Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration

Diabetologia

Volumn 52, Issue 5, 2009, Pages 921-931

  Sweet, I R ^a   Gilbert, M ^a   Maloney, E ^a   Hockenbery, D M ^b   Schwartz, M W ^a   Kim, F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Glucose 6 phosphate; Human microvascular endothelial cells; Hyperglycaemia; I B ; IKK ; Inflammation; Lactate production; Mitochondrial stress; NF B; Oxygen consumption

Indexed keywords

CARBON DIOXIDE; GLUCOSE 6 PHOSPHATASE; GLYCOLYTIC ENZYME; I KAPPA B ALPHA; LACTIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AEROBIC METABOLISM; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENDOTHELIUM CELL; ENZYME SUBSTRATE; GLUCONEOGENESIS; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; INFLAMMATION; INSULIN RESISTANCE; MICROVASCULATURE; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GLUCOSE; GLUCOSE-6-PHOSPHATE; HUMANS; HYPERGLYCEMIA; INFLAMMATION; INTERLEUKIN-6; KINETICS; MICROCIRCULATION; MITOCHONDRIA; OXYGEN CONSUMPTION;

EID: 64149104209     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1272-4     Document Type: Article

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