Targeted mutagenesis of Tsix leads to nonrandom X inactivation

Cell

Volumn 99, Issue 1, 1999, Pages 47-57

  Lee, Jeannie T ^a,b   Lu, Naifang ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; NONHUMAN; NUCLEIC ACID PROBE; PRIORITY JOURNAL; X CHROMOSOME; X CHROMOSOME INACTIVATION;

ANIMALIA; MAMMALIA;

EID: 0033214928     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80061-6     Document Type: Article

References (47)

1. Avner, P., Prissette, M., Arnaud, D., Courtier, B., Cecchi, C., and Heard, E. (1998). Molecular correlates of the murine Xce locus. Genet. Res. Camb. 72, 217-224.
2. Brockdorff, N. (1998). The role of Xist in X-inactivation. Curr. Opin. Genet. Dev. 8, 328-333.
3. Brockdorff, N., Ashworth, A., Kay, G.F., McCabe, V.M., Norris, D.P., Cooper, P.J., Swift, S., and Rastan, S. (1992). The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71, 515-526.
4. Brown, C.J., Hendrich, B.D., Rupert, J.L., Lafreniere, R.G., Xing, Y., Lawrence, J., and Willard, H.F. (1992). The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71, 527-542.
5. Carrel, L., Hunt, P.A., and Willard, H. (1996). Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. Hum. Mol. Genet. 5, 1361-1366.
6. Cattanach, B.M., and Papworth, D. (1981). Controlling elements in the mouse. V. Linkage tests with X-linked genes. Genet. Res. Camb. 38, 57-70.
7. Cattanach, B.M., and Rasberry, C. (1994). Identification of the Mus castaneus Xce allele. Mouse Genome 92, 114.
8. Clemson, C.M., McNeil, J.A., Willard, H., and Lawrence, J.B. (1996). XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure. J. Cell Biol. 132, 259-275.
9. Clerc, P., and Avner, P. (1998). Role of the region 3′ to Xist in the counting process of X-chromosome inactivation. Nat. Genet. 19, 249-253.
10. Cooper, D.W., VandeBerg, J.L., Sharman, G.B., and Poole, W.E. (1971). Phosphoglycerate kinase polymorphism in kangaroos provides further evidence for paternal X inactivation. Nat. New Biol. 230, 155-157.
11. Courtier, B., Heard, E., and Avner, P. (1995). Xce haplotypes show modified methylation in a region of the active X chromosome lying 3′ to Xist. Proc. Natl. Acad. Sci. USA 92, 3531-3535.
12. Drews, R., Blecher, S.R., Owen, D.A., and Ohno, S. (1974). Genetically directed preferential X-activation seen in mice. Cell 1, 3-8.
13. Eicher, E.M. (1970). X-autosome translocations in the mouse: Total inactivation versus partial inactivation of the X chromosome. Adv. Genet. 15, 175-259.
14. Epstein, C., Smith, S., Travis, B., and Tucker, G. (1978). Both X-chromosomes function before visible X-chromosome inactivation in female mouse embryos. Nature 274, 500-503.
15. Gartler, S.M., and Riggs, A.D. (1983). Mammalian X-chromosome inactivation. Annu. Rev. Genet. 17, 155-190.
16. Gorman, J.R., Stoep, N.v.D., Monroe, R., Cogne, M., Davidson, L., and Alt, F.W. (1996). The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity 5, 241-252.
17. Hendrich, B.D., Brown, C.J., and Willard, H.F. (1993). Evolutionary conservation of possible functional domains of the human and murine Xist genes. Hum. Mol. Genet. 2, 663-672.
18. Herzing, L.B.K., Romer, J.T., Horn, J.M., and Ashworth, A. (1997). Xist has properties of the X-chromosome inactivation centre. Nature 386, 272-275.
19. Kratzer, P.G., and Gartler, S.M. (1978). HGPRT activity changes in preimplantation mouse embryos. Nature 274, 503-504.
20. Lawrence, J.B., Singer, R.H., and Marselle, L.M. (1989). Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization. Cell 57, 493-502.
21. Lee, J.T., and Jaenisch, R. (1997). Long-range cis effects of ectopic X-inactivation centres on a mouse autosome. Nature 386, 275-279.
