Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo

Nature Cell Biology

Volumn 15, Issue 2, 2013, Pages 214-221

  Rouaux, Caroline ^a,b   Arlotta, Paola ^a  

^a HARVARD UNIVERSITY   (United States)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FEZF2; UNCLASSIFIED DRUG;

ARTICLE; CDK5R GENE; CELL DEATH; CELL LINEAGE; CELL MIGRATION; CELLULAR DISTRIBUTION; CLIM1 GENE; CORPUS CALLOSUM; DEVELOPMENTAL STAGE; FEZF2 GENE; GENE; GENE TARGETING; MITOSIS; NEOCORTEX; NERVE CELL DIFFERENTIATION; NERVE FIBER; NERVE PROJECTION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANIMALS, NEWBORN; AXONS; BIOLOGICAL MARKERS; CELL LINEAGE; CELL TRANSDIFFERENTIATION; CORPUS CALLOSUM; DNA-BINDING PROTEINS; ELECTROPORATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE REGULATORY NETWORKS; GENE TRANSFER TECHNIQUES; GESTATIONAL AGE; MICE; MITOSIS; NEOCORTEX; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEURONS; NUCLEAR REPROGRAMMING;

MAMMALIA;

EID: 84873410997     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2660     Document Type: Article

References (39)

1. Waddington, C. H. The Strategy of the Genes; A Discussion of Some Aspects of TheoreticalBiology (Allen & Unwin, 1957).
2. Ming, G. L. & Song, H. Adult neurogenesis in the mammalian central nervoussystem. Annu. Rev. Neurosci. 28, 223-250 (2005).
3. Zhao, C., Deng, W. & Gage, F. H. Mechanisms and functional implications of adult neurogenesis. Cell 132, 645-660 (2008).
4. Selvaraj, V., Plane, J. M., Williams, A. J. & Deng, W. Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends Biotechnol. 28, 214-223 (2010).
5. Vierbuchen, T. & Wernig, M. Direct lineage conversions: unnatural but useful? Nat Biotechnol. 29, 892-907 (2011).
6. Zhou, Q. & Melton, D. A. Extreme makeover: converting one cell into another. Cell Stem. Cell 3, 382-388 (2008).
7. Eggan, K. et al. Mice cloned from olfactory sensory neurons. Nature 428, 44-49 (2004).
8. Li, J., Ishii, T., Feinstein, P. & Mombaerts, P. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428, 393-399 (2004).
9. De Marco Garcia, N. V. &Jessell, T. M. Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity. Neuron 57, 217-231 (2008).
10. Sharma, K., Leonard, A. E., Lettieri, K. & Pfaff, S. L. Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature 406, 515-519 (2000).
11. Thaler, J. P. et al. A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron 41, 337-350 (2004).
12. Molyneaux, B. J., Arlotta, P., Menezes, J. R. & Macklis, J. D. Neuronal subtype specification in the cerebral cortex. Nat Rev. Neurosci. 8, 427-437 (2007).
13. Bayer, S. A. & Altman, J. Neocortical Development (Raven Press, 1991).
14. Arlotta, P. et al. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45, 207-221 (2005).
15. Chen, B., Schaevitz, L. R. & McConnell, S. K. Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc. Natl Acad. Sci. USA 102, 17184-17189 (2005).
16. Chen,J. G., Rasin, M. R., Kwan, K. Y. & Sestan, N. Zfp312 is required forsubcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Proc. Natl Acad. Sci. USA 102, 17792-17797 (2005).
17. Molyneaux, B.J., Arlotta, P., Hirata, T., Hibi, M. & Macklis, J. D. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron 47, 817-831 (2005).
18. Rouaux, C. & Arlotta, P. Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo. Nat Neurosci. 13, 1345-1347 (2010).
19. Wang, X., Qiu, R., Tsark, W. & Lu, Q. Rapid promoter analysis in developing mouse brain and genetic labeling of young neurons by doublecortin-DsRed-express. J. Neurosci. Res. 85, 3567-3573 (2007).
20. Delalle, I., Bhide, P. G., Caviness, V. S. Jr & Tsai, L. H.Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse. J. Neurocytol. 26, 283-296 (1997).
21. Tsai, L. H., Delalle, I., Caviness, V. S. Jr, Chae, T. & Harlow, E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419-423 (1994).
22. Yoneshima, H. et al. Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices. Neuroscience 137, 401-412 (2006).
23. Molyneaux, B. J. et al. Novel subtype-specificgenes identifydistinct subpopulations of callosal projection neurons. J. Neurosci. 29, 12343-12354 (2009).
24. Fishell, G. & Hanashima, C. Pyramidal neurons grow up and change their mind. Neuron 57, 333-338 (2008).
25. Matsuda, T. & Cepko, C. L. Controlled expression of transgenes introduced by in vivo electroporation. Proc. NatlAcad. Sci. USA 104, 1027-1032 (2007).
26. Huangfu, D. et al. Induction of pluripotent stem cellsfrom primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 26, 1269-1275 (2008).
27. Fame, R. M., MacDonald, J. L. & Macklis, J. D. Development, specification, and diversity of callosal projection neurons. Trends Neurosci. 34, 41-50 (2011).
28. Ozaki, H. S. & Wahlsten, D. Timing and origin of the first cortical axons to project through the corpus callosum and the subsequent emergence of callosal projection cells in mouse. J. Compit. Neurol. 400, 197-206 (1998).
29. Francis, F. et al. Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons. Neuron 23, 247-256 (1999).
30. Gleeson, J. G., Lin, P. T., Flanagan, L.A. & Walsh, C.A. Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons. Neuron 23, 257-271 (1999).
31. Matsuo, N., Kawamoto, S., Matsubara, K. & Okubo, K. Cloning and developmental expression of the murine homolog of doublecortin. Biochem. Biophys. Res. Commun. 252, 571-576 (1998).
32. Rouaux, C., Bhai, S. & Arlotta, P. Programming and reprogramming neuronal subtypes in the central nervous system. Dev. Neurobiol. 72, 1085-1098 (2012).
33. Berninger, B. et al. Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. J. Neurosci. 27, 8654-8664 (2007).
34. Heinrich, C. et al. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol. 8, 1-29 (2010).
35. Heins, N. et al. Glial cellsgenerate neurons: the role of the transcription factor Pax6. Nat Neurosci. 5, 308-315 (2002).
36. Karow, M. et al. Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells. CellStem. Cell 11, 471-476 (2012).
37. Cardin, J. A. et al. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature 459, 663-667 (2009).
38. Saito, T. & Nakatsuji, N. Efficientgene transfer intothe embryonic mouse brain using in vivo electroporation. Dev. Biol. 240, 237-246 (2001).
39. Lodato, S. et al. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron 69, 763-779 (2011).