Human interleukin-1 receptor-associated kinase-2 is essential for toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor α

Journal of Biological Chemistry

Volumn 286, Issue 27, 2011, Pages 23688-23697

  Flannery, Sinead M ^a   Keating, Sinead E ^a   Szymak, Joanna ^a   Bowie, Andrew G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE PRODUCTION; HUMAN CELLS; HUMAN PERIPHERAL BLOOD; IMMUNE RESPONSE; INTERLEUKIN-1; INTRACELLULAR SIGNALING PATHWAYS; MRNA STABILITY; POST-TRANSCRIPTIONAL; POST-TRANSCRIPTIONAL REGULATIONS; SPLICE VARIANTS; TLR SIGNALING; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTORS;

GENES; INTERFERONS; MAMMALS; SIGNALING; TRANSCRIPTION; TRANSCRIPTION FACTORS;

ENZYMES;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE SILENCING; HUMAN; HUMAN CELL; MOLECULAR STABILITY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LEUKOCYTES, MONONUCLEAR; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; NF-KAPPA B; RNA STABILITY; RNA, MESSENGER; SPECIES SPECIFICITY; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 8; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; MUS;

EID: 79959869346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.248351     Document Type: Article

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