22. Lee, J.T., Strauss, W.M., Dausman, J.A., and Jaenisch, R. (1996). A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell 86, 83-94.
23. Lee, J.T., Davidow, L.S., and Warshawsky, D. (1999a). Tsix, a gene antisense to Xist at the X-inactivation center. Nat. Genet. 21, 400-404.
24. Lee, J.T., Lu, N.F., and Han, Y. (1999b). Genetic analysis of the mouse X-inactivation center reveals an 80kb multifunction domain. Proc. Natl. Acad. Sci. USA 96, 3836-3841.
25. Li, E., Bestor, T.H., and Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926.
26. Lyon, M.F. (1961). Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 190, 372-373.
27. Lyon, M.F. (1971). Possible mechanisms of X chromosome inactivation. Nat. New Biol. 232, 229-232.
28. Lyon, M.F. (1972). X-chromosome inactivation and developmental patterns in mammals. Biol. Rev. 47, 1-35.
29. Lyon, M.F. (1996). Pinpointing the centre. Nature 379, 116-117.
30. Marahrens, Y., Loring, J., and Jaenisch, R. (1998). Role of the Xist gene in X chromosome choosing. Cell 92, 657-664.
31. Martin, G.R., and Evans, M.J. (1975). Differentiation of clonal lines of teratocarcinoma cells: Formation of embryoid bodies in vitro. Proc. Natl. Acad. Sci. USA 72, 1441-1445.
32. McMahon, A., Fosten, M., and Monk, M. (1983). X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo. J. Embryol. Exp. Morphol. 74, 207-220.
33. Monk, M., and Harper, M.I. (1979). Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos. Nature 281, 311-313.
34. Ohno, S. (1969). Evolution of sex chromosomes in mammals. Annu. Rev. Genet. 3, 495-524.
35. Panning, B., and Jaenisch, R. (1996). DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 10, 1991-2002.
36. Panning, B., Dausman, J., and Jaenisch, R. (1997). X chromosome inactivation is mediated by Xist RNA stabilization. Cell 90, 907-916.
37. Papaioannou, V., and Johnson, R. (1993). Production of chimeras and genetically defined offspring from targeted ES cells. In Gene Targeting: A Practical Approach, A.L. Joyner, ed. (Oxford, UK: Oxford University Press), pp. 107-146.
38. Penny, G.D., Kay, G.F., Sheardown, S.A., Rastan, S., and Brockdorff, N. (1996). Requirement for Xist in X chromosome inactivation. Nature 379, 131-137.
39. Plenge, R.M., Hendrich, B.D., Schwartz, C., Arena, J.F., Naumova, A., Sapienza, C., Winter, R.M., and Willard, H.F. (1997). A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Nat. Genet. 17, 353-356.
40. Rastan, S., and Brown, S.D.M. (1990). The search for the mouse X-chromosome inactivation centre. Genet. Res. Camb. 56, 99-106.
41. Rastan, S., and Robertson, E.J. (1985). X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation. J. Embryol. Exp. Morphol. 90, 379-388.
42. Sheardown, S.A., Duthie, S.M., Johnston, C.M., Newall, A.E.T., Formstone, E.J., Arkell, R.M., Nesterova, T.B., Alghisi, G.-C., Rastan, S., and Brockdorff, N. (1997). Stabilization of Xist RNA mediate initiation of X chromosome inactivation. Cell 91, 99-107.
43. Simmler, M.-C., Cattanach, B.M., Rasberry, C., Rougeulle, C., and Avner, P. (1993). Mapping the murine Xce locus with (CA)n repeats. Mamm. Genome 4, 523-530.
44. Takagi, N., and Sasaki, M. (1975). Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse. Nature 256, 640-642.
45. Torres, R.M., and Kuhn, R. (1997). Laboratory Protocols for Conditional Gene Targeting (Oxford: Oxford University Press).
46. Trask, B.J. (1991). Fluorescence in situ hybridization. Trends Genet. 7, 149-154.
47. Wurst, W., and Joyner, A.L. (1993). Production of targeted embryonic stem cell clones. In Gene Targeting: A Practical Approach, A.L. Joyner, ed. (Oxford: IRL Press), pp. 33-61.