vol.15 , pp. 214-221
    • Rouaux, C.1    Arlotta, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.