A coding IRAK2 protein variant compromises toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

Journal of Biological Chemistry

Volumn 289, Issue 33, 2014, Pages 23123-23131

  Wang, Hui ^a,m   Flannery, Sinead M ^b   Dickhof̈er, Sabine ^a   Huhn, Stefanie ^c   George, Julie ^a,n   Kubarenko, Andriy V ^a,o   Lascorz, Jesus ^c   Bevier, Melanie ^c   Willemsen, Joschka ^d   Pichulik, Tica ^a   Schafmayer, Clemens ^e,f   Binder, Marco ^d   Manoury, Béńedicte ^g   Paludan, Søren R ^h   Alarcon Riquelme, Marta ^i,j,k   Bowie, Andrew G ^b   For̈sti, Asta ^c,l   Weber, Alexander N R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^f UNIVERSITY OF KIEL   (Germany)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h AARHUS UNIVERSITY   (Denmark)

ⁱ PTS Granada   (Spain)

^j OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^k European Science Foundation   (France)

^l LUND UNIVERSITY   (Sweden)

^m NANJING MEDICAL UNIVERSITY   (China)

ⁿ UNIVERSITY OF COLOGNE   (Germany)

^o UNIVERSITY HOSPITAL BONN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; SIGNAL TRANSDUCTION;

BACTERIAL INFECTIONS; COLORECTAL CANCER; INNATE IMMUNES; PROTEIN VARIANTS; SIGNALING PATHWAYS; THERAPEUTIC INTERVENTION; TOLL-LIKE RECEPTORS; UBIQUITINATION;

INTERFERONS;

ARGININE; GLYCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; TUMOR MARKER; TUMOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CANCER SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNICITY; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HYDROGEN BOND; IMMUNOPRECIPITATION; INNATE IMMUNITY; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; UBIQUITINATION; AMINO ACID SUBSTITUTION; ANIMAL; COLORECTAL TUMOR; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MISSENSE MUTATION; PATHOLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; COLORECTAL NEOPLASMS; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; NEOPLASM PROTEINS; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84905981869     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.492934     Document Type: Article

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