Endothelial cell oxidative stress in diabetes: A key driver of cardiovascular complications?

Biochemical Society Transactions

Volumn 42, Issue 4, 2014, Pages 928-933

  Shaw, Andrew ^a   Doherty, Mary K ^a   Mutch, Nicola J ^b   MacRury, Sandra M ^a   Megson, Ian L ^a  

^a UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Cardiovascular disease; Diabetes; Endothelial cell; Glucose; Oxidative stress

Indexed keywords

GLUCOSE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL AGING; CELL VIABILITY; CONFERENCE PAPER; DIABETES MELLITUS; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY FUNCTION; SENESCENCE; ANIMAL; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; CARDIOVASCULAR DISEASES; CELL AGING; DIABETES COMPLICATIONS; ENDOTHELIUM, VASCULAR; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84905842958     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140113     Document Type: Conference Paper

References (53)

1. Zimmet, P., Alberti, K. and Shaw, J. (2001) Global and societal implications of the diabetes epidemic. Nature 414, 782-787
2. International Diabetes Federation (2012) IDF Diabetes Atlas, 6th edn, International Diabetes Federation, Brussels, (http://www.idf.org/ diabetesatlas) 3 Stumvoll, M., Goldstein, B.J. and van Haeften, T.W. (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365, 1333-1346
3. Ceriello, A. and Motz, E. (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler. Thromb. Vasc. Biol. 24, 816-823
4. Brownlee, M. (2005) The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615-1625
5. Morrish, N.J., Wang, S.L., Stevens, L.K., Fuller, J.H. and Keen, H. (2001) Mortality and causes of death in the WHO multinational study of vascular disease in diabetes. Diabetologia 44, S14-S21
6. Seufert, J. (2011) Addressing glycaemic variation. Br. J. Diabetes Vasc. Dis. 11, S2-S5
7. Temelkova-Kurktschiev, T.S., Koehler, C., Henkel, E., Leonhardt, W., Fuecker, K. and Hanefeld, M. (2000) Postchallenge plasma glucose and glycemic spikes are more strongly associated with atherosclerosis than fasting glucose or HbA1c level. Diabetes Care 23, 1830-1834
8. Su, G., Mi, S.H., Tao, H., Li, Z., Yang, H.X., Zheng, H., Zhou, Y. and Ma, C.S. (2011) Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes. Cardiovasc. Diabetol. 10, 9
9. Monnier, L., Mas, E., Ginet, C., Michel, F., Villon, L., Cristol, J.P. and Colette, C. (2006) Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295, 1681-1687
10. Hu, Y.M., Liu, W., Huang, R. and Zhang, X.Y. (2010) Postchallenge plasma glucose excursions, carotid intima-media thickness, and risk factors for atherosclerosis in Chinese population with type 2 diabetes. Atherosclerosis 210, 302-306
11. Quagliaro, L., Piconi, L., Assaloni, R., Martinelli, L., Motz, E. and Ceriello, A. (2003) Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cell. The role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 52, 2795-2804
12. El-Osta, A., Brasacchio, D., Yao, D.C., Pocai, A., Jones, P.L., Roeder, R.G., Cooper, M.E. and Brownlee, M. (2008) Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med. 205, 2409-2417
13. Ge, Q.M., Dong, Y., Zhang, H.M. and Su, Q. (2010) Effects of intermittent high glucose on oxidative stress in endothelial cells. Acta Diabetologica 47, S97-S103
14. Sun, J.Z., Xu, Y.C., Sun, S.X., Sun, Y.L. and Wang, X. (2010) Intermittent high glucose enhances cell proliferation and VEGF expression in retinal endothelial cells: the role of mitochondrial reactive oxygen species. Mol. Cell. Biochem. 343, 27-35
15. Chen, G., Chen, Y.F., Chen, H.F., Li, L.T., Yao, J., Jiang, Q.Q., Lin, X., Wen, J.P. and Lin, L.X. (2011) The effect of NF-κB pathway on proliferation and apoptosis of human umbilical vein endothelial cells induced by intermittent high glucose. Mol. Cell. Biochem. 347, 127-133
16. Yang, L.B., Qi, W.B., Lv, X.H., Feng, Y.L. and Zhang, T. (2011) Intermittent high glucose promotes expression of proinflammatory cytokines in monocytes. Inflamm. Res. 60, 367-370
17. Rakipovski, G., Raun, K. and Lykkesfeldt, J. (2011) Fluctuating hyperglycaemia increases oxidative stress response in lean rats compared to sustained hyperglycaemia despite lower glycaemic exposure. Diabetes Vasc. Dis. Res. 8, 295-298
18. Bartnik, M., Norhammar, A. and Ryden, L. (2007) Hyperglycaemia and cardiovascular disease. J. Int. Med. 262, 145-156
19. Minamino, T. and Komuro, I. (2007) Vascular cell senescence: contribution to atherosclerosis. Circ. Res. 100, 15-26
20. Beckman, J.A., Creager, M.A. and Libby, P. (2002) Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 287, 2570-2581
21. Zilversmit, D.B. (1979) Atherogenesis: postprandial phenomenon. Circulation 60, 473-485
22. Le Brocq, M., Leslie, S.J., Milliken, P. and Megson, I.L. (2008) Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities. Antioxid. Redox Signal. 10, 1631-1673
23. Droge, W. (2002) Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95
24. Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T.D., Mazur, M. and Telser, J. (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39, 44-84
