The N-terminal domain allosterically regulates cleavage and activation of the epthelial sodium channel

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 23029-23042

  Kota, Pradeep ^a   Buchner, Ginka ^b   Chakraborty, Hirak ^a,e   Dang, Yan L ^a   He, Hong ^a   Garcia, Guilherme J M ^d   Kubelka, Jan ^c   Gentzsch, Martina ^a   Stutts, M Jackson ^a   Dokholyan, Nikolay V ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF WYOMING   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL MEMBRANES; CHEMICAL ACTIVATION; ELECTROPHYSIOLOGY; PHOSPHOLIPIDS;

ALLOSTERIC MECHANISMS; ENDOPROTEOLYTIC CLEAVAGE; EPITHELIAL SODIUM CHANNELS; EXPERIMENTAL TECHNIQUES; EXTRACELLULAR DOMAINS; INTRACELLULAR SIGNALING; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; STRUCTURAL TRANSITIONS;

ENZYME ACTIVITY;

EPITHELIAL SODIUM CHANNEL; GAMMA EPITHELIAL SODIUM CHANNEL; LYSINE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TYROSINE; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; BINDING SITE; BIOPHYSICS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FLUORESCENCE SPECTROSCOPY; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RAT; ANIMAL; CHEMISTRY; GENETICS; MUTATION; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; ANIMALS; EPITHELIAL SODIUM CHANNELS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RATS;

EID: 84905986076     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.570952     Document Type: Article

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