Targeting cancer cells via the reactive oxygen species-mediated unfolded protein response with a novel synthetic polyphenol conjugate

Clinical Cancer Research

Volumn 20, Issue 16, 2014, Pages 4302-4313

  Shin, Soon Young ^a   Lee, Jong Min ^a   Lee, Mi So ^a   Koh, Dongsoo ^b   Jung, Hyeryoung ^a   Lim, Yoongho ^a   Lee, Young Han ^a  

^a Konkuk University   (South Korea)

^b Dongduk Women's University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,5 DIMETHOXYPHENYL) 1 (2 METHOXYPHENYL)PROP 2 EN 1 ONE; ANTINEOPLASTIC AGENT; CASPASE; DPP 23; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 3-(3,5-DIMETHOXYPHENYL)-1-(2-METHOXYPHENYL)PROP-2-EN-1-ONE; CHALCONE DERIVATIVE; MESSENGER RNA; POLYPHENOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL KILLING; CELL PROLIFERATION; CLONOGENESIS; CONTROLLED STUDY; DNA MICROARRAY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR VOLUME; UNFOLDED PROTEIN RESPONSE; ANIMAL; BAGG ALBINO MOUSE; CELL CYCLE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; NEOPLASMS; NUDE MOUSE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CHALCONES; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASMS; POLYPHENOLS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; UNFOLDED PROTEIN RESPONSE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905989347     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0424     Document Type: Article

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