Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation

PLoS ONE

Volumn 3, Issue 9, 2008, Pages

  Hatada, Izuho ^a   Namihira, Masakazu ^b   Morita, Sumiyo ^a   Kimura, Mika ^a   Horii, Takuro ^a   Nakashima, Kinichi ^b  

^a GUNMA UNIVERSITY   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TRANSCRIPTION FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; NERVE GROWTH FACTOR; PROTEIN S 100; S 100 CALCIUM BINDING PROTEIN BETA SUBUNIT; S-100 CALCIUM-BINDING PROTEIN BETA SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DEMETHYLATION; DEVELOPMENTAL STAGE; DNA METHYLATION; DNA MICROARRAY; EPIGENETICS; FEMALE; GENE EXPRESSION; GENOME; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; ANIMAL; BINDING SITE; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; NERVE CELL; TIME;

ANIMALS; ASTROCYTES; BINDING SITES; CELL DIFFERENTIATION; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENOME; GLIAL FIBRILLARY ACIDIC PROTEIN; MICE; MICE, INBRED ICR; NERVE GROWTH FACTORS; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; S100 PROTEINS; TIME FACTORS;

EID: 52649177210     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003189     Document Type: Article

References (37)

1. Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, et al. (1984) Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A 81: 2275-2279.
2. Bird A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16: 6-21.
3. Ohgane J, Aikawa J, Ogura A, Hattori N, Ogawa T, et al. (1998) Analysis of CpG islands of trophoblast giant cells by restriction landmark genomic scanning. Dev Genet 22: 132-140.
4. Song F, Smith JF, Kimura MT, Morrow AD, Matsuyama T, et al. (2005) Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression. Proc Natl Acad Sci U S A 102: 3336-3341.
5. Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
6. Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, et al. (2004) Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 279: 17063-17069.
7. Hattori N, Imao Y, Nishino K, Hattori N, Ohgane J, et al. (2007) Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells 12: 387-396.
8. Niwa H, Miyazaki J, Smith AG (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24: 372-376.
9. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113: 631-642.
10. Chambers I, Colby D, Robertson M, Nichols J, Lee S, et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113: 643-655.
11. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, et al. (2007) Science 318: 1917-1920.
12. Qan X, Shen Q, Goderic SK, He W, Capela A, et al. (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28: 69-80.
13. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, et al. (1997) Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278: 477-483.
14. Rajan P, McKay RD (1998) Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18: 3620-3629.
15. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, et al. (2001) DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 1: 749-758.
16. Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, et al. (2006) Genome-wide profiling of promoter methylation in human. Oncogene 25: 3059-3064.
17. Hatada I, Morita S, Kimura M, Horii T, Yamashita R, et al. (2008) Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells. J Hum Genet 53: 185-191.
18. Namihira M, Nakashima K, Taga T (2004) Developmental stage dependent regulation of DNA methylation and chromatin modification in a immature astrocyte specific gene promoter. FEBS Lett 572: 184-188.
19. Walther EU, Dichgans M, Maricich SM, Romito RR, Yang F, et al. (1998) Genomic sequences of aldolase C (Zebrin II) direct lacZ expression exclusively in non-neuronal cells of transgenic mice. Proc Natl Acad Sci U S A 95: 2615-2620.
20. Higashimori H, Sontheimer H (2007) Role of Kir4.1 channels in growth control of glia. Glia 55: 1668-1679.
21. Neusch C, Papadopoulos N, Müller M, Maletzki I, Winter SM, et al. (2006) Lack of the Kir-4.1 channel subunit abolishes K+ buffering properties of astrocytes in the ventral respiratory group: impact on extracellular K+ regulation. J Neurophysiol 95: 1843-1852.
22. Buono RJ, Lohoff FW, Sander T, Sperling MR, O'Connor MJ, et al. (2004) Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. Epilepsy Res 58: 175-183.
23. Lenzen KP, Heils A, Lorenz S, Hempelmann A, Hofels S, et al. (2005) Supportive evidence for an allelic association of the human KCNJ10 potassium channel gene with idiopathic generalized epilepsy. Epilepsy Res 63: 113-118.
24. McKinnon PJ, Margolskee (1996) RF SC1: a marker for astrocytes in the adult rodent brain is upregulated during reactive astrocytosis. Brain Res 709: 27-36.
25. Scalabrini D, Fenoglio C, Scarpini E, De Riz M, Comi C, et al. (2007) Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis. Neurosci Lett 425: 173-176.
26. Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, et al. (2005) Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS. FASEB J 19: 1854-1856.
27. Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, et al. (2008) A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 28: 264-278.
28. Czermin B, Melfi R, McCabe of D, et al. (2002) Drosophila enhancer of Zeste/ESC complexes have a histrine H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185-196.
29. Müller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, et al. (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111: 197-208.
30. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, et al. (2006) A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125: 315-326.
31. Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, et al. (2008) Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 30: 755-766.
32. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, et al. (2007) Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448: 553-560.
33. Gross RE, Mehler MF, Mabie PC, Zang Z, Santschi L, et al. (1996) Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron 17: 595-606.
34. Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, et al. (1999) Synergistic signaling in fetal brain by STAT3-Smad 1 complex bridged by p300. Science 284: 479-482.
35. Cho RJ, Campbell MJ (2000) Transcription, genomes, function. Trends Genet 16: 409-415.
36. Tanigaki K, Nogaki F, Takahashi Tashiro K, Kurooka H, et al. (2001) Notch 1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29: 45-55.
37. Hatada I, Kato A, Morita S, Obata Y, Nagaoka K, et al. (2002) A microarray-based method for detecting methylated loci. J Hum Genet 47: 448-451.