25. Cadenas, E. and Davies, K.J. A. (2000) Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29, 222-230
26. Turrens, J.F. (2003) Mitochondrial formation of reactive oxygen species. J. Physiol. 552, 335-344
27. Yu, E., Mercer, J. and Bennett, M. (2012) Mitochondria in vascular disease. Cardiovasc. Res. 95, 173-182
28. Mann, G.E., Yudilevich, D.L. and Sobrevia, L. (2003) Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. Physiol. Rev. 83, 183-252
29. Carruthers, A. (1990) Facilitated diffusion of glucose. Physiol. Rev. 70, 1135-1176
30. Mueckler, M. (1994) Facilitative glucose transporters. Eur. J. Biochem. 219, 713-725
31. Artwohl, M., Brunmair, B., Furnsinn, C., Holzenbein, T., Rainer, G., Freudenthaler, A., Porod, E.M., Huttary, N. and Baumgartner-Parzer, S.M. (2007) Insulin does not regulate glucose transport and metabolism in human endothelium. Eur. J. Clin. Invest. 37, 643-650
32. Martel, F. and Keating, E. (2009) Vascular glucose transport and the metabolic syndrome. In Oxidative Stress, Inflammation and Angiogenesis in the Metabolic Syndrome (Soares, R. and Costa, C., eds), pp. 123-146, Springer, Dordrecht
33. Alpert, E., Gruzman, A., Riahi, Y., Blejter, R., Aharoni, P., Weisinger, G., Eckel, J., Kaiser, N. and Sasson, S. (2005) Delayed autoregulation of glucose transport in vascular endothelial cells. Diabetologia 48, 752-755
34. Kaiser, N., Sasson, S., Feener, E.P., Boukobzavardi, N., Higashi, S., Moller, D.E., Davidheiser, S., Przybylski, R.J. and King, G.L. (1993) differential regulation of glucose-transport and transporters by glucose in vascular endothelial and smooth-muscle cells. Diabetes 42, 80-89
35. Sasson, S., Gorowits, N., Joost, H.G., King, G.L., Cerasi, E. and Kaiser, N. (1996) Regulation by metformin of the hexose transport system in vascular endothelial and smooth muscle cells. Br. J. Pharmacol. 117, 1318-1324
36. Krutzfeldt, A., Spahr, R., Mertens, S., Siegmund, B. and Piper, H.M. (1990) Metabolism of exogenous substrates by coronary endothelial-cells in culture. J. Mol. Cell. Cardiol. 22, 1393-1404
37. Peters, K., Kamp, G., Berz, A., Unger, R.E., Barth, S., Salamon, A., Rychly, J. and Kirkpatrick, C.J. (2009) Changes in human endothelial cell energy metabolic capacities during in vitro cultivation. The role of "aerobic glycolysis" and proliferation. Cell. Physiol.Biochem. 24, 483-492
38. Fernandes, R., Hosoya, K. and Pereira, P. (2011) Reactive oxygen species downregulate glucose transport system in retinal endothelial cells. Am. J. Physiol. Cell Physiol. 300, C927-C936
39. Paik, J.Y., Lee, K.H., Ko, B.H., Choe, Y.S., Choi, Y. and Kim, B.T. (2005) Nitric oxide stimulates F-18-FDG uptake in human endothelial cells through increased hexokinase activity and GLUT1 expression. J. Nucl. Med. 46, 365-370
40. Popov, D. (2010) Endothelial cell dysfunction in hyperglycemia: Phenotypic change, intracellular signaling modification, ultrastructural alteration, and potential clinical outcomes. Int. J. Diabetes Mellitus 2, 189-195
41. Baumgartnerparzer, S.M., Wagner, L., Pettermann, M., Grillari, J., Gessl, A. and Waldhausl, W. (1995) High-glucose-triggered apoptosis in cultured endothelial-cells. Diabetes 44, 1323-1327
42. Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H. and Ogihara, T. (2006) Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. Diabetes 55, 1660-1665
43. Brownlee, M. (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414, 813-820
44. Nishikawa, T., Edelstein, D., Du, X.L., Yamagishi, S., Matsumura, T., Kaneda, Y., Yorek, M.A., Beebe, D., Oates, P.J., Hammes, H.P. et al. (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404, 787-790
45. Schisano, B., Tripathi, G., McGee, K., McTernan, P.G. and Ceriello, A. (2011) Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia 54, 1219-1226
46. Quijano, C., Castro, L., Peluffo, G., Valez, V. and Radi, R. (2007) Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 293, H3404-H3414
47. Brandes, R.P. and Kreuzer, J. (2005) Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc. Res. 65, 16-27
48. Dikalov, S. (2011) Cross talk between mitochondria and NADPH oxidases. Free Radic. Biol. Med. 51, 1289-1301
49. Sweet, I.R., Gilbert, M., Maloney, E., Hockenbery, D.M., Schwartz, M.W. and Kim, F. (2009) Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration. Diabetologia 52, 921-931
50. Fink, B.D., Herlein, J.A., O'Malley, Y. and Sivitz, W.I. (2012) Endothelial cell and platelet bioenergetics: effect of glucose and nutrient composition. PLoS ONE 7, 12
51. Suzuki, K., Olah, G., Modis, K., Coletta, C., Kulp, G., Gero, D., Szoleczky, P., Chang, T., Zhou, Z., Wu, L. et al. (2011) Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc. Natl. Acad. Sci. U.S.A. 108, 13829-13834
52. Dranka, B.P., Hill, B.G. and Darley-Usmar, V.M. (2010) Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species. Free Radic. Biol. Med. 48, 905-914
53. Lunt, S.Y. and Vander Heiden, M.G. (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell. Dev. Biol, 27, 441-464